当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10.

Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10.

Abstract：

:The endoplasmic reticulum-mitochondria encounter structure (ERMES) connects the mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES, including maintenance of mitochondrial morphology, protein assembly and phospholipid homeostasis. Since the mitochondrial distribution and morphology protein Mdm10 is present in both ERMES and the mitochondrial sorting and assembly machinery (SAM), it is unknown how the ERMES functions are connected on a molecular level. Here we report that conserved surface areas on opposite sides of the Mdm10 β-barrel interact with SAM and ERMES, respectively. We generated point mutants to separate protein assembly (SAM) from morphology and phospholipid homeostasis (ERMES). Our study reveals that the β-barrel channel of Mdm10 serves different functions. Mdm10 promotes the biogenesis of α-helical and β-barrel proteins at SAM and functions as integral membrane anchor of ERMES, demonstrating that SAM-mediated protein assembly is distinct from ER-mitochondria contact sites.

journal_name

Nat Commun

journal_title

Nature communications

authors

Ellenrieder L,Opaliński Ł,Becker L,Krüger V,Mirus O,Straub SP,Ebell K,Flinner N,Stiller SB,Guiard B,Meisinger C,Wiedemann N,Schleiff E,Wagner R,Pfanner N,Becker T

doi

10.1038/ncomms13021

subject

Has Abstract

pub_date

2016-10-10 00:00:00

pages

13021

issn

2041-1723

pii

ncomms13021

journal_volume

7

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Direct observation of coordinated DNA movements on the nucleosome during chromatin remodelling.

    abstract：:ATP-dependent chromatin remodelling enzymes (remodellers) regulate DNA accessibility in eukaryotic genomes. Many remodellers reposition (slide) nucleosomes, however, how DNA is propagated around the histone octamer during this process is unclear. Here we examine the real-time coordination of remodeller-induced DNA mov...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-09657-1

    authors： Sabantsev A,Levendosky RF,Zhuang X,Bowman GD,Deindl S

    更新日期：2019-04-12 00:00:00

  • Active control of anapole states by structuring the phase-change alloy Ge2Sb2Te5.

    abstract：:High-index dielectric nanoparticles supporting a distinct series of Mie resonances have enabled a new class of optical antennas with unprecedented functionalities. The great wealth of multipolar responses has not only brought in new physical insight but also spurred practical applications. However, how to make such a ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-08057-1

    authors： Tian J,Luo H,Yang Y,Ding F,Qu Y,Zhao D,Qiu M,Bozhevolnyi SI

    更新日期：2019-01-23 00:00:00

  • Neutralization mechanism of a highly potent antibody against Zika virus.

    abstract：:The rapid spread of Zika virus (ZIKV), which causes microcephaly and Guillain-Barré syndrome, signals an urgency to identify therapeutics. Recent efforts to rescreen dengue virus human antibodies for ZIKV cross-neutralization activity showed antibody C10 as one of the most potent. To investigate the ability of the ant...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13679

    authors： Zhang S,Kostyuchenko VA,Ng TS,Lim XN,Ooi JSG,Lambert S,Tan TY,Widman DG,Shi J,Baric RS,Lok SM

    更新日期：2016-11-24 00:00:00

  • A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.

    abstract：:Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to RTECs can cause systemic fluid imbalance, electrolyte abnormalities and metabolic waste accumulation- manifesting as acute kidney injury (A...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-15638-6

    authors： Kim JY,Bai Y,Jayne LA,Hector RD,Persaud AK,Ong SS,Rojesh S,Raj R,Feng MJHH,Chung S,Cianciolo RE,Christman JW,Campbell MJ,Gardner DS,Baker SD,Sparreboom A,Govindarajan R,Singh H,Chen T,Poi M,Susztak K,Cobb SR,P

    更新日期：2020-04-21 00:00:00

  • A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division.

    abstract：:Genome stability relies on proper coordination of mitosis and cytokinesis, where dynamic microtubules capture and faithfully segregate chromosomes into daughter cells. With a high-content RNAi imaging screen targeting more than 2,000 human lncRNAs, we identify numerous lncRNAs involved in key steps of cell division su...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14978-7

    authors： Stojic L,Lun ATL,Mascalchi P,Ernst C,Redmond AM,Mangei J,Barr AR,Bousgouni V,Bakal C,Marioni JC,Odom DT,Gergely F

    更新日期：2020-04-15 00:00:00

  • Evidence for a palaeo-subglacial lake on the Antarctic continental shelf.

