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Photochemical formation of intricarene.

Abstract：

:Sunlight is the ultimate driver of biosynthesis but photochemical steps late in biosynthetic pathways are very rare. They appear to play a role in the formation of certain furanocembranoids isolated from Caribbean corals. One of these compounds, intricarene, has been suspected to arise from an intramolecular 1,3-dipolar cycloaddition involving an oxidopyrylium. Here we show, by a combination of experiments and theory, that the oxidopyrylium forms under photochemical conditions and that its cycloaddition occurs via a triplet state. The formation of a complex by-product can be rationalized by another photochemical step that involves a conical intersection. Our work raises the question whether intricarene is biosynthesized in the natural habitat of the corals or is an artefact formed during workup. It also demonstrates that the determination of exact irradiation spectra, in combination with quantum chemical calculations, enables the rationalization of complex reaction pathways that involve multiple excited states.

journal_name

Nat Commun

journal_title

Nature communications

authors

Stichnoth D,Kölle P,Kimbrough TJ,Riedle E,de Vivie-Riedle R,Trauner D

doi

10.1038/ncomms6597

subject

Has Abstract

pub_date

2014-12-03 00:00:00

pages

5597

issn

2041-1723

pii

ncomms6597

journal_volume

5

pub_type

杂志文章

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