Abstract:
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journal_name
Nat Communjournal_title
Nature communicationsauthors
International Multiple Sclerosis Genetics Consortium.doi
10.1038/s41467-019-10951-1subject
Has Abstractpub_date
2019-07-01 00:00:00pages
2956issue
1issn
2041-1723pii
10.1038/s41467-019-10951-1journal_volume
10pub_type
已发布勘误abstract::Proteins containing a Bin/Amphiphysin/Rvs (BAR) domain regulate membrane curvature in the cell. Recent simulations have revealed that BAR proteins assemble into linear aggregates, strongly affecting membrane curvature and its in-plane stress profile. Here, we explore the opposite question: do mechanical properties of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8219
更新日期:2015-05-26 00:00:00
abstract::Aging is characterized by a chronic, low-grade inflammation, which is a major risk factor for cardiovascular diseases. It remains poorly understood whether pro-inflammatory factors released from non-cardiac tissues contribute to the non-autonomous regulation of age-related cardiac dysfunction. Here, we report that age...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16781-w
更新日期:2020-06-10 00:00:00
abstract::COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18709-w
更新日期:2020-10-07 00:00:00
abstract::The continued development of novel drugs, proteins, and advanced materials strongly rely on our ability to self-assemble molecules in solids with the most suitable structure (polymorph) in order to exhibit desired functionalities. The search for new polymorphs remains a scientific challenge, that is at the core of cry...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11555
更新日期:2016-05-10 00:00:00
abstract::FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma ce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00578-5
更新日期:2017-09-20 00:00:00
abstract::The magnetic excitations in the cuprate superconductors might be essential for an understanding of high-temperature superconductivity. In these cuprate superconductors the magnetic excitation spectrum resembles an hour-glass and certain resonant magnetic excitations within are believed to be connected to the pairing m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6731
更新日期:2014-12-23 00:00:00
abstract::Synthetic lethality is a promising concept in cancer research, potentially opening new possibilities for the development of more effective and selective treatments. Here, we present a computational method to predict and exploit synthetic lethality in cancer metabolism. Our approach relies on the concept of genetic min...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00555-y
更新日期:2017-09-06 00:00:00
abstract::The investigations on optical angular momenta and their interactions have broadened our knowledge of light's behavior at sub-wavelength scales. Recent studies further unveil the extraordinary characteristics of transverse spin angular momentum in confined light fields and orbital angular momentum in optical vortices. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03237-5
更新日期:2018-03-02 00:00:00
abstract::Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02813-5
更新日期:2018-01-26 00:00:00
abstract::Self-assembly of proteins and inorganic nanoparticles into terminal assemblies makes possible a large family of uniformly sized hybrid colloids. These particles can be compared in terms of utility, versatility and multifunctionality to other known types of terminal assemblies. They are simple to make and offer theoret...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4593
更新日期:2014-05-20 00:00:00
abstract::Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and obs...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4518
更新日期:2014-03-27 00:00:00
abstract::Cosmic rays interact with the Earth's atmosphere to produce 14C, which can be absorbed by trees. Therefore, rapid increases of 14C in tree rings can be used to probe previous cosmic-ray events. By this method, three 14C rapidly increasing events have been found. Plausible causes of these events include large solar pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01698-8
更新日期:2017-11-14 00:00:00
abstract::The emergence of artificial intelligence (AI) and its progressively wider impact on many sectors requires an assessment of its effect on the achievement of the Sustainable Development Goals. Using a consensus-based expert elicitation process, we find that AI can enable the accomplishment of 134 targets across all the ...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-019-14108-y
更新日期:2020-01-13 00:00:00
abstract::Microbial production of isoprene from renewable feedstock is a promising alternative to traditional petroleum-based processes. Currently, efforts to improve isoprenoid production in Saccharomyces cerevisiae mainly focus on cytoplasmic engineering, whereas comprehensive engineering of multiple subcellular compartments ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12851
更新日期:2016-09-21 00:00:00
abstract::Topological insulators interacting with magnetic impurities have been reported to host several unconventional effects. These phenomena are described within the framework of gapping Dirac quasiparticles due to broken time-reversal symmetry. However, the overwhelming majority of studies demonstrate the presence of a fin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12027
更新日期:2016-06-27 00:00:00
