当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

Enterobacteria-secreted particles induce production of exosome-like S1P-containing particles by intestinal epithelium to drive Th17-mediated tumorigenesis.

Abstract：

:Gut-associated inflammation plays a crucial role in the progression of colon cancer. Here, we identify a novel pathogen-host interaction that promotes gut inflammation and the development of colon cancer. We find that enteropathogenic bacteria-secreted particles (ET-BSPs) stimulate intestinal epithelium to produce IDENs (intestinal mucosa-derived exosome-like nanoparticles) containing elevated levels of sphingosine-1-phosphate, CCL20 and prostaglandin E2 (PGE2). CCL20 and PGE2 are required for the recruitment and proliferation, respectively, of Th17 cells, and these processes also involve the MyD88-mediated pathway. By influencing the recruitment and proliferation of Th17 cells in the intestine, IDENs promote colon cancer. We demonstrate the biological effect of sphingosine-1-phosphate contained in IDENs on tumour growth in spontaneous and transplanted colon cancer mouse models. These findings provide deeper insights into how host-microbe relationships are mediated by particles secreted from both bacterial and host cells.

journal_name

Nat Commun

journal_title

Nature communications

authors

Deng Z,Mu J,Tseng M,Wattenberg B,Zhuang X,Egilmez NK,Wang Q,Zhang L,Norris J,Guo H,Yan J,Haribabu B,Miller D,Zhang HG

doi

10.1038/ncomms7956

subject

Has Abstract

pub_date

2015-04-24 00:00:00

pages

6956

issn

2041-1723

pii

ncomms7956

journal_volume

6

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life.

    abstract：:The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly understood. Conditional inactivation experiments previously demonstrated that expression of the zinc finger transcriptional repressor Blimp1/PRDM1 is essential for the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01971-w

    authors： Elias S,Morgan MA,Bikoff EK,Robertson EJ

    更新日期：2017-11-20 00:00:00

  • Structural basis of ribosomal RNA transcription regulation.

    abstract：:Ribosomal RNA (rRNA) is most highly expressed in rapidly growing bacteria and is drastically downregulated under stress conditions by the global transcriptional regulator DksA and the alarmone ppGpp. Here, we determined cryo-electron microscopy structures of the Escherichia coli RNA polymerase (RNAP) σ70 holoenzyme du...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20776-y

    authors： Shin Y,Qayyum MZ,Pupov D,Esyunina D,Kulbachinskiy A,Murakami KS

    更新日期：2021-01-22 00:00:00

  • Size-dependent kinetics during non-equilibrium lithiation of nano-sized zinc ferrite.

    abstract：:Spinel transition metal oxides (TMOs) have emerged as promising anode materials for lithium-ion batteries. It has been shown that reducing their particle size to nanoscale dimensions benefits overall electrochemical performance. Here, we use in situ transmission electron microscopy to probe the lithiation behavior of ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07831-5

    authors： Li J,Meng Q,Zhang Y,Peng L,Yu G,Marschilok AC,Wu L,Su D,Takeuchi KJ,Takeuchi ES,Zhu Y,Stach EA

    更新日期：2019-01-09 00:00:00

  • Genome-wide macroevolutionary signatures of key innovations in butterflies colonizing new host plants.

    abstract：:The mega-diversity of herbivorous insects is attributed to their co-evolutionary associations with plants. Despite abundant studies on insect-plant interactions, we do not know whether host-plant shifts have impacted both genomic adaptation and species diversification over geological times. We show that the antagonist...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20507-3

    authors： Allio R,Nabholz B,Wanke S,Chomicki G,Pérez-Escobar OA,Cotton AM,Clamens AL,Kergoat GJ,Sperling FAH,Condamine FL

    更新日期：2021-01-13 00:00:00

  • High-performance p-channel transistors with transparent Zn doped-CuI.

