Archaeogenomic evidence reveals prehistoric matrilineal dynasty.

abstract：:Recently, surface-enhanced Raman scattering nanoprobes have shown tremendous potential in oncological imaging owing to the high sensitivity and specificity of their fingerprint-like spectra. As current Raman scanners rely on a slow, point-by-point spectrum acquisition, there is an unmet need for faster imaging to cove...

journal_title：Nature communications

authors： Pal S,Ray A,Andreou C,Zhou Y,Rakshit T,Wlodarczyk M,Maeda M,Toledo-Crow R,Berisha N,Yang J,Hsu HT,Oseledchyk A,Mondal J,Zou S,Kircher MF

更新日期：2019-04-26 00:00:00

abstract：:Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on attachment) through a multi-step end-on conversion process. Upstream regulators that orchestrate this remarkable change in the plane of kinetochore-microtubule attachment in human cells are not kno...

journal_title：Nature communications

authors： Shrestha RL,Conti D,Tamura N,Braun D,Ramalingam RA,Cieslinski K,Ries J,Draviam VM

更新日期：2017-07-28 00:00:00

abstract：:Transmission through disordered samples can be controlled by illuminating a sample with waveforms corresponding to the eigenchannels of the transmission matrix (TM). But can the TM be exploited to selectively excite quasi-normal modes and so control the spatial profile and dwell time inside the medium? We show in micr...

journal_title：Nature communications

authors： Davy M,Genack AZ

更新日期：2018-11-09 00:00:00

abstract：:Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing c...

journal_title：Nature communications

authors： Watson SA,Duff J,Bardi I,Zabielska M,Atanur SS,Jabbour RJ,Simon A,Tomas A,Smolenski RT,Harding SE,Perbellini F,Terracciano CM

更新日期：2019-05-15 00:00:00

abstract：:Pattern-triggered immunity and effector-triggered immunity are two primary forms of innate immunity in land plants. The molecular components and connecting nodes of pattern-triggered immunity and effector-triggered immunity are not fully understood. Here, we report that the Arabidopsis calcium-dependent protein kinase...

journal_title：Nature communications

authors： Lu YJ,Li P,Shimono M,Corrion A,Higaki T,He SY,Day B

更新日期：2020-12-04 00:00:00

abstract：:The current study uses big data to study prosocial behavior by analyzing donations made on the GoFundMe platform. In a dataset of more than $44 million in online donations, we find that 21% were made while opting to be anonymous to the public, with survey results indicating that 11% of these anonymous donations (2.3% ...

journal_title：Nature communications

authors： Sisco MR,Weber EU

更新日期：2019-09-03 00:00:00

abstract：:Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms that prevent transcriptional interference are not well understood. Here ...

journal_title：Nature communications

authors： Yu X,Martin PGP,Michaels SD

更新日期：2019-09-25 00:00:00

abstract：:Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tra...

journal_title：Nature communications

authors： Cajuso T,Sulo P,Tanskanen T,Katainen R,Taira A,Hänninen UA,Kondelin J,Forsström L,Välimäki N,Aavikko M,Kaasinen E,Ristimäki A,Koskensalo S,Lepistö A,Renkonen-Sinisalo L,Seppälä T,Kuopio T,Böhm J,Mecklin JP,Kilpivaar

更新日期：2019-09-06 00:00:00

abstract：:Most chemical vapor deposition methods for transition metal dichalcogenides use an extremely small amount of precursor to render large single-crystal flakes, which usually causes low coverage of the materials on the substrate. In this study, a self-capping vapor-liquid-solid reaction is proposed to fabricate large-gra...

journal_title：Nature communications

authors： Chang MC,Ho PH,Tseng MF,Lin FY,Hou CH,Lin IK,Wang H,Huang PP,Chiang CH,Yang YC,Wang IT,Du HY,Wen CY,Shyue JJ,Chen CW,Chen KH,Chiu PW,Chen LC

更新日期：2020-07-23 00:00:00

abstract：:Post-translational protein modification by tyrosine sulfation has an important role in extracellular protein-protein interactions. The protein tyrosine sulfation reaction is catalysed by the Golgi enzyme called the tyrosylprotein sulfotransferase. To date, no crystal structure is available for tyrosylprotein sulfotran...

journal_title：Nature communications

authors： Teramoto T,Fujikawa Y,Kawaguchi Y,Kurogi K,Soejima M,Adachi R,Nakanishi Y,Mishiro-Sato E,Liu MC,Sakakibara Y,Suiko M,Kimura M,Kakuta Y

