当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I.

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I.

Abstract：

:A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and then from the centromere region in meiosis II. Centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage, in order to maintain sister chromatids together until their separation in meiosis II. Failures in step-wise cohesin removal result in aneuploid gametes, preventing the generation of healthy embryos. Here, we report that kinase activities of Bub1 and Mps1 are required for Sgo2 localisation to the centromere region. Mps1 inhibitor-treated oocytes are defective in centromeric cohesin protection, whereas oocytes devoid of Bub1 kinase activity, which cannot phosphorylate H2A at T121, are not perturbed in cohesin protection as long as Mps1 is functional. Mps1 and Bub1 kinase activities localise Sgo2 in meiosis I preferentially to the centromere and pericentromere respectively, indicating that Sgo2 at the centromere is required for protection.In meiosis I centromeric cohesin is protected by Sgo2 from Separase-mediated cleavage ensuring that sister chromatids are kept together until their separation in meiosis II. Here the authors demonstrate that Bub1 and Mps1 kinase activities are required for Sgo2 localisation to the centromere region.

journal_name

Nat Commun

journal_title

Nature communications

authors

El Yakoubi W,Buffin E,Cladière D,Gryaznova Y,Berenguer I,Touati SA,Gómez R,Suja JA,van Deursen JM,Wassmann K

doi

10.1038/s41467-017-00774-3

subject

Has Abstract

pub_date

2017-09-25 00:00:00

pages

694

issue

1

issn

2041-1723

pii

10.1038/s41467-017-00774-3

journal_volume

8

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Survival probability of stochastic processes beyond persistence exponents.

    abstract：:For many stochastic processes, the probability [Formula: see text] of not-having reached a target in unbounded space up to time [Formula: see text] follows a slow algebraic decay at long times, [Formula: see text]. This is typically the case of symmetric compact (i.e. recurrent) random walks. While the persistence exp...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-10841-6

    authors： Levernier N,Dolgushev M,Bénichou O,Voituriez R,Guérin T

    更新日期：2019-07-05 00:00:00

  • Molecular determinants for the strictly compartmentalized expression of kainate receptors in CA3 pyramidal cells.

    abstract：:Distinct subtypes of ionotropic glutamate receptors can segregate to specific synaptic inputs in a given neuron. Using functional mapping by focal glutamate uncaging in CA3 pyramidal cells (PCs), we observe that kainate receptors (KARs) are strictly confined to the postsynaptic elements of mossy fibre (mf) synapses an...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12738

    authors： Fièvre S,Carta M,Chamma I,Labrousse V,Thoumine O,Mulle C

    更新日期：2016-09-27 00:00:00

  • Single-cell mass cytometry and transcriptome profiling reveal the impact of graphene on human immune cells.

    abstract：:Understanding the biomolecular interactions between graphene and human immune cells is a prerequisite for its utilization as a diagnostic or therapeutic tool. To characterize the complex interactions between graphene and immune cells, we propose an integrative analytical pipeline encompassing the evaluation of molecul...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01015-3

    authors： Orecchioni M,Bedognetti D,Newman L,Fuoco C,Spada F,Hendrickx W,Marincola FM,Sgarrella F,Rodrigues AF,Ménard-Moyon C,Cesareni G,Kostarelos K,Bianco A,Delogu LG

    更新日期：2017-10-24 00:00:00

  • Interactions between Twist and other core epithelial-mesenchymal transition factors are controlled by GSK3-mediated phosphorylation.

    abstract：:A subset of transcription factors classified as neural crest 'specifiers' are also core epithelial-mesenchymal transition regulatory factors, both in the neural crest and in tumour progression. The bHLH factor Twist is among the least well studied of these factors. Here we demonstrate that Twist is required for crania...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2543

    authors： Lander R,Nasr T,Ochoa SD,Nordin K,Prasad MS,Labonne C

    更新日期：2013-01-01 00:00:00

  • Truly work-like work extraction via a single-shot analysis.

