Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy.

abstract：:A subtle balance between competing interactions in iron-based superconductors (FeSCs) can be tipped by additional interfacial interactions in a heterostructure, often inducing exotic phases with unprecedented properties. Particularly when the proximity-coupled layer is magnetically active, rich phase diagrams are expe...

journal_title：Nature communications

authors： Ok JM,Baek SH,Hoch C,Kremer RK,Park SY,Ji S,Büchner B,Park JH,Hyun SI,Shim JH,Bang Y,Moon EG,Mazin II,Kim JS

更新日期：2017-12-18 00:00:00

abstract：:Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so. Here, we map all single amino-acid mutations that increase resistance to broad a...

journal_title：Nature communications

authors： Doud MB,Lee JM,Bloom JD

更新日期：2018-04-11 00:00:00

abstract：:Gastrin-releasing peptide (GRP) functions as a neurotransmitter for non-histaminergic itch, but its site of action (sensory neurons vs spinal cord) remains controversial. To determine the role of GRP in sensory neurons, we generated a floxed Grp mouse line. We found that conditional knockout of Grp in sensory neurons ...

journal_title：Nature communications

authors： Barry DM,Liu XT,Liu B,Liu XY,Gao F,Zeng X,Liu J,Yang Q,Wilhelm S,Yin J,Tao A,Chen ZF

更新日期：2020-03-13 00:00:00

abstract：:Multiciliated ependymal (E1) cells line the brain ventricles and are essential for brain homeostasis. We previously identified in the lateral ventricles a rare ependymal subpopulation (E2) with only two cilia and unique basal bodies. Here we show that E2 cells form a distinct biciliated epithelium extending along the ...

journal_title：Nature communications

authors： Mirzadeh Z,Kusne Y,Duran-Moreno M,Cabrales E,Gil-Perotin S,Ortiz C,Chen B,Garcia-Verdugo JM,Sanai N,Alvarez-Buylla A

更新日期：2017-01-09 00:00:00

abstract：:Non-aromatic nitrogen- and oxygen-containing heterocycles such as piperidines and pyrans are prevalent components of natural products and pharmaceutical drugs. Although it has been a workhorse as a synthetic method for assembling unsaturated sp(2)-hybridized substrates, transition metal-catalysed cross-coupling chemis...

journal_title：Nature communications

authors： Ding J,Rybak T,Hall DG

更新日期：2014-11-18 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Fryirs KA,Brierley GJ,Dixon T

更新日期：2019-11-08 00:00:00

abstract：:Perovskite light emitting diodes suffer from poor operational stability, exhibiting a rapid decay of external quantum efficiency within minutes to hours after turn-on. To address this issue, we explore surface treatment of perovskite films with phenylalkylammonium iodide molecules of varying alkyl chain lengths. Combi...

journal_title：Nature communications

authors： Guo Y,Apergi S,Li N,Chen M,Yin C,Yuan Z,Gao F,Xie F,Brocks G,Tao S,Zhao N

更新日期：2021-01-28 00:00:00

abstract：:In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimuli: sound and acceleration. Each individual sensory epithelium is composed of highly heterogeneous populations of cells based on physiological and anatomical criteria. However, limited numbers of ...

journal_title：Nature communications

authors： Burns JC,Kelly MC,Hoa M,Morell RJ,Kelley MW

更新日期：2015-10-15 00:00:00

abstract：:Proton conductive materials are of significant importance and highly desired for clean energy-related applications. Discovery of practical metal-organic frameworks (MOFs) with high proton conduction remains a challenge due to the use of toxic chemicals, inconvenient ligand preparation and complication of production at...

journal_title：Nature communications

authors： Wang S,Wahiduzzaman M,Davis L,Tissot A,Shepard W,Marrot J,Martineau-Corcos C,Hamdane D,Maurin G,Devautour-Vinot S,Serre C

更新日期：2018-11-22 00:00:00

abstract：:Incited by public fascination and engineering application, water-skipping of rigid stones and spheres has received considerable study. While these objects can be coaxed to ricochet, elastic spheres demonstrate superior water-skipping ability, but little is known about the effect of large material compliance on water i...

journal_title：Nature communications

authors： Belden J,Hurd RC,Jandron MA,Bower AF,Truscott TT

更新日期：2016-02-04 00:00:00

abstract：:Protein aggregation plays a key role in neurodegenerative disease, giving rise to small oligomers that may become cytotoxic to cells. The fundamental microscopic reactions taking place during aggregation, and their rate constants, have been difficult to determine due to lack of suitable methods to identify and follow ...

journal_title：Nature communications

authors： Shammas SL,Garcia GA,Kumar S,Kjaergaard M,Horrocks MH,Shivji N,Mandelkow E,Knowles TP,Mandelkow E,Klenerman D

