Direct visualization of current-induced spin accumulation in topological insulators.

abstract：:Temporal lobe epilepsy (TLE) is the most common focal seizure disorder in adults. In many patients, transient brain insults, including status epilepticus (SE), are followed by a latent period of epileptogenesis, preceding the emergence of clinical seizures. In experimental animals, transcriptional upregulation of CaV3...

journal_title：Nature communications

authors： van Loo KM,Schaub C,Pitsch J,Kulbida R,Opitz T,Ekstein D,Dalal A,Urbach H,Beck H,Yaari Y,Schoch S,Becker AJ

更新日期：2015-10-26 00:00:00

abstract：:The friction between two adjacent tectonic plates under shear loading may dictate seismic activities. To advance the understanding of mechanisms underlying fault strength, we investigate the frictional characteristics of calcite in an aqueous environment. By conducting single-asperity friction experiments using an ato...

journal_title：Nature communications

authors： Diao Y,Espinosa-Marzal RM

更新日期：2018-06-13 00:00:00

abstract：:Spectral domain optical coherence tomography (OCT) is a widely employed, minimally invasive bio-medical imaging technique, which requires a broadband light source, typically implemented by super-luminescent diodes. Recent advances in soliton based photonic integrated frequency combs (soliton microcombs) have enabled t...

journal_title：Nature communications

authors： Marchand PJ,Riemensberger J,Skehan JC,Ho JJ,Pfeiffer MHP,Liu J,Hauger C,Lasser T,Kippenberg TJ

更新日期：2021-01-18 00:00:00

abstract：:KRAS mutations are present in over 90% of pancreatic ductal adenocarcinomas (PDAC), and drive their poor outcomes and failure to respond to targeted therapies. Here we show that Leukemia Inhibitory Factor (LIF) expression is induced specifically by oncogenic KRAS in PDAC and that LIF depletion by genetic means or by n...

journal_title：Nature communications

authors： Wang MT,Fer N,Galeas J,Collisson EA,Kim SE,Sharib J,McCormick F

更新日期：2019-07-11 00:00:00

abstract：:Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They are generated from long precursor transcripts by the primary piRNA biogenesis pathway but the factors involved in pachytene piRNA precursors processing are poorly understood. Here we show that the Tudor domain-containing 5 (TDRD5) protein is...

journal_title：Nature communications

authors： Ding D,Liu J,Midic U,Wu Y,Dong K,Melnick A,Latham KE,Chen C

更新日期：2018-01-09 00:00:00

abstract：:The radioactive element astatine exists only in trace amounts in nature. Its properties can therefore only be explored by study of the minute quantities of artificially produced isotopes or by performing theoretical calculations. One of the most important properties influencing the chemical behaviour is the energy req...

journal_title：Nature communications

authors： Rothe S,Andreyev AN,Antalic S,Borschevsky A,Capponi L,Cocolios TE,De Witte H,Eliav E,Fedorov DV,Fedosseev VN,Fink DA,Fritzsche S,Ghys L,Huyse M,Imai N,Kaldor U,Kudryavtsev Y,Köster U,Lane JF,Lassen J,Liberati V,

更新日期：2013-01-01 00:00:00

abstract：:Fatigue is a difficult multi-scale modelling problem nucleating from localised plasticity at the scale of dislocations and microstructure with significant engineering safety implications. Cold dwell fatigue is a phenomenon in titanium where stress holds at moderate temperatures lead to substantial reductions in cyclic...

journal_title：Nature communications

authors： Xu Y,Joseph S,Karamched P,Fox K,Rugg D,Dunne FPE,Dye D

更新日期：2020-11-17 00:00:00

abstract：:Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecul...

journal_title：Nature communications

authors： Chavali M,Klingener M,Kokkosis AG,Garkun Y,Felong S,Maffei A,Aguirre A

更新日期：2018-01-02 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease, characterised by increased expression of type I interferon (IFN)-regulated genes and a striking sex imbalance towards females. Through combined genetic, in silico, in vitro, and ex vivo approaches, we define CXorf21, a gene of hitherto unknown function, whic...

journal_title：Nature communications

authors： Odhams CA,Roberts AL,Vester SK,Duarte CST,Beales CT,Clarke AJ,Lindinger S,Daffern SJ,Zito A,Chen L,Jones LL,Boteva L,Morris DL,Small KS,Fernando MMA,Cunninghame Graham DS,Vyse TJ

更新日期：2019-05-15 00:00:00

abstract：:Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recently shown in Caenorha...

journal_title：Nature communications

authors： Kumsta C,Chang JT,Lee R,Tan EP,Yang Y,Loureiro R,Choy EH,Lim SHY,Saez I,Springhorn A,Hoppe T,Vilchez D,Hansen M

