ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity.

abstract：:We trained and validated risk prediction models for the three major types of skin cancer- basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma-on a cross-sectional and longitudinal dataset of 210,000 consented research participants who responded to an online survey covering personal and family histo...

journal_title：Nature communications

authors： Fontanillas P,Alipanahi B,Furlotte NA,Johnson M,Wilson CH,23andMe Research Team.,Pitts SJ,Gentleman R,Auton A

更新日期：2021-01-08 00:00:00

abstract：:Extremely metal-poor galaxies with metallicity below 10% of the solar value in the local universe are the best analogues to investigating the interstellar medium at a quasi-primitive environment in the early universe. In spite of the ongoing formation of stars in these galaxies, the presence of molecular gas (which is...

journal_title：Nature communications

authors： Shi Y,Wang J,Zhang ZY,Gao Y,Hao CN,Xia XY,Gu Q

更新日期：2016-12-09 00:00:00

abstract：:Many bacteria can exchange genetic material through horizontal gene transfer (HGT) mediated by plasmids and plasmid-borne transposable elements. Here, we study the population structure and dynamics of over 10,000 bacterial plasmids, by quantifying their genetic similarities and reconstructing a network based on their ...

journal_title：Nature communications

authors： Acman M,van Dorp L,Santini JM,Balloux F

更新日期：2020-05-15 00:00:00

abstract：:Incorporating oxophilic metals into noble metal-based catalysts represents an emerging strategy to improve the catalytic performance of electrocatalysts in fuel cells. However, effects of the distance between the noble metal and oxophilic metal active sites on the catalytic performance have rarely been investigated. H...

journal_title：Nature communications

authors： Chen L,Lu L,Zhu H,Chen Y,Huang Y,Li Y,Wang L

更新日期：2017-01-10 00:00:00

abstract：:Transforming growth factor-β (TGF-β) signaling and microRNAs (miRNAs) are important gene regulatory components in cancer. Usually in advanced malignant stages, TGF-β signaling is elevated but global miRNA expression is suppressed. Such a gene expression signature is well illustrated in a fibrosis (or mesenchymal) subt...

journal_title：Nature communications

authors： Ahn JH,Lee HS,Lee JS,Lee YS,Park JL,Kim SY,Hwang JA,Kunkeaw N,Jung SY,Kim TJ,Lee KS,Jeon SH,Lee I,Johnson BH,Choi JH,Lee YS

更新日期：2018-03-21 00:00:00

abstract：:Hypoxic damage to the developing brain due to preterm birth causes many anatomical changes, including damage to the periventricular white matter. This results in the loss of glial cells, significant disruptions in myelination, and thereby cognitive and behavioral disabilities seen throughout life. Encouragingly, these...

journal_title：Nature communications

authors： Forbes TA,Goldstein EZ,Dupree JL,Jablonska B,Scafidi J,Adams KL,Imamura Y,Hashimoto-Torii K,Gallo V

更新日期：2020-02-19 00:00:00

abstract：:FeV(O)(OH) species have long been proposed to play a key role in a wide range of biomimetic and enzymatic oxidations, including as intermediates in arene dihydroxylation catalyzed by Rieske oxygenases. However, the inability to accumulate these intermediates in solution has thus far prevented their spectroscopic and c...

journal_title：Nature communications

authors： Borrell M,Andris E,Navrátil R,Roithová J,Costas M

更新日期：2019-02-22 00:00:00

abstract：:Hydroarylation is an environmentally attractive strategy which incorporates all of the atoms contained in the substrates into the desired products. Almost all the hydroarylations of norbornene reported to date involve an exo-selective reaction. Here we show the endo-selective hydroarylation of norbornene in the Rh(I)-...

journal_title：Nature communications

authors： Shibata K,Natsui S,Tobisu M,Fukumoto Y,Chatani N

更新日期：2017-11-13 00:00:00

abstract：:The polypterids (bichirs and ropefish) are extant basal actinopterygian (ray-finned) fishes that breathe air and share similarities with extant lobe-finned sarcopterygians (lungfishes and tetrapods) in lung structure. They are also similar to some fossil sarcopterygians, including stem tetrapods, in having large paire...

journal_title：Nature communications

authors： Graham JB,Wegner NC,Miller LA,Jew CJ,Lai NC,Berquist RM,Frank LR,Long JA

更新日期：2014-01-01 00:00:00

abstract：:The manipulation of crystal orientation from the thermodynamic equilibrium states is desired in layered hybrid perovskite films to direct charge transport and enhance the perovskite devices performance. Here we report a templated growth mechanism of layered perovskites from 3D-like perovskites which can be a general d...

journal_title：Nature communications

authors： Wang J,Luo S,Lin Y,Chen Y,Deng Y,Li Z,Meng K,Chen G,Huang T,Xiao S,Huang H,Zhou C,Ding L,He J,Huang J,Yuan Y