    abstract：:Subglacial lakes are widespread beneath the Antarctic Ice Sheet but their control on ice-sheet dynamics and their ability to harbour life remain poorly characterized. Here we present evidence for a palaeo-subglacial lake on the Antarctic continental shelf. A distinct sediment facies recovered from a bedrock basin in P...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15591

    authors： Kuhn G,Hillenbrand CD,Kasten S,Smith JA,Nitsche FO,Frederichs T,Wiers S,Ehrmann W,Klages JP,Mogollón JM

    更新日期：2017-06-01 00:00:00

  • The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells.

    abstract：:Micro(mi)RNA-based post-transcriptional regulatory mechanisms have been broadly implicated in the assembly and modulation of synaptic connections required to shape neural circuits, however, relatively few specific miRNAs have been identified that control synapse formation. Using a conditional transgenic toolkit for co...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14761-8

    authors： McNeill EM,Warinner C,Alkins S,Taylor A,Heggeness H,DeLuca TF,Fulga TA,Wall DP,Griffith LC,Van Vactor D

    更新日期：2020-02-27 00:00:00

  • Chemo-mechanics of salt damage in stone.

    abstract：:Many porous materials are damaged by pressure exerted by salt crystals growing in their pores. This is a serious issue in conservation science, geomorphology, geotechnical engineering and concrete materials science. In all cases, a central question is whether crystallization pressure will cause damage. Here we present...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5823

    authors： Flatt RJ,Caruso F,Sanchez AM,Scherer GW

    更新日期：2014-09-11 00:00:00

  • Direct wavefront sensing for high-resolution in vivo imaging in scattering tissue.

    abstract：:Adaptive optics by direct imaging of the wavefront distortions of a laser-induced guide star has long been used in astronomy, and more recently in microscopy to compensate for aberrations in transparent specimens. Here we extend this approach to tissues that strongly scatter visible light by exploiting the reduced sca...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8276

    authors： Wang K,Sun W,Richie CT,Harvey BK,Betzig E,Ji N

    更新日期：2015-06-15 00:00:00

  • ABL1 regulates spindle orientation in adherent cells and mammalian skin.

    abstract：:Despite the growing evidence for the regulated spindle orientation in mammals, a systematic approach for identifying the responsible genes in mammalian cells has not been established. Here we perform a kinase-targeting RNAi screen in HeLa cells and identify ABL1 as a novel regulator of spindle orientation. Knockdown o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1634

    authors： Matsumura S,Hamasaki M,Yamamoto T,Ebisuya M,Sato M,Nishida E,Toyoshima F

    更新日期：2012-01-17 00:00:00

  • Charge order from orbital-dependent coupling evidenced by NbSe2.

    abstract：:Niobium diselenide has long served as a prototype of two-dimensional charge ordering, believed to arise from an instability of the electronic structure analogous to the one-dimensional Peierls mechanism. Despite this, various anomalous properties have recently been identified experimentally, which cannot be explained ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8034

    authors： Flicker F,van Wezel J

    更新日期：2015-05-07 00:00:00

  • Author Correction: Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

    abstract：:In the original version of this Article, the Acknowledgement section omitted financial support from the Deutsche Forschungsgemeinschaft grant SFB 958/A4. This error has now been corrected in both the PDF and HTML versions of the Article. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-018-03452-0

    authors： Paul F,Wehmeyer C,Abualrous ET,Wu H,Crabtree MD,Schöneberg J,Clarke J,Freund C,Weikl TR,Noé F

    更新日期：2018-03-09 00:00:00

  • Piwi reduction in the aged niche eliminates germline stem cells via Toll-GSK3 signaling.

    abstract：:Transposons are known to participate in tissue aging, but their effects on aged stem cells remain unclear. Here, we report that in the Drosophila ovarian germline stem cell (GSC) niche, aging-related reductions in expression of Piwi (a transposon silencer) derepress retrotransposons and cause GSC loss. Suppression of ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16858-6

    authors： Lin KY,Wang WD,Lin CH,Rastegari E,Su YH,Chang YT,Liao YF,Chang YC,Pi H,Yu BY,Chen SH,Lin CY,Lu MY,Su TY,Tzou FY,Chan CC,Hsu HJ

    更新日期：2020-06-19 00:00:00

  • Elastic anisotropy of experimental analogues of perovskite and post-perovskite help to interpret D'' diversity.