abstract::Pathogen-associated molecular patterns (PAMPs) are known to be fundamental in instigating immune responses, but their role in influencing these responses beyond their initiation is less well understood. Here, using the protozoan parasite Trypanosoma cruzi, which is deficient in strong PAMPs, we demonstrate a requireme...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3616
更新日期:2013-01-01 00:00:00
abstract::The amniote middle ear is a classical example of the evolutionary novelty. Although paleontological evidence supports the view that mammals and diapsids (modern reptiles and birds) independently acquired the middle ear after divergence from their common ancestor, the developmental bases of these transformations remain...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7853
更新日期:2015-04-22 00:00:00
abstract::In bacteria, transcription complexes stalled on DNA represent a major source of roadblocks for the DNA replication machinery that must be removed in order to prevent damaging collisions. Gram-positive bacteria contain a transcription factor HelD that is able to remove and recycle stalled complexes, but it was not know...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20157-5
更新日期:2020-12-18 00:00:00
abstract::The alloy-design strategy of combining multiple elements in near-equimolar ratios has shown great potential for producing exceptional engineering materials, often known as 'high-entropy alloys'. Understanding the elemental distribution, and, thus, the evolution of the configurational entropy during solidification, is ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6964
更新日期:2015-01-20 00:00:00
abstract::For societies with writing systems, hereditary leadership is documented as one of the hallmarks of early political complexity and governance. In contrast, it is unknown whether hereditary succession played a role in the early formation of prehistoric complex societies that lacked writing. Here we use an archaeogenomic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14115
更新日期:2017-02-21 00:00:00
abstract::Despite progress in understanding pollination network structure, the functional roles of floral sensory stimuli (visual, olfactory) have never been addressed comprehensively in a community context, even though such traits are known to mediate plant-pollinator interactions. Here, we use a comprehensive dataset of flora...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03448-w
更新日期:2018-03-12 00:00:00
abstract::Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and te...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15461
更新日期:2017-06-05 00:00:00
abstract::Exposure to extreme events is a major concern in coastal regions where growing human populations and stressed natural ecosystems are at significant risk to such phenomena. However, the complex sequence of processes that transform an event from notable to extreme can be challenging to identify and hence, limit forecast...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18339-2
更新日期:2020-09-22 00:00:00
abstract::A broad range of dynamic metasurfaces has been developed for manipulating the intensity, phase and wavefront of electromagnetic radiation from microwaves to optical frequencies. However, most of these metasurfaces operate in single-input-output state. Here, we experimentally demonstrate a reconfigurable MEMS Fano reso...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06360-5
更新日期:2018-10-03 00:00:00
abstract::Activation of innate immunity by membrane-localized receptors is conserved across eukaryotes. Plant genomes contain hundreds of such receptor-like genes and those encoding proteins with an extracellular leucine-rich repeat (LRR) domain represent the largest family. Here, we develop a high-throughput approach to study ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03010-8
更新日期:2018-02-09 00:00:00
abstract::Sunlight is the ultimate driver of biosynthesis but photochemical steps late in biosynthetic pathways are very rare. They appear to play a role in the formation of certain furanocembranoids isolated from Caribbean corals. One of these compounds, intricarene, has been suspected to arise from an intramolecular 1,3-dipol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6597
更新日期:2014-12-03 00:00:00
abstract::Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on attachment) through a multi-step end-on conversion process. Upstream regulators that orchestrate this remarkable change in the plane of kinetochore-microtubule attachment in human cells are not kno...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00209-z
更新日期:2017-07-28 00:00:00
abstract::Low-damping magnetic materials have been widely used in microwave and spintronic applications because of their low energy loss and high sensitivity. While the Gilbert damping constant can reach 10-4 to 10-5 in some insulating ferromagnets, metallic ferromagnets generally have larger damping due to magnon scattering by...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00332-x
更新日期:2017-08-10 00:00:00
abstract::Membrane-bound pyrophosphatases (M-PPases), which couple proton/sodium ion transport to pyrophosphate synthesis/hydrolysis, are important in abiotic stress resistance and in the infectivity of protozoan parasites. Here, three M-PPase structures in different catalytic states show that closure of the substrate-binding p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13596
更新日期:2016-12-06 00:00:00
abstract::Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10498
更新日期:2016-02-15 00:00:00