Regulation of cell-to-cell variability in divergent gene expression.

abstract：:There is increasing evidence from genome-wide association studies for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children, yet the effects of protein-coding variants on ALL risk have not been systematically evaluated. Here we show a missense variant in CDKN2A associate...

journal_title：Nature communications

authors： Xu H,Zhang H,Yang W,Yadav R,Morrison AC,Qian M,Devidas M,Liu Y,Perez-Andreu V,Zhao X,Gastier-Foster JM,Lupo PJ,Neale G,Raetz E,Larsen E,Bowman WP,Carroll WL,Winick N,Williams R,Hansen T,Holm JC,Mardis E,Fulton

更新日期：2015-06-24 00:00:00

abstract：:Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...

journal_title：Nature communications

authors： Kang W,Ha KS,Uhm H,Park K,Lee JY,Hohng S,Kang C

更新日期：2020-01-23 00:00:00

abstract：:Climate change is impacting fisheries worldwide with uncertain outcomes for food and nutritional security. Using management strategy evaluations for key US fisheries in the eastern Bering Sea we find that Ecosystem Based Fisheries Management (EBFM) measures forestall future declines under climate change over non-EBFM ...

journal_title：Nature communications

authors： Holsman KK,Haynie AC,Hollowed AB,Reum JCP,Aydin K,Hermann AJ,Cheng W,Faig A,Ianelli JN,Kearney KA,Punt AE

更新日期：2020-09-11 00:00:00

abstract：:Interfacial reactions between electrode and electrolyte are critical, either beneficial or detrimental, for the performance of rechargeable batteries. The general approaches of controlling interfacial reactions are either applying a coating layer on cathode or modifying the electrolyte chemistry. Here we demonstrate a...

journal_title：Nature communications

authors： Zou L,Li J,Liu Z,Wang G,Manthiram A,Wang C

更新日期：2019-08-01 00:00:00

abstract：:Topological insulators interacting with magnetic impurities have been reported to host several unconventional effects. These phenomena are described within the framework of gapping Dirac quasiparticles due to broken time-reversal symmetry. However, the overwhelming majority of studies demonstrate the presence of a fin...

journal_title：Nature communications

authors： Sessi P,Biswas RR,Bathon T,Storz O,Wilfert S,Barla A,Kokh KA,Tereshchenko OE,Fauth K,Bode M,Balatsky AV

更新日期：2016-06-27 00:00:00

abstract：:Pseudomonas aeruginosa, an opportunistic pathogen of humans, uses quorum sensing (QS) to regulate the production of extracellular products that can benefit all members of the population. P. aeruginosa can police QS-deficient cheaters by producing hydrogen cyanide, which is also QS regulated; however, the mechanism by ...

journal_title：Nature communications

authors： Yan H,Asfahl KL,Li N,Sun F,Xiao J,Shen D,Dandekar AA,Wang M

更新日期：2019-11-01 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) play a central role in synaptic plasticity, learning and memory, and are implicated in various neuronal disorders. We synthesized a diffusible photochromic glutamate analogue, azobenzene-triazole-glutamate (ATG), which is specific for NMDARs and functions as a photoswitchable ag...

journal_title：Nature communications

authors： Laprell L,Repak E,Franckevicius V,Hartrampf F,Terhag J,Hollmann M,Sumser M,Rebola N,DiGregorio DA,Trauner D

更新日期：2015-08-27 00:00:00

abstract：:The miniaturization of integrated optical circuits below the diffraction limit for high-speed manipulation of information is one of the cornerstones in plasmonics research. By coupling to surface plasmons supported on nanostructured metallic surfaces, light can be confined to the nanoscale, enabling the potential inte...

journal_title：Nature communications

authors： Raza S,Esfandyarpour M,Koh AL,Mortensen NA,Brongersma ML,Bozhevolnyi SI

更新日期：2016-12-16 00:00:00

abstract：:Molecules can efficiently and selectively convert light energy into other degrees of freedom. Disentangling the underlying ultrafast motion of electrons and nuclei of the photoexcited molecule presents a challenge to current spectroscopic approaches. Here we explore the photoexcited dynamics of molecules by an interac...

journal_title：Nature communications

authors： McFarland BK,Farrell JP,Miyabe S,Tarantelli F,Aguilar A,Berrah N,Bostedt C,Bozek JD,Bucksbaum PH,Castagna JC,Coffee RN,Cryan JP,Fang L,Feifel R,Gaffney KJ,Glownia JM,Martinez TJ,Mucke M,Murphy B,Natan A,Osipov T,

更新日期：2014-06-23 00:00:00

abstract：:Essential components of animal behaviour are modulated by dopaminergic (DA) and noradrenergic circuitry. In this study, we reveal at cellular resolution the complete set of projections ('projectome') of every single type of DA and noradrenergio neurons in the central nervous system of zebrafish larvae. The most extens...

