当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex.

X-ray structure of a carpet-like antimicrobial defensin-phospholipid membrane disruption complex.

Abstract：

:Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically bind the membrane phospholipids phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate, thereby triggering the assembly of defensin-lipid oligomers that permeabilize cell membranes. To understand this permeabilization mechanism, here we determine the crystal structure of the plant defensin NaD1 bound to PA. The structure reveals a 20-mer that adopts a concave sheet- or carpet-like topology where NaD1 dimers form one face and PA acyl chains form the other face of the sheet. Furthermore, we show that Arg39 is critical for PA binding, oligomerization and fungal cell killing. These findings identify a putative defensin-phospholipid membrane attack configuration that supports a longstanding proposed carpet mode of membrane disruption.

journal_name

Nat Commun

journal_title

Nature communications

authors

Järvå M,Lay FT,Phan TK,Humble C,Poon IKH,Bleackley MR,Anderson MA,Hulett MD,Kvansakul M

doi

10.1038/s41467-018-04434-y

subject

Has Abstract

pub_date

2018-05-17 00:00:00

pages

1962

issue

1

issn

2041-1723

pii

10.1038/s41467-018-04434-y

journal_volume

9

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Compositional boundary layers trigger liquid unmixing in a basaltic crystal mush.

    abstract：:The separation of immiscible liquids has significant implications for magma evolution and the formation of magmatic ore deposits. We combine high-resolution imaging and electron probe microanalysis with the first use of atom probe tomography on tholeiitic basaltic glass from Hawaii, the Snake River Plain, and Iceland,...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12694-5

    authors： Honour VC,Holness MB,Charlier B,Piazolo SC,Namur O,Prosa TJ,Martin I,Helz RT,Maclennan J,Jean MM

    更新日期：2019-10-23 00:00:00

  • Author Correction: Resonant out-of-phase fluorescence microscopy and remote imaging overcome spectral limitations.

    abstract：:The Peer Review File associated with this Article was updated shortly after publication to redact from the authors' point-by-point response a description of unpublished work describing how Speed OPIOM may in future be used to facilitate discrimination between FRET and direct excitation. ...

    journal_title：Nature communications

    pub_type： 杂志文章,已发布勘误

    doi：10.1038/s41467-017-02133-8

    authors： Quérard J,Zhang R,Kelemen Z,Plamont MA,Xie X,Chouket R,Roemgens I,Korepina Y,Albright S,Ipendey E,Volovitch M,Sladitschek HL,Neveu P,Gissot L,Gautier A,Faure JD,Croquette V,Le Saux T,Jullien L

    更新日期：2017-12-14 00:00:00

  • Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference.

    abstract：:The complete human genome sequence is used as a reference for next-generation sequencing analyses. However, some ethnic ancestries are under-represented in the reference genome (e.g., GRCh37) due to its bias toward European and African ancestries. Here, we perform de novo assembly of three Japanese male genomes using ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20146-8

    authors： Takayama J,Tadaka S,Yano K,Katsuoka F,Gocho C,Funayama T,Makino S,Okamura Y,Kikuchi A,Sugimoto S,Kawashima J,Otsuki A,Sakurai-Yageta M,Yasuda J,Kure S,Kinoshita K,Yamamoto M,Tamiya G

    更新日期：2021-01-11 00:00:00

  • miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models.

    abstract：:Functional depletion of the alternative splicing factors Muscleblind-like (MBNL 1 and 2) is at the basis of the neuromuscular disease myotonic dystrophy type 1 (DM1). We previously showed the efficacy of miRNA downregulation in Drosophila DM1 model. Here, we screen for miRNAs that regulate MBNL1 and MBNL2 in HeLa cell...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-04892-4

    authors： Cerro-Herreros E,Sabater-Arcis M,Fernandez-Costa JM,Moreno N,Perez-Alonso M,Llamusi B,Artero R

    更新日期：2018-06-26 00:00:00

  • Pioneer glutamatergic cells develop into a morpho-functionally distinct population in the juvenile CA3 hippocampus.

    abstract：:The developing CA3 hippocampus is comprised by highly connected hub neurons that are particularly effective in achieving network synchronization. Functional hub neurons were shown to be exclusively GABAergic, suggesting that the contribution of glutamatergic neurons to physiological synchronization processes at early ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2318

    authors： Marissal T,Bonifazi P,Picardo MA,Nardou R,Petit LF,Baude A,Fishell GJ,Ben-Ari Y,Cossart R

    更新日期：2012-01-01 00:00:00

  • PPARγ is an E3 ligase that induces the degradation of NFκB/p65.

