Abstract:
:Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of matter. To fully harness this potential, we must accurately know the X-ray properties: intensity, spectrum and temporal profile. Owing to the inherent fluctuations in free-electron lasers, this mandates a full characterization of the properties for each and every pulse. While diagnostics of these properties exist, they are often invasive and many cannot operate at a high-repetition rate. Here, we present a technique for circumventing this limitation. Employing a machine learning strategy, we can accurately predict X-ray properties for every shot using only parameters that are easily recorded at high-repetition rate, by training a model on a small set of fully diagnosed pulses. This opens the door to fully realizing the promise of next-generation high-repetition rate X-ray lasers.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sanchez-Gonzalez A,Micaelli P,Olivier C,Barillot TR,Ilchen M,Lutman AA,Marinelli A,Maxwell T,Achner A,Agåker M,Berrah N,Bostedt C,Bozek JD,Buck J,Bucksbaum PH,Montero SC,Cooper B,Cryan JP,Dong M,Feifel R,Frasinskidoi
10.1038/ncomms15461subject
Has Abstractpub_date
2017-06-05 00:00:00pages
15461issn
2041-1723pii
ncomms15461journal_volume
8pub_type
杂志文章abstract::Positive selection in the thymus provides low-affinity T-cell receptor (TCR) engagement to support the development of potentially useful self-major histocompatibility complex class I (MHC-I)-restricted T cells. Optimal positive selection of CD8(+) T cells requires cortical thymic epithelial cells that express β5t-cont...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8484
更新日期:2015-06-23 00:00:00
abstract::Hedgehog (Hh) signalling regulates embryonic development and adult tissue homoeostasis. Mutations of its pathway components including Suppressor of Fused (Sufu) and Gli/Ci predispose to cancers and congenital anomalies. The Sufu-Gli protein complex occupies a central position in the vertebrate Hh signalling pathway, e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3608
更新日期:2013-01-01 00:00:00
abstract::In eukaryotes, adventitious oxidation of erythrose-4-phosphate, an intermediate of the pentose phosphate pathway (PPP), generates 4-phosphoerythronate (4PE), which inhibits 6-phosphogluconate dehydrogenase. 4PE is detoxified by metabolite-proofreading phosphatases such as yeast Pho13. Here, we report that a similar fu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09508-z
更新日期:2019-04-04 00:00:00
abstract::Cell biologists generally consider that microtubules and actin play complementary roles in long- and short-distance transport in animal cells. On the contrary, using melanosomes of melanocytes as a model, we recently discovered that the motor protein myosin-Va works with dynamic actin tracks to drive long-range organe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17212-6
更新日期:2020-07-13 00:00:00
abstract::Topological defects in nematic liquid crystals are ubiquitous. The defects are important in understanding the fundamental properties of the systems, as well as in practical applications, such as colloidal self-assembly, optical vortex generation and templates for molecular self-assembly. Usually, spatially and tempora...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13238
更新日期:2016-11-07 00:00:00
abstract::MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12970
更新日期:2016-09-27 00:00:00
abstract::Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as a diagnostic or therapeutic tool. To characterize the complex interactions between graphene and immune cells, we propose an integrative analytical pipeline encompassing the evaluation of molecul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01015-3
更新日期:2017-10-24 00:00:00
abstract::Sintering of powders is a common means of producing bulk materials when melt casting is impossible or does not achieve a desired microstructure, and has long been pursued for nanocrystalline materials in particular. Acceleration of sintering is desirable to lower processing temperatures and times, and thus to limit un...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7858
更新日期:2015-04-22 00:00:00
abstract::The original version of this article contained an error in the spelling of the author Christian A.M. Wilson, which was incorrectly given as Christian M.A. Wilson. This has now been corrected in both the PDF and HTML versions of the article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-017-02384-5
更新日期:2017-12-14 00:00:00
abstract::MCR-1 is a lipid A modifying enzyme that confers resistance to the antibiotic colistin. Here, we analyse the impact of MCR-1 expression on E. coli morphology, fitness, competitiveness, immune stimulation and virulence. Increased expression of mcr-1 results in decreased growth rate, cell viability, competitive ability ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02149-0
更新日期:2017-12-12 00:00:00
abstract::Unusual features of the vibrational density of states D(ω) of glasses allow one to rationalize their peculiar low-temperature properties. Simulational studies of D(ω) have been restricted to studying poorly annealed glasses that may not be relevant to experiments. Here we report on D(ω) of zero-temperature glasses wit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07978-1
更新日期:2019-01-03 00:00:00
abstract::Highly regio- and enantioselective intermolecular hydroamination of alkenes is a challenging process potentially leading to valuable chiral amines. Hydroamination of alkenes via metal-catalyzed hydrogen atom transfer (HAT) with good regioselectivity and functional group tolerance has been reported, however, high enant...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14459-x
更新日期:2020-02-07 00:00:00
abstract::Topology has an increasingly important role in the physics of condensed matter, quantum systems, material science, photonics and biology, with spectacular realizations of topological concepts in liquid crystals. Here we report on long-lived hidden topological states in thermally quenched, chiral nematic droplets, form...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14594
更新日期:2017-02-21 00:00:00
abstract::Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6969
更新日期:2015-01-19 00:00:00
