Abstract:
:Remyelination occurs after spinal cord injury (SCI) but its functional relevance is unclear. We assessed the necessity of myelin regulatory factor (Myrf) in remyelination after contusive SCI by deleting the gene from platelet-derived growth factor receptor alpha positive (PDGFRα-positive) oligodendrocyte progenitor cells (OPCs) in mice prior to SCI. While OPC proliferation and density are not altered by Myrf inducible knockout after SCI, the accumulation of new oligodendrocytes is largely prevented. This greatly inhibits myelin regeneration, resulting in a 44% reduction in myelinated axons at the lesion epicenter. However, spontaneous locomotor recovery after SCI is not altered by remyelination failure. In controls with functional MYRF, locomotor recovery precedes the onset of most oligodendrocyte myelin regeneration. Collectively, these data demonstrate that MYRF expression in PDGFRα-positive cell derived oligodendrocytes is indispensable for myelin regeneration following contusive SCI but that oligodendrocyte remyelination is not required for spontaneous recovery of stepping.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Duncan GJ,Manesh SB,Hilton BJ,Assinck P,Liu J,Moulson A,Plemel JR,Tetzlaff Wdoi
10.1038/s41467-018-05473-1subject
Has Abstractpub_date
2018-08-03 00:00:00pages
3066issue
1issn
2041-1723pii
10.1038/s41467-018-05473-1journal_volume
9pub_type
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