journal_title：Nature communications

authors： Tay TL,Ronneberger O,Ryu S,Nitschke R,Driever W

更新日期：2011-01-25 00:00:00

abstract：:HIV infection causes bone loss. We previously reported that immunosuppression-mediated B-cell production of receptor activator of NF-κB ligand (RANKL) coupled with decline in osteoprotegerin correlate with decreased bone mineral density (BMD) in untreated HIV infection. Paradoxically, antiretroviral therapy (ART) wors...

journal_title：Nature communications

authors： Ofotokun I,Titanji K,Vikulina T,Roser-Page S,Yamaguchi M,Zayzafoon M,Williams IR,Weitzmann MN

更新日期：2015-09-22 00:00:00

abstract：:Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer originating from mature B-cells. Prognosis is strongly associated with molecular subgroup, although the driver mutations that distinguish the two main subgroups remain poorly defined. Through an integrative analysis of whole genomes, exomes, and transcripto...

journal_title：Nature communications

authors： Arthur SE,Jiang A,Grande BM,Alcaide M,Cojocaru R,Rushton CK,Mottok A,Hilton LK,Lat PK,Zhao EY,Culibrk L,Ennishi D,Jessa S,Chong L,Thomas N,Pararajalingam P,Meissner B,Boyle M,Davidson J,Bushell KR,Lai D,Farinha

更新日期：2018-10-01 00:00:00

abstract：:Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. These limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understandin...

journal_title：Nature communications

authors： Zhu Z,Zhang S,Liu H,Shen H,Lin X,Yang F,Zhou YJ,Jin G,Ye M,Zou H,Zhao ZK

更新日期：2012-01-01 00:00:00

abstract：:Zeolite catalysis is determined by a combination of pore architecture and Brønsted acidity. As Brønsted acid sites are formed by the substitution of AlO4 for SiO4 tetrahedra, it is of utmost importance to have information on the number as well as the location and neighbouring sites of framework aluminium. Unfortunatel...

journal_title：Nature communications

authors： Perea DE,Arslan I,Liu J,Ristanović Z,Kovarik L,Arey BW,Lercher JA,Bare SR,Weckhuysen BM

更新日期：2015-07-02 00:00:00

abstract：:Increased lipogenesis has been linked to an increased cancer risk and poor prognosis; however, the underlying mechanisms remain obscure. Here we show that phosphatidic acid phosphatase (PAP) lipin-1, which generates diglyceride precursors necessary for the synthesis of glycerolipids, interacts with and is a direct sub...

journal_title：Nature communications

authors： Song L,Liu Z,Hu HH,Yang Y,Li TY,Lin ZZ,Ye J,Chen J,Huang X,Liu DT,Zhou J,Shi Y,Zhao H,Xie C,Chen L,Song E,Lin SY,Lin SC

更新日期：2020-11-17 00:00:00

abstract：:Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...

journal_title：Nature communications

authors： Münzner U,Klipp E,Krantz M

更新日期：2019-03-21 00:00:00

abstract：:Maternal glucose levels during pregnancy impact the developing fetus, affecting metabolic health both early and later on in life. Both genetic and environmental factors influence maternal metabolism, but little is known about the genetic mechanisms that alter glucose metabolism during pregnancy. Here, we report that h...

journal_title：Nature communications

authors： Guo C,Ludvik AE,Arlotto ME,Hayes MG,Armstrong LL,Scholtens DM,Brown CD,Newgard CB,Becker TC,Layden BT,Lowe WL,Reddy TE

更新日期：2015-02-04 00:00:00

abstract：:Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A-containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Here, using high spatiotemporal resolution light-sheet microscopy ...

journal_title：Nature communications

authors： Bhagwat AR,Le Sage V,Nturibi E,Kulej K,Jones J,Guo M,Tae Kim E,Garcia BA,Weitzman MD,Shroff H,Lakdawala SS

更新日期：2020-01-07 00:00:00

abstract：:MicroRNA-155 (miR-155) is an important regulator of B cells in mice. B cells have a critical role in the pathogenesis of rheumatoid arthritis (RA). Here we show that miR-155 is highly expressed in peripheral blood B cells from RA patients compared with healthy individuals, particularly in the IgD-CD27- memory B-cell p...

journal_title：Nature communications

authors： Alivernini S,Kurowska-Stolarska M,Tolusso B,Benvenuto R,Elmesmari A,Canestri S,Petricca L,Mangoni A,Fedele AL,Di Mario C,Gigante MR,Gremese E,McInnes IB,Ferraccioli G

更新日期：2016-09-27 00:00:00

abstract：:High-harmonic generation (HHG) in gases has been the main enabling technology of attosecond science since its discovery. Recently, HHG from solids has been demonstrated, opening a lively area of research. In contrast, harmonic generation from liquids has so far remained restricted to low harmonics in the visible regim...

journal_title：Nature communications

authors： Luu TT,Yin Z,Jain A,Gaumnitz T,Pertot Y,Ma J,Wörner HJ

更新日期：2018-09-13 00:00:00

abstract：:The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, an...

