当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.

The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.

Abstract：

:The mechanisms driving the development of extracapillary lesions in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CGN) remain poorly understood. A key question is how parietal epithelial cells (PECs) invade glomerular capillaries, thereby promoting injury and kidney failure. Here we show that expression of the tetraspanin CD9 increases markedly in PECs in mouse models of CGN and FSGS, and in kidneys from individuals diagnosed with these diseases. Cd9 gene targeting in PECs prevents glomerular damage in CGN and FSGS mouse models. Mechanistically, CD9 deficiency prevents the oriented migration of PECs into the glomerular tuft and their acquisition of CD44 and β1 integrin expression. These findings highlight a critical role for de novo expression of CD9 as a common pathogenic switch driving the PEC phenotype in CGN and FSGS, while offering a potential therapeutic avenue to treat these conditions.

journal_name

Nat Commun

journal_title

Nature communications

authors

Lazareth H,Henique C,Lenoir O,Puelles VG,Flamant M,Bollée G,Fligny C,Camus M,Guyonnet L,Millien C,Gaillard F,Chipont A,Robin B,Fabrega S,Dhaun N,Camerer E,Kretz O,Grahammer F,Braun F,Huber TB,Nochy D,Mandet C,

doi

10.1038/s41467-019-11013-2

subject

Has Abstract

pub_date

2019-07-24 00:00:00

pages

3303

issue

1

issn

2041-1723

pii

10.1038/s41467-019-11013-2

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Avian UV vision enhances leaf surface contrasts in forest environments.

    abstract：:UV vision is prevalent, but we know little about its utility in common general tasks, as in resolving habitat structure. Here we visualize vegetated habitats using a multispectral camera with channels mimicking bird photoreceptor sensitivities across the UV-visible spectrum. We find that the contrast between upper and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08142-5

    authors： Tedore C,Nilsson DE

    更新日期：2019-01-22 00:00:00

  • EGFL7 reduces CNS inflammation in mouse.

    abstract：:Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells (ECs) are implicated in cell trafficking. We discovered that the expression of ECM epidermal growth factor-like protein 7 (EGFL7) is increased in the CNS vasculature of patients with multiple sclerosis (MS), and in mice with ex...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03186-z

    authors： Larochelle C,Uphaus T,Broux B,Gowing E,Paterka M,Michel L,Dudvarski Stankovic N,Bicker F,Lemaître F,Prat A,Schmidt MHH,Zipp F

    更新日期：2018-02-26 00:00:00

  • Regulation of cell-to-cell variability in divergent gene expression.

    abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms11099

    authors： Yan C,Wu S,Pocetti C,Bai L

    更新日期：2016-03-24 00:00:00

  • Phototrophic purple bacteria as optoacoustic in vivo reporters of macrophage activity.

    abstract：:Τhe morphology, physiology and immunology, of solid tumors exhibit spatial heterogeneity which complicates our understanding of cancer progression and therapy response. Understanding spatial heterogeneity necessitates high resolution in vivo imaging of anatomical and pathophysiological tumor information. We introduce ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09081-5

    authors： Peters L,Weidenfeld I,Klemm U,Loeschcke A,Weihmann R,Jaeger KE,Drepper T,Ntziachristos V,Stiel AC

    更新日期：2019-03-13 00:00:00

  • O-GlcNAcylation of SIRT1 enhances its deacetylase activity and promotes cytoprotection under stress.

    abstract：:SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the regulation of metabolism, stress responses, genome stability, and ageing. As a stress sensor, SIRT1 deacetylase activity is significantly increased during stresses, but the molecular mechanisms are not yet fully clear. Here,...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01654-6

    authors： Han C,Gu Y,Shan H,Mi W,Sun J,Shi M,Zhang X,Lu X,Han F,Gong Q,Yu W

    更新日期：2017-11-14 00:00:00

  • Causal associations between risk factors and common diseases inferred from GWAS summary data.

    abstract：:Health risk factors such as body mass index (BMI) and serum cholesterol are associated with many common diseases. It often remains unclear whether the risk factors are cause or consequence of disease, or whether the associations are the result of confounding. We develop and apply a method (called GSMR) that performs a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02317-2

    authors： Zhu Z,Zheng Z,Zhang F,Wu Y,Trzaskowski M,Maier R,Robinson MR,McGrath JJ,Visscher PM,Wray NR,Yang J

