CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking.

abstract：:Paternal epigenetic inheritance is gaining attention for its growing medical relevance. However, the form in which paternal epigenetic information is transmitted to offspring and how it influences offspring development remain poorly understood. Here we show that in C. elegans, sperm-inherited chromatin states transmit...

journal_title：Nature communications

authors： Kaneshiro KR,Rechtsteiner A,Strome S

更新日期：2019-03-20 00:00:00

abstract：:Oxygenic photosynthetic organisms perform solar energy conversion of water and CO2 to O2 and sugar at a broad range of wavelengths and light intensities. These cells also metabolize sugars using a respiratory system that functionally overlaps the photosynthetic apparatus. In this study, we describe the harvesting of p...

journal_title：Nature communications

authors： Saper G,Kallmann D,Conzuelo F,Zhao F,Tóth TN,Liveanu V,Meir S,Szymanski J,Aharoni A,Schuhmann W,Rothschild A,Schuster G,Adir N

更新日期：2018-06-04 00:00:00

abstract：:Deep penetrating nevus (DPN) is characterized by enlarged, pigmented melanocytes that extend through the dermis. DPN can be difficult to distinguish from melanoma but rarely displays aggressive biological behavior. Here, we identify a combination of mutations of the β-catenin and mitogen-activated protein kinase pathw...

journal_title：Nature communications

authors： Yeh I,Lang UE,Durieux E,Tee MK,Jorapur A,Shain AH,Haddad V,Pissaloux D,Chen X,Cerroni L,Judson RL,LeBoit PE,McCalmont TH,Bastian BC,de la Fouchardière A

更新日期：2017-09-21 00:00:00

abstract：:Current machine learning classifiers have successfully been applied to whole-genome sequencing data to identify genetic determinants of antimicrobial resistance (AMR), but they lack causal interpretation. Here we present a metabolic model-based machine learning classifier, named Metabolic Allele Classifier (MAC), that...

journal_title：Nature communications

authors： Kavvas ES,Yang L,Monk JM,Heckmann D,Palsson BO

更新日期：2020-05-22 00:00:00

abstract：:The amniote middle ear is a classical example of the evolutionary novelty. Although paleontological evidence supports the view that mammals and diapsids (modern reptiles and birds) independently acquired the middle ear after divergence from their common ancestor, the developmental bases of these transformations remain...

journal_title：Nature communications

authors： Kitazawa T,Takechi M,Hirasawa T,Adachi N,Narboux-Nême N,Kume H,Maeda K,Hirai T,Miyagawa-Tomita S,Kurihara Y,Hitomi J,Levi G,Kuratani S,Kurihara H

更新日期：2015-04-22 00:00:00

abstract：:Single-nucleotide variants that underlie phenotypic variation can affect chromatin occupancy of transcription factors (TFs). To delineate determinants of in vivo TF binding and chromatin accessibility, we introduce an approach that compares ChIP-seq and DNase-seq data sets from genetically divergent murine erythroid c...

journal_title：Nature communications

authors： Behera V,Evans P,Face CJ,Hamagami N,Sankaranarayanan L,Keller CA,Giardine B,Tan K,Hardison RC,Shi J,Blobel GA

更新日期：2018-02-22 00:00:00

abstract：:The molecular mechanisms underlying vascular inflammation and associated inflammatory vascular diseases are not well defined. Here we show that endothelial intracellular adenosine and its key regulator adenosine kinase (ADK) play important roles in vascular inflammation. Pro-inflammatory stimuli lead to endothelial in...

journal_title：Nature communications

authors： Xu Y,Wang Y,Yan S,Yang Q,Zhou Y,Zeng X,Liu Z,An X,Toque HA,Dong Z,Jiang X,Fulton DJ,Weintraub NL,Li Q,Bagi Z,Hong M,Boison D,Wu C,Huo Y

更新日期：2017-10-16 00:00:00

abstract：:The reconstruction of human-driven, Earth-shaping dynamics is important for understanding past human/environment interactions and for helping human societies that currently face global changes. However, it is often challenging to distinguish the effects of the climate from human activities on environmental changes. He...

journal_title：Nature communications

authors： Giguet-Covex C,Pansu J,Arnaud F,Rey PJ,Griggo C,Gielly L,Domaizon I,Coissac E,David F,Choler P,Poulenard J,Taberlet P

更新日期：2014-01-01 00:00:00

abstract：:The damming of rivers represents one of the most far-reaching human modifications of the flows of water and associated matter from land to sea. Dam reservoirs are hotspots of sediment accumulation, primary productivity (P) and carbon mineralization (R) along the river continuum. Here we show that for the period 1970-2...

