Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4.

Abstract:

:The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. The SUMO-targeted ubiquitin ligase RNF4 engages with SUMO chains on linked substrates and catalyses their ubiquitination, which targets substrates for proteasomal degradation. Here we use a segmental labelling approach combined with solution nuclear magnetic resonance (NMR) spectroscopy and biochemical characterization to reveal how RNF4 manipulates the conformation of the SUMO chain, thereby facilitating optimal delivery of the distal SUMO domain for ubiquitin transfer.

journal_name

Nat Commun

journal_title

Nature communications

authors

Xu Y,Plechanovová A,Simpson P,Marchant J,Leidecker O,Kraatz S,Hay RT,Matthews SJ

doi

10.1038/ncomms5217

subject

Has Abstract

pub_date

2014-06-27 00:00:00

pages

4217

issn

2041-1723

pii

ncomms5217

journal_volume

5

pub_type

杂志文章
  • Rotating-frame relaxation as a noise spectrum analyser of a superconducting qubit undergoing driven evolution.

    abstract::Gate operations in a quantum information processor are generally realized by tailoring specific periods of free and driven evolution of a quantum system. Unwanted environmental noise, which may in principle be distinct during these two periods, acts to decohere the system and increase the gate error rate. Although the...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms3337

    authors: Yan F,Gustavsson S,Bylander J,Jin X,Yoshihara F,Cory DG,Nakamura Y,Orlando TP,Oliver WD

    更新日期:2013-01-01 00:00:00

  • Extreme-ultraviolet high-harmonic generation in liquids.

    abstract::High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-06040-4

    authors: Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

    更新日期:2018-09-13 00:00:00

  • Anthropogenic combustion iron as a complex climate forcer.

    abstract::Atmospheric iron affects the global carbon cycle by modulating ocean biogeochemistry through the deposition of soluble iron to the ocean. Iron emitted by anthropogenic (fossil fuel) combustion is a source of soluble iron that is currently considered less important than other soluble iron sources, such as mineral dust ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03997-0

    authors: Matsui H,Mahowald NM,Moteki N,Hamilton DS,Ohata S,Yoshida A,Koike M,Scanza RA,Flanner MG

    更新日期:2018-04-23 00:00:00

  • Stereoselective photoredox ring-opening polymerization of O-carboxyanhydrides.

    abstract::Biodegradable polyesters with various tacticities have been synthesized by means of stereoselective ring-opening polymerization of racemic lactide and β-lactones but with limited side-chain groups. However, stereoselective synthesis of functional polyesters remains challenging from O-carboxyanhydrides that have abunda...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-03879-5

    authors: Feng Q,Yang L,Zhong Y,Guo D,Liu G,Xie L,Huang W,Tong R

    更新日期:2018-04-19 00:00:00

  • Bond competition and phase evolution on the IrTe₂ surface.

    abstract::Compounds with incommensurate structural modulations have been extensively studied in last several decades. However, the relationship between structurally incommensurate/commensurate phases and associated electronic states remains enigmatic. Here we report the coexisting of complex incommensurate structures and highly...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms6358

    authors: Li Q,Lin W,Yan J,Chen X,Gianfrancesco AG,Singh DJ,Mandrus D,Kalinin SV,Pan M

    更新日期:2014-11-07 00:00:00

  • Fast growth of large-grain and continuous MoS2 films through a self-capping vapor-liquid-solid method.

    abstract::Most chemical vapor deposition methods for transition metal dichalcogenides use an extremely small amount of precursor to render large single-crystal flakes, which usually causes low coverage of the materials on the substrate. In this study, a self-capping vapor-liquid-solid reaction is proposed to fabricate large-gra...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-17517-6

    authors: Chang MC,Ho PH,Tseng MF,Lin FY,Hou CH,Lin IK,Wang H,Huang PP,Chiang CH,Yang YC,Wang IT,Du HY,Wen CY,Shyue JJ,Chen CW,Chen KH,Chiu PW,Chen LC

    更新日期:2020-07-23 00:00:00

  • Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation.

    abstract::Substance abuse disorders are linked to alteration of circadian rhythms, although the molecular and neuronal pathways implicated have not been fully elucidated. Addictive drugs, such as cocaine, induce a rapid increase of dopamine levels in the brain. Here, we show that acute administration of cocaine triggers reprogr...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18200-6

    authors: Brami-Cherrier K,Lewis RG,Cervantes M,Liu Y,Tognini P,Baldi P,Sassone-Corsi P,Borrelli E

