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Unconventionally secreted effectors of two filamentous pathogens target plant salicylate biosynthesis.

Abstract：

:Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we show that Phytophthora sojae and Verticillium dahliae secrete isochorismatases (PsIsc1 and VdIsc1, respectively) that are required for full pathogenesis. PsIsc1 and VdIsc1 can suppress salicylate-mediated innate immunity in planta and hydrolyse isochorismate in vitro. A conserved triad of catalytic residues is essential for both functions. Thus, the two proteins are isochorismatase effectors that disrupt the plant salicylate metabolism pathway by suppressing its precursor. Furthermore, these proteins lack signal peptides, but exhibit characteristics that lead to unconventional secretion. Therefore, this secretion pathway is a novel mechanism for delivering effectors and might play an important role in host-pathogen interactions.

journal_name

Nat Commun

journal_title

Nature communications

authors

Liu T,Song T,Zhang X,Yuan H,Su L,Li W,Xu J,Liu S,Chen L,Chen T,Zhang M,Gu L,Zhang B,Dou D

doi

10.1038/ncomms5686

subject

Has Abstract

pub_date

2014-08-26 00:00:00

pages

4686

issn

2041-1723

pii

ncomms5686

journal_volume

5

pub_type

杂志文章

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