Synapsin II desynchronizes neurotransmitter release at inhibitory synapses by interacting with presynaptic calcium channels.

abstract：:Magnetized plasma interactions are ubiquitous in astrophysical and laboratory plasmas. Various physical effects have been shown to be important within colliding plasma flows influenced by opposing magnetic fields, however, experimental verification of the mechanisms within the interaction region has remained elusive. ...

journal_title：Nature communications

authors： Tubman ER,Joglekar AS,Bott AFA,Borghesi M,Coleman B,Cooper G,Danson CN,Durey P,Foster JM,Graham P,Gregori G,Gumbrell ET,Hill MP,Hodge T,Kar S,Kingham RJ,Read M,Ridgers CP,Skidmore J,Spindloe C,Thomas AGR,Treadwe

更新日期：2021-01-12 00:00:00

abstract：:Herein, we report on a significant discovery, namely, the quantitative discharging of reduced graphite forms, such as graphite intercalation compounds, graphenide dispersions and graphenides deposited on surfaces with the simple solvent benzonitrile. Because of its comparatively low reduction potential, benzonitrile i...

journal_title：Nature communications

authors： Vecera P,Holzwarth J,Edelthalhammer KF,Mundloch U,Peterlik H,Hauke F,Hirsch A

更新日期：2016-08-10 00:00:00

abstract：:The effects of high-fat diet (HFD) and postprandial endotoxemia on the development of type 2 diabetes are not fully understood. Here we show that the serine protease prostasin (PRSS8) regulates hepatic insulin sensitivity by modulating Toll-like receptor 4 (TLR4)-mediated signalling. HFD triggers the suppression of PR...

journal_title：Nature communications

authors： Uchimura K,Hayata M,Mizumoto T,Miyasato Y,Kakizoe Y,Morinaga J,Onoue T,Yamazoe R,Ueda M,Adachi M,Miyoshi T,Shiraishi N,Ogawa W,Fukuda K,Kondo T,Matsumura T,Araki E,Tomita K,Kitamura K

更新日期：2014-03-11 00:00:00

abstract：:Artificially improving traits of cultivated alfalfa (Medicago sativa L.), one of the most important forage crops, is challenging due to the lack of a reference genome and an efficient genome editing protocol, which mainly result from its autotetraploidy and self-incompatibility. Here, we generate an allele-aware chrom...

journal_title：Nature communications

authors： Chen H,Zeng Y,Yang Y,Huang L,Tang B,Zhang H,Hao F,Liu W,Li Y,Liu Y,Zhang X,Zhang R,Zhang Y,Li Y,Wang K,He H,Wang Z,Fan G,Yang H,Bao A,Shang Z,Chen J,Wang W,Qiu Q

更新日期：2020-05-19 00:00:00

abstract：:Oxygen contamination is a problem which inevitably occurs during severe plastic deformation of metallic powders by exposure to air. Although this contamination can change the morphology and properties of the consolidated materials, there is a lack of detailed information about the behavior of oxygen in nanocrystalline...

journal_title：Nature communications

authors： Guo J,Haberfehlner G,Rosalie J,Li L,Duarte MJ,Kothleitner G,Dehm G,He Y,Pippan R,Zhang Z

更新日期：2018-03-05 00:00:00

abstract：:The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or from pre-existing cardiomyocytes that re-enter the cell cycle. Here, we...

journal_title：Nature communications

authors： Sereti KI,Nguyen NB,Kamran P,Zhao P,Ranjbarvaziri S,Park S,Sabri S,Engel JL,Sung K,Kulkarni RP,Ding Y,Hsiai TK,Plath K,Ernst J,Sahoo D,Mikkola HKA,Iruela-Arispe ML,Ardehali R

更新日期：2018-02-21 00:00:00

abstract：:Leptin stimulates the sympathetic nervous system (SNS), energy expenditure, and weight loss; however, the underlying molecular mechanism remains elusive. Here, we uncover Sh2b1 in leptin receptor (LepR) neurons as a critical component of a SNS/brown adipose tissue (BAT)/thermogenesis axis. LepR neuron-specific deletio...

