Abstract:
:Despite the fundamental importance of efficient and selective synthesis of widely useful alkylarenes, the direct catalytic C(sp2)-H alkylation of unactivated arenes with a readily available alkyl halide remains elusive. Here, we report the catalytic C(sp2)-H alkylation reactions of unactivated arenes with alkyl bromides via visible-light induced Pd catalysis. The reaction proceeds smoothly under mild conditions without any skeletal rearrangement of the alkyl groups. The direct syntheses of structurally diverse linear and branched alkylarenes, including the late-stage phenylation of biologically active molecules and an orthogonal one-pot sequential Pd-catalyzed C-C bond-forming reaction, are achieved with exclusive chemoselectivity and exceptional functional group tolerance. Comprehensive mechanistic investigations through a combination of experimental and computational methods reveal a distinguishable Pd(0)/Pd(I) redox catalytic cycle and the origin of the counter-intuitive reactivity differences among alkyl halides.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Kim D,Lee GS,Kim D,Hong SHdoi
10.1038/s41467-020-19038-8subject
Has Abstractpub_date
2020-10-19 00:00:00pages
5266issue
1issn
2041-1723pii
10.1038/s41467-020-19038-8journal_volume
11pub_type
杂志文章abstract::Non-linear interactions in coherent gases are not only at the origin of bright and dark solitons and superfluids; they also give rise to phenomena such as multistability, which hold great promise for the development of advanced photonic and spintronic devices. In particular, spinor multistability in strongly coupled s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3008
更新日期:2013-01-01 00:00:00
abstract::Noble metal nanoparticles stabilized by organic ligands are important for applications in assembly, site-specific bioconjugate labelling and sensing, drug delivery and medical therapy, molecular recognition and molecular electronics, and catalysis. Here we report crystal structures and theoretical analysis of three Ag...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3422
更新日期:2013-01-01 00:00:00
abstract::Cerebral processes contribute to pain beyond the level of nociceptive input and mediate psychological and behavioural influences. However, cerebral contributions beyond nociception are not yet well characterized, leading to a predominant focus on nociception when studying pain and developing interventions. Here we use...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14211
更新日期:2017-02-14 00:00:00
abstract::Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03979-2
更新日期:2018-04-20 00:00:00
abstract::Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show that single pMHCII...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09893-5
更新日期:2019-05-14 00:00:00
abstract::Observing the crucial first few femtoseconds of photochemical reactions requires tools typically not available in the femtochemistry toolkit. Such dynamics are now within reach with the instruments provided by attosecond science. Here, we apply experimental and theoretical methods to assess the ultrafast nonadiabatic ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01133-y
更新日期:2017-10-18 00:00:00
abstract::Allergic asthma is a leading chronic disease associated with airway hyperreactivity (AHR). Type-2 innate lymphoid cells (ILC2s) are a potent source of T-helper 2 (Th2) cytokines that promote AHR and lung inflammation. As the programmed cell death protein-1 (PD-1) inhibitory axis regulates a variety of immune responses...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17813-1
更新日期:2020-08-10 00:00:00
abstract::The mammary epithelium comprises two primary cellular lineages, but the degree of heterogeneity within these compartments and their lineage relationships during development remain an open question. Here we report single-cell RNA profiling of mouse mammary epithelial cells spanning four developmental stages in the post...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01560-x
更新日期:2017-11-20 00:00:00
abstract::A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31hiEmcnhi), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31hiEmcnhi vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31hiEmcnhi endothelium but gradually ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms16003
更新日期:2017-07-07 00:00:00
abstract::Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common human congenital birth defects and imposes a substantial physical and financial burden on affected individuals. Here, we conduct a case-control-based GWAS followed by two rounds of replication; we include six independent cohorts fr...
