Abstract:
:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early postnatal stages is minimal. However, without fast GABAergic transmission, a different situation may prevail. In the adult CA3, blocking fast GABAergic transmission induces the generation of network bursts that can be triggered by the stimulation of single pyramidal neurons. Here we revisit the network function of CA3 glutamatergic neurons from a developmental viewpoint, without fast GABAergic transmission. We uncover a sub-population of early-generated glutamatergic neurons that impacts network dynamics when stimulated in the juvenile hippocampus. Additionally, this population displays characteristic morpho-physiological features in the juvenile and adult hippocampus. Therefore, the apparently homogeneous glutamatergic cell population likely displays a morpho-functional diversity rooted in temporal embryonic origins.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart Rdoi
10.1038/ncomms2318subject
Has Abstractpub_date
2012-01-01 00:00:00pages
1316issn
2041-1723pii
ncomms2318journal_volume
3pub_type
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