更新日期：2013-01-01 00:00:00

abstract：:While many tools exist for identifying and quantifying individual cell types, few methods are available to assess the relationships between cell types in organs and tissues and how these relationships change during aging or disease states. We present a quantitative method for evaluating cellular organization, using th...

journal_title：Nature communications

authors： Sornborger A,Li J,Timmons C,Lupu F,Eggenschwiler J,Takahama Y,Manley NR

更新日期：2017-05-30 00:00:00

abstract：:The change of global-mean precipitation under global warming and interannual variability is predominantly controlled by the change of atmospheric longwave radiative cooling. Here we show that tightening of the ascending branch of the Hadley Circulation coupled with a decrease in tropical high cloud fraction is key in ...

journal_title：Nature communications

authors： Su H,Jiang JH,Neelin JD,Shen TJ,Zhai C,Yue Q,Wang Z,Huang L,Choi YS,Stephens GL,Yung YL

更新日期：2017-06-07 00:00:00

abstract：:Disordered mechanical systems, when strongly deformed, have complex configuration spaces with multiple stable states and pathways connecting them. The topology of such pathways determines which states are smoothly accessible from any part of configuration space. Controlling this topology would allow us to limit access...

journal_title：Nature communications

authors： Stern M,Jayaram V,Murugan A

更新日期：2018-10-16 00:00:00

abstract：:Autophagy is the main homeostatic pathway guiding cytosolic materials for degradation by the lysosome. Maturation of autophagosomes requires their transport towards the perinuclear region of the cell, with key factors underlying both processes still poorly understood. Here we show that transport and positioning of lat...

journal_title：Nature communications

authors： Wijdeven RH,Janssen H,Nahidiazar L,Janssen L,Jalink K,Berlin I,Neefjes J

更新日期：2016-06-10 00:00:00

abstract：:Many phenomena occurring in strongly correlated quantum systems still await conclusive explanations. The absence of isolated free quarks in nature is an example. It is attributed to quark confinement, whose origin is not yet understood. The phase diagram for nuclear matter at general temperatures and densities, studie...

journal_title：Nature communications

authors： Tagliacozzo L,Celi A,Orland P,Mitchell MW,Lewenstein M

更新日期：2013-01-01 00:00:00

abstract：:Breast cancer (BC) patients diagnosed between two screenings (interval cancers) are more likely than screen-detected patients to carry rare deleterious mutations in cancer genes potentially leading to increased risk for other non-breast cancer (non-BC) tumors. In this study, we include 14,846 women diagnosed with BC o...

journal_title：Nature communications

authors： Grassmann F,He W,Eriksson M,Gabrielson M,Hall P,Czene K

更新日期：2019-10-22 00:00:00

abstract：:Metabolism is coordinated among tissues and organs via neuronal signals. Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver. Here we demonstrate that hepatic AA/mTORC1/S6K signalling modulates sys...

journal_title：Nature communications

authors： Uno K,Yamada T,Ishigaki Y,Imai J,Hasegawa Y,Sawada S,Kaneko K,Ono H,Asano T,Oka Y,Katagiri H

更新日期：2015-08-13 00:00:00

abstract：:Tunnel junctions, an established platform for high resolution spectroscopy of superconductors, require defect-free insulating barriers; however, oxides, the most common barrier, can only grow on a limited selection of materials. We show that van der Waals tunnel barriers, fabricated by exfoliation and transfer of laye...

journal_title：Nature communications

authors： Dvir T,Massee F,Attias L,Khodas M,Aprili M,Quay CHL,Steinberg H

更新日期：2018-02-09 00:00:00

abstract：:The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates...

journal_title：Nature communications

authors： Xu Y,Plechanovová A,Simpson P,Marchant J,Leidecker O,Kraatz S,Hay RT,Matthews SJ

更新日期：2014-06-27 00:00:00

abstract：:Recently, metasurfaces composed of artificially fabricated subwavelength structures have shown remarkable potential for the manipulation of light with unprecedented functionality. Here, we first demonstrate a metasurface application to realize a compact near-eye display system for augmented reality with a wide field o...

journal_title：Nature communications

authors： Lee GY,Hong JY,Hwang S,Moon S,Kang H,Jeon S,Kim H,Jeong JH,Lee B

更新日期：2018-11-01 00:00:00

abstract：:The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the ant...

journal_title：Nature communications

authors： Zhang S,Kostyuchenko VA,Ng TS,Lim XN,Ooi JSG,Lambert S,Tan TY,Widman DG,Shi J,Baric RS,Lok SM

