Synthesis of acetic acid via methanol hydrocarboxylation with CO2 and H2.

abstract：:Functional variomics provides the foundation for personalized medicine by linking genetic variation to disease expression, outcome and treatment, yet its utility is dependent on appropriate assays to evaluate mutation impact on protein function. To fully assess the effects of 106 missense and nonsense variants of PTEN...

journal_title：Nature communications

authors： Post KL,Belmadani M,Ganguly P,Meili F,Dingwall R,McDiarmid TA,Meyers WM,Herrington C,Young BP,Callaghan DB,Rogic S,Edwards M,Niciforovic A,Cau A,Rankin CH,O'Connor TP,Bamji SX,Loewen CJR,Allan DW,Pavlidis P,Haas K

更新日期：2020-04-29 00:00:00

abstract：:Bacterial Type III Secretion Systems deliver effectors into host cells to manipulate cellular processes to the advantage of the pathogen. Many host targets of these effectors are found on membranes. Therefore, to identify their targets, effectors often use specialized membrane-localization domains to localize to appro...

journal_title：Nature communications

authors： Salomon D,Guo Y,Kinch LN,Grishin NV,Gardner KH,Orth K

更新日期：2013-01-01 00:00:00

abstract：:Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by the lysosome. Maturation of autophagosomes requires their transport towards the perinuclear region of the cell, with key factors underlying both processes still poorly understood. Here we show that transport and positioning of lat...

journal_title：Nature communications

authors： Wijdeven RH,Janssen H,Nahidiazar L,Janssen L,Jalink K,Berlin I,Neefjes J

更新日期：2016-06-10 00:00:00

abstract：:Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activat...

journal_title：Nature communications

authors： Natsuizaka M,Whelan KA,Kagawa S,Tanaka K,Giroux V,Chandramouleeswaran PM,Long A,Sahu V,Darling DS,Que J,Yang Y,Katz JP,Wileyto EP,Basu D,Kita Y,Natsugoe S,Naganuma S,Klein-Szanto AJ,Diehl JA,Bass AJ,Wong KK,Rust

更新日期：2017-11-24 00:00:00

abstract：:Nanoparticle-mediated delivery of functional macromolecules is a promising method for treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have recently been highlighted as a new therapeutic strategy for the in vivo delivery of nucleotides and chemical drugs. Here we describe a new tool for...

journal_title：Nature communications

authors： Yim N,Ryu SW,Choi K,Lee KR,Lee S,Choi H,Kim J,Shaker MR,Sun W,Park JH,Kim D,Heo WD,Choi C

更新日期：2016-07-22 00:00:00

abstract：:The fossil record of crocodylians and their relatives (pseudosuchians) reveals a rich evolutionary history, prompting questions about causes of long-term decline to their present-day low biodiversity. We analyse climatic drivers of subsampled pseudosuchian biodiversity over their 250 million year history, using a comp...

journal_title：Nature communications

authors： Mannion PD,Benson RBJ,Carrano MT,Tennant JP,Judd J,Butler RJ

更新日期：2015-09-24 00:00:00

abstract：:Lysosomes are the major degradative compartments within cells, harbouring a wide variety of hydrolytic enzymes within their lumen. Release of lysosomal hydrolases from lysosomes into the cell cytoplasm results in cell death. Here we report that damaged lysosomes undergo autophagic turnover. Using a light-induced lysos...

journal_title：Nature communications

authors： Hung YH,Chen LM,Yang JY,Yang WY

更新日期：2013-01-01 00:00:00

abstract：:Thin, ultra-flexible devices that can be manufactured in a process that covers a large area will be essential to realizing low-cost, wearable electronic applications including foldable displays and medical sensors. The printing technology will be instrumental in fabricating these novel electronic devices and circuits;...

journal_title：Nature communications

authors： Fukuda K,Takeda Y,Yoshimura Y,Shiwaku R,Tran LT,Sekine T,Mizukami M,Kumaki D,Tokito S

更新日期：2014-06-20 00:00:00

abstract：:The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...

journal_title：Nature communications

authors： Zeng B,Mu G,Luo HQ,Xiang T,Mazin II,Yang H,Shan L,Ren C,Dai PC,Wen HH

更新日期：2010-11-16 00:00:00

abstract：:Hybrid organic-inorganic perovskites have attractive optoelectronic properties including exceptional solar cell performance. The improved properties of perovskites have been attributed to polaronic effects involving stabilization of localized charge character by structural deformations and polarizations. Here we exami...

journal_title：Nature communications

authors： Park M,Neukirch AJ,Reyes-Lillo SE,Lai M,Ellis SR,Dietze D,Neaton JB,Yang P,Tretiak S,Mathies RA