    abstract：:The work content of non-equilibrium systems in relation to a heat bath is often analysed in terms of expectation values of an underlying random work variable. However, when optimizing the expectation value of the extracted work, the resulting extraction process is subject to intrinsic fluctuations, uniquely determined...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2712

    authors： Aberg J

    更新日期：2013-01-01 00:00:00

  • Author Correction: The future of Blue Carbon science.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-13126-0

    authors： Macreadie PI,Anton A,Raven JA,Beaumont N,Connolly RM,Friess DA,Kelleway JJ,Kennedy H,Kuwae T,Lavery PS,Lovelock CE,Smale DA,Apostolaki ET,Atwood TB,Baldock J,Bianchi TS,Chmura GL,Eyre BD,Fourqurean JW,Hall-Spencer J

    更新日期：2019-11-08 00:00:00

  • The function of zebra stripes.

    abstract：:Despite over a century of interest, the function of zebra stripes has never been examined systematically. Here we match variation in striping of equid species and subspecies to geographic range overlap of environmental variables in multifactor models controlling for phylogeny to simultaneously test the five major expl...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4535

    authors： Caro T,Izzo A,Reiner RC Jr,Walker H,Stankowich T

    更新日期：2014-04-01 00:00:00

  • Epigenetic engineering reveals a balance between histone modifications and transcription in kinetochore maintenance.

    abstract：:Centromeres consist of specialized centrochromatin containing CENP-A nucleosomes intermingled with H3 nucleosomes carrying transcription-associated modifications. We have designed a novel synthetic biology 'in situ epistasis' analysis in which H3 dimethylated on lysine 4 (H3K4me2) demethylase LSD2 plus synthetic modul...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms13334

    authors： Molina O,Vargiu G,Abad MA,Zhiteneva A,Jeyaprakash AA,Masumoto H,Kouprina N,Larionov V,Earnshaw WC

    更新日期：2016-11-14 00:00:00

  • Spt6 is a maintenance factor for centromeric CENP-A.

    abstract：:Replication and transcription of genomic DNA requires partial disassembly of nucleosomes to allow progression of polymerases. This presents both an opportunity to remodel the underlying chromatin and a danger of losing epigenetic information. Centromeric transcription is required for stable incorporation of the centro...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16695-7

    authors： Bobkov GOM,Huang A,van den Berg SJW,Mitra S,Anselm E,Lazou V,Schunter S,Feederle R,Imhof A,Lusser A,Jansen LET,Heun P

    更新日期：2020-06-10 00:00:00

  • Magnetically driven active topography for long-term biofilm control.

    abstract：:Microbial biofilm formation on indwelling medical devices causes persistent infections that cannot be cured with conventional antibiotics. To address this unmet challenge, we engineer tunable active surface topographies with micron-sized pillars that can beat at a programmable frequency and force level in an electroma...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-16055-5

    authors： Gu H,Lee SW,Carnicelli J,Zhang T,Ren D

    更新日期：2020-05-05 00:00:00

  • Blending of animal colour patterns by hybridization.

    abstract：:Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1071

    authors： Miyazawa S,Okamoto M,Kondo S

    更新日期：2010-09-07 00:00:00

  • Author Correction: SREBP1 drives keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer.

    abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title：Nature communications

    pub_type： 已发布勘误

    doi：10.1038/s41467-019-11801-w

    authors： Perone Y,Farrugia AJ,Rodríguez-Meira A,Győrffy B,Ion C,Uggetti A,Chronopoulos A,Marrazzo P,Faronato M,Shousha S,Davies C,Steel JH,Patel N,Del Rio Hernandez A,Coombes C,Pruneri G,Lim A,Calvo F,Magnani L

    更新日期：2019-08-19 00:00:00

  • The genetic architecture of human brainstem structures and their involvement in common brain disorders.

    abstract：:Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pon...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17376-1

    authors： Elvsåshagen T,Bahrami S,van der Meer D,Agartz I,Alnæs D,Barch DM,Baur-Streubel R,Bertolino A,Beyer MK,Blasi G,Borgwardt S,Boye B,Buitelaar J,Bøen E,Celius EG,Cervenka S,Conzelmann A,Coynel D,Di Carlo P,Djurovic S,

    更新日期：2020-08-11 00:00:00

  • Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform.

    abstract：:The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mammary duct in proximit...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17102-x

    authors： Kutys ML,Polacheck WJ,Welch MK,Gagnon KA,Koorman T,Kim S,Li L,McClatchey AI,Chen CS

