Humans display a 'cooperative phenotype' that is domain general and temporally stable.

abstract：:Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg2+-functional Mg2+-BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg2+-BP...

journal_title：Nature communications

authors： Kang H,Yang B,Zhang K,Pan Q,Yuan W,Li G,Bian L

更新日期：2019-04-12 00:00:00

abstract：:Graphene and hexagonal boron nitride are typical conductor and insulator, respectively, while their hybrids hexagonal boron carbonitride are promising as a semiconductor. Here we demonstrate a direct chemical conversion reaction, which systematically converts the hexagonal carbon lattice of graphene to boron nitride, ...

journal_title：Nature communications

authors： Gong Y,Shi G,Zhang Z,Zhou W,Jung J,Gao W,Ma L,Yang Y,Yang S,You G,Vajtai R,Xu Q,MacDonald AH,Yakobson BI,Lou J,Liu Z,Ajayan PM

更新日期：2014-01-01 00:00:00

abstract：:Despite the fundamental importance of efficient and selective synthesis of widely useful alkylarenes, the direct catalytic C(sp2)-H alkylation of unactivated arenes with a readily available alkyl halide remains elusive. Here, we report the catalytic C(sp2)-H alkylation reactions of unactivated arenes with alkyl bromid...

journal_title：Nature communications

authors： Kim D,Lee GS,Kim D,Hong SH

更新日期：2020-10-19 00:00:00

abstract：:The El Niño-Southern Oscillation is the dominant mode of interannual climate variability across the Pacific Ocean basin, with influence on the global climate. The two end members of the cycle, El Niño and La Niña, force anomalous oceanographic conditions and coastal response along the Pacific margin, exposing many hea...

journal_title：Nature communications

authors： Barnard PL,Hoover D,Hubbard DM,Snyder A,Ludka BC,Allan J,Kaminsky GM,Ruggiero P,Gallien TW,Gabel L,McCandless D,Weiner HM,Cohn N,Anderson DL,Serafin KA

更新日期：2017-02-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature communications

authors： Sapkota B,Liang W,VahidMohammadi A,Karnik R,Noy A,Wanunu M

更新日期：2020-07-21 00:00:00

abstract：:The restricted availability, expense and toxicity of precious metal catalysts such as rhodium and palladium challenge the sustainability of synthetic chemistry. As such, nickel catalysts have garnered increasing attention as replacements for enyne cyclization reactions. On the other hand, bridged tricyclo[5.2.1.01,5]d...

journal_title：Nature communications

authors： Chen J,Wang Y,Ding Z,Kong W

更新日期：2020-04-20 00:00:00

abstract：:CRISPR/Cas9 technology offers novel approaches for the development of new therapies for many unmet clinical needs, including a significant number of inherited monogenic diseases. However, in vivo correction of disease-causing genes is still inefficient, especially for those diseases without selective advantage for cor...

journal_title：Nature communications

authors： Zabaleta N,Barberia M,Martin-Higueras C,Zapata-Linares N,Betancor I,Rodriguez S,Martinez-Turrillas R,Torella L,Vales A,Olagüe C,Vilas-Zornoza A,Castro-Labrador L,Lara-Astiaso D,Prosper F,Salido E,Gonzalez-Aseguinolaza G,R

更新日期：2018-12-21 00:00:00

abstract：:Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identi...

journal_title：Nature communications

authors： Swaminathan B,Thorleifsson G,Jöud M,Ali M,Johnsson E,Ajore R,Sulem P,Halvarsson BM,Eyjolfsson G,Haraldsdottir V,Hultman C,Ingelsson E,Kristinsson SY,Kähler AK,Lenhoff S,Masson G,Mellqvist UH,Månsson R,Nelander S,Ola

更新日期：2015-05-26 00:00:00

abstract：:Rapid growth in size and complexity of biological data sets has led to the 'Big Data to Knowledge' challenge. We develop advanced data integration methods for multi-level analysis of genomic, transcriptomic, ribosomal profiling, proteomic and fluxomic data. First, we show that pairwise integration of primary omics dat...

journal_title：Nature communications

authors： Ebrahim A,Brunk E,Tan J,O'Brien EJ,Kim D,Szubin R,Lerman JA,Lechner A,Sastry A,Bordbar A,Feist AM,Palsson BO

更新日期：2016-10-26 00:00:00

abstract：:Although environmental selection and spatial separation have been shown to shape the distribution and abundance of marine microorganisms, the effects of advection (physical transport) have not been directly tested. Here we examine 25 samples covering all major water masses of the Southern Ocean to determine the effect...

journal_title：Nature communications

authors： Wilkins D,van Sebille E,Rintoul SR,Lauro FM,Cavicchioli R

更新日期：2013-01-01 00:00:00

abstract：:CRISPR-Cas9 has led to great advances in gene editing for a broad spectrum of applications. To further the utility of Cas9 there have been efforts to achieve temporal control over its nuclease activity. While different approaches have focused on regulation of CRISPR interference or editing in mammalian cells, none of ...