更新日期：2018-06-28 00:00:00

abstract：:Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous attempts to identify host factors have produced largely divergent results, with few overlapping hits across different st...

journal_title：Nature communications

authors： Li B,Clohisey SM,Chia BS,Wang B,Cui A,Eisenhaure T,Schweitzer LD,Hoover P,Parkinson NJ,Nachshon A,Smith N,Regan T,Farr D,Gutmann MU,Bukhari SI,Law A,Sangesland M,Gat-Viks I,Digard P,Vasudevan S,Lingwood D,Dockre

更新日期：2020-01-09 00:00:00

abstract：:The capability to detect traces of explosives sensitively, selectively and rapidly could be of great benefit for applications relating to civilian national security and military needs. Here, we show that, when chemically modified in a multiplexed mode, nanoelectrical devices arrays enable the supersensitive discrimina...

journal_title：Nature communications

authors： Lichtenstein A,Havivi E,Shacham R,Hahamy E,Leibovich R,Pevzner A,Krivitsky V,Davivi G,Presman I,Elnathan R,Engel Y,Flaxer E,Patolsky F

更新日期：2014-06-24 00:00:00

abstract：:Interest in manipulating the magnetic order by ultrashort laser pulses has thrived since it was observed that such pulses can be used to alter the magnetization on a sub-picosecond timescale. Usually this involves demagnetization by laser heating or, in rare cases, a transient increase of magnetization. Here we demons...

journal_title：Nature communications

authors： Matsubara M,Schroer A,Schmehl A,Melville A,Becher C,Trujillo-Martinez M,Schlom DG,Mannhart J,Kroha J,Fiebig M

更新日期：2015-04-02 00:00:00

abstract：:Non-Abelian quasiparticles have been predicted to exist in a variety of condensed matter systems. Their defining property is that an adiabatic braid between two of them results in a non-trivial change of the quantum state of the system. The simplest non-Abelian quasiparticles--the Majorana bound states--can occur in o...

journal_title：Nature communications

authors： Li J,Neupert T,Bernevig BA,Yazdani A

更新日期：2016-01-21 00:00:00

abstract：:A number of modes of oscillations of particles and fields can exist in space plasmas. Since the early 1970s, space missions have observed noise-like plasma waves near the geomagnetic equator known as 'equatorial noise'. Several theories were suggested, but clear observational evidence supported by realistic modelling ...

journal_title：Nature communications

authors： Balikhin MA,Shprits YY,Walker SN,Chen L,Cornilleau-Wehrlin N,Dandouras I,Santolik O,Carr C,Yearby KH,Weiss B

更新日期：2015-07-14 00:00:00

abstract：:Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in chondrocytes causes s...

journal_title：Nature communications

authors： Mirzamohammadi F,Papaioannou G,Inloes JB,Rankin EB,Xie H,Schipani E,Orkin SH,Kobayashi T

更新日期：2016-06-22 00:00:00

abstract：:Redox-regulated effector systems that counteract oxidative stress are essential for all forms of life. Here we uncover a new paradigm for sensing oxidative stress centred on the hydrophobic core of a sensor protein. RsrA is an archetypal zinc-binding anti-sigma factor that responds to disulfide stress in the cytoplasm...

journal_title：Nature communications

authors： Rajasekar KV,Zdanowski K,Yan J,Hopper JT,Francis ML,Seepersad C,Sharp C,Pecqueur L,Werner JM,Robinson CV,Mohammed S,Potts JR,Kleanthous C

更新日期：2016-07-19 00:00:00

abstract：:Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug transporter MdfA exchanges a single proton with a single monovalent cationic drug molecule. This stoichiometry renders the efflux of divalent cationic drugs energet...

journal_title：Nature communications

authors： Fluman N,Adler J,Rotenberg SA,Brown MH,Bibi E

更新日期：2014-08-08 00:00:00

abstract：:Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance...

journal_title：Nature communications

authors： Tapper W,Jones AV,Kralovics R,Harutyunyan AS,Zoi K,Leung W,Godfrey AL,Guglielmelli P,Callaway A,Ward D,Aranaz P,White HE,Waghorn K,Lin F,Chase A,Baxter EJ,Maclean C,Nangalia J,Chen E,Evans P,Short M,Jack A,Wal

更新日期：2015-04-07 00:00:00

abstract：:As energy efficiency becomes a paramount issue in this day and age, reversible computing may serve as a critical step towards energy conservation in information technology. The inputs of reversible computing elements define the outputs and vice versa. Some reversible gates such as the Fredkin gate are also universal; ...