    abstract：:Recent studies show that the D'' layer, just above the Earth's core-mantle boundary, is composed of MgSiO3 post-perovskite and has significant lateral inhomogeneity. Here we consider the D'' diversity as related to the single-crystal elasticity of the post-perovskite phase. We measure the single-crystal elasticity of ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4453

    authors： Yoneda A,Fukui H,Xu F,Nakatsuka A,Yoshiasa A,Seto Y,Ono K,Tsutsui S,Uchiyama H,Baron AQ

    更新日期：2014-03-27 00:00:00

  • Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.

    abstract：:The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinants and the structural and functional consequences of such inter...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01575-4

    authors： Ait-Bouziad N,Lv G,Mahul-Mellier AL,Xiao S,Zorludemir G,Eliezer D,Walz T,Lashuel HA

    更新日期：2017-11-22 00:00:00

  • Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts.

    abstract：:Vascularization and efficient perfusion are long-standing challenges in cardiac tissue engineering. Here we report engineered perfusable microvascular constructs, wherein human embryonic stem cell-derived endothelial cells (hESC-ECs) are seeded both into patterned microchannels and the surrounding collagen matrix. In ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08388-7

    authors： Redd MA,Zeinstra N,Qin W,Wei W,Martinson A,Wang Y,Wang RK,Murry CE,Zheng Y

    更新日期：2019-02-04 00:00:00

  • Efficient hydrogen production on MoNi4 electrocatalysts with fast water dissociation kinetics.

    abstract：:Various platinum-free electrocatalysts have been explored for hydrogen evolution reaction in acidic solutions. However, in economical water-alkali electrolysers, sluggish water dissociation kinetics (Volmer step) on platinum-free electrocatalysts results in poor hydrogen-production activities. Here we report a MoNi4 e...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15437

    authors： Zhang J,Wang T,Liu P,Liao Z,Liu S,Zhuang X,Chen M,Zschech E,Feng X

    更新日期：2017-05-17 00:00:00

  • Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona.

    abstract：:Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma proteome. Here we report a highly parallel protein quantitation platform integrating nanoparticle (NP) protein coronas with liquid chromatography-mass spectrometry for efficient proteomic profiling. A protein corona is a protein l...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17033-7

    authors： Blume JE,Manning WC,Troiano G,Hornburg D,Figa M,Hesterberg L,Platt TL,Zhao X,Cuaresma RA,Everley PA,Ko M,Liou H,Mahoney M,Ferdosi S,Elgierari EM,Stolarczyk C,Tangeysh B,Xia H,Benz R,Siddiqui A,Carr SA,Ma P,Lan

    更新日期：2020-07-22 00:00:00

  • Modeling mitigation of influenza epidemics by baloxavir.

    abstract：:Influenza viruses annually kill 290,000-650,000 people worldwide. Antivirals can reduce death tolls. Baloxavir, the recently approved influenza antiviral, inhibits initiation of viral mRNA synthesis, whereas oseltamivir, an older drug, inhibits release of virus progeny. Baloxavir blocks virus replication more rapidly ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16585-y

    authors： Du Z,Nugent C,Galvani AP,Krug RM,Meyers LA

    更新日期：2020-06-02 00:00:00

  • Predicting dwell fatigue life in titanium alloys using modelling and experiment.

    abstract：:Fatigue is a difficult multi-scale modelling problem nucleating from localised plasticity at the scale of dislocations and microstructure with significant engineering safety implications. Cold dwell fatigue is a phenomenon in titanium where stress holds at moderate temperatures lead to substantial reductions in cyclic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19470-w

    authors： Xu Y,Joseph S,Karamched P,Fox K,Rugg D,Dunne FPE,Dye D

    更新日期：2020-11-17 00:00:00

  • A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages.

    abstract：:We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-generational lineage tracking under controlled culture conditions. We use this platform to generate whole-transcriptome profiles of primary, activated murine CD8+ T-cell and lymphocytic leukemia cell line lineages. Here we repor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10220

    authors： Kimmerling RJ,Lee Szeto G,Li JW,Genshaft AS,Kazer SW,Payer KR,de Riba Borrajo J,Blainey PC,Irvine DJ,Shalek AK,Manalis SR

    更新日期：2016-01-06 00:00:00

  • Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity.

    abstract：:Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a po...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10787

    authors： Sant'Anna R,Gallego P,Robinson LZ,Pereira-Henriques A,Ferreira N,Pinheiro F,Esperante S,Pallares I,Huertas O,Almeida MR,Reixach N,Insa R,Velazquez-Campoy A,Reverter D,Reig N,Ventura S

