Abstract:
:The originally published version of this Article contained errors in Figure 4. In panel b, the square and diamond labels associated with the uppermost survival curve were incorrectly displayed as 'n' and 'u', respectively. These errors have now been corrected in both the PDF and HTML versions of the Article.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Wang P,Li X,Wang J,Gao D,Li Y,Li H,Chu Y,Zhang Z,Liu H,Jiang G,Cheng Z,Wang S,Dong J,Feng B,Chard LS,Lemoine NR,Wang Ydoi
10.1038/s41467-017-02205-9subject
Has Abstractpub_date
2018-01-10 00:00:00pages
203issue
1issn
2041-1723pii
10.1038/s41467-017-02205-9journal_volume
9pub_type
杂志文章,已发布勘误abstract::Polycomb repressive complexes 1 and 2 (PRC1 and 2) play a critical role in the epigenetic regulation of transcription during cellular differentiation, stem cell pluripotency and neoplastic progression. Here we show that the polycomb group protein EED, a core component of PRC2, physically interacts with and functions a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4127
更新日期:2014-01-01 00:00:00
abstract::Centromeres are specified epigenetically through the deposition of the centromere-specific histone H3 variant CENP-A. However, how additional epigenetic features are involved in centromere specification is unknown. Here, we find that histone H4 Lys5 and Lys12 acetylation (H4K5ac and H4K12ac) primarily occur within the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13465
更新日期:2016-11-04 00:00:00
abstract::Molecular spins have become key enablers for exploring magnetic interactions, quantum information processes and many-body effects in metals. Metal-organic molecules, in particular, let the spin state of the core metal ion to be modified according to its organic environment, allowing localized magnetic moments to emerg...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13751
更新日期:2016-12-12 00:00:00
abstract::Mycobacterium tuberculosis is a pathogen with a unique cell envelope including very long fatty acids, implicated in bacterial resistance and host immune modulation. FasR is a TetR-like transcriptional activator that plays a central role in sensing mycobacterial long-chain fatty acids and regulating lipid biosynthesis....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17504-x
更新日期:2020-07-24 00:00:00
abstract::Idiopathic scoliosis (IS) is a common paediatric musculoskeletal disease that displays a strong female bias. By performing a genome-wide association study (GWAS) of 3,102 individuals, we identify significant associations with 20p11.22 SNPs for females (P=6.89 × 10(-9)) but not males (P=0.71). This association with IS ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7452
更新日期:2015-03-18 00:00:00
abstract::Nanocarrier administration has primarily been restricted to intermittent bolus injections with limited available options for sustained delivery in vivo. Here, we demonstrate that cylinder-to-sphere transitions of self-assembled filomicelle (FM) scaffolds can be employed for sustained delivery of monodisperse micellar ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03001-9
更新日期:2018-02-12 00:00:00
abstract::After stroke, peripheral immune cells are activated and these systemic responses may amplify brain damage, but how the injured brain sends out signals to trigger systemic inflammation remains unclear. Here we show that a brain-to-cervical lymph node (CLN) pathway is involved. In rats subjected to focal cerebral ischem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13324-w
更新日期:2019-11-22 00:00:00
abstract::Sequencing of a single-cell genome requires DNA amplification, a process prone to introducing bias and errors into the amplified genome. Here we introduce a novel multiple displacement amplification (MDA) method based on the unique DNA primase features of Thermus thermophilus (Tth) PrimPol. TthPrimPol displays a poten...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13296
更新日期:2016-11-29 00:00:00
abstract::The rapid development of scientific CMOS (sCMOS) technology has greatly advanced optical microscopy for biomedical research with superior sensitivity, resolution, field-of-view, and frame rates. However, for sCMOS sensors, the parallel charge-voltage conversion and different responsivity at each pixel induces extra re...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13841-8
更新日期:2020-01-03 00:00:00
abstract::Prediction of Indian summer monsoon rainfall (ISMR) is at the heart of tropical climate prediction. Despite enormous progress having been made in predicting ISMR since 1886, the operational forecasts during recent decades (1989-2012) have little skill. Here we show, with both dynamical and physical-empirical models, t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8154
更新日期:2015-05-18 00:00:00
abstract::Although multiphoton-pumped lasing from a solution of chromophores is important in the emerging fields of nonlinear optofluidics and bio-photonics, conventionally used organic dyes are often rendered unsuitable because of relatively small multiphoton absorption cross-sections and low photostability. Here, we demonstra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9513
更新日期:2015-09-30 00:00:00
abstract::The development of efficient reactions for the one-pot construction of bicyclic ring systems bearing two quaternary carbon centres at their bridgehead positions represents a significant challenge to synthetic chemistry. The development of new methods capable of overcoming this challenge is highly desirable, because th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6707
更新日期:2014-12-08 00:00:00
abstract::Main group elements usually assume a typical oxidation state while forming compounds with other species. Group I elements are usually in the +1 state in inorganic materials. Our recent work reveals that pressure may make the inner shell 5p electrons of Cs reactive, causing Cs to expand beyond the +1 oxidation state. H...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5861
更新日期:2014-09-10 00:00:00
