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DNA punch cards for storing data on native DNA sequences via enzymatic nicking.

Abstract：

:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid the above problems is using readily available native DNA. As the sequence content of native DNA is fixed, one can modify the topology instead to encode information. Here, we introduce DNA punch cards, a macromolecular storage mechanism in which data is written in the form of nicks at predetermined positions on the backbone of native double-stranded DNA. The platform accommodates parallel nicking on orthogonal DNA fragments and enzymatic toehold creation that enables single-bit random-access and in-memory computations. We use Pyrococcus furiosus Argonaute to punch files into the PCR products of Escherichia coli genomic DNA and accurately reconstruct the encoded data through high-throughput sequencing and read alignment.

journal_name

Nat Commun

journal_title

Nature communications

authors

Tabatabaei SK,Wang B,Athreya NBM,Enghiad B,Hernandez AG,Fields CJ,Leburton JP,Soloveichik D,Zhao H,Milenkovic O

doi

10.1038/s41467-020-15588-z

subject

Has Abstract

pub_date

2020-04-08 00:00:00

pages

1742

issue

1

issn

2041-1723

pii

10.1038/s41467-020-15588-z

journal_volume

11

pub_type

杂志文章

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