Transient auditory nerve demyelination as a new mechanism for hidden hearing loss.

abstract：:The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article. ...

journal_title：Nature communications

authors： Zhang W,Zhang D,Chen Q,Wu J,Ouyang Z,Xia Y

更新日期：2019-02-19 00:00:00

abstract：:Microfluidic multipoles (MFMs) have been realized experimentally and hold promise for "open-space" biological and chemical surface processing. Whereas convective flow can readily be predicted using hydraulic-electrical analogies, the design of advanced microfluidic multipole is constrained by the lack of simple, accur...

journal_title：Nature communications

authors： Goyette PA,Boulais É,Normandeau F,Laberge G,Juncker D,Gervais T

更新日期：2019-04-16 00:00:00

abstract：:Insects that use ephemeral resources must rapidly digest nutrients and simultaneously protect them from competitors. Here we use burying beetles (Nicrophorus vespilloides), which feed their offspring on vertebrate carrion, to investigate the digestive and defensive basis of carrion utilization. We characterize gene ex...

journal_title：Nature communications

authors： Vogel H,Shukla SP,Engl T,Weiss B,Fischer R,Steiger S,Heckel DG,Kaltenpoth M,Vilcinskas A

更新日期：2017-05-09 00:00:00

abstract：:Symmetry-breaking phase transitions are an example of non-equilibrium processes that require real-time treatment, a major challenge in strongly coupled systems without long-lived quasiparticles. Holographic duality provides such an approach by mapping strongly coupled field theories in D dimensions into weakly coupled...

journal_title：Nature communications

authors： Sonner J,Del Campo A,Zurek WH

更新日期：2015-06-23 00:00:00

abstract：:RNA viruses are characterized by a high mutation rate, a buffer against environmental change. Nevertheless, the means by which random mutation improves viral fitness is not well characterized. Here we report the X-ray crystal structure of the receptor-binding domain (RBD) of the human coronavirus, HCoV-229E, in comple...

journal_title：Nature communications

authors： Wong AHM,Tomlinson ACA,Zhou D,Satkunarajah M,Chen K,Sharon C,Desforges M,Talbot PJ,Rini JM

更新日期：2017-11-23 00:00:00

abstract：:Nonequilibrium atomic structures can host exotic and technologically relevant properties in otherwise conventional materials. Oxygen octahedral rotation forms a fundamental atomic distortion in perovskite oxides, but only a few patterns are predominantly present at equilibrium. This has restricted the range of possibl...

journal_title：Nature communications

authors： Kim JR,Jang J,Go KJ,Park SY,Roh CJ,Bonini J,Kim J,Lee HG,Rabe KM,Lee JS,Choi SY,Noh TW,Lee D

更新日期：2020-10-02 00:00:00

abstract：:Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...

journal_title：Nature communications

authors： Fraley SI,Feng Y,Giri A,Longmore GD,Wirtz D

更新日期：2012-03-06 00:00:00

abstract：:Coupling vibrational transitions to resonant optical modes creates vibrational polaritons shifted from the uncoupled molecular resonances and provides a convenient way to modify the energetics of molecular vibrations. This approach is a viable method to explore controlling chemical reactivity. In this work, we report ...

journal_title：Nature communications

authors： Dunkelberger AD,Spann BT,Fears KP,Simpkins BS,Owrutsky JC

更新日期：2016-11-22 00:00:00

abstract：:RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and consumption and di...

journal_title：Nature communications

authors： Zhang C,Seo J,Murakami K,Salem ESB,Bernhard E,Borra VJ,Choi K,Yuan CL,Chan CC,Chen X,Huang T,Weirauch MT,Divanovic S,Qi NR,Thomas HE,Mercer CA,Siomi H,Nakamura T

更新日期：2018-09-10 00:00:00

abstract：:Gluconeogenesis is a fundamental feature of hepatocytes. Whether this gluconeogenic activity is also present in malignant hepatocytes remains unexplored. A better understanding of this biological process may lead to novel therapeutic strategies. Here we show that gluconeogenesis is not present in mouse or human malign...

journal_title：Nature communications

authors： Ma R,Zhang W,Tang K,Zhang H,Zhang Y,Li D,Li Y,Xu P,Luo S,Cai W,Ji T,Katirai F,Ye D,Huang B

更新日期：2013-01-01 00:00:00

abstract：:Recent research has explored the spatiotemporal modulation of permittivity to break Lorentz reciprocity in a manner compatible with integrated-circuit fabrication. However, permittivity modulation is inherently weak and accompanied by loss due to carrier injection, particularly at higher frequencies, resulting in larg...