journal_title：Nature communications

authors： Jiang L,Su H,Wu X,Shen H,Kim MH,Li Y,Myers MG Jr,Owyang C,Rui L

更新日期：2020-03-23 00:00:00

abstract：:Many cancer cells display enhanced glycolysis and suppressed mitochondrial metabolism. This phenomenon, known as the Warburg effect, is critical for tumor development. However, how cancer cells coordinate glucose metabolism through glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle is largely unknown. We ...

journal_title：Nature communications

authors： Nie H,Ju H,Fan J,Shi X,Cheng Y,Cang X,Zheng Z,Duan X,Yi W

更新日期：2020-01-07 00:00:00

abstract：:A diversity of self-propelled chemical motors, based on Marangoni propulsive forces, has been developed in recent years. However, most motors are non-functional due to poor performance, a lack of control, and the use of toxic materials. To overcome these limitations, we have developed multifunctional and biodegradable...

journal_title：Nature communications

authors： Pena-Francesch A,Giltinan J,Sitti M

更新日期：2019-07-18 00:00:00

abstract：:The control of matter motion at liquid-gas interfaces opens an opportunity to create two-dimensional materials with remotely tunable properties. In analogy with optical lattices used in ultra-cold atom physics, such materials can be created by a wave field capable of dynamically guiding matter into periodic spatial st...

journal_title：Nature communications

authors： Francois N,Xia H,Punzmann H,Fontana PW,Shats M

更新日期：2017-02-09 00:00:00

abstract：:Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically ...

journal_title：Nature communications

authors： Järvå M,Lay FT,Phan TK,Humble C,Poon IKH,Bleackley MR,Anderson MA,Hulett MD,Kvansakul M

更新日期：2018-05-17 00:00:00

abstract：:Fatty acids (FAs) are not only essential components of cellular energy storage and structure, but play crucial roles in signalling. Here we present a toolkit of photoswitchable FA analogues (FAAzos) that incorporate an azobenzene photoswitch along the FA chain. By modifying the FAAzos to resemble capsaicin, we prepare...

journal_title：Nature communications

authors： Frank JA,Moroni M,Moshourab R,Sumser M,Lewin GR,Trauner D

更新日期：2015-05-22 00:00:00

abstract：:Past studies of the end-Permian extinction (EPE), the largest biotic crisis of the Phanerozoic, have not resolved the timing of events in southern high-latitudes. Here we use palynology coupled with high-precision CA-ID-TIMS dating of euhedral zircons from continental sequences of the Sydney Basin, Australia, to show ...

journal_title：Nature communications

authors： Fielding CR,Frank TD,McLoughlin S,Vajda V,Mays C,Tevyaw AP,Winguth A,Winguth C,Nicoll RS,Bocking M,Crowley JL

更新日期：2019-01-23 00:00:00

abstract：:The interband cascade laser differs from any other class of semiconductor laser, conventional or cascaded, in that most of the carriers producing population inversion are generated internally, at semimetallic interfaces within each stage of the active region. Here we present simulations demonstrating that all previous...

journal_title：Nature communications

authors： Vurgaftman I,Bewley WW,Canedy CL,Kim CS,Kim M,Merritt CD,Abell J,Lindle JR,Meyer JR

更新日期：2011-12-13 00:00:00

abstract：:Nanoparticles attached just above a flat metallic surface can trap optical fields in the nanoscale gap. This enables local spectroscopy of a few molecules within each coupled plasmonic hotspot, with near thousand-fold enhancement of the incident fields. As a result of non-radiative relaxation pathways, the plasmons in...

journal_title：Nature communications

authors： de Nijs B,Benz F,Barrow SJ,Sigle DO,Chikkaraddy R,Palma A,Carnegie C,Kamp M,Sundararaman R,Narang P,Scherman OA,Baumberg JJ

更新日期：2017-10-20 00:00:00

abstract：:Biological tissues exhibit complex spatial heterogeneity that directs the functions of multicellular organisms. Quantifying protein expression is essential for elucidating processes within complex biological assemblies. Imaging mass spectrometry (IMS) is a powerful emerging tool for mapping the spatial distribution of...