abstract::X-chromosome inactivation (XCI), i.e., the inactivation of one of the female X chromosomes, restores equal expression of X-chromosomal genes between females and males. However, ~10% of genes show variable degrees of escape from XCI between females, although little is known about the causes of variable XCI. Using a dis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05714-3
更新日期:2018-09-14 00:00:00
abstract::Plasmids are important members of the bacterial mobile gene pool, and are among the most important contributors to horizontal gene transfer between bacteria. They typically harbour a wide spectrum of host beneficial traits, such as antibiotic resistance, inserted into their backbones. Although these inserted elements ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1267
更新日期:2011-01-01 00:00:00
abstract::Environmental metabolomes are fundamentally coupled to microbially-linked biogeochemical processes within ecosystems. However, significant gaps exist in our understanding of their spatiotemporal organization, limiting our ability to uncover transferrable principles and predict ecosystem function. We propose that a the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19989-y
更新日期:2020-12-11 00:00:00
abstract::The discovery of quantum spin-Hall (QSH) insulators has brought topology to the forefront of condensed matter physics. While a QSH state from spin-orbit coupling can be fully understood in terms of band theory, fascinating many-body effects are expected if it instead results from spontaneous symmetry breaking. Here, w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10372-0
更新日期:2019-06-14 00:00:00
abstract::The clockwork of plant circadian oscillators has been resolved through investigations in Arabidopsis thaliana. The circadian oscillator is an important regulator of much of plant physiology, though many of the mechanisms are unclear. New findings demonstrate that the oscillator adjusts phase and period in response to ...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-019-08398-5
更新日期:2019-02-01 00:00:00
abstract::A reliable method for recording evoked synaptic events in identified neurons in Caenorhabditis elegans would greatly accelerate our understanding of its nervous system at the molecular, cellular and network levels. Here we describe a method for recording synaptic currents and potentials from identified neurons in near...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1304
更新日期:2011-01-01 00:00:00
abstract::Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical description, reminiscent of Onsager's trajectory ...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-019-11402-7
更新日期:2019-08-23 00:00:00
abstract::Tuning the thermodynamic state of a material has a tremendous impact on its performance. In the case of polymers placed in proximity of a solid wall, this is possible by annealing above the glass transition temperature, Tg, which induces the formation of an adsorbed layer. Whether heating to higher temperatures would ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18216-y
更新日期:2020-08-28 00:00:00
abstract::Albedo-a primary control on surface melt-varies considerably across the Greenland Ice Sheet yet the specific surface types that comprise its dark zone remain unquantified. Here we use UAV imagery to attribute seven distinct surface types to observed albedo along a 25 km transect dissecting the western, ablating sector...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03353-2
更新日期:2018-03-14 00:00:00
abstract::Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we sho...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5686
更新日期:2014-08-26 00:00:00
abstract::Quintulene, a non-graphitic cycloarene with fivefold symmetry, has remained synthetically elusive due to its high molecular strain originating from its curved structure. Here we report the construction of extended quintulene, which was unambiguously characterized by mass and NMR spectroscopy. The extended quintulene r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17691-7
更新日期:2020-08-07 00:00:00
abstract::Genetic studies of Neolithic and Bronze Age skeletons from Europe have provided evidence for strong population genetic changes at the beginning and the end of the Neolithic period. To further understand the implications of these in Southern Central Europe, we analyze 96 ancient genomes from Switzerland, Southern Germa...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/s41467-020-15560-x
更新日期:2020-04-20 00:00:00
abstract::Cavity quantum electrodynamics describes the fundamental interactions between light and matter, and how they can be controlled by shaping the local environment. For example, optical microcavities allow high-efficiency detection and manipulation of single atoms. In this regime, fluctuations of atom number are on the or...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1428
更新日期:2011-08-09 00:00:00
abstract::In fragmented forests, tree diversity declines near edges but the ecological processes underlying this loss of diversity remain poorly understood. Theory predicts that top-down regulation of seedling recruitment by insect herbivores and fungal pathogens contributes to maintaining tree diversity in forests, but it is u...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06997-2
更新日期:2018-10-30 00:00:00
abstract::CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate that Cep63-deficient mice recapitulate Seckel syndrome pathology. The attrition of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8676
更新日期:2015-07-09 00:00:00
abstract::Alternative splicing and alternative polyadenylation (APA) of pre-mRNAs greatly contribute to transcriptome diversity, coding capacity of a genome and gene regulatory mechanisms in eukaryotes. Second-generation sequencing technologies have been extensively used to analyse transcriptomes. However, a major limitation of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11706
更新日期:2016-06-24 00:00:00
abstract::Health care workers (HCW) are a high-risk population to acquire SARS-CoV-2 infection from patients or other fellow HCW. This study aims at estimating the seroprevalence against SARS-CoV-2 in a random sample of HCW from a large hospital in Spain. Of the 578 participants recruited from 28 March to 9 April 2020, 54 (9.3%...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17318-x
更新日期:2020-07-08 00:00:00