更新日期：2020-01-29 00:00:00

abstract：:Interactions between absorbers and plasmonic metasurfaces can give rise to unique optical properties not present for either of the individual materials and can influence the performance of a host of optical sensing and thin-film optoelectronic applications. Here we identify three distinct mode types of absorber-coated...

journal_title：Nature communications

authors： Petoukhoff CE,O'Carroll DM

更新日期：2015-08-14 00:00:00

abstract：:Genetic studies have shown that obesity risk is heritable and that, of the many common variants now associated with body mass index, those in an intron of the fat mass and obesity-associated (FTO) gene have the largest effect. The size of the UK Biobank, and its joint measurement of genetic, anthropometric and lifesty...

journal_title：Nature communications

authors： Young AI,Wauthier F,Donnelly P

更新日期：2016-09-06 00:00:00

abstract：:Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is incompletely understood. Here, we show that CX3CR1 deficiency promotes muscle repair and rescues ...

journal_title：Nature communications

authors： Arnold L,Perrin H,de Chanville CB,Saclier M,Hermand P,Poupel L,Guyon E,Licata F,Carpentier W,Vilar J,Mounier R,Chazaud B,Benhabiles N,Boissonnas A,Combadiere B,Combadiere C

更新日期：2015-12-03 00:00:00

abstract：:The growth of large-domain single crystalline graphene with the controllable number of layers is of central importance for large-scale integration of graphene devices. Here we report a new pathway to greatly reduce the graphene nucleation density from ~10(6) to 4 nuclei cm(-2), enabling the growth of giant single crys...

journal_title：Nature communications

authors： Zhou H,Yu WJ,Liu L,Cheng R,Chen Y,Huang X,Liu Y,Wang Y,Huang Y,Duan X

更新日期：2013-01-01 00:00:00

abstract：:Despite the pursuit of quantum advantages in various applications, the power of quantum computers in executing neural network has mostly remained unknown, primarily due to a missing tool that effectively designs a neural network suitable for quantum circuit. Here, we present a neural network and quantum circuit co-des...

journal_title：Nature communications

authors： Jiang W,Xiong J,Shi Y

更新日期：2021-01-25 00:00:00

abstract：:Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex vasculature of the kidney remains a daunting task. The molecular pathways that specify and sustain functional, phenotypic and structural heterogeneity of the kidney vasculature are unknown. Here, we employ high-throughput bulk and...

journal_title：Nature communications

authors： Barry DM,McMillan EA,Kunar B,Lis R,Zhang T,Lu T,Daniel E,Yokoyama M,Gomez-Salinero JM,Sureshbabu A,Cleaver O,Di Lorenzo A,Choi ME,Xiang J,Redmond D,Rabbany SY,Muthukumar T,Rafii S

更新日期：2019-12-13 00:00:00

abstract：:Motile plant structures such as Mimosa pudica leaves, Impatiens glandulifera seedpods, and Dionaea muscipula leaves exhibit fast nastic movements in a few seconds or less. This motion is stimuli-independent mechanical movement following theorema egregium rules. Artificial analogs of tropistic motion in plants are exem...

journal_title：Nature communications

authors： Tian Z,Xu B,Wan G,Han X,Di Z,Chen Z,Mei Y

更新日期：2021-01-21 00:00:00

abstract：:Physical and electrochemical phenomena at the surfaces of transition metal oxides and their coupling to local functionality remains one of the enigmas of condensed matter physics. Understanding the emergent physical phenomena at surfaces requires the capability to probe the local composition, map order parameter field...

journal_title：Nature communications

authors： Gai Z,Lin W,Burton JD,Fuchigami K,Snijders PC,Ward TZ,Tsymbal EY,Shen J,Jesse S,Kalinin SV,Baddorf AP

更新日期：2014-07-24 00:00:00

abstract：:Type I modular polyketide synthases assemble diverse bioactive natural products. Such multienzymes typically use malonyl and methylmalonyl-CoA building blocks for polyketide chain assembly. However, in several cases more exotic alkylmalonyl-CoA extender units are also known to be incorporated. In all examples studied ...

journal_title：Nature communications

authors： Ray L,Valentic TR,Miyazawa T,Withall DM,Song L,Milligan JC,Osada H,Takahashi S,Tsai SC,Challis GL

更新日期：2016-12-21 00:00:00

abstract：:The photons in circularly polarized light can transfer their quantized spin angular momentum to micro- and nanostructures via absorption and scattering. This normally exerts positive torque on the objects wher the sign (i.e., handedness or angular direction) follows that of the spin angular momentum. Here we show that...

journal_title：Nature communications

authors： Han F,Parker JA,Yifat Y,Peterson C,Gray SK,Scherer NF,Yan Z

更新日期：2018-11-20 00:00:00

abstract：:The realization that mitigation efforts to reduce carbon dioxide emissions have, until now, been relatively ineffective has led to an increasing interest in climate engineering as a possible means of preventing the potentially catastrophic consequences of climate change. While many studies have addressed the potential...