journal_title：Nature communications

authors： Dinc T,Tymchenko M,Nagulu A,Sounas D,Alu A,Krishnaswamy H

更新日期：2017-10-06 00:00:00

abstract：:Nervous systems exhibit myriad cell types, but understanding how this diversity arises is hampered by the difficulty to visualize and genetically-probe specific lineages, especially at early developmental stages prior to expression of unique molecular markers. Here, we use a genetic immortalization method to analyze t...

journal_title：Nature communications

authors： Chai PC,Cruchet S,Wigger L,Benton R

更新日期：2019-02-07 00:00:00

abstract：:Fibronectin fibrils within the extracellular matrix play central roles in physiological and pathological processes, yet many structural details about their hierarchical and molecular assembly remain unknown. Here we combine site-specific protein labelling with single-molecule localization by stepwise photobleaching or...

journal_title：Nature communications

authors： Früh SM,Schoen I,Ries J,Vogel V

更新日期：2015-06-04 00:00:00

abstract：:16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...

journal_title：Nature communications

authors： Moreau CA,Urchs SGW,Kuldeep K,Orban P,Schramm C,Dumas G,Labbe A,Huguet G,Douard E,Quirion PO,Lin A,Kushan L,Grot S,Luck D,Mendrek A,Potvin S,Stip E,Bourgeron T,Evans AC,Bearden CE,Bellec P,Jacquemont S

更新日期：2020-10-19 00:00:00

abstract：:Phospholipids are elemental building-block molecules for biological membranes. Biosynthesis of phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthetase (Cds) is an integral membrane enzym...

journal_title：Nature communications

authors： Liu X,Yin Y,Wu J,Liu Z

更新日期：2014-06-27 00:00:00

abstract：:MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...

journal_title：Nature communications

authors： Meng L,Liu C,Lü J,Zhao Q,Deng S,Wang G,Qiao J,Zhang C,Zhen L,Lu Y,Li W,Zhang Y,Pestell RG,Fan H,Chen YH,Liu Z,Yu Z

更新日期：2017-01-03 00:00:00

abstract：:Formation of amyloid-beta (Aβ) oligomer pores in the membrane of neurons has been proposed to explain neurotoxicity in Alzheimer's disease (AD). Here, we present the three-dimensional structure of an Aβ oligomer formed in a membrane mimicking environment, namely an Aβ(1-42) tetramer, which comprises a six stranded β-s...

journal_title：Nature communications

authors： Ciudad S,Puig E,Botzanowski T,Meigooni M,Arango AS,Do J,Mayzel M,Bayoumi M,Chaignepain S,Maglia G,Cianferani S,Orekhov V,Tajkhorshid E,Bardiaux B,Carulla N

更新日期：2020-06-15 00:00:00

abstract：:To know the properties of a particle or a wave, one should measure how its energy changes with its momentum. The relation between them is called the dispersion relation, which encodes essential information of the kinetics. In a magnet, the wave motion of atomic spins serves as an elementary excitation, called a spin w...

journal_title：Nature communications

authors： Hashimoto Y,Daimon S,Iguchi R,Oikawa Y,Shen K,Sato K,Bossini D,Tabuchi Y,Satoh T,Hillebrands B,Bauer GEW,Johansen TH,Kirilyuk A,Rasing T,Saitoh E

更新日期：2017-06-12 00:00:00

abstract：:We introduce a microfluidic platform that enables off-chip single-cell RNA-seq after multi-generational lineage tracking under controlled culture conditions. We use this platform to generate whole-transcriptome profiles of primary, activated murine CD8+ T-cell and lymphocytic leukemia cell line lineages. Here we repor...

journal_title：Nature communications

authors： Kimmerling RJ,Lee Szeto G,Li JW,Genshaft AS,Kazer SW,Payer KR,de Riba Borrajo J,Blainey PC,Irvine DJ,Shalek AK,Manalis SR

更新日期：2016-01-06 00:00:00

abstract：:Receptor families of the innate immune response engage in 'cross-talk' to tailor optimal immune responses against invading pathogens. However, these responses are subject to multiple levels of regulation to keep in check aberrant inflammatory signals. Here, we describe a role for the orphan receptor interleukin-17 rec...

journal_title：Nature communications

authors： Mellett M,Atzei P,Bergin R,Horgan A,Floss T,Wurst W,Callanan JJ,Moynagh PN

更新日期：2015-03-26 00:00:00

abstract：:Mutations in fused in sarcoma (FUS) lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and severity. This suggests that unknown genetic factors contribute to disease pathogenesis. Here we show the identification of muscleblind as a novel modifier of FUS-mediated neurodegeneration in vi...