    更新日期：2018-01-15 00:00:00

  • Ecosystem-based fisheries management forestalls climate-driven collapse.

    abstract：:Climate change is impacting fisheries worldwide with uncertain outcomes for food and nutritional security. Using management strategy evaluations for key US fisheries in the eastern Bering Sea we find that Ecosystem Based Fisheries Management (EBFM) measures forestall future declines under climate change over non-EBFM ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18300-3

    authors： Holsman KK,Haynie AC,Hollowed AB,Reum JCP,Aydin K,Hermann AJ,Cheng W,Faig A,Ianelli JN,Kearney KA,Punt AE

    更新日期：2020-09-11 00:00:00

  • Author Correction: The energy cost of polypeptide knot formation and its folding consequences.

    abstract：:The original version of this article contained an error in the spelling of the author Christian A.M. Wilson, which was incorrectly given as Christian M.A. Wilson. This has now been corrected in both the PDF and HTML versions of the article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-017-02384-5

    authors： Bustamante A,Sotelo-Campos J,Guerra DG,Floor M,Wilson CAM,Bustamante C,Báez M

    更新日期：2017-12-14 00:00:00

  • Reversible induction of mitophagy by an optogenetic bimodular system.

    abstract：:Autophagy-mediated degradation of mitochondria (mitophagy) is a key process in cellular quality control. Although mitophagy impairment is involved in several patho-physiological conditions, valuable methods to induce mitophagy with low toxicity in vivo are still lacking. Herein, we describe a new optogenetic tool to s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09487-1

    authors： D'Acunzo P,Strappazzon F,Caruana I,Meneghetti G,Di Rita A,Simula L,Weber G,Del Bufalo F,Dalla Valle L,Campello S,Locatelli F,Cecconi F

    更新日期：2019-04-04 00:00:00

  • Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy.

    abstract：:Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes. Here, we study genomic clustering in the benzylisoquinoline alkaloid (BIA) pathway in opium poppy (Papaver somniferum), exploring relationships between g...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15040-2

    authors： Li Q,Ramasamy S,Singh P,Hagel JM,Dunemann SM,Chen X,Chen R,Yu L,Tucker JE,Facchini PJ,Yeaman S

    更新日期：2020-03-04 00:00:00

  • Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity.

    abstract：:Previous transcriptomic profiling studies have typically focused on separately analyzing mRNA expression, alternative splicing and alternative polyadenylation differences between cell and tissue types. However, the relative contribution of these three transcriptomic regulatory layers to cell type specification is poor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20483-8

    authors： Ha KCH,Sterne-Weiler T,Morris Q,Weatheritt RJ,Blencowe BJ

    更新日期：2021-01-12 00:00:00

  • Improved GPCR ligands from nanobody tethering.

    abstract：:Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell types of choice based on that antibody's specificity. Here we develop a new type of conjugate that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused via their C-termini. We address act...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15884-8

    authors： Cheloha RW,Fischer FA,Woodham AW,Daley E,Suminski N,Gardella TJ,Ploegh HL

    更新日期：2020-04-29 00:00:00

  • Atomically defined angstrom-scale all-carbon junctions.

    abstract：:Full-carbon electronics at the scale of several angstroms is an expeimental challenge, which could be overcome by exploiting the versatility of carbon allotropes. Here, we investigate charge transport through graphene/single-fullerene/graphene hybrid junctions using a single-molecule manipulation technique. Such sub-n...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09793-8

    authors： Tan Z,Zhang D,Tian HR,Wu Q,Hou S,Pi J,Sadeghi H,Tang Z,Yang Y,Liu J,Tan YZ,Chen ZB,Shi J,Xiao Z,Lambert C,Xie SY,Hong W

    更新日期：2019-04-15 00:00:00

  • Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis.

    abstract：:Somatic mutations contribute to tumorigenesis. Although these mutations occur in all proliferating cells, their accumulation under non-malignant conditions, such as in autoimmune disorders, has not been investigated. Here, we show that patients with newly diagnosed rheumatoid arthritis have expanded CD8+ T-cell clones...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15869

    authors： Savola P,Kelkka T,Rajala HL,Kuuliala A,Kuuliala K,Eldfors S,Ellonen P,Lagström S,Lepistö M,Hannunen T,Andersson EI,Khajuria RK,Jaatinen T,Koivuniemi R,Repo H,Saarela J,Porkka K,Leirisalo-Repo M,Mustjoki S

