当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids.

Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids.

Abstract：

:The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low- and high-grade lung neuroendocrine neoplasms.

journal_name

Nat Commun

journal_title

Nature communications

authors

Alcala N,Leblay N,Gabriel AAG,Mangiante L,Hervas D,Giffon T,Sertier AS,Ferrari A,Derks J,Ghantous A,Delhomme TM,Chabrier A,Cuenin C,Abedi-Ardekani B,Boland A,Olaso R,Meyer V,Altmuller J,Le Calvez-Kelm F,Durand G,V

doi

10.1038/s41467-019-11276-9

subject

Has Abstract

pub_date

2019-08-20 00:00:00

pages

3407

issue

1

issn

2041-1723

pii

10.1038/s41467-019-11276-9

journal_volume

10

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Author Correction: Adaptive individual variation in phenological responses to perceived predation levels.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-13715-z

    authors： Abbey-Lee RN,Dingemanse NJ

    更新日期：2019-12-06 00:00:00

  • Transient auditory nerve demyelination as a new mechanism for hidden hearing loss.

    abstract：:Hidden hearing loss (HHL) is a recently described auditory neuropathy believed to contribute to speech discrimination and intelligibility deficits in people with normal audiological tests. Animals and humans with HHL have normal auditory thresholds but defective cochlear neurotransmission, that is, reduced suprathresh...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14487

    authors： Wan G,Corfas G

    更新日期：2017-02-17 00:00:00

  • Relativistic magnetic reconnection driven by a laser interacting with a micro-scale plasma slab.

    abstract：:Magnetic reconnection (MR) is a fundamental plasma process associated with conversion of the magnetic field energy into kinetic plasma energy, which is invoked to explain many non-thermal signatures in astrophysical events. Here we demonstrate that ultrafast relativistic MR in a magnetically dominated regime can be tr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04065-3

    authors： Yi L,Shen B,Pukhov A,Fülöp T

    更新日期：2018-04-23 00:00:00

  • Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing.

    abstract：:Nucleosomes containing the histone H3 variant CENP-A are the epigenetic mark of centromeres, the kinetochore assembly sites required for chromosome segregation. HJURP is the CENP-A chaperone, which associates with Mis18α, Mis18β, and M18BP1 to target centromeres and deposit new CENP-A. How these proteins interact to p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12019-6

    authors： Pan D,Walstein K,Take A,Bier D,Kaiser N,Musacchio A

    更新日期：2019-09-06 00:00:00

  • The energy cost of polypeptide knot formation and its folding consequences.

    abstract：:Knots are natural topologies of chains. Yet, little is known about spontaneous knot formation in a polypeptide chain-an event that can potentially impair its folding-and about the effect of a knot on the stability and folding kinetics of a protein. Here we used optical tweezers to show that the free energy cost to for...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01691-1

    authors： Bustamante A,Sotelo-Campos J,Guerra DG,Floor M,Wilson CAM,Bustamante C,Báez M

    更新日期：2017-11-17 00:00:00

  • Functional roles of Aves class-specific cis-regulatory elements on macroevolution of bird-specific features.

    abstract：:Unlike microevolutionary processes, little is known about the genetic basis of macroevolutionary processes. One of these magnificent examples is the transition from non-avian dinosaurs to birds that has created numerous evolutionary innovations such as self-powered flight and its associated wings with flight feathers....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14229

    authors： Seki R,Li C,Fang Q,Hayashi S,Egawa S,Hu J,Xu L,Pan H,Kondo M,Sato T,Matsubara H,Kamiyama N,Kitajima K,Saito D,Liu Y,Gilbert MT,Zhou Q,Xu X,Shiroishi T,Irie N,Tamura K,Zhang G

    更新日期：2017-02-06 00:00:00

  • The genetic architecture of human brainstem structures and their involvement in common brain disorders.

    abstract：:Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pon...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17376-1

    authors： Elvsåshagen T,Bahrami S,van der Meer D,Agartz I,Alnæs D,Barch DM,Baur-Streubel R,Bertolino A,Beyer MK,Blasi G,Borgwardt S,Boye B,Buitelaar J,Bøen E,Celius EG,Cervenka S,Conzelmann A,Coynel D,Di Carlo P,Djurovic S,

