Abstract:
:Maternal glucose levels during pregnancy impact the developing fetus, affecting metabolic health both early and later on in life. Both genetic and environmental factors influence maternal metabolism, but little is known about the genetic mechanisms that alter glucose metabolism during pregnancy. Here, we report that haplotypes previously associated with gestational hyperglycaemia in the third trimester disrupt regulatory element activity and reduce expression of the nearby HKDC1 gene. We further find that experimentally reducing or increasing HKDC1 expression reduces or increases hexokinase activity, respectively, in multiple cellular models; in addition, purified HKDC1 protein has hexokinase activity in vitro. Together, these results suggest a novel mechanism of gestational glucose regulation in which the effects of genetic variants in multiple regulatory elements alter glucose homeostasis by coordinately reducing expression of the novel hexokinase HKDC1.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Guo C,Ludvik AE,Arlotto ME,Hayes MG,Armstrong LL,Scholtens DM,Brown CD,Newgard CB,Becker TC,Layden BT,Lowe WL,Reddy TEdoi
10.1038/ncomms7069subject
Has Abstractpub_date
2015-02-04 00:00:00pages
6069issn
2041-1723pii
ncomms7069journal_volume
6pub_type
杂志文章abstract::Rabies virus (RABV) causes fatal encephalitis in more than 59,000 people yearly. Upon the bite of an infected animal, the development of clinical disease can be prevented with post-exposure prophylaxis (PEP), which includes the administration of Rabies immunoglobulin (RIG). However, the high cost and limited availabil...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14398-7
更新日期:2020-01-30 00:00:00
abstract::Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain st...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08500-x
更新日期:2019-02-06 00:00:00
abstract::The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13021
更新日期:2016-10-10 00:00:00
abstract::Determining nanoscale protein distribution via Photoactivated Localization Microscopy (PALM) mandates precise knowledge of the applied fluorophore's blinking properties to counteract overcounting artifacts that distort the resulting biomolecular distributions. Here, we present a readily applicable methodology to deter...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18726-9
更新日期:2020-10-05 00:00:00
abstract::The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2318
更新日期:2012-01-01 00:00:00
abstract::New exotic phenomena have recently been discovered in oxides of paramagnetic Ir(4+) ions, widely known as 'iridates'. Their remarkable properties originate from concerted effects of the crystal field, magnetic interactions and strong spin-orbit coupling, characteristic of 5d metal ions. Despite numerous experimental r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12195
更新日期:2016-07-20 00:00:00
abstract::Hybridomas, fusions of primary mouse B cells and myelomas, are stable, rapidly-proliferating cell lines widely utilized for antibody screening and production. Antibody specificity of a hybridoma clone is determined by the immunoglobulin sequence of the primary B cell. Here we report a platform for rapid reprogramming ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12535
更新日期:2016-08-17 00:00:00
abstract::How stem cells give rise to epidermis is unclear despite the crucial role the epidermis plays in barrier and appendage formation. Here we use single cell-RNA sequencing to interrogate basal stem cell heterogeneity of human interfollicular epidermis and find four spatially distinct stem cell populations at the top and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18075-7
更新日期:2020-08-25 00:00:00
abstract::Knowing which proteins and RNAs directly interact is essential for understanding cellular mechanisms. Unfortunately, discovering such interactions is costly and often unreliable. To overcome these limitations, we developed rec-YnH, a new yeast two and three-hybrid-based screening pipeline capable of detecting interact...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06128-x
更新日期:2018-09-14 00:00:00
abstract::Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activation and, if defective, is associated with autoimmune disease, yet its impact on specific B cell tolerance chec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09434-0
更新日期:2019-04-29 00:00:00
abstract::The Mycobacterium tuberculosis (Mtb) electron transport chain (ETC) has received significant attention as a drug target, however its vulnerability may be affected by its flexibility in response to disruption. Here we determine the effect of the ETC inhibitors bedaquiline, Q203 and clofazimine on the Mtb ETC, and the v...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12393
更新日期:2016-08-10 00:00:00
abstract::A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16003
更新日期:2017-07-07 00:00:00
abstract::Mangrove forests hold some of the highest densities of carbon recorded in any ecosystem, but have experienced widespread deforestation through conversion to aquaculture and agriculture. Alongside deforestation, mangroves have shown simultaneous natural expansion in some parts of the world, and considerable investments...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18118-z
更新日期:2020-08-26 00:00:00
abstract::Most motile bacteria navigate within gradients of external chemical stimuli by regulating the length of randomly oriented swimming episodes. Magnetotactic bacteria are characterized by chains of intracellular ferromagnetic nanoparticles and their ability to sense the geomagnetic field, which is believed to facilitate ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6398
更新日期:2014-11-14 00:00:00