    更新日期:2020-09-07 00:00:00

  • Age and pattern of the southern high-latitude continental end-Permian extinction constrained by multiproxy analysis.

    abstract::Past studies of the end-Permian extinction (EPE), the largest biotic crisis of the Phanerozoic, have not resolved the timing of events in southern high-latitudes. Here we use palynology coupled with high-precision CA-ID-TIMS dating of euhedral zircons from continental sequences of the Sydney Basin, Australia, to show ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-07934-z

    authors: Fielding CR,Frank TD,McLoughlin S,Vajda V,Mays C,Tevyaw AP,Winguth A,Winguth C,Nicoll RS,Bocking M,Crowley JL

    更新日期:2019-01-23 00:00:00

  • Visualization of lithium-ion transport and phase evolution within and between manganese oxide nanorods.

    abstract::Multiple lithium-ion transport pathways and local phase changes upon lithiation in silver hollandite are revealed via in situ microscopy including electron diffraction, imaging and spectroscopy, coupled with density functional theory and phase field calculations. We report unexpected inter-nanorod lithium-ion transpor...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15400

    authors: Xu F,Wu L,Meng Q,Kaltak M,Huang J,Durham JL,Fernandez-Serra M,Sun L,Marschilok AC,Takeuchi ES,Takeuchi KJ,Hybertsen MS,Zhu Y

    更新日期:2017-05-24 00:00:00

  • Impurity-band transport in organic spin valves.

    abstract::The central phenomenon in the field of organic spintronics is the large magnetoresistance in thick organic spin valves. A prerequisite for understanding the magnetoresistance is a reliable description of the device resistance, or the I-V characteristics. Here I show that the observed I-V characteristics in the organic...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5842

    authors: Yu ZG

    更新日期:2014-09-09 00:00:00

  • π-phase modulated monolayer supercritical lens.

    abstract::The emerging monolayer transition metal dichalcogenides have provided an unprecedented material platform for miniaturized opto-electronic devices with integrated functionalities. Although excitonic light-matter interactions associated with their direct bandgaps have received tremendous research efforts, wavefront engi...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-20278-x

    authors: Qin F,Liu B,Zhu L,Lei J,Fang W,Hu D,Zhu Y,Ma W,Wang B,Shi T,Cao Y,Guan BO,Qiu CW,Lu Y,Li X

    更新日期:2021-01-04 00:00:00

  • Zero-temperature glass transition in two dimensions.

    abstract::Liquids cooled towards the glass transition temperature transform into amorphous solids that have a wide range of applications. While the nature of this transformation is understood rigorously in the mean-field limit of infinite spatial dimensions, the problem remains wide open in physical dimensions. Nontrivial finit...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09512-3

    authors: Berthier L,Charbonneau P,Ninarello A,Ozawa M,Yaida S

    更新日期:2019-04-03 00:00:00

  • Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.

    abstract::A subset of transcription factors classified as neural crest 'specifiers' are also core epithelial-mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The bHLH factor Twist is among the least well studied of these factors. Here we demonstrate that Twist is required for crania...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2543

    authors: Lander R,Nasr T,Ochoa SD,Nordin K,Prasad MS,Labonne C

    更新日期:2013-01-01 00:00:00

  • Tailoring nanoscopic confines to maximize catalytic activity of hydronium ions.

    abstract::Acid catalysis by hydronium ions is ubiquitous in aqueous-phase organic reactions. Here we show that hydronium ion catalysis, exemplified by intramolecular dehydration of cyclohexanol, is markedly influenced by steric constraints, yielding turnover rates that increase by up to two orders of magnitude in tight confines...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15442

    authors: Shi H,Eckstein S,Vjunov A,Camaioni DM,Lercher JA

    更新日期:2017-05-25 00:00:00

  • India's potential for integrating solar and on- and offshore wind power into its energy system.

    abstract::This paper considers options for a future Indian power economy in which renewables, wind and solar, could meet 80% of anticipated 2040 power demand supplanting the country's current reliance on coal. Using a cost optimization model, here we show that renewables could provide a source of power cheaper or at least compe...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-020-18318-7

    authors: Lu T,Sherman P,Chen X,Chen S,Lu X,McElroy M

    更新日期:2020-09-21 00:00:00

  • High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.