    abstract：:'Ideal' transparent p-type semiconductors are required for the integration of high-performance thin-film transistors (TFTs) and circuits. Although CuI has recently attracted attention owing to its excellent opto-electrical properties, solution processability, and low-temperature synthesis, the uncontrolled copper vaca...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18006-6

    authors： Liu A,Zhu H,Park WT,Kim SJ,Kim H,Kim MG,Noh YY

    更新日期：2020-08-27 00:00:00

  • Were changes in stress state responsible for the 2019 Ridgecrest, California, earthquakes?

    abstract：:Monitoring the Earth's stress state plays a role in our understanding of an earthquake's mechanism and in the distribution of hazards. Crustal deformation due to the July 2019 earthquake sequence in Ridgecrest (California) that culminated in a preceding quake of magnitude (M) 6.4 and a subsequent M7.1 quake caused str...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16867-5

    authors： Nanjo KZ

    更新日期：2020-06-17 00:00:00

  • Rheb activation disrupts spine synapse formation through accumulation of syntenin in tuberous sclerosis complex.

    abstract：:Rheb is a small GTP-binding protein and its GTPase activity is activated by the complex of Tsc1 and Tsc2 whose mutations cause tuberous sclerosis complex (TSC). We previously reported that cultured TSC neurons showed impaired spine synapse morphogenesis in an mTORC1-independent manner. Here we show that the PDZ protei...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7842

    authors： Sugiura H,Yasuda S,Katsurabayashi S,Kawano H,Endo K,Takasaki K,Iwasaki K,Ichikawa M,Kobayashi T,Hino O,Yamagata K

    更新日期：2015-04-16 00:00:00

  • Author Correction: Infralimbic cortex is required for learning alternatives to prelimbic promoted associations through reciprocal connectivity.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-11205-w

    authors： Mukherjee A,Caroni P

    更新日期：2019-07-12 00:00:00

  • Thermal transport in phononic crystals and the observation of coherent phonon scattering at room temperature.

    abstract：:Large reductions in the thermal conductivity of thin silicon membranes have been demonstrated in various porous structures. However, the role of coherent boundary scattering in such structures has become a matter of some debate. Here we report on the first experimental observation of coherent phonon boundary scatterin...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8228

    authors： Alaie S,Goettler DF,Su M,Leseman ZC,Reinke CM,El-Kady I

    更新日期：2015-06-24 00:00:00

  • Exploring the ternary interactions in Cu-ZnO-ZrO2 catalysts for efficient CO2 hydrogenation to methanol.

    abstract：:The synergistic interaction among different components in complex catalysts is one of the crucial factors in determining catalytic performance. Here we report the interactions among the three components in controlling the catalytic performance of Cu-ZnO-ZrO2 (CZZ) catalyst for CO2 hydrogenation to methanol. The in sit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09072-6

    authors： Wang Y,Kattel S,Gao W,Li K,Liu P,Chen JG,Wang H

    更新日期：2019-03-11 00:00:00

  • Bimolecular recombination in methylammonium lead triiodide perovskite is an inverse absorption process.

    abstract：:Photovoltaic devices based on metal halide perovskites are rapidly improving in efficiency. Once the Shockley-Queisser limit is reached, charge-carrier extraction will be limited only by radiative bimolecular recombination of electrons with holes. Yet, this fundamental process, and its link with material stoichiometry...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02670-2

    authors： Davies CL,Filip MR,Patel JB,Crothers TW,Verdi C,Wright AD,Milot RL,Giustino F,Johnston MB,Herz LM

    更新日期：2018-01-18 00:00:00

  • Magnon dark modes and gradient memory.

    abstract：:Extensive efforts have been expended in developing hybrid quantum systems to overcome the short coherence time of superconducting circuits by introducing the naturally long-lived spin degree of freedom. Among all the possible materials, single-crystal yttrium iron garnet has shown up recently as a promising candidate ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9914

    authors： Zhang X,Zou CL,Zhu N,Marquardt F,Jiang L,Tang HX

    更新日期：2015-11-16 00:00:00

  • Broadband multi-magnon relaxometry using a quantum spin sensor for high frequency ferromagnetic dynamics sensing.