journal_title:Nature communications
pub_type: 杂志文章,meta分析
doi:10.1038/ncomms7414
更新日期:2015-03-16 00:00:00
abstract::Thin, ultra-flexible devices that can be manufactured in a process that covers a large area will be essential to realizing low-cost, wearable electronic applications including foldable displays and medical sensors. The printing technology will be instrumental in fabricating these novel electronic devices and circuits;...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5147
更新日期:2014-06-20 00:00:00
abstract::Circular RNAs (circRNAs) have recently gained substantial attention in the cancer research field where most, including the putative oncogene ciRS-7 (CDR1as), have been proposed to function as competitive endogenous RNAs (ceRNAs) by sponging specific microRNAs. Here, we report the first spatially resolved cellular expr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18355-2
更新日期:2020-09-11 00:00:00
abstract::Understanding the response of granular matter to intrusion of solid objects is key to modelling many aspects of behaviour of granular matter, including plastic flow. Here we report a general model for such a quasistatic process. Using a range of experiments, we first show that the relation between the penetration dept...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03344-3
更新日期:2018-03-16 00:00:00
abstract::Since the formulation of the geometric phase by Berry, its relevance has been demonstrated in a large variety of physical systems. However, a geometric phase of the most fundamental spin-1/2 system, the electron spin, has not been observed directly and controlled independently from dynamical phases. Here we report exp...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3526
更新日期:2013-01-01 00:00:00
abstract::The hallmark of Salmonella Typhimurium infection is an acute intestinal inflammatory response, which is mediated through the action of secreted bacterial effector proteins. The pro-inflammatory Salmonella effector SopA is a HECT-like E3 ligase, which was previously proposed to activate host RING ligases TRIM56 and TRI...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14004
更新日期:2017-01-13 00:00:00
abstract::MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with hi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13964
更新日期:2017-01-03 00:00:00
abstract::Emerging evidence supports roles of enhancer RNAs (eRNAs) in regulating target gene. Here, we study eRNA regulation and function during skeletal myoblast differentiation. We provide a panoramic view of enhancer transcription and categorization of eRNAs. Master transcription factor MyoD is crucial in activating eRNA pr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13598-0
更新日期:2019-12-19 00:00:00
abstract::Topology has an increasingly important role in the physics of condensed matter, quantum systems, material science, photonics and biology, with spectacular realizations of topological concepts in liquid crystals. Here we report on long-lived hidden topological states in thermally quenched, chiral nematic droplets, form...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14594
更新日期:2017-02-21 00:00:00
abstract::Subglacial lakes are widespread beneath the Antarctic Ice Sheet but their control on ice-sheet dynamics and their ability to harbour life remain poorly characterized. Here we present evidence for a palaeo-subglacial lake on the Antarctic continental shelf. A distinct sediment facies recovered from a bedrock basin in P...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15591
更新日期:2017-06-01 00:00:00
abstract::Six CO2 fixation pathways are known to operate in photoautotrophic and chemoautotrophic microorganisms. Here, we describe chemolithoautotrophic growth of the sulphate-reducing bacterium Desulfovibrio desulfuricans (strain G11) with hydrogen and sulphate as energy substrates. Genomic, transcriptomic, proteomic and meta...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18906-7
更新日期:2020-10-09 00:00:00
abstract::Transthyretin (TTR) is a plasma homotetrameric protein implicated in fatal systemic amyloidoses. TTR tetramer dissociation precedes pathological TTR aggregation. Native state stabilizers are promising drugs to treat TTR amyloidoses. Here we repurpose tolcapone, an FDA-approved molecule for Parkinson's disease, as a po...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10787
更新日期:2016-02-23 00:00:00
abstract::Columnar joints form by cracking during cooling-induced contraction of lava, allowing hydrothermal fluid circulation. A lack of direct observations of their formation has led to ambiguity about the temperature window of jointing and its impact on fluid flow. Here we develop a novel thermo-mechanical experiment to disc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03842-4
更新日期:2018-04-12 00:00:00
abstract::How are memories transferred from short-term to long-term storage? Systems-level memory consolidation is thought to be dependent on the coordinated interplay of cortical slow waves, thalamo-cortical sleep spindles and hippocampal ripple oscillations. However, it is currently unclear how the selective interaction of th...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11444-x
更新日期:2019-08-08 00:00:00
abstract::Aerosol-cloud interactions constitute the largest source of uncertainty in global radiative forcing estimates, hampering our understanding of climate evolution. Recent empirical evidence suggests surface tension depression by organic aerosol to significantly influence the formation of cloud droplets, and hence cloud o...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12982-0
更新日期:2019-11-18 00:00:00
abstract::Visual brain areas exhibit tuning characteristics well suited for image statistics present in our natural environment. However, visual sensation is an active process, and if there are any brain areas that ought to be particularly in tune with natural scene statistics, it would be sensory-motor areas critical for guidi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-05302-5
更新日期:2018-07-20 00:00:00
abstract::Activation of free fatty acid receptor 1 (GPR40) by synthetic partial and full agonists occur via distinct allosteric sites. A crystal structure of GPR40-TAK-875 complex revealed the allosteric site for the partial agonist. Here we report the 2.76-Å crystal structure of human GPR40 in complex with a synthetic full ago...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01240-w
更新日期:2018-04-25 00:00:00
abstract::The original HTML version of this Article had an incorrect Published online date of 20 March 2019; it should have been 18 March 2019. This has been corrected in the HTML version of the Article. The PDF version was correct from the time of publication. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-019-09797-4
更新日期:2019-04-18 00:00:00
abstract::Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identi...
journal_title:Nature communications
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1038/ncomms8213
更新日期:2015-05-26 00:00:00
abstract::Metal halide perovskites feature crystalline-like electronic band structures and liquid-like physical properties. The crystal-liquid duality enables optoelectronic devices with unprecedented performance and a unique opportunity to chemically manipulate the structure with low energy input. In this work, we leverage the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19009-z
更新日期:2020-10-16 00:00:00
abstract::This corrects the article DOI: 10.1038/ncomms14013. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/ncomms15795
更新日期:2017-08-14 00:00:00