Abstract:
:The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular mechanisms that determine TRPM8 abundance at the plasma membrane. Here we demonstrate constitutive transport of TRPM8 towards the plasma membrane in atypical, non-acidic transport vesicles that contain lysosomal-associated membrane protein 1 (LAMP1), and provide evidence that vesicle-associated membrane protein 7 (VAMP7) mediates fusion of these vesicles with the plasma membrane. In line herewith, VAMP7-deficient mice exhibit reduced functional expression of TRPM8 in sensory neurons and concomitant deficits in cold avoidance and icilin-induced cold hypersensitivity. Our results uncover a cellular pathway that controls functional plasma membrane incorporation of a temperature-sensitive TRP channel, and thus regulates thermosensitivity in vivo.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ghosh D,Pinto S,Danglot L,Vandewauw I,Segal A,Van Ranst N,Benoit M,Janssens A,Vennekens R,Vanden Berghe P,Galli T,Vriens J,Voets Tdoi
10.1038/ncomms10489subject
Has Abstractpub_date
2016-02-04 00:00:00pages
10489issn
2041-1723pii
ncomms10489journal_volume
7pub_type
杂志文章abstract::A major goal of synthetic biology is to reprogram living organisms to solve pressing challenges in manufacturing, environmental remediation, and healthcare. Recombinase devices can efficiently encode complex logic in many species, yet current designs are performed on a case-by-case basis, limiting their scalability an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08391-y
更新日期:2019-01-28 00:00:00
abstract::As a major CO2 sink, the North Atlantic, especially its subpolar gyre region, is essential for the global carbon cycle. Decadal fluctuations of CO2 uptake in the North Atlantic subpolar gyre region are associated with the evolution of the North Atlantic Oscillation, the Atlantic meridional overturning circulation, oce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11076
更新日期:2016-03-30 00:00:00
abstract::BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer drivers, among which ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16936-9
更新日期:2020-06-26 00:00:00
abstract::Under climate warming, migratory birds should align reproduction dates with advancing plant and arthropod phenology. To arrive on the breeding grounds earlier, migrants may speed up spring migration by curtailing the time spent en route, possibly at the cost of decreased survival rates. Based on a decades-long series ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06673-5
更新日期:2018-10-15 00:00:00
abstract::Among various flat optical devices, metasurfaces have presented their great ability in efficient manipulation of light fields and have been proposed for variety of devices with specific functionalities. However, due to the high phase dispersion of their building blocks, metasurfaces significantly suffer from large chr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00166-7
更新日期:2017-08-04 00:00:00
abstract::Activation of innate immunity by membrane-localized receptors is conserved across eukaryotes. Plant genomes contain hundreds of such receptor-like genes and those encoding proteins with an extracellular leucine-rich repeat (LRR) domain represent the largest family. Here, we develop a high-throughput approach to study ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03010-8
更新日期:2018-02-09 00:00:00
abstract::Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely ap...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15762
更新日期:2017-06-13 00:00:00
abstract::It has been postulated that synaptic potentiation during waking is offset by a homoeostatic reduction in net synaptic strength during sleep. However, molecular mechanisms to support such a process are lacking. Here we demonstrate that deficiencies in the RNA-editing gene Adar increase sleep due to synaptic dysfunction...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10512
更新日期:2016-01-27 00:00:00
abstract::The original version of this Article contained an error in the spelling of the author David Bulkley, which was incorrectly given as David Bulkey. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-019-09422-4
更新日期:2019-03-26 00:00:00
abstract::Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8118
更新日期:2015-05-22 00:00:00
abstract::Electron-rich dienes have revolutionized the synthesis of complex compounds since the discovery of the legendary Diels-Alder cycloaddition reaction. This highly efficient bond-forming process has served as a fundamental strategy to assemble many structurally formidable molecules. Amino silyloxy butadienes are arguably...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7913
更新日期:2015-04-21 00:00:00
abstract::Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11451-y
更新日期:2019-08-13 00:00:00
abstract::Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14830
更新日期:2017-04-03 00:00:00
abstract::NLRP3 is a cytosolic sensor triggered by different pathogen- and self-derived signals that plays a central role in a variety of pathological conditions, including sterile inflammation. The leucine-rich repeat domain is present in several innate immune receptors, where it is frequently responsible for sensing danger si...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07573-4