journal_title：Nature communications

authors： Casci I,Krishnamurthy K,Kour S,Tripathy V,Ramesh N,Anderson EN,Marrone L,Grant RA,Oliver S,Gochenaur L,Patel K,Sterneckert J,Gleixner AM,Donnelly CJ,Ruepp MD,Sini AM,Zuccaro E,Pennuto M,Pasinelli P,Pandey UB

更新日期：2019-12-06 00:00:00

abstract：:Chemotherapy remains a mainstay of cancer treatment but its use is often limited by the development of adverse reactions. Severe loss of body weight (cachexia) is a frequent cause of death in cancer patients and is exacerbated by chemotherapy. We show that genetic inactivation of vascular endothelial growth factor (VE...

journal_title：Nature communications

authors： Klose R,Krzywinska E,Castells M,Gotthardt D,Putz EM,Kantari-Mimoun C,Chikdene N,Meinecke AK,Schrödter K,Helfrich I,Fandrey J,Sexl V,Stockmann C

更新日期：2016-08-19 00:00:00

abstract：:Pools of carbon dioxide are found in natural geological accumulations and in engineered storage in saline aquifers. It has been thought that once this CO2 dissolves in the formation water, making it denser, convection streams will transport it efficiently to depth, but this may not be so. Here, we assess theoretically...

journal_title：Nature communications

authors： Cardoso SS,Andres JT

更新日期：2014-12-11 00:00:00

abstract：:Quasicrystals, materials with aperiodic long-range order, have been found in intermetallics, soft materials such as colloids and supermolecules, and also in two-dimensional monolayer films. Here we present the first example of three-dimensional growth of a single-element quasicrystalline film. Using a hitherto unexplo...

journal_title：Nature communications

authors： Sharma HR,Nozawa K,Smerdon JA,Nugent PJ,McLeod I,Dhanak VR,Shimoda M,Ishii Y,Tsai AP,McGrath R

更新日期：2013-01-01 00:00:00

abstract：:Broomcorn millet (Panicum miliaceum L.) has strong tolerance to abiotic stresses, and is probably one of the oldest crops, with its earliest cultivation that dated back to ca. ~10,000 years. We report here its genome assembly through a combination of PacBio sequencing, BioNano, and Hi-C (in vivo) mapping. The 18 super...

journal_title：Nature communications

authors： Shi J,Ma X,Zhang J,Zhou Y,Liu M,Huang L,Sun S,Zhang X,Gao X,Zhan W,Li P,Wang L,Lu P,Zhao H,Song W,Lai J

更新日期：2019-01-25 00:00:00

abstract：:Understanding human cooperation is of major interest across the natural and social sciences. But it is unclear to what extent cooperation is actually a general concept. Most research on cooperation has implicitly assumed that a person's behaviour in one cooperative context is related to their behaviour in other settin...

journal_title：Nature communications

authors： Peysakhovich A,Nowak MA,Rand DG

更新日期：2014-09-16 00:00:00

abstract：:Multidrug resistance (MDR) represents a global threat to health. Here, we used whole genome sequencing to characterise Pseudomonas aeruginosa MDR clinical isolates from a hospital in Thailand. Using long-read sequence data we obtained complete sequences of two closely related megaplasmids (>420 kb) carrying large arra...

journal_title：Nature communications

authors： Cazares A,Moore MP,Hall JPJ,Wright LL,Grimes M,Emond-Rhéault JG,Pongchaikul P,Santanirand P,Levesque RC,Fothergill JL,Winstanley C

更新日期：2020-03-13 00:00:00

abstract：:Ionic liquids (ILs) are emerging as superior solvents for numerous industrial applications, including the pretreatment of biomass for the microbial production of biofuels. However, some of the most effective ILs used to solubilize cellulose inhibit microbial growth, decreasing efficiency in the overall process. Here w...

journal_title：Nature communications

authors： Ruegg TL,Kim EM,Simmons BA,Keasling JD,Singer SW,Lee TS,Thelen MP

更新日期：2014-03-26 00:00:00

abstract：:Neurons can activate pathways that destroy the whole cell via apoptosis or selectively degenerate only the axon (pruning). Both apoptosis and axon degeneration require Bax and caspases. Here we demonstrate that despite this overlap, the pathways mediating axon degeneration during apoptosis versus axon pruning are dist...

journal_title：Nature communications

authors： Cusack CL,Swahari V,Hampton Henley W,Michael Ramsey J,Deshmukh M

更新日期：2013-01-01 00:00:00

abstract：:Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent spec...

journal_title：Nature communications

authors： Agier N,Delmas S,Zhang Q,Fleiss A,Jaszczyszyn Y,van Dijk E,Thermes C,Weigt M,Cosentino-Lagomarsino M,Fischer G

更新日期：2018-06-06 00:00:00