abstract::The interconversion of charge and spin currents via spin-Hall effect is essential for spintronics. Energy-efficient and deterministic switching of magnetization can be achieved when spin polarizations of these spin currents are collinear with the magnetization. However, symmetry conditions generally restrict spin pola...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17999-4
更新日期:2020-09-16 00:00:00
abstract::Plasma wakefield accelerators have been used to accelerate electron and positron particle beams with gradients that are orders of magnitude larger than those achieved in conventional accelerators. In addition to being accelerated by the plasma wakefield, the beam particles also experience strong transverse forces that...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11785
更新日期:2016-06-02 00:00:00
abstract::Self-assembly of electroactive molecules is a promising route to new types of functional semiconductors. Here we report a capsule-shaped molecule that assembles itself into a cellular semiconducting material. The interior space of the capsule with a volume of ~415 Å3 is a nanoenvironment that can accommodate a guest. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04246-0
更新日期:2018-05-16 00:00:00
abstract::Carotenoid cleavage dioxygenases (CCDs) form hormones and signaling molecules. Here we show that a member of an overlooked plant CCD subfamily from rice, that we name Zaxinone Synthase (ZAS), can produce zaxinone, a novel apocarotenoid metabolite in vitro. Loss-of-function mutants (zas) contain less zaxinone, exhibit ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08461-1
更新日期:2019-02-18 00:00:00
abstract::Ubiquitous satellite communications are in a leading position for bridging the digital divide. Fulfilling such a mission will require satellite services on par with fibre services, both in bandwidth and cost. Achieving such a performance requires a new generation of communications payloads powered by large-scale proce...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10077-4
更新日期:2019-04-30 00:00:00
abstract::Ultra-small, magic-sized metal nanoclusters represent an important new class of materials with properties between molecules and particles. However, their small size challenges the conventional methods for structure characterization. Here we present the structure of ultra-stable Au144(SR)60 magic-sized nanoclusters obt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11859
更新日期:2016-06-14 00:00:00
abstract::Tibetan wheat is grown under environmental constraints at high-altitude conditions, but its underlying adaptation mechanism remains unknown. Here, we present a draft genome sequence of a Tibetan semi-wild wheat (Triticum aestivum ssp. tibetanum Shao) accession Zang1817 and re-sequence 245 wheat accessions, including w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18738-5
更新日期:2020-10-08 00:00:00
abstract::A new paradigm for cellulose depolymerization by fungi focuses on an oxidative mechanism involving cellobiose dehydrogenases (CDH) and copper-dependent lytic polysaccharide monooxygenases (LPMO); however, mechanistic studies have been hampered by the lack of structural information regarding CDH. CDH contains a haem-bi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8542
更新日期:2015-07-07 00:00:00
abstract::Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been systematically studied so far. Here we perform gene copy number analysis (n=54), genome/exome (n=44) and transcriptome (n=69) sequencing of pulmonary carcinoids and obs...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4518
更新日期:2014-03-27 00:00:00
abstract::In many dynamical systems and complex networks time delays appear naturally in feedback loops or coupling connections of individual elements. Moreover, in a whole class of systems, these delay times can depend on the state of the system. Nevertheless, so far the understanding of the impact of such state-dependent dela...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8425
更新日期:2015-06-17 00:00:00
abstract::Plasmacytoid dendritic cells (pDC) are type I interferon-producing cells with critical functions in a number of human illnesses; however, their molecular regulation is incompletely understood. Here we show the role of Src family kinases (SFK) in mouse and human pDCs. pDCs express Fyn and Lyn and their activating resid...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14830
更新日期:2017-04-03 00:00:00
abstract::The possibility of measuring binding of small-molecule drugs to desired targets in live cells could provide a better understanding of drug action. However, current approaches mostly yield static data, require lysis or rely on indirect assays and thus often provide an incomplete understanding of drug action. Here, we p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4946
更新日期:2014-05-28 00:00:00
abstract::Considering the rapid increase of CO2 emission, especially from power plants, there is a constant need for materials which can effectively eliminate post-combustion CO2 (the main component: CO2/N2 = 15/85). Here, we show the design and synthesis of a Cu(II) metal-organic framework (FJI-H14) with a high density of acti...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01166-3
更新日期:2017-11-01 00:00:00
abstract::In the original version of this Article, an additional double-headed arrow was inadvertently included within Fig. 3e. This error has been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-019-08615-1
更新日期:2019-02-12 00:00:00
abstract::The insulin/IGF-1 signalling pathway is a key regulator of metabolism and the rate of ageing. We previously documented that systemic inactivation of phosphoinositide 3-kinase (PI3K) p110α, the principal PI3K isoform that positively regulates insulin signalling, results in a beneficial metabolic effect in aged mice. He...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09514-1
更新日期:2019-04-04 00:00:00
abstract::In high magnetic fields, two-dimensional electron systems can form a number of phases in which interelectron repulsion plays the central role, since the kinetic energy is frozen out by Landau quantization. These phases include the well-known liquids of the fractional quantum Hall effect, as well as solid phases with b...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5154
更新日期:2014-06-20 00:00:00