The transcript cleavage factor paralogue TFS4 is a potent RNA polymerase inhibitor.

abstract：:Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear. We show herein that the DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles...

journal_title：Nature communications

authors： Xu X,Huang S,Zhang B,Huang F,Chi W,Fu J,Wang G,Li S,Jiang Q,Zhang C

更新日期：2017-04-27 00:00:00

abstract：:Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information proces...

journal_title：Nature communications

authors： Moore S,Meschkat M,Ruhwedel T,Trevisiol A,Tzvetanova ID,Battefeld A,Kusch K,Kole MHP,Strenzke N,Möbius W,de Hoz L,Nave KA

更新日期：2020-10-30 00:00:00

abstract：:Direct reciprocity is a mechanism for cooperation among humans. Many of our daily interactions are repeated. We interact repeatedly with our family, friends, colleagues, members of the local and even global community. In the theory of repeated games, it is a tacit assumption that the various games that a person plays ...

journal_title：Nature communications

authors： Reiter JG,Hilbe C,Rand DG,Chatterjee K,Nowak MA

更新日期：2018-02-07 00:00:00

abstract：:Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercellular transfer of mutp53's invasive/migratory gain-of-function by incre...

journal_title：Nature communications

authors： Novo D,Heath N,Mitchell L,Caligiuri G,MacFarlane A,Reijmer D,Charlton L,Knight J,Calka M,McGhee E,Dornier E,Sumpton D,Mason S,Echard A,Klinkert K,Secklehner J,Kruiswijk F,Vousden K,Macpherson IR,Blyth K,Bailey P,

更新日期：2018-11-29 00:00:00

abstract：:Mapping neuroanatomy is a foundational goal towards understanding brain function. Electron microscopy (EM) has been the gold standard for connectivity analysis because nanoscale resolution is necessary to unambiguously resolve synapses. However, molecular information that specifies cell types is often lost in EM recon...

journal_title：Nature communications

authors： Shen FY,Harrington MM,Walker LA,Cheng HPJ,Boyden ES,Cai D

更新日期：2020-09-15 00:00:00

abstract：:Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis....

journal_title：Nature communications

authors： Lara J,Diacovich L,Trajtenberg F,Larrieux N,Malchiodi EL,Fernández MM,Gago G,Gramajo H,Buschiazzo A

更新日期：2020-07-24 00:00:00

abstract：:A universally accepted explanation for why liquids sometimes vitrify rather than crystallize remains hotly pursued, despite the ubiquity of glass in our everyday lives, the utilization of the glass transition in innumerable modern technologies, and nearly a century of theoretical and experimental investigation. Among ...

journal_title：Nature communications

authors： Teich EG,van Anders G,Glotzer SC

更新日期：2019-01-08 00:00:00

abstract：:The force generated by the actomyosin cytoskeleton controls focal adhesion dynamics during cell migration. This process is thought to involve the mechanical unfolding of talin to expose cryptic vinculin-binding sites. However, the ability of the actomyosin cytoskeleton to directly control the formation of a talin-vinc...

journal_title：Nature communications

authors： Ciobanasu C,Faivre B,Le Clainche C

更新日期：2014-01-01 00:00:00

abstract：:The midge, Belgica antarctica, is the only insect endemic to Antarctica, and thus it offers a powerful model for probing responses to extreme temperatures, freeze tolerance, dehydration, osmotic stress, ultraviolet radiation and other forms of environmental stress. Here we present the first genome assembly of an extre...

journal_title：Nature communications

authors： Kelley JL,Peyton JT,Fiston-Lavier AS,Teets NM,Yee MC,Johnston JS,Bustamante CD,Lee RE,Denlinger DL

更新日期：2014-08-12 00:00:00

abstract：:The diversity reflected by >100 different neural cell types fundamentally contributes to brain function and a central idea is that neuronal identity can be inferred from genetic information. Recent large-scale transcriptomic assays seem to confirm this hypothesis, but a lack of morphological information has limited th...

journal_title：Nature communications

authors： Que L,Lukacsovich D,Luo W,Földy C

更新日期：2021-01-04 00:00:00

abstract：:Aviation emissions of nitrogen oxides (NOx) alter the composition of the atmosphere, perturbing the greenhouse gases ozone and methane, resulting in positive and negative radiative forcing effects, respectively. In 1981, the International Civil Aviation Organization adopted a first certification standard for the regul...