    abstract::Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has recently been demonstrated, suggesting a novel therapeutic strategy for cardiac repair. However, current approaches are inefficient. Here we demonstr...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms9243

    authors: Zhao Y,Londono P,Cao Y,Sharpe EJ,Proenza C,O'Rourke R,Jones KL,Jeong MY,Walker LA,Buttrick PM,McKinsey TA,Song K

    更新日期:2015-09-10 00:00:00

  • Electrostrictive microelectromechanical fibres and textiles.

    abstract::Microelectromechanical systems (MEMS) enable many modern-day technologies, including actuators, motion sensors, drug delivery systems, projection displays, etc. Currently, MEMS fabrication techniques are primarily based on silicon micromachining processes, resulting in rigid and low aspect ratio structures. In this st...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-017-01558-5

    authors: Khudiyev T,Clayton J,Levy E,Chocat N,Gumennik A,Stolyarov AM,Joannopoulos J,Fink Y

    更新日期:2017-11-10 00:00:00

  • Implementing a strand of a scalable fault-tolerant quantum computing fabric.

    abstract::With favourable error thresholds and requiring only nearest-neighbour interactions on a lattice, the surface code is an error-correcting code that has garnered considerable attention. At the heart of this code is the ability to perform a low-weight parity measurement of local code qubits. Here we demonstrate high-fide...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5015

    authors: Chow JM,Gambetta JM,Magesan E,Abraham DW,Cross AW,Johnson BR,Masluk NA,Ryan CA,Smolin JA,Srinivasan SJ,Steffen M

    更新日期:2014-06-24 00:00:00

  • The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.

    abstract::The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-11013-2

    authors: Lazareth H,Henique C,Lenoir O,Puelles VG,Flamant M,Bollée G,Fligny C,Camus M,Guyonnet L,Millien C,Gaillard F,Chipont A,Robin B,Fabrega S,Dhaun N,Camerer E,Kretz O,Grahammer F,Braun F,Huber TB,Nochy D,Mandet C,

    更新日期:2019-07-24 00:00:00

  • New Blatter-type radicals from a bench-stable carbene.

    abstract::Stable benzotriazinyl radicals (Blatter's radicals) recently attracted considerable interest as building blocks for functional materials. The existing strategies to derivatize Blatter's radicals are limited, however, and synthetic routes are complex. Here, we report that an inexpensive, commercially available, analyti...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms15088

    authors: Grant JA,Lu Z,Tucker DE,Hockin BM,Yufit DS,Fox MA,Kataky R,Chechik V,O'Donoghue AC

    更新日期:2017-05-15 00:00:00

  • The fecal resistome of dairy cattle is associated with diet during nursing.

    abstract::Antimicrobial resistance is a global public health concern, and livestock play a significant role in selecting for resistance and maintaining such reservoirs. Here we study the succession of dairy cattle resistome during early life using metagenomic sequencing, as well as the relationship between resistome, gut microb...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-12111-x

    authors: Liu J,Taft DH,Maldonado-Gomez MX,Johnson D,Treiber ML,Lemay DG,DePeters EJ,Mills DA

    更新日期:2019-09-27 00:00:00

  • Epidermal phospholipase Cδ1 regulates granulocyte counts and systemic interleukin-17 levels in mice.

    abstract::Phospholipase C is a key enzyme in phosphoinositide turnover. Although its functions have been extensively studied at the cellular level, many questions remain concerning its functions at the organ and individual animal levels. Here we demonstrate that mice lacking phospholipase Cδ1 develop granulocytosis associated w...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms1960

    authors: Kanemaru K,Nakamura Y,Sato K,Kojima R,Takahashi S,Yamaguchi M,Ichinohe M,Kiyonari H,Shioi G,Kabashima K,Nakahigashi K,Asagiri M,Jamora C,Yamaguchi H,Fukami K

    更新日期:2012-07-17 00:00:00

  • Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity.