    abstract：:Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. Th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2270

    authors： Hou Y,Moreau F,Chadee K

    更新日期：2012-01-01 00:00:00

  • A strategy to discover new organizers identifies a putative heart organizer.

    abstract：:Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablatio...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12656

    authors： Anderson C,Khan MAF,Wong F,Solovieva T,Oliveira NMM,Baldock RA,Tickle C,Burt DW,Stern CD

    更新日期：2016-08-25 00:00:00

  • MURC deficiency in smooth muscle attenuates pulmonary hypertension.

    abstract：:Emerging evidence suggests that caveolin-1 (Cav1) is associated with pulmonary arterial hypertension. MURC (also called Cavin-4) is a member of the cavin family, which regulates caveolar formation and functions together with caveolins. Here, we show that hypoxia increased Murc mRNA expression in the mouse lung, and th...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12417

    authors： Nakanishi N,Ogata T,Naito D,Miyagawa K,Taniguchi T,Hamaoka T,Maruyama N,Kasahara T,Nishi M,Matoba S,Ueyama T

    更新日期：2016-08-22 00:00:00

  • Emergence of orbital angular moment at van Hove singularity in graphene/h-BN moiré superlattice.

    abstract：:Bloch electrons lacking inversion symmetry exhibit orbital magnetic moments owing to the rotation around their center of mass; this moment induces a valley splitting in a magnetic field. For the graphene/h-BN moiré superlattice, inversion symmetry is broken by the h-BN. The superlattice potential generates a series of...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19043-x

    authors： Moriya R,Kinoshita K,Crosse JA,Watanabe K,Taniguchi T,Masubuchi S,Moon P,Koshino M,Machida T

    更新日期：2020-10-23 00:00:00

  • Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics.

    abstract：:Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18718-9

    authors： Kato A,Adachi S,Kawano S,Takeshima K,Watanabe M,Kitazume S,Sato R,Kusano H,Koyanagi N,Maruzuru Y,Arii J,Hatta T,Natsume T,Kawaguchi Y

    更新日期：2020-09-29 00:00:00

  • Efficient non-Markovian quantum dynamics using time-evolving matrix product operators.

    abstract：:In order to model realistic quantum devices it is necessary to simulate quantum systems strongly coupled to their environment. To date, most understanding of open quantum systems is restricted either to weak system-bath couplings or to special cases where specific numerical techniques become effective. Here we present...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-05617-3

    authors： Strathearn A,Kirton P,Kilda D,Keeling J,Lovett BW

    更新日期：2018-08-20 00:00:00

  • Amplified seasonal cycle in hydroclimate over the Amazon river basin and its plume region.

    abstract：:The Amazon river basin receives ~2000 mm of precipitation annually and contributes ~17% of global river freshwater input to the oceans; its hydroclimatic variations can exert profound impacts on the marine ecosystem in the Amazon plume region (APR) and have potential far-reaching influences on hydroclimate over the tr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18187-0

    authors： Liang YC,Lo MH,Lan CW,Seo H,Ummenhofer CC,Yeager S,Wu RJ,Steffen JD

    更新日期：2020-09-01 00:00:00

  • Collective dynamics of strain-coupled nanomechanical pillar resonators.

    abstract：:Semiconductur nano- and micropillars represent a promising platform for hybrid nanodevices. Their ability to couple to a broad variety of nanomechanical, acoustic, charge, spin, excitonic, polaritonic, or electromagnetic excitations is utilized in fields as diverse as force sensing or optoelectronics. In order to full...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13309-9

    authors： Doster J,Hoenl S,Lorenz H,Paulitschke P,Weig EM

    更新日期：2019-11-20 00:00:00

  • New particle formation in the remote marine boundary layer.

    abstract：:Marine low clouds play an important role in the climate system, and their properties are sensitive to cloud condensation nuclei concentrations. While new particle formation represents a major source of cloud condensation nuclei globally, the prevailing view is that new particle formation rarely occurs in remote marine...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20773-1

    authors： Zheng G,Wang Y,Wood R,Jensen MP,Kuang C,McCoy IL,Matthews A,Mei F,Tomlinson JM,Shilling JE,Zawadowicz MA,Crosbie E,Moore R,Ziemba L,Andreae MO,Wang J

    更新日期：2021-01-22 00:00:00

  • Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation.

