A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division.

abstract：:To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical de...

journal_title：Nature communications

authors： Jin K,Sam IH,Po KHL,Lin D,Ghazvini Zadeh EH,Chen S,Yuan Y,Li X

更新日期：2016-08-03 00:00:00

abstract：:Pulse oximetry is a ubiquitous non-invasive medical sensing method for measuring pulse rate and arterial blood oxygenation. Conventional pulse oximeters use expensive optoelectronic components that restrict sensing locations to finger tips or ear lobes due to their rigid form and area-scaling complexity. In this work,...

journal_title：Nature communications

authors： Lochner CM,Khan Y,Pierre A,Arias AC

更新日期：2014-12-10 00:00:00

abstract：:Protein expression evolves under greater evolutionary constraint than mRNA levels, and translation efficiency represents a primary determinant of protein levels during stimuli adaptation. This raises the question as to the translatome remodelers that titrate protein output from mRNA populations. Here, we uncover a net...

journal_title：Nature communications

authors： Ho JJD,Balukoff NC,Theodoridis PR,Wang M,Krieger JR,Schatz JH,Lee S

更新日期：2020-05-29 00:00:00

abstract：:Range expansions are central to two ecological issues reshaping patterns of global biodiversity: biological invasions and climate change. Traditional theory considers range expansion as the outcome of the demographic processes of birth, death and dispersal, while ignoring the evolutionary implications of such processe...

journal_title：Nature communications

authors： Weiss-Lehman C,Hufbauer RA,Melbourne BA

更新日期：2017-01-27 00:00:00

abstract：:Variation in body iron is associated with or causes diseases, including anaemia and iron overload. Here, we analyse genetic association data on biochemical markers of iron status from 11 European-population studies, with replication in eight additional cohorts (total up to 48,972 subjects). We find 11 genome-wide-sign...

journal_title：Nature communications

authors： Benyamin B,Esko T,Ried JS,Radhakrishnan A,Vermeulen SH,Traglia M,Gögele M,Anderson D,Broer L,Podmore C,Luan J,Kutalik Z,Sanna S,van der Meer P,Tanaka T,Wang F,Westra HJ,Franke L,Mihailov E,Milani L,Hälldin J,Win

更新日期：2014-10-29 00:00:00

abstract：:Processing within the anterior cingulate cortex (ACC) is crucial for the patterning of appropriate behavior, and ACC dysfunction following chronic drug use is thought to play a major role in drug addiction. However, cortical pyramidal projection neurons can be subdivided into two major types (intratelencephalic (IT) a...

journal_title：Nature communications

authors： Garcia AF,Crummy EA,Webb IG,Nooney MN,Ferguson SM

更新日期：2021-01-08 00:00:00

abstract：:Embedding tunable quantum emitters in a photonic bandgap structure enables control of dissipative and dispersive interactions between emitters and their photonic bath. Operation in the transmission band, outside the gap, allows for studying waveguide quantum electrodynamics in the slow-light regime. Alternatively, tun...

journal_title：Nature communications

authors： Mirhosseini M,Kim E,Ferreira VS,Kalaee M,Sipahigil A,Keller AJ,Painter O

更新日期：2018-09-12 00:00:00

abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...

journal_title：Nature communications

authors： Li S,Yuan B,Cao J,Chen J,Chen J,Qiu J,Zhao XM,Wang X,Qiu Z,Cheng TL

更新日期：2020-11-17 00:00:00

abstract：:Self-assembly of electroactive molecules is a promising route to new types of functional semiconductors. Here we report a capsule-shaped molecule that assembles itself into a cellular semiconducting material. The interior space of the capsule with a volume of ~415 Å3 is a nanoenvironment that can accommodate a guest. ...

journal_title：Nature communications

authors： Zhang B,Hernández Sánchez R,Zhong Y,Ball M,Terban MW,Paley D,Billinge SJL,Ng F,Steigerwald ML,Nuckolls C

更新日期：2018-05-16 00:00:00

abstract：:The spindle assembly checkpoint (SAC) arrests cells in mitosis by sensing unattached kinetochores, until all chromosomes are bi-oriented by spindle microtubules. Kinetochore accumulation of the SAC component Mad1-Mad2 is crucial for SAC activation. However, the mechanism by which Mad1-Mad2 accumulation at kinetochores...

journal_title：Nature communications

authors： Zhou H,Wang T,Zheng T,Teng J,Chen J

更新日期：2016-01-08 00:00:00

abstract：:RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and di...

