Fluctuations between multiple EF-G-induced chimeric tRNA states during translocation on the ribosome.

abstract：:The negative phase of the Interdecadal Pacific Oscillation (IPO), a dominant mode of multi-decadal variability of sea surface temperatures (SSTs) in the Pacific, contributed to the reduced rate of global surface temperature warming in the early 2000s. A proposed mechanism for IPO multidecadal variability indicates tha...

journal_title：Nature communications

authors： Meehl GA,Hu A,Teng H

更新日期：2016-06-02 00:00:00

abstract：:Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...

journal_title：Nature communications

authors： Fraley SI,Feng Y,Giri A,Longmore GD,Wirtz D

更新日期：2012-03-06 00:00:00

abstract：:Recent advances in nonlinear optics have revolutionized integrated photonics, providing on-chip solutions to a wide range of new applications. Currently, state of the art integrated nonlinear photonic devices are mainly based on dielectric material platforms, such as Si3N4 and SiO2. While semiconductor materials featu...

journal_title：Nature communications

authors： Chang L,Xie W,Shu H,Yang QF,Shen B,Boes A,Peters JD,Jin W,Xiang C,Liu S,Moille G,Yu SP,Wang X,Srinivasan K,Papp SB,Vahala K,Bowers JE

更新日期：2020-03-12 00:00:00

abstract：:Though the concept of Berry force was proposed thirty years ago, little is known about the practical consequences of this force as far as chemical dynamics are concerned. Here, we report that when molecular dynamics pass near a conical intersection, a massive Berry force can appear as a result of even a small amount o...

journal_title：Nature communications

authors： Wu Y,Subotnik JE

更新日期：2021-01-29 00:00:00

abstract：:Observing the crucial first few femtoseconds of photochemical reactions requires tools typically not available in the femtochemistry toolkit. Such dynamics are now within reach with the instruments provided by attosecond science. Here, we apply experimental and theoretical methods to assess the ultrafast nonadiabatic ...

journal_title：Nature communications

authors： Galbraith MCE,Scheit S,Golubev NV,Reitsma G,Zhavoronkov N,Despré V,Lépine F,Kuleff AI,Vrakking MJJ,Kornilov O,Köppel H,Mikosch J

更新日期：2017-10-18 00:00:00

abstract：:Biodiversity-ecosystem functioning (BEF) experiments have shown that local species richness promotes ecosystem functioning and stability. Whether this also applies under real-world conditions is still debated. Here, we focus on larger scales of space, time and ecological organization. We develop a quasi-experimental d...

journal_title：Nature communications

authors： Oehri J,Schmid B,Schaepman-Strub G,Niklaus PA

更新日期：2020-01-09 00:00:00

abstract：:Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...

journal_title：Nature communications

authors： Jiang H,Zhou C,Zhang Z,Wang Q,Wei H,Shi W,Li J,Wang Z,Ou Y,Wang W,Wang H,Zhang Q,Sun W,Sun P,Yang S

更新日期：2020-10-12 00:00:00

abstract：:Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. The mPFC contains multiple types of pyramidal cells, but it is unclear whether a particular subtype mediates th...

journal_title：Nature communications

authors： Hare BD,Shinohara R,Liu RJ,Pothula S,DiLeone RJ,Duman RS

更新日期：2019-01-15 00:00:00

abstract：:Dimensionality reduction is often used to visualize complex expression profiling data. Here, we use the Uniform Manifold Approximation and Projection (UMAP) method on published transcript profiles of 1484 single gene deletions of Saccharomyces cerevisiae. Proximity in low-dimensional UMAP space identifies groups of ge...

journal_title：Nature communications

authors： Dorrity MW,Saunders LM,Queitsch C,Fields S,Trapnell C

更新日期：2020-03-24 00:00:00

abstract：:Orai channels are required for store-operated Ca(2+) entry (SOCE) in multiple cell types. Septins are a class of GTP-binding proteins that function as diffusion barriers in cells. Here we show that Septin 7 acts as a 'molecular brake' on activation of Orai channels in Drosophila neurons. Lowering Septin 7 levels resul...

journal_title：Nature communications

authors： Deb BK,Pathak T,Hasan G

更新日期：2016-05-26 00:00:00

abstract：:Epilepsy is a common brain disorder throughout history. Epilepsy-related ligand-receptor complex, LGI1-ADAM22, regulates synaptic transmission and has emerged as a determinant of brain excitability, as their mutations and acquired LGI1 autoantibodies cause epileptic disorders in human. Here, we report the crystal stru...