    更新日期：2020-07-06 00:00:00

  • Blocking transport resonances via Kondo many-body entanglement in quantum dots.

    abstract：:Many-body entanglement is at the heart of the Kondo effect, which has its hallmark in quantum dots as a zero-bias conductance peak at low temperatures. It signals the emergence of a conducting singlet state formed by a localized dot degree of freedom and conduction electrons. Carbon nanotubes offer the possibility to ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12442

    authors： Niklas M,Smirnov S,Mantelli D,Margańska M,Nguyen NV,Wernsdorfer W,Cleuziou JP,Grifoni M

    更新日期：2016-08-16 00:00:00

  • Stereoselective photoredox ring-opening polymerization of O-carboxyanhydrides.

    abstract：:Biodegradable polyesters with various tacticities have been synthesized by means of stereoselective ring-opening polymerization of racemic lactide and β-lactones but with limited side-chain groups. However, stereoselective synthesis of functional polyesters remains challenging from O-carboxyanhydrides that have abunda...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03879-5

    authors： Feng Q,Yang L,Zhong Y,Guo D,Liu G,Xie L,Huang W,Tong R

    更新日期：2018-04-19 00:00:00

  • Frequency-dependent recruitment of V2a interneurons during fictive locomotion in the mouse spinal cord.

    abstract：:The principles governing the recruitment of interneurons during acceleration in vertebrate locomotion are unknown. In the mouse, the V2a spinal interneurons are dispensable for left-right coordination at low locomotor frequencies, but their function is essential for maintaining left-right coordination at high frequenc...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1276

    authors： Zhong G,Sharma K,Harris-Warrick RM

    更新日期：2011-01-01 00:00:00

  • Very-Low-Frequency transmitters bifurcate energetic electron belt in near-earth space.

    abstract：:Very-Low-Frequency (VLF) transmitters operate worldwide mostly at frequencies of 10-30 kilohertz for submarine communications. While it has been of intense scientific interest and practical importance to understand whether VLF transmitters can affect the natural environment of charged energetic particles, for decades ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-18545-y

    authors： Hua M,Li W,Ni B,Ma Q,Green A,Shen X,Claudepierre SG,Bortnik J,Gu X,Fu S,Xiang Z,Reeves GD

    更新日期：2020-09-24 00:00:00

  • Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

    abstract：:Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a...

    journal_title：Nature communications

    pub_type： 杂志文章,meta分析

    doi：10.1038/s41467-018-04109-8

    authors： Dadaev T,Saunders EJ,Newcombe PJ,Anokian E,Leongamornlert DA,Brook MN,Cieza-Borrella C,Mijuskovic M,Wakerell S,Olama AAA,Schumacher FR,Berndt SI,Benlloch S,Ahmed M,Goh C,Sheng X,Zhang Z,Muir K,Govindasami K,Lophatan

    更新日期：2018-06-11 00:00:00

  • How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin.

    abstract：:Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so. Here, we map all single amino-acid mutations that increase resistance to broad a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-03665-3

    authors： Doud MB,Lee JM,Bloom JD

    更新日期：2018-04-11 00:00:00

  • IL-17-producing γδ T cells enhance bone regeneration.

    abstract：:Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the specific immune cell subsets and mediators of healing are not en...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10928

    authors： Ono T,Okamoto K,Nakashima T,Nitta T,Hori S,Iwakura Y,Takayanagi H

    更新日期：2016-03-11 00:00:00

  • Spatially inhomogeneous competition between superconductivity and the charge density wave in YBa2Cu3O6.67.

    abstract：:The charge density wave in the high-temperature superconductor YBa2Cu3O7-x (YBCO) has two different ordering tendencies differentiated by their c-axis correlations. These correspond to ferro- (F-CDW) and antiferro- (AF-CDW) couplings between CDWs in neighbouring CuO2 bilayers. This discovery has prompted several funda...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14536-1

    authors： Choi J,Ivashko O,Blackburn E,Liang R,Bonn DA,Hardy WN,Holmes AT,Christensen NB,Hücker M,Gerber S,Gutowski O,Rütt U,Zimmermann MV,Forgan EM,Hayden SM,Chang J

    更新日期：2020-02-20 00:00:00

  • Self-assembly of DNA nanotubes with controllable diameters.

