Abstract:
:Cancer cells often display altered cell-surface glycans compared to their nontransformed counterparts. However, functional contributions of glycans to cancer initiation and progression remain poorly understood. Here, from expression-based analyses across cancer lineages, we found that melanomas exhibit significant transcriptional changes in glycosylation-related genes. This gene signature revealed that, compared to normal melanocytes, melanomas downregulate I-branching glycosyltransferase, GCNT2, leading to a loss of cell-surface I-branched glycans. We found that GCNT2 inversely correlated with clinical progression and that loss of GCNT2 increased melanoma xenograft growth, promoted colony formation, and enhanced cell survival. Conversely, overexpression of GCNT2 decreased melanoma xenograft growth, inhibited colony formation, and increased cell death. More focused analyses revealed reduced signaling responses of two representative glycoprotein families modified by GCNT2, insulin-like growth factor receptor and integrins. Overall, these studies reveal how subtle changes in glycan structure can regulate several malignancy-associated pathways and alter melanoma signaling, growth, and survival.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJdoi
10.1038/s41467-018-05795-0subject
Has Abstractpub_date
2018-08-22 00:00:00pages
3368issue
1issn
2041-1723pii
10.1038/s41467-018-05795-0journal_volume
9pub_type
杂志文章abstract::With its light weight, low cost and high efficiency even at low operation frequency, the triboelectric nanogenerator is considered a potential solution for self-powered sensor networks and large-scale renewable blue energy. As an energy harvester, its output power density and efficiency are dictated by the triboelectr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00131-4
更新日期:2017-07-20 00:00:00
abstract::The ability to identify cause-effect relations is an essential component of the scientific method. The identification of causal relations is generally accomplished through statistical trials where alternative hypotheses are tested against each other. Traditionally, such trials have been based on classical statistics. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09383-8
更新日期:2019-04-01 00:00:00
abstract::Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16350-1
更新日期:2020-05-15 00:00:00
abstract::In humans, males have lower recombination rates than females over the majority of the genome, but the opposite is usually true near the telomeres. These broad-scale differences have been known for decades, yet little is known about differences at the fine scale. By combining data sets, we have collected recombination ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14994
更新日期:2017-04-25 00:00:00
abstract::Metallic nanostructures exhibit a multitude of optical resonances associated with localized surface plasmon excitations. Recent observations of plasmonic phenomena at the sub-nanometre to atomic scale have stimulated the development of various sophisticated theoretical approaches for their description. Here instead we...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4809
更新日期:2014-05-02 00:00:00
abstract::The Johnson-Kendall-Roberts theory is the basis of modern contact mechanics. It describes how two deformable objects adhere together, driven by adhesion energy and opposed by elasticity. Here we characterize the indentation of glass particles into soft, silicone substrates using confocal microscopy. We show that, wher...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3728
更新日期:2013-01-01 00:00:00
abstract::Replication-Factor-C (RFC) and RFC-like complexes (RLCs) mediate chromatin engagement of the proliferating cell nuclear antigen (PCNA). It remains controversial how RFC and RLCs cooperate to regulate PCNA loading and unloading. Here, we show the distinct PCNA loading or unloading activity of each clamp loader. ATAD5-R...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10376-w
更新日期:2019-06-03 00:00:00
abstract::Maternal glucose levels during pregnancy impact the developing fetus, affecting metabolic health both early and later on in life. Both genetic and environmental factors influence maternal metabolism, but little is known about the genetic mechanisms that alter glucose metabolism during pregnancy. Here, we report that h...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7069
更新日期:2015-02-04 00:00:00
abstract::Carbon forms one of nature's strongest chemical bonds; its allotropes having provided some of the most exciting scientific discoveries in recent times. The possibility of inter-allotropic transformations/hybridization of carbon is hence a topic of immense fundamental and technological interest. Such modifications usua...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5941
更新日期:2014-09-15 00:00:00
abstract::Standard optical tweezers rely on optical forces arising when a focused laser beam interacts with a microscopic particle: scattering forces, pushing the particle along the beam direction, and gradient forces, attracting it towards the high-intensity focal spot. Importantly, the incoming laser beam is not affected by t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10662-7
更新日期:2019-06-18 00:00:00
abstract::Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause cellular toxicity is still not clear, even in simpler cellular systems. We reasoned that deep mutagene...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12101-z
更新日期:2019-09-13 00:00:00
abstract::Biocatalytic cyclization is highly desirable for efficient synthesis of biologically derived chemical substances, such as the commodity chemicals ε-caprolactam and δ-valerolactam. To identify biocatalysts in lactam biosynthesis, we develop a caprolactam-detecting genetic enzyme screening system (CL-GESS). The Alcalige...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07488-0
更新日期:2018-11-29 00:00:00
