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Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults.

Abstract：

:Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain structure and functional connectivity in a population-based cohort of 549 older adults. A combined lifestyle risk score was associated with decreased gyrification in left premotor and right prefrontal cortex, and higher functional connectivity to sensorimotor and prefrontal cortex. While structural differences were driven by alcohol consumption, physical activity, and social integration, higher functional connectivity was driven by smoking. Results suggest that combining differentially contributing lifestyle variables may be more than the sum of its parts. Associations generally were neither altered by adjustment for genetic risk, nor by depressive symptomatology or education, underlining the relevance of daily habits for brain health.

journal_name

Nat Commun

journal_title

Nature communications

authors

Bittner N,Jockwitz C,Mühleisen TW,Hoffstaedter F,Eickhoff SB,Moebus S,Bayen UJ,Cichon S,Zilles K,Amunts K,Caspers S

doi

10.1038/s41467-019-08500-x

subject

Has Abstract

pub_date

2019-02-06 00:00:00

pages

621

issue

1

issn

2041-1723

pii

10.1038/s41467-019-08500-x

journal_volume

10

pub_type

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