    abstract：:The spatial organization of chromosomes has key functional roles, yet how chromosomes fold remains poorly understood at the single-molecule level. Here, we employ models of polymer physics to investigate DNA loci in human HCT116 and IMR90 wild-type and cohesin depleted cells. Model predictions on single-molecule struc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17141-4

    authors： Conte M,Fiorillo L,Bianco S,Chiariello AM,Esposito A,Nicodemi M

    更新日期：2020-07-03 00:00:00

  • Long-range ballistic transport of Brown-Zak fermions in graphene superlattices.

    abstract：:In quantizing magnetic fields, graphene superlattices exhibit a complex fractal spectrum often referred to as the Hofstadter butterfly. It can be viewed as a collection of Landau levels that arise from quantization of Brown-Zak minibands recurring at rational (p/q) fractions of the magnetic flux quantum per superlatti...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-19604-0

    authors： Barrier J,Kumaravadivel P,Krishna Kumar R,Ponomarenko LA,Xin N,Holwill M,Mullan C,Kim M,Gorbachev RV,Thompson MD,Prance JR,Taniguchi T,Watanabe K,Grigorieva IV,Novoselov KS,Mishchenko A,Fal'ko VI,Geim AK,Berdyugin AI

    更新日期：2020-11-13 00:00:00

  • Self-similarity of contact line depinning from textured surfaces.

    abstract：:The mobility of drops on surfaces is important in many biological and industrial processes, but the phenomena governing their adhesion, which is dictated by the morphology of the three-phase contact line, remain unclear. Here we describe a technique for measuring the dynamic behaviour of the three-phase contact line a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2482

    authors： Paxson AT,Varanasi KK

    更新日期：2013-01-01 00:00:00

  • Drug and disease signature integration identifies synergistic combinations in glioblastoma.

    abstract：:Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could benefit greatly from patient-specific targeted therapies that maximize treatment efficacy. Here we report a platform termed SynergySeq to identi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07659-z

    authors： Stathias V,Jermakowicz AM,Maloof ME,Forlin M,Walters W,Suter RK,Durante MA,Williams SL,Harbour JW,Volmar CH,Lyons NJ,Wahlestedt C,Graham RM,Ivan ME,Komotar RJ,Sarkaria JN,Subramanian A,Golub TR,Schürer SC,Ayad NG

    更新日期：2018-12-14 00:00:00

  • MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB.

    abstract：:Autophagy is the major cellular pathway by which macromolecules are degraded, and amino acid depletion powerfully activates autophagy. MAP4K3, or germinal-center kinase-like kinase, is required for robust cell growth in response to amino acids, but the basis for MAP4K3 regulation of cellular metabolic disposition rema...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03340-7

    authors： Hsu CL,Lee EX,Gordon KL,Paz EA,Shen WC,Ohnishi K,Meisenhelder J,Hunter T,La Spada AR

    更新日期：2018-03-05 00:00:00

  • The viral protein corona directs viral pathogenesis and amyloid aggregation.

    abstract：:Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncy...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10192-2

    authors： Ezzat K,Pernemalm M,Pålsson S,Roberts TC,Järver P,Dondalska A,Bestas B,Sobkowiak MJ,Levänen B,Sköld M,Thompson EA,Saher O,Kari OK,Lajunen T,Sverremark Ekström E,Nilsson C,Ishchenko Y,Malm T,Wood MJA,Power UF,Masic

    更新日期：2019-05-27 00:00:00

  • Carrier multiplication detected through transient photocurrent in device-grade films of lead selenide quantum dots.

    abstract：:In carrier multiplication, the absorption of a single photon results in two or more electron-hole pairs. Quantum dots are promising materials for implementing carrier multiplication principles in real-life technologies. So far, however, most of research in this area has focused on optical studies of solution samples w...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9185

    authors： Gao J,Fidler AF,Klimov VI

    更新日期：2015-09-08 00:00:00

  • Actin-based confinement of calcium responses during Shigella invasion.

    abstract：:Shigella, the agent of bacillary dysentery, invades epithelial cells by locally inducing actin reorganization. Upon cell invasion, Shigella induces calcium (Ca(2+)) signalling, but its role in invasion has remained unclear. Here we show that components involved in inositol 1, 4, 5- trisphosphate (InsP3) signalling are...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2561

    authors： Tran Van Nhieu G,Kai Liu B,Zhang J,Pierre F,Prigent S,Sansonetti P,Erneux C,Kuk Kim J,Suh PG,Dupont G,Combettes L

    更新日期：2013-01-01 00:00:00

  • Interfacial Fe5C2-Cu catalysts toward low-pressure syngas conversion to long-chain alcohols.