journal_title：Nature communications

authors： Maavara T,Lauerwald R,Regnier P,Van Cappellen P

更新日期：2017-05-17 00:00:00

abstract：:Skill learning is instantiated by changes to functional connectivity within premotor circuits, but whether the specificity of learning depends on structured changes to inhibitory circuitry remains unclear. We used slice electrophysiology to measure connectivity changes associated with song learning in the avian analog...

journal_title：Nature communications

authors： Miller MN,Cheung CYJ,Brainard MS

更新日期：2017-12-13 00:00:00

abstract：:Sclerosing stromal tumor (SST) of the ovary is a rare type of sex cord-stromal tumor (SCST), whose genetic underpinning is currently unknown. Here, using whole-exome, targeted capture and RNA-sequencing, we report recurrent FHL2-GLI2 fusion genes in 65% (17/26) of SSTs and other GLI2 rearrangements in additional 15% (...

journal_title：Nature communications

authors： Kim SH,Da Cruz Paula A,Basili T,Dopeso H,Bi R,Pareja F,da Silva EM,Gularte-Mérida R,Sun Z,Fujisawa S,Smith CG,Ferrando L,Martins Sebastião AP,Bykov Y,Li A,Silveira C,Ashley CW,Stylianou A,Selenica P,Samore WR,Jung

更新日期：2020-01-02 00:00:00

abstract：:Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytically, often through matrix metalloproteinases. Here we ...

journal_title：Nature communications

authors： Wade RJ,Bassin EJ,Rodell CB,Burdick JA

更新日期：2015-03-23 00:00:00

abstract：:Organic semiconductors enable the fabrication of a range of lightweight and mechanically flexible optoelectronic devices. Most organic semiconductor lasers, however, have remained rigid until now, predominantly due to the need for a support substrate. Here, we use a simple fabrication process to make membrane-based, s...

journal_title：Nature communications

authors： Karl M,Glackin JME,Schubert M,Kronenberg NM,Turnbull GA,Samuel IDW,Gather MC

更新日期：2018-05-01 00:00:00

abstract：:The recent emergence of nanofluidics has highlighted the exceptional properties of graphene and its boron-nitride counterpart as confining nanomaterials for water and ion transport. Surprisingly, ionic transport experiments have unveiled a consequent electrification of the water/carbon surfaces, with a contrasting res...

journal_title：Nature communications

authors： Grosjean B,Bocquet ML,Vuilleumier R

更新日期：2019-04-10 00:00:00

abstract：:Osteoderms are bones embedded within the dermis, and are common to select members of most major tetrapod lineages. The largest known animals that bear osteoderms are members of Titanosauria, a diverse clade of sauropod dinosaurs. Here we report on two titanosaur osteoderms recovered from the Upper Cretaceous Maevarano...

journal_title：Nature communications

authors： Curry Rogers K,D'Emic M,Rogers R,Vickaryous M,Cagan A

更新日期：2011-11-29 00:00:00

abstract：:Isolators, or optical diodes, are devices enabling unidirectional light propagation by using non-reciprocal optical materials, namely materials able to break Lorentz reciprocity. The realization of isolators at terahertz frequencies is a very important open challenge made difficult by the intrinsically lossy propagati...

journal_title：Nature communications

authors： Tamagnone M,Moldovan C,Poumirol JM,Kuzmenko AB,Ionescu AM,Mosig JR,Perruisseau-Carrier J

更新日期：2016-04-06 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS. We generated and characterized induced pluripotent stem cells (iPSCs) from ALS patients with dif...

journal_title：Nature communications

authors： Guo W,Naujock M,Fumagalli L,Vandoorne T,Baatsen P,Boon R,Ordovás L,Patel A,Welters M,Vanwelden T,Geens N,Tricot T,Benoy V,Steyaert J,Lefebvre-Omar C,Boesmans W,Jarpe M,Sterneckert J,Wegner F,Petri S,Bohl D,Vande

更新日期：2017-10-11 00:00:00

abstract：:Transcription errors occur in all living cells; however, it is unknown how these errors affect cellular health. To answer this question, we monitor yeast cells that are genetically engineered to display error-prone transcription. We discover that these cells suffer from a profound loss in proteostasis, which sensitize...

journal_title：Nature communications

authors： Vermulst M,Denney AS,Lang MJ,Hung CW,Moore S,Moseley MA,Thompson JW,Madden V,Gauer J,Wolfe KJ,Summers DW,Schleit J,Sutphin GL,Haroon S,Holczbauer A,Caine J,Jorgenson J,Cyr D,Kaeberlein M,Strathern JN,Duncan MC,E

更新日期：2015-08-25 00:00:00

abstract：:Mutators represent a successful strategy in rapidly adapting asexual populations, but theory predicts their eventual extinction due to their unsustainably large deleterious load. While antimutator invasions have been documented experimentally, important discrepancies among studies remain currently unexplained. Here we...