更新日期：2015-04-30 00:00:00

abstract：:Proper regulation of energy storage in adipose tissue is crucial for maintaining insulin sensitivity and molecules contributing to this process have not been fully revealed. Here we show that type II transmembrane protein tenomodulin (TNMD) is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive...

journal_title：Nature communications

authors： Senol-Cosar O,Flach RJ,DiStefano M,Chawla A,Nicoloro S,Straubhaar J,Hardy OT,Noh HL,Kim JK,Wabitsch M,Scherer PE,Czech MP

更新日期：2016-02-16 00:00:00

abstract：:Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...

journal_title：Nature communications

authors： Kang W,Ha KS,Uhm H,Park K,Lee JY,Hohng S,Kang C

更新日期：2020-01-23 00:00:00

abstract：:CDKL5 deficiency disorder (CDD) is characterized by epilepsy, intellectual disability, and autistic features, and CDKL5-deficient mice exhibit a constellation of behavioral phenotypes reminiscent of the human disorder. We previously found that CDKL5 dysfunction in forebrain glutamatergic neurons results in deficits in...

journal_title：Nature communications

authors： Tang S,Terzic B,Wang IJ,Sarmiento N,Sizov K,Cui Y,Takano H,Marsh ED,Zhou Z,Coulter DA

更新日期：2019-06-14 00:00:00

abstract：:Surface charge density is the key factor for developing high performance triboelectric nanogenerators (TENG). The previously invented charge excitation TENG provides a most efficient way to achieve maximum charge output of a TENG device. Herein, criteria to quantitatively evaluate the contact efficiency and air breakd...

journal_title：Nature communications

authors： Liu Y,Liu W,Wang Z,He W,Tang Q,Xi Y,Wang X,Guo H,Hu C

更新日期：2020-03-27 00:00:00

abstract：:The development of native-like HIV-1 envelope (Env) trimer antigens has enabled the induction of neutralizing antibody (NAb) responses against neutralization-resistant HIV-1 strains in animal models. However, NAb responses are relatively weak and narrow in specificity. Displaying antigens in a multivalent fashion on n...

journal_title：Nature communications

authors： Brouwer PJM,Antanasijevic A,Berndsen Z,Yasmeen A,Fiala B,Bijl TPL,Bontjer I,Bale JB,Sheffler W,Allen JD,Schorcht A,Burger JA,Camacho M,Ellis D,Cottrell CA,Behrens AJ,Catalano M,Del Moral-Sánchez I,Ketas TJ,LaBranche

更新日期：2019-09-19 00:00:00

abstract：:The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respirato...

journal_title：Nature communications

authors： Gancheva S,Ouni M,Jelenik T,Koliaki C,Szendroedi J,Toledo FGS,Markgraf DF,Pesta DH,Mastrototaro L,De Filippo E,Herder C,Jähnert M,Weiss J,Strassburger K,Schlensak M,Schürmann A,Roden M

更新日期：2019-09-13 00:00:00

abstract：:The temporal resolution of ultrafast electron diffraction and microscopy experiments is currently limited by the available experimental techniques for the generation and characterization of electron bunches with single femtosecond or attosecond durations. Here, we present proof of principle experiments of an optical g...

journal_title：Nature communications

authors： Kozák M,McNeur J,Leedle KJ,Deng H,Schönenberger N,Ruehl A,Hartl I,Harris JS,Byer RL,Hommelhoff P

更新日期：2017-01-25 00:00:00

abstract：:Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However, Notch1 can be stochastically activated to promote carcinogenesis in murine models of SCC. Activat...

journal_title：Nature communications

authors： Natsuizaka M,Whelan KA,Kagawa S,Tanaka K,Giroux V,Chandramouleeswaran PM,Long A,Sahu V,Darling DS,Que J,Yang Y,Katz JP,Wileyto EP,Basu D,Kita Y,Natsugoe S,Naganuma S,Klein-Szanto AJ,Diehl JA,Bass AJ,Wong KK,Rust

更新日期：2017-11-24 00:00:00

abstract：:POT1 and TPP1 are part of the shelterin complex and are essential for telomere length regulation and maintenance. Naturally occurring mutations of the telomeric POT1-TPP1 complex are implicated in familial glioma, melanoma and chronic lymphocytic leukaemia. Here we report the atomic structure of the interacting portio...

journal_title：Nature communications

authors： Rice C,Shastrula PK,Kossenkov AV,Hills R,Baird DM,Showe LC,Doukov T,Janicki S,Skordalakes E

更新日期：2017-04-10 00:00:00

abstract：:Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from ...