journal_title：Nature communications

authors： Piehowski PD,Zhu Y,Bramer LM,Stratton KG,Zhao R,Orton DJ,Moore RJ,Yuan J,Mitchell HD,Gao Y,Webb-Robertson BM,Dey SK,Kelly RT,Burnum-Johnson KE

更新日期：2020-01-07 00:00:00

abstract：:Tunneling is a fundamental quantum process with no classical equivalent, which can compete with Coulomb interactions to give rise to complex phenomena. Phosphorus dopants in silicon can be placed with atomic precision to address the different regimes arising from this competition. However, they exploit wavefunctions r...

journal_title：Nature communications

authors： Voisin B,Bocquel J,Tankasala A,Usman M,Salfi J,Rahman R,Simmons MY,Hollenberg LCL,Rogge S

更新日期：2020-11-30 00:00:00

abstract：:The original version of this Article contained errors in Fig. 3. In panel a, bars from a chart depicting the percentage of antibody-positive individuals in non-infectious and infectious groups were inadvertently included in place of bars depicting the percentage of infectious individuals, as described in the Article a...

journal_title：Nature communications

authors： Stone WJR,Campo JJ,Ouédraogo AL,Meerstein-Kessel L,Morlais I,Da D,Cohuet A,Nsango S,Sutherland CJ,van de Vegte-Bolmer M,Siebelink-Stoter R,van Gemert GJ,Graumans W,Lanke K,Shandling AD,Pablo JV,Teng AA,Jones S,de Jong

更新日期：2018-04-11 00:00:00

abstract：:Iron Regulatory Protein 1 (IRP1) is a bifunctional cytosolic iron sensor. When iron levels are normal, IRP1 harbours an iron-sulphur cluster (holo-IRP1), an enzyme with aconitase activity. When iron levels fall, IRP1 loses the cluster (apo-IRP1) and binds to iron-responsive elements (IREs) in messenger RNAs (mRNAs) en...

journal_title：Nature communications

authors： Huynh N,Ou Q,Cox P,Lill R,King-Jones K

更新日期：2019-11-29 00:00:00

abstract：:Adult cardiac tissue undergoes a rapid process of dedifferentiation when cultured outside the body. The in vivo environment, particularly constant electromechanical stimulation, is fundamental to the regulation of cardiac structure and function. We investigated the role of electromechanical stimulation in preventing c...

journal_title：Nature communications

authors： Watson SA,Duff J,Bardi I,Zabielska M,Atanur SS,Jabbour RJ,Simon A,Tomas A,Smolenski RT,Harding SE,Perbellini F,Terracciano CM

更新日期：2019-05-15 00:00:00

abstract：:Two waves of DNA methylation reprogramming occur during mammalian embryogenesis; during preimplantation development and during primordial germ cell (PGC) formation. However, it is currently unclear how evolutionarily conserved these processes are. Here we characterise the DNA methylomes of zebrafish PGCs at four devel...

journal_title：Nature communications

authors： Skvortsova K,Tarbashevich K,Stehling M,Lister R,Irimia M,Raz E,Bogdanovic O

更新日期：2019-07-11 00:00:00

abstract：:Inversions are one type of structural variants linked to phenotypic differences and adaptation in multiple organisms. However, there is still very little information about polymorphic inversions in the human genome due to the difficulty of their detection. Here, we develop a new high-throughput genotyping method based...

journal_title：Nature communications

authors： Giner-Delgado C,Villatoro S,Lerga-Jaso J,Gayà-Vidal M,Oliva M,Castellano D,Pantano L,Bitarello BD,Izquierdo D,Noguera I,Olalde I,Delprat A,Blancher A,Lalueza-Fox C,Esko T,O'Reilly PF,Andrés AM,Ferretti L,Puig M,Cáce

更新日期：2019-09-17 00:00:00

abstract：:In just 20 years of history, the field of optomechanics has achieved impressive progress, stepping into the quantum regime just 5 years ago. Such remarkable advance relies on the technological revolution of nano-optomechanical systems, whose sensitivity towards thermal decoherence is strongly limited due to their ultr...