journal_title：Nature communications

authors： Skowron A,Lee DS,De León RR,Lim LL,Owen B

更新日期：2021-01-25 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:The transcription factor MafB is expressed by monocytes and macrophages. Efferocytosis (apoptotic cell uptake) by macrophages is important for inhibiting the development of autoimmune diseases, and is greatly reduced in Mafb-deficient macrophages. Here, we show the expression of the first protein in the classical comp...

journal_title：Nature communications

authors： Tran MTN,Hamada M,Jeon H,Shiraishi R,Asano K,Hattori M,Nakamura M,Imamura Y,Tsunakawa Y,Fujii R,Usui T,Kulathunga K,Andrea CS,Koshida R,Kamei R,Matsunaga Y,Kobayashi M,Oishi H,Kudo T,Takahashi S

更新日期：2017-11-22 00:00:00

abstract：:Past studies of the end-Permian extinction (EPE), the largest biotic crisis of the Phanerozoic, have not resolved the timing of events in southern high-latitudes. Here we use palynology coupled with high-precision CA-ID-TIMS dating of euhedral zircons from continental sequences of the Sydney Basin, Australia, to show ...

journal_title：Nature communications

authors： Fielding CR,Frank TD,McLoughlin S,Vajda V,Mays C,Tevyaw AP,Winguth A,Winguth C,Nicoll RS,Bocking M,Crowley JL

更新日期：2019-01-23 00:00:00

abstract：:Mechanically flexible mobile phones have been long anticipated due to the rapid development of thin-film electronics in the last couple of decades. However, to date, no such phone has been developed, largely due to a lack of flexible electronic components that are fast enough for the required wireless communications, ...

journal_title：Nature communications

authors： Zhang J,Li Y,Zhang B,Wang H,Xin Q,Song A

更新日期：2015-07-03 00:00:00

abstract：:The signaling diversity of GABAergic interneurons to post-synaptic neurons is crucial to generate the functional heterogeneity that characterizes brain circuits. Whether this diversity applies to other brain cells, such as the glial cells astrocytes, remains unexplored. Using optogenetics and two-photon functional ima...

journal_title：Nature communications

authors： Mariotti L,Losi G,Lia A,Melone M,Chiavegato A,Gómez-Gonzalo M,Sessolo M,Bovetti S,Forli A,Zonta M,Requie LM,Marcon I,Pugliese A,Viollet C,Bettler B,Fellin T,Conti F,Carmignoto G

更新日期：2018-01-08 00:00:00

abstract：:In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...

journal_title：Nature communications

authors： Somasundaram R,Zhang G,Fukunaga-Kalabis M,Perego M,Krepler C,Xu X,Wagner C,Hristova D,Zhang J,Tian T,Wei Z,Liu Q,Garg K,Griss J,Hards R,Maurer M,Hafner C,Mayerhöfer M,Karanikas G,Jalili A,Bauer-Pohl V,Weihsengru

更新日期：2017-09-19 00:00:00

abstract：:Self-assembly of large multi-component systems is a common strategy for the bottom-up construction of discrete, well-defined, nanoscopic-sized cages. Icosahedral or pseudospherical viral capsids, built up from hundreds of identical proteins, constitute typical examples of the complexity attained by biological self-ass...

journal_title：Nature communications

authors： Pasquale S,Sattin S,Escudero-Adán EC,Martínez-Belmonte M,de Mendoza J

更新日期：2012-04-17 00:00:00

abstract：:Stimulation of TNFR1 by TNFα can promote three distinct alternative mechanisms of cell death: necroptosis, RIPK1-independent and -dependent apoptosis. How cells decide which way to die is unclear. Here, we report that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulati...

journal_title：Nature communications

authors： Geng J,Ito Y,Shi L,Amin P,Chu J,Ouchida AT,Mookhtiar AK,Zhao H,Xu D,Shan B,Najafov A,Gao G,Akira S,Yuan J

更新日期：2017-08-25 00:00:00

abstract：:Aqueous nanofibres constructed by the self-assembly of small amphiphilic molecules can become entangled to form hydrogels that have a variety of applications including tissue engineering, and controlled drug delivery. The hydrogels are formed through the random physical cross-linkings of flexible nanofibres. Here we r...

journal_title：Nature communications

authors： Huang Z,Lee H,Lee E,Kang SK,Nam JM,Lee M

更新日期：2011-09-06 00:00:00

abstract：:Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could introduce site-specific...

journal_title：Nature communications

authors： Yang L,Briggs AW,Chew WL,Mali P,Guell M,Aach J,Goodman DB,Cox D,Kan Y,Lesha E,Soundararajan V,Zhang F,Church G