journal_title：Nature communications

authors： Iwasaki RS,Ozdilek BA,Garst AD,Choudhury A,Batey RT

更新日期：2020-03-13 00:00:00

abstract：:Enzymatic digestion for protein sequencing usually requires much time, and does not always result in high sequence coverage. Here we report the use of aqueous microdroplets to accelerate enzymatic reactions and, in particular, to improve protein sequencing. When a room temperature aqueous solution containing 10 µM myo...

journal_title：Nature communications

authors： Zhong X,Chen H,Zare RN

更新日期：2020-02-26 00:00:00

abstract：:Semaphorins and their transmembrane receptors, Plexins, are key regulators of axon guidance and development of neuronal connectivity. B-type Plexins respond to Class IV semaphorins and mediate a variety of developmental functions. Here we report that the expression of Plexin-B2 and its high-affinity ligand, Sema4C, pe...

journal_title：Nature communications

authors： Paldy E,Simonetti M,Worzfeld T,Bali KK,Vicuña L,Offermanns S,Kuner R

更新日期：2017-08-02 00:00:00

abstract：:Organic semiconductors are usually polycyclic aromatic hydrocarbons and their analogs containing heteroatom substitution. Bioinspired materials chemistry of organic electronics promises new charge transport mechanism and specific molecular recognition with biomolecules. We discover organic semiconductors from deoxyrib...

journal_title：Nature communications

authors： Zhang F,Lemaur V,Choi W,Kafle P,Seki S,Cornil J,Beljonne D,Diao Y

更新日期：2019-09-16 00:00:00

abstract：:Polar van der Waals chalcogenophosphates exhibit unique properties, such as negative electrostriction and multi-well ferrielectricity, and enable combining dielectric and 2D electronic materials. Using low temperature piezoresponse force microscopy, we revealed coexistence of piezoelectric and non-piezoelectric phases...

journal_title：Nature communications

authors： Dziaugys A,Kelley K,Brehm JA,Tao L,Puretzky A,Feng T,O'Hara A,Neumayer S,Chyasnavichyus M,Eliseev EA,Banys J,Vysochanskii Y,Ye F,Chakoumakos BC,Susner MA,McGuire MA,Kalinin SV,Ganesh P,Balke N,Pantelides ST,Morozo

更新日期：2020-07-17 00:00:00

abstract：:Invariant natural killer T cells have a distinct developmental pathway from conventional αβ T cells. Here we demonstrate that the transcriptional repressor NKAP is required for invariant natural killer T cell but not conventional T cell development. In CD4-cre NKAP conditional knockout mice, invariant natural killer T...

journal_title：Nature communications

authors： Thapa P,Das J,McWilliams D,Shapiro M,Sundsbak R,Nelson-Holte M,Tangen S,Anderson J,Desiderio S,Hiebert S,Sant'angelo DB,Shapiro VS

更新日期：2013-01-01 00:00:00

abstract：:Parallel single-cell sequencing protocols represent powerful methods for investigating regulatory relationships, including epigenome-transcriptome interactions. Here, we report a single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling. scNMT-seq (single-cell nucleosome, met...

journal_title：Nature communications

authors： Clark SJ,Argelaguet R,Kapourani CA,Stubbs TM,Lee HJ,Alda-Catalinas C,Krueger F,Sanguinetti G,Kelsey G,Marioni JC,Stegle O,Reik W

更新日期：2018-02-22 00:00:00

abstract：:Intermolecular halogen bonds are ideally suited for designing new molecular assemblies because of their strong directionality and the possibility of tuning the interactions by using different types of halogens or molecular moieties. Due to these unique properties of the halogen bonds, numerous areas of application hav...

journal_title：Nature communications

authors： Tschakert J,Zhong Q,Martin-Jimenez D,Carracedo-Cosme J,Romero-Muñiz C,Henkel P,Schlöder T,Ahles S,Mollenhauer D,Wegner HA,Pou P,Pérez R,Schirmeisen A,Ebeling D

更新日期：2020-11-06 00:00:00

abstract：:Roughly a third (~30 ppm) of the carbon dioxide (CO2) that entered the ocean during ice ages is attributed to biological mechanisms. A leading hypothesis for the biological drawdown of CO2 is iron (Fe) fertilisation of the high latitudes, but modelling efforts attribute at most 10 ppm to this mechanism, leaving ~20 pp...

journal_title：Nature communications

authors： Buchanan PJ,Chase Z,Matear RJ,Phipps SJ,Bindoff NL

更新日期：2019-10-10 00:00:00

abstract：:Circadian rhythms of cell division have been observed in several lineages of eukaryotes, especially photosynthetic unicellular eukaryotes. However, the mechanism underlying the circadian regulation of the cell cycle and the nature of the advantage conferred remain unknown. Here, using the unicellular red alga Cyanidio...

journal_title：Nature communications

authors： Miyagishima SY,Fujiwara T,Sumiya N,Hirooka S,Nakano A,Kabeya Y,Nakamura M