    abstract::To cause food-borne botulism, botulinum neurotoxin (BoNT) in the gastrointestinal lumen must traverse the intestinal epithelial barrier. However, the mechanism by which BoNT crosses the intestinal epithelial barrier remains unclear. BoNTs are produced along with one or more non-toxic components, with which they form p...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms7255

    authors: Matsumura T,Sugawara Y,Yutani M,Amatsu S,Yagita H,Kohda T,Fukuoka S,Nakamura Y,Fukuda S,Hase K,Ohno H,Fujinaga Y

    更新日期:2015-02-17 00:00:00

  • Uncovering many-body correlations in nanoscale nuclear spin baths by central spin decoherence.

    abstract::Central spin decoherence caused by nuclear spin baths is often a critical issue in various quantum computing schemes, and it has also been used for sensing single-nuclear spins. Recent theoretical studies suggest that central spin decoherence can act as a probe of many-body physics in spin baths; however, identificati...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms5822

    authors: Ma WL,Wolfowicz G,Zhao N,Li SS,Morton JJ,Liu RB

    更新日期:2014-09-10 00:00:00

  • Brain-actuated functional electrical stimulation elicits lasting arm motor recovery after stroke.

    abstract::Brain-computer interfaces (BCI) are used in stroke rehabilitation to translate brain signals into intended movements of the paralyzed limb. However, the efficacy and mechanisms of BCI-based therapies remain unclear. Here we show that BCI coupled to functional electrical stimulation (FES) elicits significant, clinicall...

    journal_title:Nature communications

    pub_type: 杂志文章,随机对照试验

    doi:10.1038/s41467-018-04673-z

    authors: Biasiucci A,Leeb R,Iturrate I,Perdikis S,Al-Khodairy A,Corbet T,Schnider A,Schmidlin T,Zhang H,Bassolino M,Viceic D,Vuadens P,Guggisberg AG,Millán JDR

    更新日期:2018-06-20 00:00:00

  • Pressure-tuning the quantum spin Hamiltonian of the triangular lattice antiferromagnet Cs2CuCl4.

    abstract::Quantum triangular-lattice antiferromagnets are important prototype systems to investigate numerous phenomena of the geometrical frustration in condensed matter. Apart from highly unusual magnetic properties, they possess a rich phase diagram (ranging from an unfrustrated square lattice to a quantum spin liquid), yet ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-019-09071-7

    authors: Zvyagin SA,Graf D,Sakurai T,Kimura S,Nojiri H,Wosnitza J,Ohta H,Ono T,Tanaka H

    更新日期:2019-03-06 00:00:00

  • RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.

    abstract::Zinc-finger nuclease, transcription activator-like effector nuclease and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are becoming major tools for genome editing. Importantly, knock-in in several non-rodent species has been finally achieved thanks to these custo...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms10548

    authors: Song J,Yang D,Xu J,Zhu T,Chen YE,Zhang J

    更新日期:2016-01-28 00:00:00

  • Reconciling glacial Antarctic water stable isotopes with ice sheet topography and the isotopic paleothermometer.

    abstract::Stable water isotope records from Antarctica are key for our understanding of Quaternary climate variations. However, the exact quantitative interpretation of these important climate proxy records in terms of surface temperature, ice sheet height and other climatic changes is still a matter of debate. Here we report r...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/s41467-018-05430-y

    authors: Werner M,Jouzel J,Masson-Delmotte V,Lohmann G

    更新日期:2018-08-30 00:00:00

  • Tunable ferroelectricity in artificial tri-layer superlattices comprised of non-ferroic components.

    abstract::Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms2061

    authors: Rogdakis K,Seo JW,Viskadourakis Z,Wang Y,Qune LF,Choi E,Burton JD,Tsymbal EY,Lee J,Panagopoulos C

    更新日期:2012-01-01 00:00:00

  • Coral snakes predict the evolution of mimicry across New World snakes.

    abstract::Batesian mimicry, in which harmless species (mimics) deter predators by deceitfully imitating the warning signals of noxious species (models), generates striking cases of phenotypic convergence that are classic examples of evolution by natural selection. However, mimicry of venomous coral snakes has remained controver...

    journal_title:Nature communications

    pub_type: 杂志文章

    doi:10.1038/ncomms11484

    authors: Davis Rabosky AR,Cox CL,Rabosky DL,Title PO,Holmes IA,Feldman A,McGuire JA

    更新日期:2016-05-05 00:00:00