journal_title：Nature communications

authors： Zhang C,Seo J,Murakami K,Salem ESB,Bernhard E,Borra VJ,Choi K,Yuan CL,Chan CC,Chen X,Huang T,Weirauch MT,Divanovic S,Qi NR,Thomas HE,Mercer CA,Siomi H,Nakamura T

更新日期：2018-09-10 00:00:00

abstract：:The fracture toughness of glassy materials remains poorly understood. In large part, this is due to the disordered, intrinsically non-equilibrium nature of the glass structure, which challenges its theoretical description and experimental determination. We show that the notch fracture toughness of metallic glasses exh...

journal_title：Nature communications

authors： Ketkaew J,Chen W,Wang H,Datye A,Fan M,Pereira G,Schwarz UD,Liu Z,Yamada R,Dmowski W,Shattuck MD,O'Hern CS,Egami T,Bouchbinder E,Schroers J

更新日期：2018-08-16 00:00:00

abstract：:Seed germination and young seedling establishment should be tightly regulated to maximize plant survival and thereby enable successful propagation. Plants have evolved developmental signalling networks to integrate environmental cues for proper control of these critical processes, in which brassinosteroids are known t...

journal_title：Nature communications

authors： Ryu H,Cho H,Bae W,Hwang I

更新日期：2014-06-18 00:00:00

abstract：:Membrane transporters actively translocate their substrate by undergoing large-scale structural transitions between inward- (IF) and outward-facing (OF) states ('alternating-access' mechanism). Despite extensive structural studies, atomic-level mechanistic details of such structural transitions, and as importantly, th...

journal_title：Nature communications

authors： Moradi M,Enkavi G,Tajkhorshid E

更新日期：2015-09-29 00:00:00

abstract：:G-protein-coupled receptor (GPCR) expression is extensively studied in bulk cDNA, but heterogeneity and functional patterning of GPCR expression in individual vascular cells is poorly understood. Here, we perform a microfluidic-based single-cell GPCR expression analysis in primary smooth muscle cells (SMC) and endothe...

journal_title：Nature communications

authors： Kaur H,Carvalho J,Looso M,Singh P,Chennupati R,Preussner J,Günther S,Albarrán-Juárez J,Tischner D,Classen S,Offermanns S,Wettschureck N

更新日期：2017-06-16 00:00:00

abstract：:Theoretical and experimental results have revealed that the lithium-ion storage capacity for nitrogen-doped graphene largely depends on the nitrogen-doping level. However, most nitrogen-doped carbon materials used for lithium-ion batteries are reported to have a nitrogen content of approximately 10 wt% because a highe...

journal_title：Nature communications

authors： Zheng F,Yang Y,Chen Q

更新日期：2014-11-06 00:00:00

abstract：:Previous studies have revealed that nucleosomes impede elongation of RNA polymerase II (RNAPII). Recent observations suggest a role for ATP-dependent chromatin remodellers in modulating this process, but direct in vivo evidence for this is unknown. Here using fission yeast, we identify Fun30Fft3 as a chromatin remodel...

journal_title：Nature communications

authors： Lee J,Choi ES,Seo HD,Kang K,Gilmore JM,Florens L,Washburn MP,Choe J,Workman JL,Lee D

更新日期：2017-02-20 00:00:00

abstract：:According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...

journal_title：Nature communications

authors： Gerstung M,Beisel C,Rechsteiner M,Wild P,Schraml P,Moch H,Beerenwinkel N

更新日期：2012-05-01 00:00:00

abstract：:Early detection has the potential to reduce cancer mortality, but an effective screening test must demonstrate asymptomatic cancer detection years before conventional diagnosis in a longitudinal study. In the Taizhou Longitudinal Study (TZL), 123,115 healthy subjects provided plasma samples for long-term storage and w...

journal_title：Nature communications

authors： Chen X,Gole J,Gore A,He Q,Lu M,Min J,Yuan Z,Yang X,Jiang Y,Zhang T,Suo C,Li X,Cheng L,Zhang Z,Niu H,Li Z,Xie Z,Shi H,Zhang X,Fan M,Wang X,Yang Y,Dang J,McConnell C,Zhang J,Wang J,Yu S,Ye W,Gao Y,

更新日期：2020-07-21 00:00:00

abstract：:The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and m...