journal_title：Nature communications

authors： Cohen E,Dolev S,Rosenblit M

更新日期：2016-04-26 00:00:00

abstract：:Polarization-driven resistive switching in ferroelectric tunnel junctions (FTJs)--structures composed of two electrodes separated by an ultrathin ferroelectric barrier--offers new physics and materials functionalities, as well as exciting opportunities for the next generation of non-volatile memories and logic devices...

journal_title：Nature communications

authors： Lu H,Lipatov A,Ryu S,Kim DJ,Lee H,Zhuravlev MY,Eom CB,Tsymbal EY,Sinitskii A,Gruverman A

更新日期：2014-11-24 00:00:00

abstract：:Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we identify numerous lncRNAs involved in key steps of cell division su...

journal_title：Nature communications

authors： Stojic L,Lun ATL,Mascalchi P,Ernst C,Redmond AM,Mangei J,Barr AR,Bousgouni V,Bakal C,Marioni JC,Odom DT,Gergely F

更新日期：2020-04-15 00:00:00

abstract：:Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...

journal_title：Nature communications

authors： Zakhary MJ,Gibaud T,Kaplan CN,Barry E,Oldenbourg R,Meyer RB,Dogic Z

更新日期：2014-01-01 00:00:00

abstract：:Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper uptake via the induction of a metalloreductase, STEAP4. IL-17-induced ...

journal_title：Nature communications

authors： Liao Y,Zhao J,Bulek K,Tang F,Chen X,Cai G,Jia S,Fox PL,Huang E,Pizarro TT,Kalady MF,Jackson MW,Bao S,Sen GC,Stark GR,Chang CJ,Li X

更新日期：2020-02-14 00:00:00

abstract：:Complex oxide heterointerfaces and van der Waals heterostructures present two versatile but intrinsically different platforms for exploring emergent quantum phenomena and designing new functionalities. The rich opportunity offered by the synergy between these two classes of materials, however, is yet to be charted. He...

journal_title：Nature communications

authors： Li D,Huang X,Xiao Z,Chen H,Zhang L,Hao Y,Song J,Shao DF,Tsymbal EY,Lu Y,Hong X

更新日期：2020-03-17 00:00:00

abstract：:Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV...

journal_title：Nature communications

authors： Pérez-Guzmán EX,Pantoja P,Serrano-Collazo C,Hassert MA,Ortiz-Rosa A,Rodríguez IV,Giavedoni L,Hodara V,Parodi L,Cruz L,Arana T,White LJ,Martínez MI,Weiskopf D,Brien JD,de Silva A,Pinto AK,Sariol CA

更新日期：2019-09-20 00:00:00

abstract：:Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp2 network and destroying the tubes electronic and optoelectronic features. Here we present a non-destructive, cova...

journal_title：Nature communications

authors： Setaro A,Adeli M,Glaeske M,Przyrembel D,Bisswanger T,Gordeev G,Maschietto F,Faghani A,Paulus B,Weinelt M,Arenal R,Haag R,Reich S

更新日期：2017-01-30 00:00:00

abstract：:Electronic structure heterogeneities are ubiquitous in two-dimensional graphene and profoundly impact the transport properties of this material. Here we show the mapping of discrete electronic domains within a single graphene sheet using scanning transmission X-ray microscopy in conjunction with ab initio density func...

journal_title：Nature communications

authors： Schultz BJ,Patridge CJ,Lee V,Jaye C,Lysaght PS,Smith C,Barnett J,Fischer DA,Prendergast D,Banerjee S

更新日期：2011-06-28 00:00:00

abstract：:Diamond photonics is an ever-growing field of research driven by the prospects of harnessing diamond and its colour centres as suitable hardware for solid-state quantum applications. The last two decades have seen the field shaped by the nitrogen-vacancy (NV) centre with both breakthrough fundamental physics demonstra...

journal_title：Nature communications

authors： Bradac C,Gao W,Forneris J,Trusheim ME,Aharonovich I

更新日期：2019-12-09 00:00:00

abstract：:The naked mole-rat (NMR, Heterocephalus glaber), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response to reprogramming induction. In this study, we generate NMR-induced pluripotent stem cells (NMR-iPSCs...

journal_title：Nature communications

authors： Miyawaki S,Kawamura Y,Oiwa Y,Shimizu A,Hachiya T,Bono H,Koya I,Okada Y,Kimura T,Tsuchiya Y,Suzuki S,Onishi N,Kuzumaki N,Matsuzaki Y,Narita M,Ikeda E,Okanoya K,Seino K,Saya H,Okano H,Miura K

更新日期：2016-05-10 00:00:00