    更新日期：2020-08-11 00:00:00

  • Dynamic anticrack propagation in snow.

    abstract：:Continuum numerical modeling of dynamic crack propagation has been a great challenge over the past decade. This is particularly the case for anticracks in porous materials, as reported in sedimentary rocks, deep earthquakes, landslides, and snow avalanches, as material inter-penetration further complicates the problem...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05181-w

    authors： Gaume J,Gast T,Teran J,van Herwijnen A,Jiang C

    更新日期：2018-08-03 00:00:00

  • Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA.

    abstract：:Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template muc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-14200-3

    authors： Kang W,Ha KS,Uhm H,Park K,Lee JY,Hohng S,Kang C

    更新日期：2020-01-23 00:00:00

  • Export of a single drug molecule in two transport cycles by a multidrug efflux pump.

    abstract：:Secondary multidrug transporters use ion concentration gradients to energize the removal from cells of various antibiotics. The Escherichia coli multidrug transporter MdfA exchanges a single proton with a single monovalent cationic drug molecule. This stoichiometry renders the efflux of divalent cationic drugs energet...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5615

    authors： Fluman N,Adler J,Rotenberg SA,Brown MH,Bibi E

    更新日期：2014-08-08 00:00:00

  • Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization.

    abstract：:Bone tissue, by definition, is an organic-inorganic nanocomposite, where metabolically active cells are embedded within a matrix that is heavily calcified on the nanoscale. Currently, there are no strategies that replicate these definitive characteristics of bone tissue. Here we describe a biomimetic approach where a ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11455-8

    authors： Thrivikraman G,Athirasala A,Gordon R,Zhang L,Bergan R,Keene DR,Jones JM,Xie H,Chen Z,Tao J,Wingender B,Gower L,Ferracane JL,Bertassoni LE

    更新日期：2019-08-06 00:00:00

  • Combining high-throughput phenotyping and genome-wide association studies to reveal natural genetic variation in rice.

    abstract：:Even as the study of plant genomics rapidly develops through the use of high-throughput sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-throughput rice phenotyping facility (HRPF) to monitor 13 traditional agronomic traits and 2 newly defined traits during the rice growth p...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms6087

    authors： Yang W,Guo Z,Huang C,Duan L,Chen G,Jiang N,Fang W,Feng H,Xie W,Lian X,Wang G,Luo Q,Zhang Q,Liu Q,Xiong L

    更新日期：2014-10-08 00:00:00

  • Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice.

    abstract：:VRC01-class broadly neutralizing HIV-1 antibodies protect animals from experimental infection and could contribute to an effective vaccine response. Their predicted germline forms (gl) bind Env inefficiently, which may explain why they are not elicited by HIV-1 Env-immunization. Here we show that an optimized Env immu...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10618

    authors： McGuire AT,Gray MD,Dosenovic P,Gitlin AD,Freund NT,Petersen J,Correnti C,Johnsen W,Kegel R,Stuart AB,Glenn J,Seaman MS,Schief WR,Strong RK,Nussenzweig MC,Stamatatos L

    更新日期：2016-02-24 00:00:00

  • Selectively exciting quasi-normal modes in open disordered systems.

    abstract：:Transmission through disordered samples can be controlled by illuminating a sample with waveforms corresponding to the eigenchannels of the transmission matrix (TM). But can the TM be exploited to selectively excite quasi-normal modes and so control the spatial profile and dwell time inside the medium? We show in micr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07180-3

    authors： Davy M,Genack AZ

    更新日期：2018-11-09 00:00:00

  • Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period.

    abstract：:Priming of the mucosal immune system during the postnatal period substantially influences host-microbial interaction and susceptibility to immune-mediated diseases in adult life. The underlying mechanisms are ill defined. Here we show that shortly after birth, CD4 T cells populate preformed lymphoid structures in the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8725

    authors： Torow N,Yu K,Hassani K,Freitag J,Schulz O,Basic M,Brennecke A,Sparwasser T,Wagner N,Bleich A,Lochner M,Weiss S,Förster R,Pabst O,Hornef MW

