Abstract:
:Antimicrobial resistance is a global public health concern, and livestock play a significant role in selecting for resistance and maintaining such reservoirs. Here we study the succession of dairy cattle resistome during early life using metagenomic sequencing, as well as the relationship between resistome, gut microbiota, and diet. In our dataset, the gut of dairy calves serves as a reservoir of 329 antimicrobial resistance genes (ARGs) presumably conferring resistance to 17 classes of antibiotics, and the abundance of ARGs declines gradually during nursing. ARGs appear to co-occur with antibacterial biocide or metal resistance genes. Colostrum is a potential source of ARGs observed in calves at day 2. The dynamic changes in the resistome are likely a result of gut microbiota assembly, which is closely associated with diet transition in dairy calves. Modifications in the resistome may be possible via early-life dietary interventions to reduce overall antimicrobial resistance.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Liu J,Taft DH,Maldonado-Gomez MX,Johnson D,Treiber ML,Lemay DG,DePeters EJ,Mills DAdoi
10.1038/s41467-019-12111-xsubject
Has Abstractpub_date
2019-09-27 00:00:00pages
4406issue
1issn
2041-1723pii
10.1038/s41467-019-12111-xjournal_volume
10pub_type
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