更新日期:2018-12-05 00:00:00
abstract::Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can reco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6683
更新日期:2014-12-16 00:00:00
abstract::Creatine kinase (CK) and lactate dehydrogenase (LDH) are widely used markers of tissue damage. To search for sequence variants influencing serum levels of CK and LDH, 28.3 million sequence variants identified through whole-genome sequencing of 2,636 Icelanders were imputed into 63,159 and 98,585 people with CK and LDH...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10572
更新日期:2016-02-03 00:00:00
abstract::The quantum spin Hall (QSH) phase is an exotic phenomena in condensed-matter physics. Here we show that a minimal basis of three orbitals (s, px, py) is required to produce a QSH phase via nearest-neighbour hopping in a two-dimensional trigonal lattice. Tight-binding model analyses and calculations show that the QSH p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12746
更新日期:2016-09-07 00:00:00
abstract::Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02052-8
更新日期:2017-11-29 00:00:00
abstract::Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08500-x
更新日期:2019-02-06 00:00:00
abstract::Accurate pathogenicity prediction of missense variants is critically important in genetic studies and clinical diagnosis. Previously published prediction methods have facilitated the interpretation of missense variants but have limited performance. Here, we describe MVP (Missense Variant Pathogenicity prediction), a n...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20847-0
更新日期:2021-01-21 00:00:00
abstract::Merons are nontrivial topological spin textures highly relevant for many phenomena in solid state physics. Despite their importance, direct observation of such vortex quasiparticles is scarce and has been limited to a few complex materials. Here, we show the emergence of merons and antimerons in recently discovered tw...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20497-2
更新日期:2021-01-08 00:00:00
abstract::Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis that a gradual dec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7946
更新日期:2015-04-21 00:00:00
abstract::Glucagon promotes hepatic gluconeogenesis and maintains whole-body glucose levels during fasting. The regulatory factors that are involved in fasting glucagon response are not well understood. Here we report a role of p52, a key activator of the noncanonical nuclear factor-kappaB signaling, in hepatic glucagon respons...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12351-x
更新日期:2019-09-20 00:00:00
abstract::The brain identifies potentially salient features within continuous information streams to process hierarchical temporal events. This requires the compression of information streams, for which effective computational principles are yet to be explored. Backpropagating action potentials can induce synaptic plasticity in...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15367-w
更新日期:2020-03-25 00:00:00
abstract::Arctic warming can influence tundra ecosystem function with consequences for climate feedbacks, wildlife and human communities. Yet ecological change across the Arctic tundra biome remains poorly quantified due to field measurement limitations and reliance on coarse-resolution satellite data. Here, we assess decadal c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18479-5
更新日期:2020-09-22 00:00:00
abstract::Under hypoxia, most of glucose is converted to secretory lactate, which leads to the overuse of glutamine-carbon. However, under such a condition how glutamine nitrogen is disposed to avoid over-accumulating ammonia remains to be determined. Here we identify a metabolic flux of glutamine to secretory dihydroorotate, w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08033-9
更新日期:2019-01-14 00:00:00
abstract::Supported atomic clusters with uniform metal sites and definite low-nuclearity are intermediate states between single-atom catalysts (SACs) and nanoparticles in size. Benefiting from the presence of metal-metal bonds, supported atomic clusters can trigger synergistic effects among every metal atom, which contributes t...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-19571-6
更新日期:2020-11-18 00:00:00
abstract::In Arabidopsis thaliana, CONSTANS (CO) plays an essential role in the regulation of photoperiodic flowering under long-day conditions. CO protein is stable only in the afternoon of long days, when it induces the expression of FLOWERING LOCUS T (FT), which promotes flowering. The blue-light photoreceptor FLAVIN-BINDING...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02476-2
更新日期:2017-12-22 00:00:00
abstract::Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains essential metabolic functions of the liver, and autophagy-deficient murine models develop benign adenomas and hepatomegaly, which have been attributed to activat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07338-z
更新日期:2018-11-23 00:00:00
abstract::Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project d...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/ncomms9559
更新日期:2015-10-01 00:00:00