abstract::Cognitive brain networks such as the default-mode network (DMN), frontoparietal network, and salience network, are key functional networks of the human brain. Here we show that the rapid evolutionary cortical expansion of cognitive networks in the human brain, and most pronounced the DMN, runs parallel with high expre...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12764-8
更新日期:2019-10-24 00:00:00
abstract::A broad range of dynamic metasurfaces has been developed for manipulating the intensity, phase and wavefront of electromagnetic radiation from microwaves to optical frequencies. However, most of these metasurfaces operate in single-input-output state. Here, we experimentally demonstrate a reconfigurable MEMS Fano reso...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06360-5
更新日期:2018-10-03 00:00:00
abstract::Natural systems frequently exploit intricate multiscale and multiphasic structures to achieve functionalities beyond those of man-made systems. Although understanding the chemical make-up of these systems is essential, the passive and active mechanics within biological systems are crucial when considering the many nat...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/ncomms8418
更新日期:2015-07-06 00:00:00
abstract::Priming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8725
更新日期:2015-07-21 00:00:00
abstract::Despite rapid advances in genome engineering technologies, inserting genes into precise locations in the human genome remains an outstanding problem. It has been suggested that site-specific recombinases can be adapted towards use as transgene delivery vectors. The specificity of recombinases can be altered either wit...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3509
更新日期:2013-01-01 00:00:00
abstract::The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11838
更新日期:2016-06-20 00:00:00
abstract::An invisibility cloak should completely hide an object from an observer, ideally across the visible spectrum and for all angles of incidence and polarizations of light, in three dimensions. However, until now, all such devices have been limited to either small bandwidths or have disregarded the phase of the impinging ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12813-2
更新日期:2019-10-24 00:00:00
abstract::Bipolaron states, in which two electrons or two holes occupy a single molecule or conjugated polymer segment, are typically considered to be negligible in organic semiconductor devices due to Coulomb repulsion between the two charges. Here we use charge modulation spectroscopy to reveal a bipolaron sheet density >1010...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02459-3
更新日期:2017-12-21 00:00:00
abstract::Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here, we present the crystallographic structure of human FALDH, t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5439
更新日期:2014-07-22 00:00:00
abstract::Intense ultrashort X-ray pulses produced by modern free-electron lasers (FELs) allow one to probe biological systems, inorganic materials and molecular reaction dynamics with nanoscale spatial and femtoscale temporal resolution. These experiments require the knowledge, and possibly the control, of the spectro-temporal...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9075
更新日期:2015-08-20 00:00:00
abstract::The exploration of chemical space for new reactivity, reactions and molecules is limited by the need for separate work-up-separation steps searching for molecules rather than reactivity. Herein we present a system that can autonomously evaluate chemical reactivity within a network of 64 possible reaction combinations ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15733
更新日期:2017-06-09 00:00:00
abstract::Low-light-level imaging techniques have application in many diverse fields, ranging from biological sciences to security. A high-quality digital camera based on a multi-megapixel array will typically record an image by collecting of order 10(5) photons per pixel, but by how much could this photon flux be reduced? In t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6913
更新日期:2015-01-05 00:00:00
abstract::Single-nucleotide substitutions are a defining characteristic of cancer genomes. Many single-nucleotide substitutions in cancer genomes arise because of errors in DNA replication, which is spatio-temporally stratified. Here we propose that DNA replication patterns help shape the mutational landscapes of normal and can...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2502
更新日期:2013-01-01 00:00:00
abstract::In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimuli: sound and acceleration. Each individual sensory epithelium is composed of highly heterogeneous populations of cells based on physiological and anatomical criteria. However, limited numbers of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9557
更新日期:2015-10-15 00:00:00
abstract::In the original version of this Article, an incorrect sample size was provided for the number of relict species (443 instead of 442) and the number of relict forests (423 instead of 422). These errors have been corrected in both the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-07727-4
更新日期:2018-12-04 00:00:00
abstract::Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectroscopy that inhibito...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10638
更新日期:2016-02-25 00:00:00
abstract::EGFR is required for animal development, and dysregulation of EGFR is critically implicated in malignant transformation. However, the molecular mechanism underlying the regulation of EGFR expression remains poorly explored. Here we report that the zinc-finger protein ZNF516 is a transcription repressor. ZNF516 is phys...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00702-5
更新日期:2017-09-25 00:00:00
abstract::While molecular water-oxidation catalysts are remarkably rapid, oxidative and hydrolytic processes in water can convert their active transition metals to colloidal metal oxides or hydroxides that, while quite reactive, are insoluble or susceptible to precipitation. In response, we propose using oxidatively-inert ligan...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07281-z
更新日期:2018-11-20 00:00:00