journal_title：Nature communications

authors： Kuchenbaecker K,Telkar N,Reiker T,Walters RG,Lin K,Eriksson A,Gurdasani D,Gilly A,Southam L,Tsafantakis E,Karaleftheri M,Seeley J,Kamali A,Asiki G,Millwood IY,Holmes M,Du H,Guo Y,Kumari M,Dedoussis G,Li L,Chen Z

更新日期：2019-09-24 00:00:00

abstract：:Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorha...

journal_title：Nature communications

authors： Kumsta C,Chang JT,Lee R,Tan EP,Yang Y,Loureiro R,Choy EH,Lim SHY,Saez I,Springhorn A,Hoppe T,Vilchez D,Hansen M

更新日期：2019-12-11 00:00:00

abstract：:The fate of the enormous amount of reactive nitrogen released to the environment by human activities in India is unknown. Here we show occurrence of seasonal stratification and generally low concentrations of dissolved inorganic combined nitrogen, and high molecular nitrogen (N2) to argon ratio, thus suggesting season...

journal_title：Nature communications

authors： Naqvi SWA,Lam P,Narvenkar G,Sarkar A,Naik H,Pratihary A,Shenoy DM,Gauns M,Kurian S,Damare S,Duret M,Lavik G,Kuypers MMM

更新日期：2018-03-28 00:00:00

abstract：:Interfacial water constitutes a formidable barrier to strong surface bonding, hampering the development of water-resistant synthetic adhesives. Notwithstanding this obstacle, the Asian green mussel Perna viridis attaches firmly to underwater surfaces via a proteinaceous secretion (byssus). Extending beyond the current...

journal_title：Nature communications

authors： Petrone L,Kumar A,Sutanto CN,Patil NJ,Kannan S,Palaniappan A,Amini S,Zappone B,Verma C,Miserez A

更新日期：2015-10-28 00:00:00

abstract：:Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs remains largely undefined. Through analysis of transcriptome microarray data, we identify a long noncoding RNA (lncRNA) called lncBRM, which is highly e...

journal_title：Nature communications

authors： Zhu P,Wang Y,Wu J,Huang G,Liu B,Ye B,Du Y,Gao G,Tian Y,He L,Fan Z

更新日期：2016-12-01 00:00:00

abstract：:Approximately half of the world's population lives in the tropics, and future changes in the hydrological cycle will impact not just the freshwater supplies but also energy production in areas dependent upon hydroelectric power. It is vital that we understand the mechanisms/processes that affect tropical precipitation...

journal_title：Nature communications

authors： Winter A,Zanchettin D,Miller T,Kushnir Y,Black D,Lohmann G,Burnett A,Haug GH,Estrella-Martínez J,Breitenbach SF,Beaufort L,Rubino A,Cheng H

更新日期：2015-07-14 00:00:00

abstract：:Lithium metal is an ideal anode for lithium batteries due to its low electrochemical potential and high theoretical capacity. However, safety issues arising from lithium dendrite growth have significantly reduced the practical applicability of lithium metal batteries. Here, we report the addition of octaphenyl polyoxy...

journal_title：Nature communications

authors： Dai H,Gu X,Dong J,Wang C,Lai C,Sun S

更新日期：2020-01-31 00:00:00

abstract：:State-of-the-art techniques allow researchers to record large numbers of spike trains in parallel for many hours. With enough such data, we should be able to infer the connectivity among neurons. Here we develop a method for reconstructing neuronal circuitry by applying a generalized linear model (GLM) to spike cross-...

journal_title：Nature communications

authors： Kobayashi R,Kurita S,Kurth A,Kitano K,Mizuseki K,Diesmann M,Richmond BJ,Shinomoto S

更新日期：2019-10-02 00:00:00

abstract：:Janus, patchy, stripe-like, or random arrangements of molecules within the ligand shell of nanoparticles affect many properties. Among all existing ligand shell morphology characterization methods, the one based on mass spectroscopy is arguably the simplest. Its greatest limitation is that the results are qualitative....

journal_title：Nature communications

authors： Luo Z,Zhao Y,Darwish T,Wang Y,Hou J,Stellacci F

更新日期：2018-10-26 00:00:00

abstract：:Thermal melanism theory states that dark-colored ectotherm organisms are at an advantage at low temperature due to increased warming. This theory is generally supported for ectotherm animals, however, the function of colors in the fungal kingdom is largely unknown. Here, we test whether the color lightness of mushroom...

journal_title：Nature communications

authors： Krah FS,Büntgen U,Schaefer H,Müller J,Andrew C,Boddy L,Diez J,Egli S,Freckleton R,Gange AC,Halvorsen R,Heegaard E,Heideroth A,Heibl C,Heilmann-Clausen J,Høiland K,Kar R,Kauserud H,Kirk PM,Kuyper TW,Krisai-Greilhub

更新日期：2019-06-28 00:00:00