abstract::HIV persists in latently infected CD4+ T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed at the surface of persistently infected cells. However, whether PD-1 plays a functional role in HIV latency and reservoir persistence remains unknown. Using CD4+...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08798-7
更新日期:2019-02-18 00:00:00
abstract::Continuum numerical modeling of dynamic crack propagation has been a great challenge over the past decade. This is particularly the case for anticracks in porous materials, as reported in sedimentary rocks, deep earthquakes, landslides, and snow avalanches, as material inter-penetration further complicates the problem...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05181-w
更新日期:2018-08-03 00:00:00
abstract::Explosive energy release is a common phenomenon occurring in magnetized plasma systems ranging from laboratories, Earth's magnetosphere, the solar corona and astrophysical environments. Its physical explanation is usually attributed to magnetic reconnection in a thin current sheet. Here we report the important role of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1753
更新日期:2012-03-20 00:00:00
abstract::Action potential (AP) generation is the key to information-processing in the brain. Although APs are normally initiated in the axonal initial segment, developmental adaptation or prolonged network activity may alter the initiation site geometry thus affecting cell excitability. Here we find that hippocampal dentate gr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4817
更新日期:2014-05-23 00:00:00
abstract::Crystalline phase transitions caused by external stimuli have been used to detect physical changes in the solid-state properties. This study presents the mechanical switching of crystals of ferrocene-containing rotaxane controlled by focused laser light. The expansion and contraction of the crystals can be driven by t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13321
更新日期:2016-11-03 00:00:00
abstract::Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14229
更新日期:2017-02-06 00:00:00
abstract::Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11620-z
更新日期:2019-08-16 00:00:00
abstract::High-speed light emitters integrated on silicon chips can enable novel architectures for silicon-based optoelectronics, such as on-chip optical interconnects, and silicon photonics. However, conventional light sources based on compound semiconductors face major challenges for their integration with a silicon-based pla...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03695-x
更新日期:2018-03-29 00:00:00
abstract::A conspicuous 60° bend of the Hawaiian-Emperor Chain in the north-western Pacific Ocean has variously been interpreted as the result of an abrupt Pacific plate motion change in the Eocene (∼47 Ma), a rapid southward drift of the Hawaiian hotspot before the formation of the bend, or a combination of these two causes. P...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15660
更新日期:2017-06-05 00:00:00
abstract::Viscous electron fluids have emerged recently as a new paradigm of strongly-correlated electron transport in solids. Here we report on a direct observation of the transition to this long-sought-for state of matter in a high-mobility electron system in graphene. Unexpectedly, the electron flow is found to be interactio...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07004-4
更新日期:2018-10-31 00:00:00
abstract::Nonsense-mediated decay (NMD) eliminates transcripts with premature termination codons. Although NMD-induced loss-of-function has been shown to contribute to the genesis of particular cancers, its global functional consequence in tumours has not been characterized. Here we develop an algorithm to predict NMD and apply...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15943
更新日期:2017-06-26 00:00:00
abstract::Humans survive and thrive through social exchange. Yet, social dependency also comes at a cost. Perceived social isolation, or loneliness, affects physical and mental health, cognitive performance, overall life expectancy, and increases vulnerability to Alzheimer's disease-related dementias. Despite severe consequence...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20039-w
更新日期:2020-12-15 00:00:00
abstract::Coalescence is an essential phenomenon that governs the equilibrium behaviour in a variety of systems from intercellular transport to planetary formation. In this report, we study coalescence pathways of circularly shaped two-dimensional colloidal membranes, which are one rod-length-thick liquid-like monolayers of ali...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4063
更新日期:2014-01-01 00:00:00
abstract::One of the fundamental design paradigms in organic photovoltaic device engineering is based on the idea that charge separation is an extrinsically driven process requiring an interface for exciton fission. This idea has driven an enormous materials science engineering effort focused on construction of domain sizes com...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10629
更新日期:2016-02-25 00:00:00
abstract::SecB chaperones assist protein export by binding both unfolded proteins and the SecA motor. Certain SecB homologs can also control toxin-antitoxin (TA) systems known to modulate bacterial growth in response to stress. In such TA-chaperone (TAC) systems, SecB assists the folding and prevents degradation of the antitoxi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08747-4
更新日期:2019-02-15 00:00:00
abstract::LNK (SH2B3) is a key negative regulator of JAK-STAT signaling which has been extensively studied in malignant hematopoietic diseases. We found that LNK is significantly elevated in cutaneous melanoma; this elevation is correlated with hyperactive signaling of the RAS-RAF-MEK pathway. Elevated LNK enhances cell growth ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09711-y
更新日期:2019-05-20 00:00:00