    abstract：:Long-chain alcohols synthesis (LAS, C5+OH) from syngas provides a promising route for the conversion of coal/biomass/natural gas into high-value chemicals. Cu-Fe binary catalysts, with the merits of cost effectiveness and high CO conversion, have attracted considerable attention. Here we report a nano-construct of a F...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13691-4

    authors： Li Y,Gao W,Peng M,Zhang J,Sun J,Xu Y,Hong S,Liu X,Liu X,Wei M,Zhang B,Ma D

    更新日期：2020-01-03 00:00:00

  • Coherence and modality of driven interlayer-coupled magnetic vortices.

    abstract：:The high-frequency dynamics of mode-coupled magnetic vortices have generated great interest for spintronic technologies, such as spin-torque nano-oscillators. While the spectroscopic characteristics of vortex oscillators have been reported, direct imaging of driven coupled magnetic quasi-particles is essential to the ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4760

    authors： Pulecio JF,Warnicke P,Pollard SD,Arena DA,Zhu Y

    更新日期：2014-04-30 00:00:00

  • Formation pathways of mesoporous silica nanoparticles with dodecagonal tiling.

    abstract：:Considerable progress in the fabrication of quasicrystals demonstrates that they can be realized in a broad range of materials. However, the development of chemistries enabling direct experimental observation of early quasicrystal growth pathways remains challenging. Here, we report the synthesis of four surfactant-di...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00351-8

    authors： Sun Y,Ma K,Kao T,Spoth KA,Sai H,Zhang D,Kourkoutis LF,Elser V,Wiesner U

    更新日期：2017-08-15 00:00:00

  • A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis.

    abstract：:YUCCA (YUC) proteins constitute a family of flavin monooxygenases (FMOs), with an important role in auxin (IAA) biosynthesis. Here we report that Arabidopsis plants overexpressing YUC6 display enhanced IAA-related phenotypes and exhibit improved drought stress tolerance, low rate of water loss and controlled ROS accum...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9041

    authors： Cha JY,Kim WY,Kang SB,Kim JI,Baek D,Jung IJ,Kim MR,Li N,Kim HJ,Nakajima M,Asami T,Sabir JS,Park HC,Lee SY,Bohnert HJ,Bressan RA,Pardo JM,Yun DJ

    更新日期：2015-08-28 00:00:00

  • Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction.

    abstract：:The interior of the neuronal cell nucleus is a highly organized three-dimensional (3D) structure where regions of the genome that are linearly millions of bases apart establish sub-structures with specialized functions. To investigate neuronal chromatin organization and dynamics in vivo, we generated bitransgenic mice...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5450

    authors： Ito S,Magalska A,Alcaraz-Iborra M,Lopez-Atalaya JP,Rovira V,Contreras-Moreira B,Lipinski M,Olivares R,Martinez-Hernandez J,Ruszczycki B,Lujan R,Geijo-Barrientos E,Wilczynski GM,Barco A

    更新日期：2014-07-18 00:00:00

  • Licensing MLH1 sites for crossover during meiosis.

    abstract：:During meiosis, homologous chromosomes synapse and recombine at sites marked by the binding of the mismatch repair protein MLH1. In hexaploid wheat, the Ph1 locus has a major effect on whether crossover occurs between homologues or between related homoeologues. Here we report that--in wheat-rye hybrids where homologue...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5580

    authors： Martín AC,Shaw P,Phillips D,Reader S,Moore G

    更新日期：2014-08-06 00:00:00

  • Urban areas as hotspots for bees and pollination but not a panacea for all insects.

    abstract：:Urbanisation is an important global driver of biodiversity change, negatively impacting some species groups whilst providing opportunities for others. Yet its impact on ecosystem services is poorly investigated. Here, using a replicated experimental design, we test how Central European cities impact flying insects and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14496-6

    authors： Theodorou P,Radzevičiūtė R,Lentendu G,Kahnt B,Husemann M,Bleidorn C,Settele J,Schweiger O,Grosse I,Wubet T,Murray TE,Paxton RJ

    更新日期：2020-01-29 00:00:00

  • Tuning thermal conductivity in molybdenum disulfide by electrochemical intercalation.

    abstract：:Thermal conductivity of two-dimensional (2D) materials is of interest for energy storage, nanoelectronics and optoelectronics. Here, we report that the thermal conductivity of molybdenum disulfide can be modified by electrochemical intercalation. We observe distinct behaviour for thin films with vertically aligned bas...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13211

    authors： Zhu G,Liu J,Zheng Q,Zhang R,Li D,Banerjee D,Cahill DG

    更新日期：2016-10-21 00:00:00