journal_title：Nature communications

authors： Chalfin L,Dayan M,Levy DR,Austad SN,Miller RA,Iraqi FA,Dulac C,Kimchi T

更新日期：2014-08-05 00:00:00

abstract：:In the evolutionary arms race between microbes, their parasites, and their neighbours, the capacity for rapid protein diversification is a potent weapon. Diversity-generating retroelements (DGRs) use mutagenic reverse transcription and retrohoming to generate myriad variants of a target gene. Originally discovered in ...

journal_title：Nature communications

authors： Paul BG,Bagby SC,Czornyj E,Arambula D,Handa S,Sczyrba A,Ghosh P,Miller JF,Valentine DL

更新日期：2015-03-23 00:00:00

abstract：:Distal appendages (DAPs) are nanoscale, pinwheel-like structures protruding from the distal end of the centriole that mediate membrane docking during ciliogenesis, marking the cilia base around the ciliary gate. Here we determine a super-resolved multiplex of 16 centriole-distal-end components. Surprisingly, rather th...

journal_title：Nature communications

authors： Yang TT,Chong WM,Wang WJ,Mazo G,Tanos B,Chen Z,Tran TMN,Chen YD,Weng RR,Huang CE,Jane WN,Tsou MB,Liao JC

更新日期：2018-05-22 00:00:00

abstract：:In nature, plant tendrils can produce two fundamental motion modes, bending and chiral twisting (helical curling) distortions, under the stimuli of sunlight, humidity, wetting or other atmospheric conditions. To date, many artificial plant-like mechanical machines have been developed. Although some previously reported...

journal_title：Nature communications

authors： Wang M,Lin BP,Yang H

更新日期：2016-12-22 00:00:00

abstract：:An evolutionary account of human language as a neurobiological system must distinguish between human-unique neurocognitive processes supporting language and evolutionarily conserved, domain-general processes that can be traced back to our primate ancestors. Neuroimaging studies across species may determine whether can...

journal_title：Nature communications

authors： Wilson B,Kikuchi Y,Sun L,Hunter D,Dick F,Smith K,Thiele A,Griffiths TD,Marslen-Wilson WD,Petkov CI

更新日期：2015-11-17 00:00:00

abstract：:Hepatitis B virus (HBV) can integrate into the human genome, contributing to genomic instability and hepatocarcinogenesis. Here by conducting high-throughput viral integration detection and RNA sequencing, we identify 4,225 HBV integration events in tumour and adjacent non-tumour samples from 426 patients with HCC. We...

journal_title：Nature communications

authors： Zhao LH,Liu X,Yan HX,Li WY,Zeng X,Yang Y,Zhao J,Liu SP,Zhuang XH,Lin C,Qin CJ,Zhao Y,Pan ZY,Huang G,Liu H,Zhang J,Wang RY,Yang Y,Wen W,Lv GS,Zhang HL,Wu H,Huang S,Wang MD,Tang L,Cao HZ,Wang L,Lee TL

更新日期：2016-10-05 00:00:00

abstract：:Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme that regulates plasma membrane (PM) fluidity. Here we report that SMPDL3b excess, as observed in podocytes in diabetic kidney disease (DKD), impairs insulin receptor isoform B-dependent pro-survival insulin signaling by interfering with insu...

journal_title：Nature communications

authors： Mitrofanova A,Mallela SK,Ducasa GM,Yoo TH,Rosenfeld-Gur E,Zelnik ID,Molina J,Varona Santos J,Ge M,Sloan A,Kim JJ,Pedigo C,Bryn J,Volosenco I,Faul C,Zeidan YH,Garcia Hernandez C,Mendez AJ,Leibiger I,Burke GW,Futerm

更新日期：2019-06-19 00:00:00

abstract：:Much controversy exists regarding the structural organization of the yeast centromeric nucleosome and the role of the nonhistone protein, Scm3, in its assembly and architecture. Here we show that the substitution of H3 with its centromeric variant Cse4 results in octameric nucleosomes that organize DNA in a left-hande...

journal_title：Nature communications

authors： Dechassa ML,Wyns K,Li M,Hall MA,Wang MD,Luger K

更新日期：2011-01-01 00:00:00

abstract：:Low-damping magnetic materials have been widely used in microwave and spintronic applications because of their low energy loss and high sensitivity. While the Gilbert damping constant can reach 10-4 to 10-5 in some insulating ferromagnets, metallic ferromagnets generally have larger damping due to magnon scattering by...

journal_title：Nature communications

authors： Lee AJ,Brangham JT,Cheng Y,White SP,Ruane WT,Esser BD,McComb DW,Hammel PC,Yang F

更新日期：2017-08-10 00:00:00

abstract：:Cryptochrome (Cry) 1 and Cry2 are regarded as critical components for circadian rhythm generation in mammals. Nevertheless, cultured suprachiasmatic nucleus (SCN) of neonatal Cry double deficient (Cry1(-/-)/Cry2(-/-)) mice exhibit circadian rhythms that damp out in several cycles. Here, by combining bioluminescence im...

journal_title：Nature communications

authors： Ono D,Honma S,Honma K

更新日期：2013-01-01 00:00:00