更新日期：2019-12-11 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms14454. ...

journal_title：Nature communications

authors： Bengtsson NE,Hall JK,Odom GL,Phelps MP,Andrus CR,Hawkins RD,Hauschka SD,Chamberlain JR,Chamberlain JS

更新日期：2017-06-23 00:00:00

abstract：:Photoelectrochemical (PEC) water splitting promises a solution to the problem of large-scale solar energy storage. However, its development has been impeded by the poor performance of photoanodes, particularly in their capability for photovoltage generation. Many examples employing photovoltaic modules to correct the ...

journal_title：Nature communications

authors： Jang JW,Du C,Ye Y,Lin Y,Yao X,Thorne J,Liu E,McMahon G,Zhu J,Javey A,Guo J,Wang D

更新日期：2015-06-16 00:00:00

abstract：:Scalable, integrative methods to understand mechanisms that link genetic variants with phenotypes are needed. Here we derive a mathematical expression to compute PrediXcan (a gene mapping approach) results using summary data (S-PrediXcan) and show its accuracy and general robustness to misspecified reference sets. We ...

journal_title：Nature communications

authors： Barbeira AN,Dickinson SP,Bonazzola R,Zheng J,Wheeler HE,Torres JM,Torstenson ES,Shah KP,Garcia T,Edwards TL,Stahl EA,Huckins LM,GTEx Consortium.,Nicolae DL,Cox NJ,Im HK

更新日期：2018-05-08 00:00:00

abstract：:Mappings of classical computation onto statistical mechanics models have led to remarkable successes in addressing some complex computational problems. However, such mappings display thermodynamic phase transitions that may prevent reaching solution even for easy problems known to be solvable in polynomial time. Here ...

journal_title：Nature communications

authors： Chamon C,Mucciolo ER,Ruckenstein AE,Yang ZC

更新日期：2017-05-12 00:00:00

abstract：:Migrating cells move across diverse assemblies of extracellular matrix (ECM) that can be separated by micron-scale gaps. For membranes to protrude and reattach across a gap, actin filaments, which are relatively weak as single filaments, must polymerize outward from adhesion sites to push membranes towards distant sit...

journal_title：Nature communications

authors： Garbett D,Bisaria A,Yang C,McCarthy DG,Hayer A,Moerner WE,Svitkina TM,Meyer T

更新日期：2020-09-23 00:00:00

abstract：:Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 in T cells, a late-onset disease is still inducible, despite a great reduction in acute inflammation. We here reveal that development of this late onset disease...

journal_title：Nature communications

authors： Raveney BJ,Oki S,Hohjoh H,Nakamura M,Sato W,Murata M,Yamamura T

更新日期：2015-10-05 00:00:00

abstract：:Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in vivo and aberrations in this process are associated with several human diseas...

journal_title：Nature communications

authors： Liu Y,Gupta GD,Barnabas DD,Agircan FG,Mehmood S,Wu D,Coyaud E,Johnson CM,McLaughlin SH,Andreeva A,Freund SMV,Robinson CV,Cheung SWT,Raught B,Pelletier L,van Breugel M

更新日期：2018-04-30 00:00:00

abstract：:Highly specific Cas9 nucleases derived from SpCas9 are valuable tools for genome editing, but their wide applications are hampered by a lack of knowledge governing guide RNA (gRNA) activity. Here, we perform a genome-scale screen to measure gRNA activity for two highly specific SpCas9 variants (eSpCas9(1.1) and SpCas9...

journal_title：Nature communications

authors： Wang D,Zhang C,Wang B,Li B,Wang Q,Liu D,Wang H,Zhou Y,Shi L,Lan F,Wang Y

更新日期：2019-09-19 00:00:00

abstract：:Protein-protein interactions featuring intricate binding epitopes remain challenging targets for synthetic inhibitors. Interactions of NEMO, a scaffolding protein central to NF-κB signaling, exemplify this challenge. Various regulators are known to interact with different coiled coil regions of NEMO, but the topologic...

journal_title：Nature communications

authors： Sadek J,Wuo MG,Rooklin D,Hauenstein A,Hong SH,Gautam A,Wu H,Zhang Y,Cesarman E,Arora PS

更新日期：2020-04-14 00:00:00

abstract：:All-inorganic perovskites have a special place in halide perovskite family because of their potential for better stability. However, the representative cesium lead iodide (CsPbI3) is metastable and spontaneously converts to the non-perovskite structure at room temperature. Here, we demonstrate that what appears to be ...

journal_title：Nature communications

authors： Ke W,Spanopoulos I,Stoumpos CC,Kanatzidis MG

更新日期：2018-11-14 00:00:00

abstract：:Knowledge of key drivers and therapeutic targets in mucosal melanoma is limited due to the paucity of comprehensive mutation data on this rare tumor type. To better understand the genomic landscape of mucosal melanoma, here we describe whole genome sequencing analysis of 67 tumors and validation of driver gene mutatio...