更新日期：2016-11-02 00:00:00

abstract：:The nitrogen-vacancy (NV) centre in diamond is a promising candidate for a solid-state qubit. However, its charge state is known to be unstable, discharging from the qubit state NV(-) into the neutral state NV(0) under various circumstances. Here we demonstrate that the charge state can be controlled by an electrolyti...

journal_title：Nature communications

authors： Grotz B,Hauf MV,Dankerl M,Naydenov B,Pezzagna S,Meijer J,Jelezko F,Wrachtrup J,Stutzmann M,Reinhard F,Garrido JA

更新日期：2012-03-06 00:00:00

abstract：:Tomography--cross-sectional imaging based on measuring radiation transmitted through an object along different directions--enables non-invasive imaging of hidden stationary objects, such as internal bodily organs, from their sequentially measured projections. Here we adapt tomographic methods to visualize--in one lase...

journal_title：Nature communications

authors： Li Z,Zgadzaj R,Wang X,Chang YY,Downer MC

更新日期：2014-01-01 00:00:00

abstract：:The liver integrates multiple metabolic pathways to warrant systemic energy homeostasis. An excessive lipogenic flux due to chronic dietary stimulation contributes to the development of hepatic steatosis, dyslipidemia and hyperglycemia. Here we show that the oxidoreductase retinol saturase (RetSat) is involved in the ...

journal_title：Nature communications

authors： Heidenreich S,Witte N,Weber P,Goehring I,Tolkachov A,von Loeffelholz C,Döcke S,Bauer M,Stockmann M,Pfeiffer AFH,Birkenfeld AL,Pietzke M,Kempa S,Muenzner M,Schupp M

更新日期：2017-08-30 00:00:00

abstract：:The coastal sea levels along the Northeast Coast of North America show significant year-to-year fluctuations in a general upward trend. The analysis of long-term tide gauge records identified an extreme sea-level rise (SLR) event during 2009-10. Within this 2-year period, the coastal sea level north of New York City j...

journal_title：Nature communications

authors： Goddard PB,Yin J,Griffies SM,Zhang S

更新日期：2015-02-24 00:00:00

abstract：:In humans, mutations in the PIEZO2 gene, which encodes for a mechanosensitive ion channel, were found to result in skeletal abnormalities including scoliosis and hip dysplasia. Here, we show in mice that loss of Piezo2 expression in the proprioceptive system recapitulates several human skeletal abnormalities. While lo...

journal_title：Nature communications

authors： Assaraf E,Blecher R,Heinemann-Yerushalmi L,Krief S,Carmel Vinestock R,Biton IE,Brumfeld V,Rotkopf R,Avisar E,Agar G,Zelzer E

更新日期：2020-06-23 00:00:00

abstract：:Loss of seed dispersal is a key agronomical trait targeted by ancient human selection and has been regarded as a milestone of crop domestication. In this study, in the legume crop soybean Glycine max (L.) Merr. which provides vegetable oils and proteins for humans, we show that the key cellular feature of the shatteri...

journal_title：Nature communications

authors： Dong Y,Yang X,Liu J,Wang BH,Liu BL,Wang YZ

更新日期：2014-01-01 00:00:00

abstract：:Hydrogen spillover phenomenon is well-documented in hydrogenation catalysis but still highly disputed in hydrogen storage. Until now, the existence of hydrogen spillover through metal-organic frameworks (MOFs) remains a topic of ongoing debate and how far the split hydrogen atoms diffuse in such materials is unknown. ...

journal_title：Nature communications

authors： Zhan G,Zeng HC

更新日期：2018-09-17 00:00:00

abstract：:Gate operations in a quantum information processor are generally realized by tailoring specific periods of free and driven evolution of a quantum system. Unwanted environmental noise, which may in principle be distinct during these two periods, acts to decohere the system and increase the gate error rate. Although the...

journal_title：Nature communications

authors： Yan F,Gustavsson S,Bylander J,Jin X,Yoshihara F,Cory DG,Nakamura Y,Orlando TP,Oliver WD

更新日期：2013-01-01 00:00:00

abstract：:Intercalation-based inorganic materials that change their colours upon ion insertion/extraction lay an important foundation for existing electrochromic technology. However, using only such inorganic electrochromic materials, it is very difficult to achieve the utmost goal of full-colour tunability for future electroch...

journal_title：Nature communications

authors： Wang Z,Wang X,Cong S,Chen J,Sun H,Chen Z,Song G,Geng F,Chen Q,Zhao Z

更新日期：2020-01-16 00:00:00