Abstract:
:The divalent carbene carbon centre in cyclic (alkyl)(amino)carbenes (CAACs) is known to exhibit transition-metal-like insertion into E-H σ-bonds (E = H, N, Si, B, P, C, O) with formation of new, strong C-E and C-H bonds. Although subsequent transformations of the products represent an attractive strategy for metal-free synthesis, few examples have been reported. Herein we describe the dehydrogenation of phosphine-boranes, RR'PH·BH3, using a CAAC, which behaves as a stoichiometric hydrogen acceptor to release monomeric phosphinoboranes, [RR'PBH2], under mild conditions. The latter species are transient intermediates that either polymerise to the corresponding polyphosphinoboranes, [RR'PBH2]n (R = Ph; R' = H, Ph or Et), or are trapped in the form of CAAC-phosphinoborane adducts, CAAC·H2BPRR' (R = R' = tBu; R = R' = Mes). In contrast to previously established methods such as transition metal-catalysed dehydrocoupling, which only yield P-monosubstituted polymers, [RHPBH2]n, the CAAC-mediated route also provides access to P-disubstituted polymers, [RR'PBH2]n (R = Ph; R' = Ph or Et).
journal_name
Nat Communjournal_title
Nature communicationsauthors
Oldroyd NL,Chitnis SS,Annibale VT,Arz MI,Sparkes HA,Manners Idoi
10.1038/s41467-019-08967-8subject
Has Abstractpub_date
2019-03-26 00:00:00pages
1370issue
1issn
2041-1723pii
10.1038/s41467-019-08967-8journal_volume
10pub_type
杂志文章abstract::How spatial and temporal information are integrated to determine the direction of cell migration remains poorly understood. Here, by precise microfluidics emulation of dynamic chemoattractant waves, we demonstrate that, in Dictyostelium, directional movement as well as activation of small guanosine triphosphatase Ras ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6367
更新日期:2014-11-06 00:00:00
abstract::Clustering of the T-cell receptor (TCR) is thought to initiate downstream signalling. However, the detection of protein clustering with high spatial and temporal resolution remains challenging. Here we establish a Förster resonance energy transfer (FRET) sensor, named CliF, which reports intermolecular associations of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15100
更新日期:2017-04-28 00:00:00
abstract::Transition metal dichalcogenides have attracted research interest over the last few decades due to their interesting structural chemistry, unusual electronic properties, rich intercalation chemistry and wide spectrum of potential applications. Despite the fact that the majority of related research focuses on semicondu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11038
更新日期:2016-03-14 00:00:00
abstract::Transition metal oxides with a perovskite crystal structure exhibit a variety of physical properties associated with the lattice. Among these materials, strontium ruthenate (SrRuO3) displays unusually strong coupling of charge, spin and lattice degrees of freedom that can give rise to the photostriction, that is, chan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15108
更新日期:2017-04-24 00:00:00
abstract::Adenovirus is a nuclear replicating DNA virus reliant on host RNA processing machinery. Processing and metabolism of cellular RNAs can be regulated by METTL3, which catalyzes the addition of N6-methyladenosine (m6A) to mRNAs. While m6A-modified adenoviral RNAs have been previously detected, the location and function o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19787-6
更新日期:2020-11-26 00:00:00
abstract::Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12026-7
更新日期:2019-09-24 00:00:00
abstract::Invasive plant species threaten native biodiversity, ecosystems, agriculture, industry and human health worldwide, lending urgency to the search for predictors of plant invasiveness outside native ranges. There is much conflicting evidence about which plant characteristics best predict invasiveness. Here we use a glob...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13556-w
更新日期:2019-12-06 00:00:00
abstract::In the Arctic, environmental factors governing microbial degradation of soil carbon (C) in active layer and permafrost are poorly understood. Here we determined the functional potential of soil microbiomes horizontally and vertically across a cryoperturbed polygonal landscape in Alaska. With comparative metagenomics, ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03089-z
更新日期:2018-02-22 00:00:00
abstract::It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11353
更新日期:2016-04-18 00:00:00
abstract::Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtB...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09273-z
更新日期:2019-03-20 00:00:00
abstract::Modulation of epigenetic patterns has promising efficacy for treating cancer. 5-Hydroxymethylated cytosine (5-hmC) is an epigenetic mark potentially important in cancer. Here we report that 5-hmC is an epigenetic hallmark of prostate cancer (PCa) progression. A member of the ten-eleven translocation (TET) proteins, wh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9219
更新日期:2015-09-25 00:00:00
abstract::Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00823-x
更新日期:2017-09-26 00:00:00
abstract::Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant tra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05795-0
更新日期:2018-08-22 00:00:00
abstract::Hybrid quantum systems are essential for the realization of distributed quantum networks. In particular, piezo-mechanics operating at typical superconducting qubit frequencies features low thermal excitations, and offers an appealing platform to bridge superconducting quantum processors and optical telecommunication c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17053-3
更新日期:2020-06-26 00:00:00
abstract::Mass extinction events are short-lived and characterized by catastrophic biosphere collapse and subsequent reorganization. Their abrupt nature necessitates a similarly short-lived trigger, and large igneous province magmatism is often implicated. However, large igneous provinces are long-lived compared to mass extinct...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/s41467-017-00083-9