journal_title：Nature communications

authors： Yamagata A,Miyazaki Y,Yokoi N,Shigematsu H,Sato Y,Goto-Ito S,Maeda A,Goto T,Sanbo M,Hirabayashi M,Shirouzu M,Fukata Y,Fukata M,Fukai S

更新日期：2018-04-18 00:00:00

abstract：:Since the pioneering proposal of the replicon model of DNA replication 50 years ago, the predicted replicons have not been identified and quantified at the cellular level. Here, we combine conventional and super-resolution microscopy of replication sites in live and fixed cells with computational image analysis. We co...

journal_title：Nature communications

authors： Chagin VO,Casas-Delucchi CS,Reinhart M,Schermelleh L,Markaki Y,Maiser A,Bolius JJ,Bensimon A,Fillies M,Domaing P,Rozanov YM,Leonhardt H,Cardoso MC

更新日期：2016-04-07 00:00:00

abstract：:The emergence of antibiotic resistant bacteria is a major threat to the practice of modern medicine. Photobactericidal agents have obtained significant attention as promising candidates to kill bacteria, and they have been extensively studied. However, to obtain photobactericidal activity, an intense white light sourc...

journal_title：Nature communications

authors： Hwang GB,Huang H,Wu G,Shin J,Kafizas A,Karu K,Toit HD,Alotaibi AM,Mohammad-Hadi L,Allan E,MacRobert AJ,Gavriilidis A,Parkin IP

更新日期：2020-03-05 00:00:00

abstract：:Ferromagnetism is usually deemed incompatible with superconductivity. Consequently, the coexistence of superconductivity and ferromagnetism is usually observed only in elegantly designed multi-ingredient structures in which the two competing electronic states originate from separate structural components. Here we repo...

journal_title：Nature communications

authors： Zhu X,Guo Y,Cheng H,Dai J,An X,Zhao J,Tian K,Wei S,Cheng Zeng X,Wu C,Xie Y

更新日期：2016-04-04 00:00:00

abstract：:Zika virus (ZIKV) is an emerging mosquito borne flavivirus and a major public health concern causing severe disease. Due to the presence of a lipid membrane and structural heterogeneity, attaining an atomic resolution structure is challenging, but important to understand virus assembly and life cycle mechanisms that o...

journal_title：Nature communications

authors： DiNunno NM,Goetschius DJ,Narayanan A,Majowicz SA,Moustafa I,Bator CM,Hafenstein SL,Jose J

更新日期：2020-10-02 00:00:00

abstract：:Perovskite light-emitting diodes (LEDs) are attracting great attention due to their efficient and narrow emission. Quasi-two-dimensional perovskites with Ruddlesden-Popper-type layered structures can enlarge exciton binding energy and confine charge carriers and are considered good candidate materials for efficient LE...

journal_title：Nature communications

authors： Yang X,Zhang X,Deng J,Chu Z,Jiang Q,Meng J,Wang P,Zhang L,Yin Z,You J

更新日期：2018-02-08 00:00:00

abstract：:The cycling of iron and organic matter (OM) is thought to have been a major biogeochemical cycle in the early ferruginous oceans which contributed to the deposition of banded iron formations (BIF). However, BIF are deficient in OM, which is postulated to be the result of near-complete oxidation of OM during iron reduc...

journal_title：Nature communications

authors： Dodd MS,Papineau D,Pirajno F,Wan Y,Karhu JA

更新日期：2019-11-04 00:00:00

abstract：:Here we present a new approach to diffraction imaging of amyloid fibrils, combining a free-standing graphene support and single nanofocused X-ray pulses of femtosecond duration from an X-ray free-electron laser. Due to the very low background scattering from the graphene support and mutual alignment of filaments, diff...

journal_title：Nature communications

authors： Seuring C,Ayyer K,Filippaki E,Barthelmess M,Longchamp JN,Ringler P,Pardini T,Wojtas DH,Coleman MA,Dörner K,Fuglerud S,Hammarin G,Habenstein B,Langkilde AE,Loquet A,Meents A,Riek R,Stahlberg H,Boutet S,Hunter MS,Ko

更新日期：2018-05-09 00:00:00

abstract：:The assembly of actin filaments into distinct cytoskeletal structures plays a critical role in cell physiology, but how proteins localize differentially to these structures within a shared cytoplasm remains unclear. Here, we show that the actin-binding domains of accessory proteins can be sensitive to filament conform...