journal_title：Nature communications

authors： Tavernarakis A,Stavrinadis A,Nowak A,Tsioutsios I,Bachtold A,Verlot P

更新日期：2018-02-14 00:00:00

abstract：:Many heritable mutualisms, in which beneficial symbionts are transmitted vertically between host generations, originate as antagonisms with parasite dispersal constrained by the host. Only after the parasite gains control over its transmission is the symbiosis expected to transition from antagonism to mutualism. Here,...

journal_title：Nature communications

authors： Mondo SJ,Lastovetsky OA,Gaspar ML,Schwardt NH,Barber CC,Riley R,Sun H,Grigoriev IV,Pawlowska TE

更新日期：2017-11-29 00:00:00

abstract：:Angiogenesis is a dynamic process relying on endothelial cell rearrangements within vascular tubes, yet the underlying mechanisms and functional relevance are poorly understood. Here we show that PI3Kα regulates endothelial cell rearrangements using a combination of a PI3Kα-selective inhibitor and endothelial-specific...

journal_title：Nature communications

authors： Angulo-Urarte A,Casado P,Castillo SD,Kobialka P,Kotini MP,Figueiredo AM,Castel P,Rajeeve V,Milà-Guasch M,Millan J,Wiesner C,Serra H,Muixi L,Casanovas O,Viñals F,Affolter M,Gerhardt H,Huveneers S,Belting HG,Cutillas

更新日期：2018-11-16 00:00:00

abstract：:Long-term depression (LTD) underlies learning and memory in various brain regions. Although postsynaptic AMPA receptor trafficking mediates LTD, its underlying molecular mechanisms remain largely unclear. Here we show that stargazin, a transmembrane AMPA receptor regulatory protein, forms a ternary complex with adapto...

journal_title：Nature communications

authors： Matsuda S,Kakegawa W,Budisantoso T,Nomura T,Kohda K,Yuzaki M

更新日期：2013-01-01 00:00:00

abstract：:When pressure is applied, the molecules inside a crystal undergo significant changes of their stereoelectronic properties. The most interesting are those enhancing the reactivity of systems that would be otherwise rather inert at ambient conditions. Before a reaction can occur, however, a molecule must be activated, w...

journal_title：Nature communications

authors： Casati N,Kleppe A,Jephcoat AP,Macchi P

更新日期：2016-03-16 00:00:00

abstract：:A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and then from the centromere region in meiosis II. Centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage, in order to maintain sister chromatids together...

journal_title：Nature communications

authors： El Yakoubi W,Buffin E,Cladière D,Gryaznova Y,Berenguer I,Touati SA,Gómez R,Suja JA,van Deursen JM,Wassmann K

更新日期：2017-09-25 00:00:00

abstract：:Exploitation of the oxidation behaviour in an environmentally sensitive semiconductor is significant to modulate its electronic properties and develop unique applications. Here, we demonstrate a native oxidation-inspired InSe field-effect transistor as an artificial synapse in device level that benefits from the boost...

journal_title：Nature communications

authors： Yang FS,Li M,Lee MP,Ho IY,Chen JY,Ling H,Li Y,Chang JK,Yang SH,Chang YM,Lee KC,Chou YC,Ho CH,Li W,Lien CH,Lin YF

更新日期：2020-06-12 00:00:00

abstract：:Purely organic room temperature phosphorescence (RTP) has attracted wide attention recently due to its various application potentials. However, ultralong RTP (URTP) with high efficiency is still rarely achieved. Herein, by dissolving 1,8-naphthalic anhydride in certain organic solid hosts, URTP with a lifetime of over...

journal_title：Nature communications

authors： Zhang X,Du L,Zhao W,Zhao Z,Xiong Y,He X,Gao PF,Alam P,Wang C,Li Z,Leng J,Liu J,Zhou C,Lam JWY,Phillips DL,Zhang G,Tang BZ

更新日期：2019-11-14 00:00:00