更新日期：2014-05-08 00:00:00

abstract：:High-grade serous ovarian cancers (HGSOC) have been subdivided into molecular subtypes. The mesenchymal HGSOC subgroup, defined by stromal-related gene signatures, is invariably associated with poor patient survival. We demonstrate that stroma exerts a key function in mesenchymal HGSOC. We highlight stromal heterogene...

journal_title：Nature communications

authors： Givel AM,Kieffer Y,Scholer-Dahirel A,Sirven P,Cardon M,Pelon F,Magagna I,Gentric G,Costa A,Bonneau C,Mieulet V,Vincent-Salomon A,Mechta-Grigoriou F

更新日期：2018-03-13 00:00:00

abstract：:Charge-to-spin conversion in various materials is the key for the fundamental understanding of spin-orbitronics and efficient magnetization manipulation. Here we report the direct spatial imaging of current-induced spin accumulation at the channel edges of Bi2Se3 and BiSbTeSe2 topological insulators as well as Pt by a...

journal_title：Nature communications

authors： Liu Y,Besbas J,Wang Y,He P,Chen M,Zhu D,Wu Y,Lee JM,Wang L,Moon J,Koirala N,Oh S,Yang H

更新日期：2018-06-27 00:00:00

abstract：:The CCCTC-binding zinc-finger protein (CTCF)-mediated network of long-range chromatin interactions is important for genome organization and function. Although this network has been considered largely invariant, we find that it exhibits extensive cell-type-specific interactions that contribute to cell identity. Here, w...

journal_title：Nature communications

authors： Kai Y,Andricovich J,Zeng Z,Zhu J,Tzatsos A,Peng W

更新日期：2018-10-11 00:00:00

abstract：:In quantizing magnetic fields, graphene superlattices exhibit a complex fractal spectrum often referred to as the Hofstadter butterfly. It can be viewed as a collection of Landau levels that arise from quantization of Brown-Zak minibands recurring at rational (p/q) fractions of the magnetic flux quantum per superlatti...

journal_title：Nature communications

authors： Barrier J,Kumaravadivel P,Krishna Kumar R,Ponomarenko LA,Xin N,Holwill M,Mullan C,Kim M,Gorbachev RV,Thompson MD,Prance JR,Taniguchi T,Watanabe K,Grigorieva IV,Novoselov KS,Mishchenko A,Fal'ko VI,Geim AK,Berdyugin AI

更新日期：2020-11-13 00:00:00

abstract：:Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals and, in particular, the influence of common genetic variants during this process has not been characte...

journal_title：Nature communications

authors： Cuomo ASE,Seaton DD,McCarthy DJ,Martinez I,Bonder MJ,Garcia-Bernardo J,Amatya S,Madrigal P,Isaacson A,Buettner F,Knights A,Natarajan KN,HipSci Consortium.,Vallier L,Marioni JC,Chhatriwala M,Stegle O

更新日期：2020-02-10 00:00:00

abstract：:β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting common...

journal_title：Nature communications

authors： Bende NS,Dziemborowicz S,Mobli M,Herzig V,Gilchrist J,Wagner J,Nicholson GM,King GF,Bosmans F

更新日期：2014-07-11 00:00:00

abstract：:Specialized cells in the medial entorhinal cortex (mEC), such as speed cells, head direction (HD) cells, and grid cells, are thought to support spatial navigation. To determine whether these computations are dependent on local circuits, we record neuronal activity in mEC layers II and III and optogenetically perturb l...

journal_title：Nature communications

authors： Zutshi I,Fu ML,Lilascharoen V,Leutgeb JK,Lim BK,Leutgeb S

更新日期：2018-09-12 00:00:00

abstract：:It has previously been shown that the relative reliability of model-based and model-free reinforcement-learning (RL) systems plays a role in the allocation of behavioral control between them. However, the role of task complexity in the arbitration between these two strategies remains largely unknown. Here, using a com...

journal_title：Nature communications

authors： Kim D,Park GY,O Doherty JP,Lee SW

更新日期：2019-12-16 00:00:00

abstract：:Biomolecular X-ray structures typically provide a static, time- and ensemble-averaged view of molecular ensembles in crystals. In the absence of rigid-body motions and lattice defects, B-factors are thought to accurately reflect the structural heterogeneity of such ensembles. In order to study the effects of averaging...

journal_title：Nature communications

authors： Kuzmanic A,Pannu NS,Zagrovic B

更新日期：2014-01-01 00:00:00

abstract：:DNA replication and repair enzyme Flap Endonuclease 1 (FEN1) is vital for genome integrity, and FEN1 mutations arise in multiple cancers. FEN1 precisely cleaves single-stranded (ss) 5'-flaps one nucleotide into duplex (ds) DNA. Yet, how FEN1 selects for but does not incise the ss 5'-flap was enigmatic. Here we combine...

journal_title：Nature communications

authors： Tsutakawa SE,Thompson MJ,Arvai AS,Neil AJ,Shaw SJ,Algasaier SI,Kim JC,Finger LD,Jardine E,Gotham VJB,Sarker AH,Her MZ,Rashid F,Hamdan SM,Mirkin SM,Grasby JA,Tainer JA

更新日期：2017-06-27 00:00:00