journal_title：Nature communications

authors： Couce A,Tenaillon O

更新日期：2019-07-15 00:00:00

abstract：:Vascularization and efficient perfusion are long-standing challenges in cardiac tissue engineering. Here we report engineered perfusable microvascular constructs, wherein human embryonic stem cell-derived endothelial cells (hESC-ECs) are seeded both into patterned microchannels and the surrounding collagen matrix. In ...

journal_title：Nature communications

authors： Redd MA,Zeinstra N,Qin W,Wei W,Martinson A,Wang Y,Wang RK,Murry CE,Zheng Y

更新日期：2019-02-04 00:00:00

abstract：:The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Zhang W,Zhang D,Chen Q,Wu J,Ouyang Z,Xia Y

更新日期：2019-02-19 00:00:00

abstract：:In high magnetic fields, two-dimensional electron systems can form a number of phases in which interelectron repulsion plays the central role, since the kinetic energy is frozen out by Landau quantization. These phases include the well-known liquids of the fractional quantum Hall effect, as well as solid phases with b...

journal_title：Nature communications

authors： Hatke AT,Liu Y,Magill BA,Moon BH,Engel LW,Shayegan M,Pfeiffer LN,West KW,Baldwin KW

更新日期：2014-06-20 00:00:00

abstract：:The appearance of detritus shed from mountain ranges along the northern margin of the Tibetan Plateau heralds the Cenozoic development of high topography. Current estimates of the age of the basal conglomerate in the Qaidam basin place this event in Paleocene-Eocene. Here we present new magnetostratigraphy and mammali...

journal_title：Nature communications

authors： Wang W,Zheng W,Zhang P,Li Q,Kirby E,Yuan D,Zheng D,Liu C,Wang Z,Zhang H,Pang J

更新日期：2017-06-21 00:00:00

abstract：:Plasma dynamics critically depends on density and temperature, thus well-controlled experimental realizations are essential benchmarks for theoretical models. The formation of an ultracold plasma can be triggered by ionizing a tunable number of atoms in a micrometer-sized volume of a 87Rb Bose-Einstein condensate (BEC...

journal_title：Nature communications

authors： Kroker T,Großmann M,Sengstock K,Drescher M,Wessels-Staarmann P,Simonet J

更新日期：2021-01-26 00:00:00

abstract：:In-plane anisotropic ground states are ubiquitous in correlated solids such as pnictides, cuprates and manganites. They can arise from doping Mott insulators and compete with phases such as superconductivity; however, their origins are debated. Strong coupling between lattice, charge, orbital and spin degrees of freed...

journal_title：Nature communications

authors： Miller TA,Chhajlany RW,Tagliacozzo L,Green B,Kovalev S,Prabhakaran D,Lewenstein M,Gensch M,Wall S

更新日期：2015-09-18 00:00:00

abstract：:In the lead-up to the Cretaceous/Paleogene mass extinction, dinosaur diversity is argued to have been either in long-term decline, or thriving until their sudden demise. The latest Cretaceous (Campanian-Maastrichtian [83-66 Ma]) of North America provides the best record to address this debate, but even here diversity ...

journal_title：Nature communications

authors： Chiarenza AA,Mannion PD,Lunt DJ,Farnsworth A,Jones LA,Kelland SJ,Allison PA

更新日期：2019-03-06 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Rees-Garbutt J,Chalkley O,Landon S,Purcell O,Marucci L,Grierson C

更新日期：2020-05-06 00:00:00

abstract：:Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...

journal_title：Nature communications

authors： Förg M,Colombier L,Patel RK,Lindlau J,Mohite AD,Yamaguchi H,Glazov MM,Hunger D,Högele A

更新日期：2019-08-16 00:00:00

abstract：:The efficiency of an heat engine is traditionally defined as the ratio of its average output work over its average input heat. Its highest possible value was discovered by Carnot in 1824 and is a cornerstone concept in thermodynamics. It led to the discovery of the second law and to the definition of the Kelvin temper...

journal_title：Nature communications

authors： Verley G,Esposito M,Willaert T,Van den Broeck C

更新日期：2014-09-15 00:00:00

abstract：:Methods for site-selective chemistry on proteins are in high demand for the synthesis of chemically modified biopharmaceuticals, as well as for applications in chemical biology, biosensors and more. Inadvertent N-terminal gluconoylation has been reported during expression of proteins with an N-terminal His tag. Here w...

journal_title：Nature communications

authors： Martos-Maldonado MC,Hjuler CT,Sørensen KK,Thygesen MB,Rasmussen JE,Villadsen K,Midtgaard SR,Kol S,Schoffelen S,Jensen KJ

更新日期：2018-08-17 00:00:00