    更新日期：2017-06-21 00:00:00

  • Unique behaviour of dinitrogen-bridged dimolybdenum complexes bearing pincer ligand towards catalytic formation of ammonia.

    abstract：:It is vital to design effective nitrogen fixation systems that operate under mild conditions, and to this end we recently reported an example of the catalytic formation of ammonia using a dinitrogen-bridged dimolybdenum complex bearing a pincer ligand, where up to twenty three equivalents of ammonia were produced base...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4737

    authors： Tanaka H,Arashiba K,Kuriyama S,Sasada A,Nakajima K,Yoshizawa K,Nishibayashi Y

    更新日期：2014-04-28 00:00:00

  • Dynamic changes of muscle insulin sensitivity after metabolic surgery.

    abstract：:The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respirato...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12081-0

    authors： Gancheva S,Ouni M,Jelenik T,Koliaki C,Szendroedi J,Toledo FGS,Markgraf DF,Pesta DH,Mastrototaro L,De Filippo E,Herder C,Jähnert M,Weiss J,Strassburger K,Schlensak M,Schürmann A,Roden M

    更新日期：2019-09-13 00:00:00

  • Hydrogen spillover through Matryoshka-type (ZIFs@)n-1ZIFs nanocubes.

    abstract：:Hydrogen spillover phenomenon is well-documented in hydrogenation catalysis but still highly disputed in hydrogen storage. Until now, the existence of hydrogen spillover through metal-organic frameworks (MOFs) remains a topic of ongoing debate and how far the split hydrogen atoms diffuse in such materials is unknown. ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06269-z

    authors： Zhan G,Zeng HC

    更新日期：2018-09-17 00:00:00

  • Biosynthesis of the mycotoxin tenuazonic acid by a fungal NRPS-PKS hybrid enzyme.

    abstract：:Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9758

    authors： Yun CS,Motoyama T,Osada H

    更新日期：2015-10-27 00:00:00

  • The induction and function of the anti-inflammatory fate of TH17 cells.

    abstract：:TH17 cells exemplify environmental immune adaptation: they can acquire both a pathogenic and an anti-inflammatory fate. However, it is not known whether the anti-inflammatory fate is merely a vestigial trait, or whether it serves to preserve the integrity of the host tissues. Here we show that the capacity of TH17 cel...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17097-5

    authors： Xu H,Agalioti T,Zhao J,Steglich B,Wahib R,Vesely MCA,Bielecki P,Bailis W,Jackson R,Perez D,Izbicki J,Licona-Limón P,Kaartinen V,Geginat J,Esplugues E,Tolosa E,Huber S,Flavell RA,Gagliani N

    更新日期：2020-07-03 00:00:00

  • Crystal structure of mammalian acid sphingomyelinase.

    abstract：:Acid sphingomyelinase (ASMase, ASM, SMPD1) converts sphingomyelin into ceramide, modulating membrane properties and signal transduction. Inactivating mutations in ASMase cause Niemann-Pick disease, and its inhibition is also beneficial in models of depression and cancer. To gain a better understanding of this critical...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12196

    authors： Gorelik A,Illes K,Heinz LX,Superti-Furga G,Nagar B

    更新日期：2016-07-20 00:00:00

  • Metal-free dehydropolymerisation of phosphine-boranes using cyclic (alkyl)(amino)carbenes as hydrogen acceptors.

    abstract：:The divalent carbene carbon centre in cyclic (alkyl)(amino)carbenes (CAACs) is known to exhibit transition-metal-like insertion into E-H σ-bonds (E = H, N, Si, B, P, C, O) with formation of new, strong C-E and C-H bonds. Although subsequent transformations of the products represent an attractive strategy for metal-fre...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08967-8

    authors： Oldroyd NL,Chitnis SS,Annibale VT,Arz MI,Sparkes HA,Manners I

    更新日期：2019-03-26 00:00:00

  • MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.

    abstract：:Histone H2AX and MDC1 are key DNA repair and DNA-damage signalling proteins. When DNA double-strand breaks (DSBs) occur, H2AX is phosphorylated and then recruits MDC1, which in turn serves as a docking platform to promote the localization of other factors, including 53BP1, to DSB sites. Here, by using CRISPR-Cas9 engi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12929-5

    authors： Salguero I,Belotserkovskaya R,Coates J,Sczaniecka-Clift M,Demir M,Jhujh S,Wilson MD,Jackson SP