journal_title：Nature communications

authors： Keller DP,Feng EY,Oschlies A

更新日期：2014-02-25 00:00:00

abstract：:Thrombocytosis is present in more than 30% of patients with solid malignancies and correlates with worsened patient survival. Tumor cell interaction with various cellular components of the tumor microenvironment including platelets is crucial for tumor growth and metastasis. Although it is known that platelets can inf...

journal_title：Nature communications

authors： Haemmerle M,Taylor ML,Gutschner T,Pradeep S,Cho MS,Sheng J,Lyons YM,Nagaraja AS,Dood RL,Wen Y,Mangala LS,Hansen JM,Rupaimoole R,Gharpure KM,Rodriguez-Aguayo C,Yim SY,Lee JS,Ivan C,Hu W,Lopez-Berestein G,Wong ST,

更新日期：2017-08-21 00:00:00

abstract：:Knowledge of the RNA three-dimensional structure, either in isolation or as part of RNP complexes, is fundamental to understand the mechanism of numerous cellular processes. Because of its flexibility, RNA represents a challenge for crystallization, while the large size of cellular complexes brings solution-state NMR ...

journal_title：Nature communications

authors： Marchanka A,Simon B,Althoff-Ospelt G,Carlomagno T

更新日期：2015-05-11 00:00:00

abstract：:NHE9 (SLC9A9) is an endosomal cation/proton antiporter with orthologues in yeast and bacteria. Rare, missense substitutions in NHE9 are genetically linked with autism but have not been functionally evaluated. Here we use evolutionary conservation analysis to build a model structure of NHE9 based on the crystal structu...

journal_title：Nature communications

authors： Kondapalli KC,Hack A,Schushan M,Landau M,Ben-Tal N,Rao R

更新日期：2013-01-01 00:00:00

abstract：:Energy metabolism has been repeatedly linked to amyotrophic lateral sclerosis (ALS). Yet, motor neuron (MN) metabolism remains poorly studied and it is unknown if ALS MNs differ metabolically from healthy MNs. To address this question, we first performed a metabolic characterization of induced pluripotent stem cells (...

journal_title：Nature communications

authors： Vandoorne T,Veys K,Guo W,Sicart A,Vints K,Swijsen A,Moisse M,Eelen G,Gounko NV,Fumagalli L,Fazal R,Germeys C,Quaegebeur A,Fendt SM,Carmeliet P,Verfaillie C,Van Damme P,Ghesquière B,De Bock K,Van Den Bosch L

更新日期：2019-09-12 00:00:00

abstract：:Sensitive detection of protein interactions and post-translational modifications of native proteins is a challenge for research and diagnostic purposes. A method for this, which could be used in point-of-care devices and high-throughput screening, should be reliable, cost effective and robust. To achieve this, here we...

journal_title：Nature communications

authors： Koos B,Cane G,Grannas K,Löf L,Arngården L,Heldin J,Clausson CM,Klaesson A,Hirvonen MK,de Oliveira FM,Talibov VO,Pham NT,Auer M,Danielson UH,Haybaeck J,Kamali-Moghaddam M,Söderberg O

更新日期：2015-06-12 00:00:00

abstract：:Maintenance of working memory is thought to involve the activity of prefrontal neuronal populations with strong recurrent connections. However, it was recently shown that distractors evoke a morphing of the prefrontal population code, even when memories are maintained throughout the delay. How can a morphing code main...

journal_title：Nature communications

authors： Parthasarathy A,Tang C,Herikstad R,Cheong LF,Yen SC,Libedinsky C

更新日期：2019-11-01 00:00:00

abstract：:Biodiversity changes are lagging behind current climate warming. The underlying determinants of this climatic debt are unknown and yet critical to understand the impacts of climate change on the present biota and improve forecasts of biodiversity changes. Here we assess determinants of climatic debt accumulated in Fre...

journal_title：Nature communications

authors： Bertrand R,Riofrío-Dillon G,Lenoir J,Drapier J,de Ruffray P,Gégout JC,Loreau M

更新日期：2016-08-26 00:00:00

abstract：:Textiles that are capable of harvesting biomechanical energy via triboelectric effects are of interest for self-powered wearable electronics. Fabrication of conformable and durable textiles with high triboelectric outputs remains challenging. Here we propose a washable skin-touch-actuated textile-based triboelectric n...

journal_title：Nature communications

authors： Xiong J,Cui P,Chen X,Wang J,Parida K,Lin MF,Lee PS

更新日期：2018-10-15 00:00:00

abstract：:Highly sensitive and specific non-invasive molecular imaging methods are particularly desirable for the early detection of cancers. Here we report a near-infrared optical imaging probe highly specific to the hypoxic tumour microenvironment to detect tumour and cancer cells with the sensitivity to a few thousands cance...

journal_title：Nature communications

authors： Zheng X,Wang X,Mao H,Wu W,Liu B,Jiang X

更新日期：2015-01-05 00:00:00