    abstract：:Development of sensitive local probes of magnon dynamics is essential to further understand the physical processes that govern magnon generation, propagation, scattering, and relaxation. Quantum spin sensors like the NV center in diamond have long spin lifetimes and their relaxation can be used to sense magnetic field...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19121-0

    authors： McCullian BA,Thabt AM,Gray BA,Melendez AL,Wolf MS,Safonov VL,Pelekhov DV,Bhallamudi VP,Page MR,Hammel PC

    更新日期：2020-10-16 00:00:00

  • Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.

    abstract：:Glucocorticoids are among the most commonly used anti-inflammatory agents. Despite the enormous efforts in elucidating the glucocorticoid-mediated anti-inflammatory actions, how glucocorticoids tightly control overactive inflammatory response is not fully understood. Here we show that glucocorticoids suppress bacteria...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7062

    authors： Miyata M,Lee JY,Susuki-Miyata S,Wang WY,Xu H,Kai H,Kobayashi KS,Flavell RA,Li JD

    更新日期：2015-01-14 00:00:00

  • Islands contribute disproportionately high amounts of evolutionary diversity in passerine birds.

    abstract：:Island systems generally have fewer species than continental areas due to their small size and geographical isolation. Low island diversity reduces the possibility of exportation of island lineages and island systems are not thought to have a major influence on the build-up of continental diversity. However, the view ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9538

    authors： Jønsson KA,Holt BG

    更新日期：2015-10-05 00:00:00

  • Ranking of non-coding pathogenic variants and putative essential regions of the human genome.

    abstract：:A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be determinants of critical functions. Here we train a machine learning model using functional, mutational an...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13212-3

    authors： Wells A,Heckerman D,Torkamani A,Yin L,Sebat J,Ren B,Telenti A,di Iulio J

    更新日期：2019-11-20 00:00:00

  • The late stage of COPI vesicle fission requires shorter forms of phosphatidic acid and diacylglycerol.

    abstract：:Studies on vesicle formation by the Coat Protein I (COPI) complex have contributed to a basic understanding of how vesicular transport is initiated. Phosphatidic acid (PA) and diacylglycerol (DAG) have been found previously to be required for the fission stage of COPI vesicle formation. Here, we find that PA with vary...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11324-4

    authors： Park SY,Yang JS,Li Z,Deng P,Zhu X,Young D,Ericsson M,Andringa RLH,Minnaard AJ,Zhu C,Sun F,Moody DB,Morris AJ,Fan J,Hsu VW

    更新日期：2019-07-30 00:00:00

  • Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-020-15793-w

    authors： Hayes MG,Urbanek M,Ehrmann DA,Armstrong LL,Lee JY,Sisk R,Karaderi T,Barber TM,McCarthy MI,Franks S,Lindgren CM,Welt CK,Diamanti-Kandarakis E,Panidis D,Goodarzi MO,Azziz R,Zhang Y,James RG,Olivier M,Kissebah AH,Rep

    更新日期：2020-04-28 00:00:00

  • Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences.

    abstract：:The turnover of messenger RNAs (mRNAs) is a key regulatory step of gene expression in eukaryotic cells. Due to the complexity of the mammalian degradation machinery, the contribution of decay factors to the directionality of mRNA decay is poorly understood. Here we characterize a molecular tool to interrogate mRNA tur...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13691

    authors： Boehm V,Gerbracht JV,Marx MC,Gehring NH

    更新日期：2016-12-05 00:00:00

  • Magneto-nanosensor platform for probing low-affinity protein-protein interactions and identification of a low-affinity PD-L1/PD-L2 interaction.

    abstract：:Substantial efforts have been made to understand the interactions between immune checkpoint receptors and their ligands targeted in immunotherapies against cancer. To carefully characterize the complete network of interactions involved and the binding affinities between their extracellular domains, an improved kinetic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12220

    authors： Lee JR,Bechstein DJ,Ooi CC,Patel A,Gaster RS,Ng E,Gonzalez LC,Wang SX

    更新日期：2016-07-22 00:00:00

  • Cavity-control of interlayer excitons in van der Waals heterostructures.

    abstract：:Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11620-z

    authors： Förg M,Colombier L,Patel RK,Lindlau J,Mohite AD,Yamaguchi H,Glazov MM,Hunger D,Högele A