    更新日期：2015-07-21 00:00:00

  • Reliable detection of subclonal single-nucleotide variants in tumour cell populations.

    abstract：:According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSN...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1814

    authors： Gerstung M,Beisel C,Rechsteiner M,Wild P,Schraml P,Moch H,Beerenwinkel N

    更新日期：2012-05-01 00:00:00

  • Three-dimensional protonic conductivity in porous organic cage solids.

    abstract：:Proton conduction is a fundamental process in biology and in devices such as proton exchange membrane fuel cells. To maximize proton conduction, three-dimensional conduction pathways are preferred over one-dimensional pathways, which prevent conduction in two dimensions. Many crystalline porous solids to date show one...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12750

    authors： Liu M,Chen L,Lewis S,Chong SY,Little MA,Hasell T,Aldous IM,Brown CM,Smith MW,Morrison CA,Hardwick LJ,Cooper AI

    更新日期：2016-09-13 00:00:00

  • High-throughput single-cell rheology in complex samples by dynamic real-time deformability cytometry.

    abstract：:In life sciences, the material properties of suspended cells have attained significance close to that of fluorescent markers but with the advantage of label-free and unbiased sample characterization. Until recently, cell rheological measurements were either limited by acquisition throughput, excessive post processing,...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08370-3

    authors： Fregin B,Czerwinski F,Biedenweg D,Girardo S,Gross S,Aurich K,Otto O

    更新日期：2019-01-24 00:00:00

  • Fast cavity-enhanced atom detection with low noise and high fidelity.

    abstract：:Cavity quantum electrodynamics describes the fundamental interactions between light and matter, and how they can be controlled by shaping the local environment. For example, optical microcavities allow high-efficiency detection and manipulation of single atoms. In this regime, fluctuations of atom number are on the or...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1428

    authors： Goldwin J,Trupke M,Kenner J,Ratnapala A,Hinds EA

    更新日期：2011-08-09 00:00:00

  • Mitochondria-adaptor TRAK1 promotes kinesin-1 driven transport in crowded environments.

    abstract：:Intracellular trafficking of organelles, driven by kinesin-1 stepping along microtubules, underpins essential cellular processes. In absence of other proteins on the microtubule surface, kinesin-1 performs micron-long runs. Under crowding conditions, however, kinesin-1 motility is drastically impeded. It is thus uncle...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16972-5

    authors： Henrichs V,Grycova L,Barinka C,Nahacka Z,Neuzil J,Diez S,Rohlena J,Braun M,Lansky Z

    更新日期：2020-06-19 00:00:00

  • The utility of serology for elimination surveillance of trachoma.

    abstract：:Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low-transmission and post-elimination settings. Anal...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07852-0

    authors： Pinsent A,Solomon AW,Bailey RL,Bid R,Cama A,Dean D,Goodhew B,Gwyn SE,Jack KR,Kandel RP,Kama M,Massae P,Macleod C,Mabey DCW,Migchelsen S,Müller A,Sandi F,Sokana O,Taoaba R,Tekeraoi R,Martin DL,White MT

    更新日期：2018-12-21 00:00:00

  • Polarization curling and flux closures in multiferroic tunnel junctions.

    abstract：:Formation of domain walls in ferroelectrics is not energetically favourable in low-dimensional systems. Instead, vortex-type structures are formed that are driven by depolarization fields occurring in such systems. Consequently, polarization vortices have only been experimentally found in systems in which these fields...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13484

    authors： Peters JJP,Apachitei G,Beanland R,Alexe M,Sanchez AM

    更新日期：2016-11-16 00:00:00

  • Cell-permeable organic fluorescent probes for live-cell long-term super-resolution imaging reveal lysosome-mitochondrion interactions.

