Abstract:
:Recent developments in stem cell biology have enabled the study of cell fate decisions in early human development that are impossible to study in vivo. However, understanding how development varies across individuals and, in particular, the influence of common genetic variants during this process has not been characterised. Here, we exploit human iPS cell lines from 125 donors, a pooled experimental design, and single-cell RNA-sequencing to study population variation of endoderm differentiation. We identify molecular markers that are predictive of differentiation efficiency of individual lines, and utilise heterogeneity in the genetic background across individuals to map hundreds of expression quantitative trait loci that influence expression dynamically during differentiation and across cellular contexts.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Cuomo ASE,Seaton DD,McCarthy DJ,Martinez I,Bonder MJ,Garcia-Bernardo J,Amatya S,Madrigal P,Isaacson A,Buettner F,Knights A,Natarajan KN,HipSci Consortium.,Vallier L,Marioni JC,Chhatriwala M,Stegle Odoi
10.1038/s41467-020-14457-zsubject
Has Abstractpub_date
2020-02-10 00:00:00pages
810issue
1issn
2041-1723pii
10.1038/s41467-020-14457-zjournal_volume
11pub_type
杂志文章abstract::Evidence from animal and human studies has suggested that the amygdala plays a role in detecting threat and in directing attention to the eyes. Nevertheless, there has been no systematic investigation of whether the amygdala specifically facilitates attention to the eyes or whether other features can also drive attent...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10161
更新日期:2015-12-14 00:00:00
abstract::Memory metamaterials are artificial media that sustain transformed electromagnetic properties without persistent external stimuli. Previous memory metamaterials were realized with phase-change materials, such as vanadium dioxide or chalcogenide glasses, which exhibit memory behaviour with respect to electrically/optic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10429
更新日期:2016-01-27 00:00:00
abstract::Hox genes have been shown to be essential in vertebrate neural circuit formation and their depletion has resulted in homeotic transformations with neuron loss and miswiring. Here we quantifiy four eye movements in the zebrafish mutant valentino and hox3 knockdowns, and find that contrary to the classical model, oculom...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5221
更新日期:2014-06-25 00:00:00
abstract::In the central nervous system, most synapses show a fast mode of neurotransmitter release known as synchronous release followed by a phase of asynchronous release, which extends over tens of milliseconds to seconds. Synapsin II (SYN2) is a member of the multigene synapsin family (SYN1/2/3) of synaptic vesicle phosphop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2515
更新日期:2013-01-01 00:00:00
abstract::Decision making in dynamic environments requires discounting old evidence that may no longer inform the current state of the world. Previous work found that humans discount old evidence in a dynamic environment, but do not discount at the optimal rate. Here we investigated whether rats can optimally discount evidence ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06561-y
更新日期:2018-10-15 00:00:00
abstract::The development of atomic-scale structures revealing novel transport phenomena is a major goal of nanotechnology. Examples include chains of atoms that form while stretching a transition metal contact or the predicted formation of magnetic order in these chains, the existence of which is still debated. Here we report ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7172
更新日期:2015-02-04 00:00:00
abstract::The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cel...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7003
更新日期:2015-01-29 00:00:00
abstract::All common genome-wide association (GWA) methods rely on population structure correction, to avoid false genotype-to-phenotype associations. However, population structure correction is a stringent penalization, which also impedes identification of real associations. Using recent statistical advances, we developed a ne...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13299
更新日期:2016-11-10 00:00:00
abstract::The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA. The mechanistic details of the initiation and early stages of capsid assembly remain to be delineated. We present coarse-grai...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11568
更新日期:2016-05-13 00:00:00
abstract::Progranulin (GRN) loss-of-function mutations leading to progranulin protein (PGRN) haploinsufficiency are prevalent genetic causes of frontotemporal dementia. Reports also indicated PGRN-mediated neuroprotection in models of Alzheimer's and Parkinson's disease; thus, increasing PGRN levels is a promising therapeutic f...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11992
更新日期:2016-06-30 00:00:00
abstract::Excessive nitrogen runoff leads to degraded water quality, harming human and ecosystem health. We examine the impact of changes in land use and land management for six combinations of socioeconomic pathways and climate outcomes, and find that societal choices will substantially impact riverine total nitrogen loading (...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08884-w
更新日期:2019-02-26 00:00:00
abstract::The Lyme disease agent, Borrelia burgdorferi, colonizes the gut of the tick Ixodes scapularis, which transmits the pathogen to vertebrate hosts including humans. Here we show that B. burgdorferi colonization increases the expression of several tick gut genes including pixr, encoding a secreted gut protein with a Reele...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00208-0
更新日期:2017-08-04 00:00:00
abstract::Treatments that stimulate neuronal excitability enhance motor performance after stroke. cAMP-response-element binding protein (CREB) is a transcription factor that plays a key role in neuronal excitability. Increasing the levels of CREB with a viral vector in a small pool of motor neurons enhances motor recovery after...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04445-9
更新日期:2018-06-08 00:00:00