    更新日期：2019-08-16 00:00:00

  • High precision epidermal radio frequency antenna via nanofiber network for wireless stretchable multifunction electronics.

    abstract：:Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19367-8

    authors： Zhang Y,Huo Z,Wang X,Han X,Wu W,Wan B,Wang H,Zhai J,Tao J,Pan C,Wang ZL

    更新日期：2020-11-06 00:00:00

  • Photonic zero mode in a non-Hermitian photonic lattice.

    abstract：:Zero-energy particles (such as Majorana fermions) are newly predicted quasiparticles and are expected to play an important role in fault-tolerant quantum computation. In conventional Hermitian quantum systems, however, such zero states are vulnerable and even become vanishing if couplings with surroundings are of the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03822-8

    authors： Pan M,Zhao H,Miao P,Longhi S,Feng L

    更新日期：2018-04-03 00:00:00

  • Author Correction: PQM-1 controls hypoxic survival via regulation of lipid metabolism.

    abstract：:A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19868-6. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-19868-6

    authors： Heimbucher T,Hog J,Gupta P,Murphy CT

    更新日期：2020-11-20 00:00:00

  • Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.

    abstract：:Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090G, located near NFKB1, on astrocytes. We demonst...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07785-8

    authors： Ponath G,Lincoln MR,Levine-Ritterman M,Park C,Dahlawi S,Mubarak M,Sumida T,Airas L,Zhang S,Isitan C,Nguyen TD,Raine CS,Hafler DA,Pitt D

    更新日期：2018-12-17 00:00:00

  • C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.

    abstract：:Controlled macrophage differentiation and activation in the initiation and resolution of inflammation is crucial for averting progression to chronic inflammatory and autoimmune diseases. Here we show a negative feedback mechanism for proinflammatory IFN-γ activation of macrophages driven by macrophage-associated matri...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04717-4

    authors： Dufour A,Bellac CL,Eckhard U,Solis N,Klein T,Kappelhoff R,Fortelny N,Jobin P,Rozmus J,Mark J,Pavlidis P,Dive V,Barbour SJ,Overall CM

    更新日期：2018-06-20 00:00:00

  • Nanoscale determination of the mass enhancement factor in the lightly doped bulk insulator lead selenide.

    abstract：:Bismuth chalcogenides and lead telluride/selenide alloys exhibit exceptional thermoelectric properties that could be harnessed for power generation and device applications. Since phonons play a significant role in achieving these desired properties, quantifying the interaction between phonons and electrons, which is e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7559

    authors： Zeljkovic I,Scipioni KL,Walkup D,Okada Y,Zhou W,Sankar R,Chang G,Wang YJ,Lin H,Bansil A,Chou F,Wang Z,Madhavan V

    更新日期：2015-03-27 00:00:00

  • Consistent population declines but idiosyncratic range shifts in Alpine orchids under global change.

    abstract：:Mountains are plant biodiversity hotspots considered particularly vulnerable to multiple environmental changes. Here, we quantify population changes and range-shift dynamics along elevational gradients over the last three decades for c. two-thirds of the orchid species of the European Alps. Local extinctions were more...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19680-2

    authors： Geppert C,Perazza G,Wilson RJ,Bertolli A,Prosser F,Melchiori G,Marini L

    更新日期：2020-11-17 00:00:00

  • Author Correction: High permeability sub-nanometre sieve composite MoS2 membranes.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-020-17422-y

    authors： Sapkota B,Liang W,VahidMohammadi A,Karnik R,Noy A,Wanunu M

    更新日期：2020-07-21 00:00:00

  • Diversity-oriented synthetic strategy for developing a chemical modulator of protein-protein interaction.

    abstract：:Diversity-oriented synthesis (DOS) can provide a collection of diverse and complex drug-like small molecules, which is critical in the development of new chemical probes for biological research of undruggable targets. However, the design and synthesis of small-molecule libraries with improved biological relevance as w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13196

    authors： Kim J,Jung J,Koo J,Cho W,Lee WS,Kim C,Park W,Park SB

    更新日期：2016-10-24 00:00:00