更新日期:2017-07-31 00:00:00
abstract::The sensitivity of quantum magnetometer is challenged by control errors and, especially in the solid state, by their short coherence times. Refocusing techniques can overcome these limitations and improve the sensitivity to periodic fields, but they come at the cost of reduced bandwidth and cannot be applied to sense ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2375
更新日期:2013-01-01 00:00:00
abstract::Assembly of infectious influenza A viruses (IAV) is a complex process involving transport from the nucleus to the plasma membrane. Rab11A-containing recycling endosomes have been identified as a platform for intracellular transport of viral RNA (vRNA). Here, using high spatiotemporal resolution light-sheet microscopy ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13838-3
更新日期:2020-01-07 00:00:00
abstract::Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of substrate compliance in live tissues has not been accomplished to date. Here we propose that stem cells can be regulated solely through in situ modulation of tissue biomechanics. By first establishing, via high-resolution Brillou...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09331-6
更新日期:2019-04-03 00:00:00
abstract::Device applications of graphene such as ultrafast transistors and photodetectors benefit from the combination of both high-quality p- and n-doped components prepared in a large-scale manner with spatial control and seamless connection. Here we develop a well-controlled chemical vapour deposition process for direct gro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2286
更新日期:2012-01-01 00:00:00
abstract::The current study uses big data to study prosocial behavior by analyzing donations made on the GoFundMe platform. In a dataset of more than $44 million in online donations, we find that 21% were made while opting to be anonymous to the public, with survey results indicating that 11% of these anonymous donations (2.3% ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11852-z
更新日期:2019-09-03 00:00:00
abstract::The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2712
更新日期:2013-01-01 00:00:00
abstract::FinO-domain proteins are a widespread family of bacterial RNA-binding proteins with regulatory functions. Their target spectrum ranges from a single RNA pair, in the case of plasmid-encoded FinO, to global RNA regulons, as with enterobacterial ProQ. To assess whether the FinO domain itself is intrinsically selective o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16650-6
更新日期:2020-06-04 00:00:00
abstract::The Cdc45-MCM-GINS (CMG) helicase unwinds DNA during the elongation step of eukaryotic genome duplication and this process depends on the MCM ATPase function. Whether CMG translocation occurs on single- or double-stranded DNA and how ATP hydrolysis drives DNA unwinding remain open questions. Here we use cryo-electron ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10708
更新日期:2016-02-18 00:00:00
abstract::A central paradigm in conservation biology is that population bottlenecks reduce genetic diversity and population viability. In an era of biodiversity loss and climate change, understanding the determinants and consequences of bottlenecks is therefore an important challenge. However, as most studies focus on single sp...
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/s41467-018-06695-z
更新日期:2018-11-16 00:00:00
abstract::Sensors using nitrogen-vacancy centers in diamond are a promising tool for small-volume nuclear magnetic resonance (NMR) spectroscopy, but the limited sensitivity remains a challenge. Here we show nearly two orders of magnitude improvement in concentration sensitivity over previous nitrogen-vacancy and picoliter NMR s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00266-4
更新日期:2017-08-04 00:00:00
abstract::The development of malaria parasites throughout their various life cycle stages is coordinated by changes in gene expression. We previously showed that the three-dimensional organization of the Plasmodium falciparum genome is strongly associated with gene expression during its replication cycle inside red blood cells....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04295-5
更新日期:2018-05-15 00:00:00
abstract::Semiconductor III-V photonic crystal (PC) laser is regarded as a promising ultra-compact light source with unique advantages of ultralow energy consumption and small footprint for the next generation of Si-based on-chip optical interconnects. However, the significant material dissimilarities between III-V materials an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14736-9
更新日期:2020-02-20 00:00:00
abstract::Control of the collective response of plasma particles to intense laser light is intrinsic to relativistic optics, the development of compact laser-driven particle and radiation sources, as well as investigations of some laboratory astrophysics phenomena. We recently demonstrated that a relativistic plasma aperture pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12891
更新日期:2016-09-14 00:00:00
abstract::Chloride intracellular channel 4 (CLIC4) is a mammalian homologue of EXC-4 whose mutation is associated with cystic excretory canals in nematodes. Here we show that CLIC4-null mouse embryos exhibit impaired renal tubulogenesis. In both developing and developed kidneys, CLIC4 is specifically enriched in the proximal tu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10412
更新日期:2016-01-20 00:00:00
abstract::Carbon-based three-dimensional aerographite networks, built from interconnected hollow tubular tetrapods of multilayer graphene, are ultra-lightweight materials recently discovered and ideal for advanced multifunctional applications. In order to predict the bulk mechanical behaviour of networks it is very important to...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14982
更新日期:2017-04-12 00:00:00