Abstract:
:The cellular mechanisms driving cardiac tissue formation remain poorly understood, largely due to the structural and functional complexity of the heart. It is unclear whether newly generated myocytes originate from cardiac stem/progenitor cells or from pre-existing cardiomyocytes that re-enter the cell cycle. Here, we identify the source of new cardiomyocytes during mouse development and after injury. Our findings suggest that cardiac progenitors maintain proliferative potential and are the main source of cardiomyocytes during development; however, the onset of αMHC expression leads to reduced cycling capacity. Single-cell RNA sequencing reveals a proliferative, "progenitor-like" population abundant in early embryonic stages that decreases to minimal levels postnatally. Furthermore, cardiac injury by ligation of the left anterior descending artery was found to activate cardiomyocyte proliferation in neonatal but not adult mice. Our data suggest that clonal dominance of differentiating progenitors mediates cardiac development, while a distinct subpopulation of cardiomyocytes may have the potential for limited proliferation during late embryonic development and shortly after birth.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Sereti KI,Nguyen NB,Kamran P,Zhao P,Ranjbarvaziri S,Park S,Sabri S,Engel JL,Sung K,Kulkarni RP,Ding Y,Hsiai TK,Plath K,Ernst J,Sahoo D,Mikkola HKA,Iruela-Arispe ML,Ardehali Rdoi
10.1038/s41467-018-02891-zsubject
Has Abstractpub_date
2018-02-21 00:00:00pages
754issue
1issn
2041-1723pii
10.1038/s41467-018-02891-zjournal_volume
9pub_type
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