journal_title：Nature communications

authors： Newell F,Kong Y,Wilmott JS,Johansson PA,Ferguson PM,Cui C,Li Z,Kazakoff SH,Burke H,Dodds TJ,Patch AM,Nones K,Tembe V,Shang P,van der Weyden L,Wong K,Holmes O,Lo S,Leonard C,Wood S,Xu Q,Rawson RV,Mukhopadhyay P

更新日期：2019-07-18 00:00:00

abstract：:The extent and importance of endogenous viral elements have been extensively described in animals but are much less well understood in plants. Here we describe a new genus of Caulimoviridae called 'Florendovirus', members of which have colonized the genomes of a large diversity of flowering plants, sometimes at very h...

journal_title：Nature communications

authors： Geering AD,Maumus F,Copetti D,Choisne N,Zwickl DJ,Zytnicki M,McTaggart AR,Scalabrin S,Vezzulli S,Wing RA,Quesneville H,Teycheney PY

更新日期：2014-11-10 00:00:00

abstract：:Phospholipids are elemental building-block molecules for biological membranes. Biosynthesis of phosphatidylinositol, phosphatidylglycerol and phosphatidylserine requires a central liponucleotide intermediate named cytidine-diphosphate diacylglycerol (CDP-DAG). The CDP-DAG synthetase (Cds) is an integral membrane enzym...

journal_title：Nature communications

authors： Liu X,Yin Y,Wu J,Liu Z

更新日期：2014-06-27 00:00:00

abstract：:In the Arctic, environmental factors governing microbial degradation of soil carbon (C) in active layer and permafrost are poorly understood. Here we determined the functional potential of soil microbiomes horizontally and vertically across a cryoperturbed polygonal landscape in Alaska. With comparative metagenomics, ...

journal_title：Nature communications

authors： Taş N,Prestat E,Wang S,Wu Y,Ulrich C,Kneafsey T,Tringe SG,Torn MS,Hubbard SS,Jansson JK

更新日期：2018-02-22 00:00:00

abstract：:Generous behaviour is known to increase happiness, which could thereby motivate generosity. In this study, we use functional magnetic resonance imaging and a public pledge for future generosity to investigate the brain mechanisms that link generous behaviour with increases in happiness. Participants promised to spend ...

journal_title：Nature communications

authors： Park SQ,Kahnt T,Dogan A,Strang S,Fehr E,Tobler PN

更新日期：2017-07-11 00:00:00

abstract：:Upgrading C1 chemicals (for example, CO, CO/H2, MeOH and CO2) with C-C bond formation is essential for the synthesis of bulk chemicals. In general, these industrially important processes (for example, Fischer Tropsch) proceed at drastic reaction conditions (>250 °C; high pressure) and suffer from low selectivity, whic...

journal_title：Nature communications

authors： Dong K,Elangovan S,Sang R,Spannenberg A,Jackstell R,Junge K,Li Y,Beller M

更新日期：2016-07-05 00:00:00

abstract：:Understanding the behaviour of thermally excited many-particle systems, composed of a single particle type having a well-defined shape and size, is important in condensed matter, notably protein crystallization. Here we observe and explain the origin of local chiral symmetry breaking in a surprisingly simple system of...

journal_title：Nature communications

authors： Zhao K,Bruinsma R,Mason TG

更新日期：2012-05-01 00:00:00

abstract：:Tuning the thermodynamic state of a material has a tremendous impact on its performance. In the case of polymers placed in proximity of a solid wall, this is possible by annealing above the glass transition temperature, Tg, which induces the formation of an adsorbed layer. Whether heating to higher temperatures would ...

journal_title：Nature communications

authors： Monnier X,Napolitano S,Cangialosi D

更新日期：2020-08-28 00:00:00

abstract：:Knowledge of cell type composition in disease relevant tissues is an important step towards the identification of cellular targets of disease. We present MuSiC, a method that utilizes cell-type specific gene expression from single-cell RNA sequencing (RNA-seq) data to characterize cell type compositions from bulk RNA-...

journal_title：Nature communications

authors： Wang X,Park J,Susztak K,Zhang NR,Li M

更新日期：2019-01-22 00:00:00

abstract：:The responses of atmospheric variability to Tibetan Plateau (TP) snow cover (TPSC) at seasonal, interannual and decadal time scales have been extensively investigated. However, the atmospheric response to faster subseasonal variability of TPSC has been largely ignored. Here, we show that the subseasonal variability of...

journal_title：Nature communications

authors： Li W,Guo W,Qiu B,Xue Y,Hsu PC,Wei J

更新日期：2018-10-12 00:00:00