    更新日期：2016-02-23 00:00:00

  • Cervical epithelial damage promotes Ureaplasma parvum ascending infection, intrauterine inflammation and preterm birth induction in mice.

    abstract：:Around 40% of preterm births are attributed to ascending intrauterine infection, and Ureaplasma parvum (UP) is commonly isolated in these cases. Here we present a mouse model of ascending UP infection that resembles human disease, using vaginal inoculation combined with mild cervical injury induced by a common spermic...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14089-y

    authors： Pavlidis I,Spiller OB,Sammut Demarco G,MacPherson H,Howie SEM,Norman JE,Stock SJ

    更新日期：2020-01-10 00:00:00

  • A simple and versatile design concept for fluorophore derivatives with intramolecular photostabilization.

    abstract：:Intramolecular photostabilization via triple-state quenching was recently revived as a tool to impart synthetic organic fluorophores with 'self-healing' properties. To date, utilization of such fluorophore derivatives is rare due to their elaborate multi-step synthesis. Here we present a general strategy to covalently...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10144

    authors： van der Velde JH,Oelerich J,Huang J,Smit JH,Aminian Jazi A,Galiani S,Kolmakov K,Guoridis G,Eggeling C,Herrmann A,Roelfes G,Cordes T

    更新日期：2016-01-11 00:00:00

  • Rapid visualization of grain boundaries in monolayer MoS2 by multiphoton microscopy.

    abstract：:Grain boundaries have a major effect on the physical properties of two-dimensional layered materials. Therefore, it is important to develop simple, fast and sensitive characterization methods to visualize grain boundaries. Conventional Raman and photoluminescence methods have been used for detecting grain boundaries; ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15714

    authors： Karvonen L,Säynätjoki A,Huttunen MJ,Autere A,Amirsolaimani B,Li S,Norwood RA,Peyghambarian N,Lipsanen H,Eda G,Kieu K,Sun Z

    更新日期：2017-06-05 00:00:00

  • Robust quantum valley Hall effect for vortices in an interacting bosonic quantum fluid.

    abstract：:Topologically protected pseudospin transport, analogous to the quantum spin Hall effect, cannot be strictly implemented for photons and in general bosons because of the lack of symmetry-protected pseudospins. Here we show that the required protection can be provided by the real-space topological excitation of an inter...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06520-7

    authors： Bleu O,Malpuech G,Solnyshkov DD

    更新日期：2018-09-28 00:00:00

  • Phylogenomic analysis sheds light on the evolutionary pathways towards acoustic communication in Orthoptera.

    abstract：:Acoustic communication is enabled by the evolution of specialised hearing and sound producing organs. In this study, we performed a large-scale macroevolutionary study to understand how both hearing and sound production evolved and affected diversification in the insect order Orthoptera, which includes many familiar s...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18739-4

    authors： Song H,Béthoux O,Shin S,Donath A,Letsch H,Liu S,McKenna DD,Meng G,Misof B,Podsiadlowski L,Zhou X,Wipfler B,Simon S

    更新日期：2020-10-02 00:00:00

  • Fast growth of large-grain and continuous MoS2 films through a self-capping vapor-liquid-solid method.

    abstract：:Most chemical vapor deposition methods for transition metal dichalcogenides use an extremely small amount of precursor to render large single-crystal flakes, which usually causes low coverage of the materials on the substrate. In this study, a self-capping vapor-liquid-solid reaction is proposed to fabricate large-gra...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17517-6

    authors： Chang MC,Ho PH,Tseng MF,Lin FY,Hou CH,Lin IK,Wang H,Huang PP,Chiang CH,Yang YC,Wang IT,Du HY,Wen CY,Shyue JJ,Chen CW,Chen KH,Chiu PW,Chen LC

    更新日期：2020-07-23 00:00:00

  • Polarization curling and flux closures in multiferroic tunnel junctions.

    abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13484

    authors： Peters JJP,Apachitei G,Beanland R,Alexe M,Sanchez AM

    更新日期：2016-11-16 00:00:00

  • Time-resolved diffraction of shock-released SiO2 and diaplectic glass formation.

    abstract：:Understanding how rock-forming minerals transform under shock loading is critical for modeling collisions between planetary bodies, interpreting the significance of shock features in minerals and for using them as diagnostic indicators of impact conditions, such as shock pressure. To date, our understanding of the for...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01791-y

    authors： Gleason AE,Bolme CA,Lee HJ,Nagler B,Galtier E,Kraus RG,Sandberg R,Yang W,Langenhorst F,Mao WL

    更新日期：2017-11-14 00:00:00