    abstract：:The synthesis of DNA nanotubes is an important area in nanobiotechnology. Different methods to assemble DNA nanotubes have been reported, and control over the width of the nanotubes has been achieved by programmed subunits of DNA tiles. Here we report the self-assembly of DNA nanotubes with controllable diameters. The...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms1535

    authors： Wilner OI,Orbach R,Henning A,Teller C,Yehezkeli O,Mertig M,Harries D,Willner I

    更新日期：2011-11-15 00:00:00

  • Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity.

    abstract：:Previous transcriptomic profiling studies have typically focused on separately analyzing mRNA expression, alternative splicing and alternative polyadenylation differences between cell and tissue types. However, the relative contribution of these three transcriptomic regulatory layers to cell type specification is poor...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20483-8

    authors： Ha KCH,Sterne-Weiler T,Morris Q,Weatheritt RJ,Blencowe BJ

    更新日期：2021-01-12 00:00:00

  • Cavity-control of interlayer excitons in van der Waals heterostructures.

    abstract：:Monolayer transition metal dichalcogenides integrated in optical microcavities host exciton-polaritons as a hallmark of the strong light-matter coupling regime. Analogous concepts for hybrid light-matter systems employing spatially indirect excitons with a permanent electric dipole moment in heterobilayer crystals pro...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11620-z

    authors： Förg M,Colombier L,Patel RK,Lindlau J,Mohite AD,Yamaguchi H,Glazov MM,Hunger D,Högele A

    更新日期：2019-08-16 00:00:00

  • Constant-intensity waves and their modulation instability in non-Hermitian potentials.

    abstract：:In all of the diverse areas of science where waves play an important role, one of the most fundamental solutions of the corresponding wave equation is a stationary wave with constant intensity. The most familiar example is that of a plane wave propagating in free space. In the presence of any Hermitian potential, a wa...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms8257

    authors： Makris KG,Musslimani ZH,Christodoulides DN,Rotter S

    更新日期：2015-07-08 00:00:00

  • Microbial abundance, activity and population genomic profiling with mOTUs2.

    abstract：:Metagenomic sequencing has greatly improved our ability to profile the composition of environmental and host-associated microbial communities. However, the dependency of most methods on reference genomes, which are currently unavailable for a substantial fraction of microbial species, introduces estimation biases. We ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08844-4

    authors： Milanese A,Mende DR,Paoli L,Salazar G,Ruscheweyh HJ,Cuenca M,Hingamp P,Alves R,Costea PI,Coelho LP,Schmidt TSB,Almeida A,Mitchell AL,Finn RD,Huerta-Cepas J,Bork P,Zeller G,Sunagawa S

    更新日期：2019-03-04 00:00:00

  • Optical patterning of trapped charge in nitrogen-doped diamond.

    abstract：:The nitrogen-vacancy (NV) centre in diamond is emerging as a promising platform for solid-state quantum information processing and nanoscale metrology. Of interest in these applications is the manipulation of the NV charge, which can be attained by optical excitation. Here, we use two-colour optical microscopy to inve...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12660

    authors： Jayakumar H,Henshaw J,Dhomkar S,Pagliero D,Laraoui A,Manson NB,Albu R,Doherty MW,Meriles CA

    更新日期：2016-08-30 00:00:00

  • Neural processes mediating contextual influences on human choice behaviour.

    abstract：:Contextual influences on choice are ubiquitous in ecological settings. Current evidence suggests that subjective values are normalized with respect to the distribution of potentially available rewards. However, how this context-sensitivity is realised in the brain remains unknown. To address this, here we examine func...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12416

    authors： Rigoli F,Friston KJ,Dolan RJ

    更新日期：2016-08-18 00:00:00

  • Direct imaging of structural disordering and heterogeneous dynamics of fullerene molecular liquid.

    abstract：:Structural rearrangements govern the various properties of disordered systems and visualization of these dynamical processes can provide critical information on structural deformation and phase transformation of the systems. However, direct imaging of individual atoms or molecules in a disordered state is quite challe...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12320-4

    authors： Choe J,Lee Y,Park J,Kim Y,Kim CU,Kim K

    更新日期：2019-09-27 00:00:00