journal_title：Nature communications

authors： Ding J,Chen K,Liu H,Huang L,Chen Y,Lv Y,Yang Q,Guo Q,Han Z,Lambon Ralph MA

更新日期：2020-05-22 00:00:00

abstract：:Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate them in antibacterial host defence, yet their functions in protection against clinically important pathogens are unknown. Here we show th...

journal_title：Nature communications

authors： Wang H,D'Souza C,Lim XY,Kostenko L,Pediongco TJ,Eckle SBG,Meehan BS,Shi M,Wang N,Li S,Liu L,Mak JYW,Fairlie DP,Iwakura Y,Gunnersen JM,Stent AW,Godfrey DI,Rossjohn J,Westall GP,Kjer-Nielsen L,Strugnell RA,McClusk

更新日期：2018-08-22 00:00:00

abstract：:BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer drivers, among which ...

journal_title：Nature communications

authors： Miao K,Lei JH,Valecha MV,Zhang A,Xu J,Wang L,Lyu X,Chen S,Miao Z,Zhang X,Su SM,Shao F,Rajendran BK,Bao J,Zeng J,Sun H,Chen P,Tan K,Chen Q,Wong KH,Xu X,Deng CX

更新日期：2020-06-26 00:00:00

abstract：:Longevity is influenced by genetic and environmental factors, but the underlying mechanisms remain elusive. Here, we functionally characterise a Drosophila small nucleolar RNA (snoRNA), named jouvence whose loss of function reduces lifespan. The genomic region of jouvence rescues the longevity in mutant, while its ove...

journal_title：Nature communications

authors： Soulé S,Mellottée L,Arab A,Chen C,Martin JR

更新日期：2020-02-20 00:00:00

abstract：:Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

journal_title：Nature communications

authors： Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

更新日期：2016-09-27 00:00:00

abstract：:Sponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symbioses. Here we present a global Porifera microbiome survey, set out to establish the ecological and evolutionary drivers of these host-microbe interactions. We show that sponges are a reservoir of exceptional microbia...

journal_title：Nature communications

authors： Thomas T,Moitinho-Silva L,Lurgi M,Björk JR,Easson C,Astudillo-García C,Olson JB,Erwin PM,López-Legentil S,Luter H,Chaves-Fonnegra A,Costa R,Schupp PJ,Steindler L,Erpenbeck D,Gilbert J,Knight R,Ackermann G,Victor Lopez

更新日期：2016-06-16 00:00:00

abstract：:Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor ce...

journal_title：Nature communications

authors： Duncan GJ,Manesh SB,Hilton BJ,Assinck P,Liu J,Moulson A,Plemel JR,Tetzlaff W

更新日期：2018-08-03 00:00:00

abstract：:We show how the kinetics of a fast and irreversible chemical reaction in a nanocrystalline material at high temperature can be studied using nanosecond electron pulses in an electron microscope. Infrared laser pulses first heat a nanocrystalline oxide layer on a carbon film, then single nanosecond electron pulses allo...

journal_title：Nature communications

authors： Sinha SK,Khammari A,Picher M,Roulland F,Viart N,LaGrange T,Banhart F

更新日期：2019-08-13 00:00:00

abstract：:Topological superconductor is attracting growing interest for its potential application to topological quantum computation. The superconducting proximity effect on the topological insulator surface state is one promising way to yield topological superconductivity. The superconductivity realized at the interface betwee...

journal_title：Nature communications

authors： Yasuda K,Yasuda H,Liang T,Yoshimi R,Tsukazaki A,Takahashi KS,Nagaosa N,Kawasaki M,Tokura Y

更新日期：2019-06-21 00:00:00

abstract：:Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accur...

journal_title：Nature communications

authors： Goyette PA,Boulais É,Normandeau F,Laberge G,Juncker D,Gervais T

更新日期：2019-04-16 00:00:00

abstract：:Deep learning algorithms have been successfully used in medical image classification. In the next stage, the technology of acquiring explainable knowledge from medical images is highly desired. Here we show that deep learning algorithm enables automated acquisition of explainable features from diagnostic annotation-fr...

journal_title：Nature communications

authors： Yamamoto Y,Tsuzuki T,Akatsuka J,Ueki M,Morikawa H,Numata Y,Takahara T,Tsuyuki T,Tsutsumi K,Nakazawa R,Shimizu A,Maeda I,Tsuchiya S,Kanno H,Kondo Y,Fukumoto M,Tamiya G,Ueda N,Kimura G

更新日期：2019-12-18 00:00:00