journal_title：Nature communications

authors： Harris AR,Jreij P,Belardi B,Joffe AM,Bausch AR,Fletcher DA

更新日期：2020-11-25 00:00:00

abstract：:Gap junction channels mediate intercellular signalling that is crucial in tissue development, homeostasis and pathologic states such as cardiac arrhythmias, cancer and trauma. To explore the mechanism by which Ca(2+) blocks intercellular communication during tissue injury, we determined the X-ray crystal structures of...

journal_title：Nature communications

authors： Bennett BC,Purdy MD,Baker KA,Acharya C,McIntire WE,Stevens RC,Zhang Q,Harris AL,Abagyan R,Yeager M

更新日期：2016-01-12 00:00:00

abstract：:Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and subsequent characterization of heterogeneous expression of ASIC3 in the dorsal root ganglion (DRG). ASIC3 is ...

journal_title：Nature communications

authors： Lin SH,Cheng YR,Banks RW,Min MY,Bewick GS,Chen CC

更新日期：2016-05-10 00:00:00

abstract：:Nacre-mimetics hold great promise as mechanical high-performance and functional materials. Here we demonstrate large progress of mechanical and functional properties of self-assembled polymer/nanoclay nacre-mimetics by using synthetic nanoclays with aspect ratios covering three orders in magnitude (25-3,500). We estab...

journal_title：Nature communications

authors： Das P,Malho JM,Rahimi K,Schacher FH,Wang B,Demco DE,Walther A

更新日期：2015-01-20 00:00:00

abstract：:Semiconductor-based surface-enhanced Raman spectroscopy (SERS) substrates represent a new frontier in the field of SERS. However, the application of semiconductor materials as SERS substrates is still seriously impeded by their low SERS enhancement and inferior detection sensitivity, especially for non-metal-oxide sem...

journal_title：Nature communications

authors： Zheng Z,Cong S,Gong W,Xuan J,Li G,Lu W,Geng F,Zhao Z

更新日期：2017-12-08 00:00:00

abstract：:The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the longitudinal axis of the adult human hippocampus can be predicted within 2...

journal_title：Nature communications

authors： Vogel JW,La Joie R,Grothe MJ,Diaz-Papkovich A,Doyle A,Vachon-Presseau E,Lepage C,Vos de Wael R,Thomas RA,Iturria-Medina Y,Bernhardt B,Rabinovici GD,Evans AC

更新日期：2020-02-19 00:00:00

abstract：:Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-chain fatty acids (...

journal_title：Nature communications

authors： Coutzac C,Jouniaux JM,Paci A,Schmidt J,Mallardo D,Seck A,Asvatourian V,Cassard L,Saulnier P,Lacroix L,Woerther PL,Vozy A,Naigeon M,Nebot-Bral L,Desbois M,Simeone E,Mateus C,Boselli L,Grivel J,Soularue E,Lepage P,

更新日期：2020-05-01 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:Coordination of outer membrane constriction with septation is critical to faithful division in Gram-negative bacteria and vital to the barrier function of the membrane. This coordination requires the recruitment of the peptidoglycan-binding outer-membrane lipoprotein Pal at division sites by the Tol system. Here, we s...

journal_title：Nature communications

authors： Szczepaniak J,Holmes P,Rajasekar K,Kaminska R,Samsudin F,Inns PG,Rassam P,Khalid S,Murray SM,Redfield C,Kleanthous C

更新日期：2020-03-11 00:00:00

abstract：:Achieving control over the directionality of active colloids is essential for their use in practical applications such as cargo carriers in microfluidic devices. So far, guidance of spherical Janus colloids was mainly realized using specially engineered magnetic multilayer coatings combined with external magnetic fiel...

journal_title：Nature communications

authors： Simmchen J,Katuri J,Uspal WE,Popescu MN,Tasinkevych M,Sánchez S

更新日期：2016-02-09 00:00:00

abstract：:Compartmentalization of the gut microbiota is thought to be important to system function, but the extent of spatial organization in the gut ecosystem remains poorly understood. Here, we profile the murine colonic microbiota along longitudinal and lateral axes using laser capture microdissection. We found fine-scale sp...

journal_title：Nature communications

authors： Riva A,Kuzyk O,Forsberg E,Siuzdak G,Pfann C,Herbold C,Daims H,Loy A,Warth B,Berry D

更新日期：2019-09-25 00:00:00

abstract：:The dominant dipolar component of the Earth's magnetic field has been steadily weakening for at least the last 170 years. Prior to these direct measurements, archaeomagnetic records show short periods of significantly elevated geomagnetic intensity. These striking phenomena are not captured by current field models and...

journal_title：Nature communications

authors： de Groot LV,Biggin AJ,Dekkers MJ,Langereis CG,Herrero-Bervera E

更新日期：2013-01-01 00:00:00