abstract::One of the important challenges in condensed matter science is to understand ultrafast, atomic-scale fluctuations that dictate dynamic processes in equilibrium and non-equilibrium materials. Here, we report an important step towards reaching that goal by using a state-of-the-art perfect crystal based split-and-delay s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04178-9
更新日期:2018-04-27 00:00:00
abstract::Organic conjugated polymers demonstrate great potential in transistors, solar cells and light-emitting diodes, whose performances are fundamentally governed by charge transport. However, the morphology-property relationships and the underpinning charge transport mechanisms remain unclear. Particularly, whether the non...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-20238-5
更新日期:2021-01-04 00:00:00
abstract::Riboswitches are naturally occurring RNA aptamers that regulate gene expression by binding to specific small molecules. Riboswitches control the expression of essential bacterial genes and are important models for RNA-small molecule recognition. Here, we report the discovery of a class of synthetic small molecules tha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09493-3
更新日期:2019-04-02 00:00:00
abstract::Some bacteria can feed on fungi, a phenomenon known as mycophagy. Here we show that a prophage tail-like protein (Bg_9562) is essential for mycophagy in Burkholderia gladioli strain NGJ1. The purified protein causes hyphal disintegration and inhibits growth of several fungal species. Disruption of the Bg_9562 gene abo...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-00529-0
更新日期:2017-09-01 00:00:00
abstract::Bacterial autotransporters comprise a 12-stranded membrane-embedded β-barrel domain, which must be folded in a process that entraps segments of an N-terminal passenger domain. This first stage of autotransporter folding determines whether subsequent translocation can deliver the N-terminal domain to its functional for...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5239
更新日期:2014-06-26 00:00:00
abstract::Suspension-feeding fishes such as goldfish and whale sharks retain prey without clogging their oral filters, whereas clogging is a major expense in industrial crossflow filtration of beer, dairy foods and biotechnology products. Fishes' abilities to retain particles that are smaller than the pore size of the gill-rake...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11092
更新日期:2016-03-29 00:00:00
abstract::The exocyst is an essential component of the secretory pathway required for delivery of basolateral proteins to the plasma membranes of epithelial cells. Delivery occurs adjacent to tight junctions (TJ), suggesting that it recognizes a receptor at this location. However, no such receptor has been identified. The Par3 ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14867
更新日期:2017-03-30 00:00:00
abstract::Large-scale genomic data highlight the complexity and diversity of the molecular changes that drive cancer progression. Statistical analysis of cancer data from different tissues can guide drug repositioning as well as the design of targeted treatments. Here, we develop an improved Bayesian network model for tumour mu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06867-x
更新日期:2018-10-19 00:00:00
abstract::The gyrotropic rotation around the equilibrium position constitutes the fundamental excitation of magnetic vortices in nanostructures. The frequency of this mode varies with material and sample geometry, but is independent of the vortex handedness and its core direction. Here, we demonstrate that this degeneracy is li...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7409
更新日期:2015-03-03 00:00:00
abstract::Organic light-emitting diodes utilizing thermally activated delayed fluorescence is a potential solution for achieving stable blue devices. Sky-blue devices (CIEy < 0.4) with high stability and high external quantum efficiency (>15%) at 1000 cd m-2 based on either delayed fluorescence or phosphorescence are still limi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07482-6
更新日期:2018-11-28 00:00:00
abstract::Tumour cells secrete exosomes that are involved in the remodelling of the tumour-stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), whic...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14041
更新日期:2017-01-09 00:00:00
abstract::Epitaxy is widely employed to create highly oriented crystalline films. A less appreciated, but nonetheless powerful means of creating such films is via topotactic transformation, in which a chemical reaction transforms a single crystal of one phase into a single crystal of a different phase, which inherits its orient...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8716
更新日期:2015-07-16 00:00:00
abstract::Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtB...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09273-z
更新日期:2019-03-20 00:00:00
abstract::The accumulation of protein aggregates is involved in the onset of many neurodegenerative diseases. Aggrephagy is a selective type of autophagy that counteracts neurodegeneration by degrading such aggregates. In this study, we found that LC3C cooperates with lysosomal TECPR1 to promote the degradation of disease-relat...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16689-5
更新日期:2020-06-12 00:00:00
abstract::Single spins in the solid state offer a unique opportunity to store and manipulate quantum information, and to perform quantum-enhanced sensing of local fields and charges. Optical control of these systems using techniques developed in atomic physics has yet to exploit all the advantages of the solid state. Here we de...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2519
更新日期:2013-01-01 00:00:00
abstract::A variety of flexible and stretchable electronics have been reported for use in flexible electronic devices or biomedical applications. The practical and wider application of such flexible electronics has been limited because commercial electronic components are difficult to be directly integrated into flexible stretc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1980
更新日期:2012-01-01 00:00:00
abstract::The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or from pre-existing cardiomyocytes that re-enter the cell cycle. Here, we...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02891-z
更新日期:2018-02-21 00:00:00