    更新日期：2019-11-15 00:00:00

  • Structural basis of ion transport and inhibition in ferroportin.

    abstract：:Ferroportin is an iron exporter essential for releasing cellular iron into circulation. Ferroportin is inhibited by a peptide hormone, hepcidin. In humans, mutations in ferroportin lead to ferroportin diseases that are often associated with accumulation of iron in macrophages and symptoms of iron deficiency anemia. He...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19458-6

    authors： Pan Y,Ren Z,Gao S,Shen J,Wang L,Xu Z,Yu Y,Bachina P,Zhang H,Fan X,Laganowsky A,Yan N,Zhou M

    更新日期：2020-11-10 00:00:00

  • Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing.

    abstract：:Manipulation of proteins by chemical modification is a powerful way to decipher their function. However, most ribosome-dependent and semi-synthetic methods have limitations in the number and type of modifications that can be introduced, especially in live cells. Here, we present an approach to incorporate single or mu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16208-6

    authors： Khoo KK,Galleano I,Gasparri F,Wieneke R,Harms H,Poulsen MH,Chua HC,Wulf M,Tampé R,Pless SA

    更新日期：2020-05-08 00:00:00

  • A metallic molybdenum dioxide with high stability for surface enhanced Raman spectroscopy.

    abstract：:Compared with noble metals, semiconductors with surface plasmon resonance effect are another type of SERS substrate materials. The main obstacles so far are that the semiconducting materials are often unstable and easy to be further oxidized or decomposed by laser irradiating or contacting with corrosive substances. H...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14903

    authors： Zhang Q,Li X,Ma Q,Zhang Q,Bai H,Yi W,Liu J,Han J,Xi G

    更新日期：2017-04-24 00:00:00

  • A unified neurocognitive model of semantics language social behaviour and face recognition in semantic dementia.

    abstract：:The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and m...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16089-9

    authors： Ding J,Chen K,Liu H,Huang L,Chen Y,Lv Y,Yang Q,Guo Q,Han Z,Lambon Ralph MA

    更新日期：2020-05-22 00:00:00

  • Summer warming explains widespread but not uniform greening in the Arctic tundra biome.

    abstract：:Arctic warming can influence tundra ecosystem function with consequences for climate feedbacks, wildlife and human communities. Yet ecological change across the Arctic tundra biome remains poorly quantified due to field measurement limitations and reliance on coarse-resolution satellite data. Here, we assess decadal c...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18479-5

    authors： Berner LT,Massey R,Jantz P,Forbes BC,Macias-Fauria M,Myers-Smith I,Kumpula T,Gauthier G,Andreu-Hayles L,Gaglioti BV,Burns P,Zetterberg P,D'Arrigo R,Goetz SJ

    更新日期：2020-09-22 00:00:00

  • Examining charitable giving in real-world online donations.

    abstract：:The current study uses big data to study prosocial behavior by analyzing donations made on the GoFundMe platform. In a dataset of more than $44 million in online donations, we find that 21% were made while opting to be anonymous to the public, with survey results indicating that 11% of these anonymous donations (2.3% ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11852-z

    authors： Sisco MR,Weber EU

    更新日期：2019-09-03 00:00:00

  • Quantum nanophotonics with group IV defects in diamond.

    abstract：:Diamond photonics is an ever-growing field of research driven by the prospects of harnessing diamond and its colour centres as suitable hardware for solid-state quantum applications. The last two decades have seen the field shaped by the nitrogen-vacancy (NV) centre with both breakthrough fundamental physics demonstra...

    journal_title：Nature communications

    pub_type： 杂志文章,评审

    doi：10.1038/s41467-019-13332-w

    authors： Bradac C,Gao W,Forneris J,Trusheim ME,Aharonovich I

    更新日期：2019-12-09 00:00:00

  • A plasma-treated chalcogenide switch device for stackable scalable 3D nanoscale memory.

    abstract：:Stackable select devices such as the oxide p-n junction diode and the Schottky diode (one-way switch) have been proposed for non-volatile unipolar resistive switching devices; however, bidirectional select devices (or two-way switch) need to be developed for bipolar resistive switching devices. Here we report on a ful...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms3629

    authors： Lee MJ,Lee D,Cho SH,Hur JH,Lee SM,Seo DH,Kim DS,Yang MS,Lee S,Hwang E,Uddin MR,Kim H,Chung UI,Park Y,Yoo IK

    更新日期：2013-01-01 00:00:00