    abstract：:Characterizing the long-term nanometer-scale interactions between lysosomes and mitochondria in live cells is essential for understanding their functions but remains challenging due to limitations of the existing fluorescent probes. Here, we develop cell-permeable organic fluorescent probes for lysosomes with excellen...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01503-6

    authors： Han Y,Li M,Qiu F,Zhang M,Zhang YH

    更新日期：2017-11-03 00:00:00

  • A clustering-independent method for finding differentially expressed genes in single-cell transcriptome data.

    abstract：:A common analysis of single-cell sequencing data includes clustering of cells and identifying differentially expressed genes (DEGs). How cell clusters are defined has important consequences for downstream analyses and the interpretation of results, but is often not straightforward. To address this difficulty, we prese...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17900-3

    authors： Vandenbon A,Diez D

    更新日期：2020-08-28 00:00:00

  • Mutation bias and GC content shape antimutator invasions.

    abstract：:Mutators represent a successful strategy in rapidly adapting asexual populations, but theory predicts their eventual extinction due to their unsustainably large deleterious load. While antimutator invasions have been documented experimentally, important discrepancies among studies remain currently unexplained. Here we...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11217-6

    authors： Couce A,Tenaillon O

    更新日期：2019-07-15 00:00:00

  • Possible observation of highly itinerant quantum magnetic monopoles in the frustrated pyrochlore Yb2Ti2O7.

    abstract：:The low-energy elementary excitations in frustrated quantum magnets have fascinated researchers for decades. In frustrated Ising magnets on a pyrochlore lattice possessing macroscopically degenerate spin-ice ground states, the excitations have been discussed in terms of classical magnetic monopoles, which do not conta...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10807

    authors： Tokiwa Y,Yamashita T,Udagawa M,Kittaka S,Sakakibara T,Terazawa D,Shimoyama Y,Terashima T,Yasui Y,Shibauchi T,Matsuda Y

    更新日期：2016-02-25 00:00:00

  • Ecosystem-based fisheries management forestalls climate-driven collapse.

    abstract：:Climate change is impacting fisheries worldwide with uncertain outcomes for food and nutritional security. Using management strategy evaluations for key US fisheries in the eastern Bering Sea we find that Ecosystem Based Fisheries Management (EBFM) measures forestall future declines under climate change over non-EBFM ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18300-3

    authors： Holsman KK,Haynie AC,Hollowed AB,Reum JCP,Aydin K,Hermann AJ,Cheng W,Faig A,Ianelli JN,Kearney KA,Punt AE

    更新日期：2020-09-11 00:00:00

  • Radiation-induced DNA damage and repair effects on 3D genome organization.

    abstract：:The three-dimensional structure of chromosomes plays an important role in gene expression regulation and also influences the repair of radiation-induced DNA damage. Genomic aberrations that disrupt chromosome spatial domains can lead to diseases including cancer, but how the 3D genome structure responds to DNA damage ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20047-w

    authors： Sanders JT,Freeman TF,Xu Y,Golloshi R,Stallard MA,Hill AM,San Martin R,Balajee AS,McCord RP

    更新日期：2020-12-02 00:00:00

  • Action boosts episodic memory encoding in humans via engagement of a noradrenergic system.

    abstract：:We are constantly interacting with our environment whilst we encode memories. However, how actions influence memory formation remains poorly understood. Goal-directed movement engages the locus coeruleus (LC), the main source of noradrenaline in the brain. Noradrenaline is also known to enhance episodic encoding, sugg...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11358-8

    authors： Yebra M,Galarza-Vallejo A,Soto-Leon V,Gonzalez-Rosa JJ,de Berker AO,Bestmann S,Oliviero A,Kroes MCW,Strange BA

    更新日期：2019-08-06 00:00:00

  • Anthropogenic combustion iron as a complex climate forcer.

    abstract：:Atmospheric iron affects the global carbon cycle by modulating ocean biogeochemistry through the deposition of soluble iron to the ocean. Iron emitted by anthropogenic (fossil fuel) combustion is a source of soluble iron that is currently considered less important than other soluble iron sources, such as mineral dust ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03997-0

    authors： Matsui H,Mahowald NM,Moteki N,Hamilton DS,Ohata S,Yoshida A,Koike M,Scanza RA,Flanner MG

    更新日期：2018-04-23 00:00:00