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MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.

Abstract：

:Regulation of transcription elongation by RNA polymerase II (Pol II) is a key regulatory step in gene transcription. Recently, the little elongation complex (LEC)-which contains the transcription elongation factor ELL/EAF-was found to be required for the transcription of Pol II-dependent small nuclear RNA (snRNA) genes. Here we show that the human Mediator subunit MED26 plays a role in the recruitment of LEC to a subset of snRNA genes through direct interaction of EAF and the N-terminal domain (NTD) of MED26. Loss of MED26 in cells decreases the occupancy of LEC at a subset of snRNA genes and results in a reduction in their transcription. Our results suggest that the MED26-NTD functions as a molecular switch in the exchange of TBP-associated factor 7 (TAF7) for LEC to facilitate the transition from initiation to elongation during transcription of a subset of snRNA genes.

journal_name

Nat Commun

journal_title

Nature communications

authors

Takahashi H,Takigawa I,Watanabe M,Anwar D,Shibata M,Tomomori-Sato C,Sato S,Ranjan A,Seidel CW,Tsukiyama T,Mizushima W,Hayashi M,Ohkawa Y,Conaway JW,Conaway RC,Hatakeyama S

doi

10.1038/ncomms6941

subject

Has Abstract

pub_date

2015-01-09 00:00:00

pages

5941

issn

2041-1723

pii

ncomms6941

journal_volume

6

pub_type

杂志文章

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