更新日期：2016-11-24 00:00:00

abstract：:The damming of rivers represents one of the most far-reaching human modifications of the flows of water and associated matter from land to sea. Dam reservoirs are hotspots of sediment accumulation, primary productivity (P) and carbon mineralization (R) along the river continuum. Here we show that for the period 1970-2...

journal_title：Nature communications

authors： Maavara T,Lauerwald R,Regnier P,Van Cappellen P

更新日期：2017-05-17 00:00:00

abstract：:Subduction zone magmas are more oxidised on eruption than those at mid-ocean ridges. This is attributed either to oxidising components, derived from subducted lithosphere (slab) and added to the mantle wedge, or to oxidation processes occurring during magma ascent via differentiation. Here we provide direct evidence f...

journal_title：Nature communications

authors： Bénard A,Klimm K,Woodland AB,Arculus RJ,Wilke M,Botcharnikov RE,Shimizu N,Nebel O,Rivard C,Ionov DA

更新日期：2018-08-29 00:00:00

abstract：:CD4(+) Th17 are heterogeneous in terms of cytokine production and capacity to initiate autoimmune diseases, such as experimental autoimmune encephalomyelitis (EAE). Here we demonstrate that experimental priming of encephalitogenic Th cells expressing RORγt and T-bet and producing IL-17A, IFN-γ and GM-CSF but not IL-10...

journal_title：Nature communications

authors： Ronchi F,Basso C,Preite S,Reboldi A,Baumjohann D,Perlini L,Lanzavecchia A,Sallusto F

更新日期：2016-05-18 00:00:00

abstract：:Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside reverse-transcriptase inhibitors (NRTI), drugs approved to treat HIV-1 and hepatitis B infections, also block inflam...

journal_title：Nature communications

authors： Ambati J,Magagnoli J,Leung H,Wang SB,Andrews CA,Fu D,Pandey A,Sahu S,Narendran S,Hirahara S,Fukuda S,Sun J,Pandya L,Ambati M,Pereira F,Varshney A,Cummings T,Hardin JW,Edun B,Bennett CL,Ambati K,Fowler BJ,Kerur

更新日期：2020-09-23 00:00:00

abstract：:MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop structure. In plants, the ribonuclease type III DICER-LIKE1 assisted by accessory proteins cleaves the precursor to releas...

journal_title：Nature communications

authors： Rojas AML,Drusin SI,Chorostecki U,Mateos JL,Moro B,Bologna NG,Bresso EG,Schapire A,Rasia RM,Moreno DM,Palatnik JF

更新日期：2020-10-21 00:00:00

abstract：:Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymerize outward from adhesion sites to push membranes towards distant sit...

journal_title：Nature communications

authors： Garbett D,Bisaria A,Yang C,McCarthy DG,Hayer A,Moerner WE,Svitkina TM,Meyer T

更新日期：2020-09-23 00:00:00

abstract：:The cation channel TRPM8 plays a central role in the somatosensory system, as a key sensor of innocuously cold temperatures and cooling agents. Although increased functional expression of TRPM8 has been implicated in various forms of pathological cold hypersensitivity, little is known about the cellular and molecular ...

journal_title：Nature communications

authors： Ghosh D,Pinto S,Danglot L,Vandewauw I,Segal A,Van Ranst N,Benoit M,Janssens A,Vennekens R,Vanden Berghe P,Galli T,Vriens J,Voets T

更新日期：2016-02-04 00:00:00

abstract：:The causes of impaired skeletal muscle mass and strength during aging are well-studied in healthy populations. Less is known on pathological age-related muscle wasting and weakness termed sarcopenia, which directly impacts physical autonomy and survival. Here, we compare genome-wide transcriptional changes of sarcopen...

journal_title：Nature communications

authors： Migliavacca E,Tay SKH,Patel HP,Sonntag T,Civiletto G,McFarlane C,Forrester T,Barton SJ,Leow MK,Antoun E,Charpagne A,Seng Chong Y,Descombes P,Feng L,Francis-Emmanuel P,Garratt ES,Giner MP,Green CO,Karaz S,Kothandaram

更新日期：2019-12-20 00:00:00

abstract：:Mangrove forests hold some of the highest densities of carbon recorded in any ecosystem, but have experienced widespread deforestation through conversion to aquaculture and agriculture. Alongside deforestation, mangroves have shown simultaneous natural expansion in some parts of the world, and considerable investments...

journal_title：Nature communications

authors： Richards DR,Thompson BS,Wijedasa L

更新日期：2020-08-26 00:00:00