当前位置： SCI文献检索 > Nature Communications期刊下所有文献 > Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.

Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control.

Abstract：

:Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified in high eukaryotes. Here, we report a mammalian tRNA/rRNA-targeting endoribonuclease: SLFN13, a member of the Schlafen family. Structural study reveals a unique pseudo-dimeric U-pillow-shaped architecture of the SLFN13 N'-domain that may clamp base-paired RNAs. SLFN13 is able to digest tRNAs and rRNAs in vitro, and the endonucleolytic cleavage dissevers 11 nucleotides from the 3'-terminus of tRNA at the acceptor stem. The cytoplasmically localised SLFN13 inhibits protein synthesis in 293T cells. Moreover, SLFN13 restricts HIV replication in a nucleolytic activity-dependent manner. According to these observations, we term SLFN13 RNase S13. Our study provides insights into the modulation of translational machinery in high eukaryotes, and sheds light on the functional mechanisms of the Schlafen family.

journal_name

Nat Commun

journal_title

Nature communications

authors

Yang JY,Deng XY,Li YS,Ma XC,Feng JX,Yu B,Chen Y,Luo YL,Wang X,Chen ML,Fang ZX,Zheng FX,Li YP,Zhong Q,Kang TB,Song LB,Xu RH,Zeng MS,Chen W,Zhang H,Xie W,Gao S

doi

10.1038/s41467-018-03544-x

subject

Has Abstract

pub_date

2018-03-21 00:00:00

pages

1165

issue

1

issn

2041-1723

pii

10.1038/s41467-018-03544-x

journal_volume

9

pub_type

杂志文章

相关文献

Nature Communications文献大全
  • Time-resolved diffraction of shock-released SiO2 and diaplectic glass formation.

    abstract：:Understanding how rock-forming minerals transform under shock loading is critical for modeling collisions between planetary bodies, interpreting the significance of shock features in minerals and for using them as diagnostic indicators of impact conditions, such as shock pressure. To date, our understanding of the for...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-01791-y

    authors： Gleason AE,Bolme CA,Lee HJ,Nagler B,Galtier E,Kraus RG,Sandberg R,Yang W,Langenhorst F,Mao WL

    更新日期：2017-11-14 00:00:00

  • PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis.

    abstract：:Increased aerobic glycolysis in endothelial cells of atheroprone areas of blood vessels has been hypothesized to drive increased inflammation and lesion burden but direct links remain to be established. Here we show that endothelial cells exposed to disturbed flow in vivo and in vitro exhibit increased levels of prote...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07132-x

    authors： Yang Q,Xu J,Ma Q,Liu Z,Sudhahar V,Cao Y,Wang L,Zeng X,Zhou Y,Zhang M,Xu Y,Wang Y,Weintraub NL,Zhang C,Fukai T,Wu C,Huang L,Han Z,Wang T,Fulton DJ,Hong M,Huo Y

    更新日期：2018-11-07 00:00:00

  • Self-assembly of ordered graphene nanodot arrays.

    abstract：:The ability to fabricate nanoscale domains of uniform size in two-dimensional materials could potentially enable new applications in nanoelectronics and the development of innovative metamaterials. However, achieving even minimal control over the growth of two-dimensional lateral heterostructures at such extreme dimen...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-00042-4

    authors： Camilli L,Jørgensen JH,Tersoff J,Stoot AC,Balog R,Cassidy A,Sadowski JT,Bøggild P,Hornekær L

    更新日期：2017-06-29 00:00:00

  • Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration.

    abstract：:The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for understanding cancer vulnerabilities. Integrated analyses of these data to assess differential dependency across genes and cell lines are challenging due to confo...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06916-5

    authors： McFarland JM,Ho ZV,Kugener G,Dempster JM,Montgomery PG,Bryan JG,Krill-Burger JM,Green TM,Vazquez F,Boehm JS,Golub TR,Hahn WC,Root DE,Tsherniak A

    更新日期：2018-11-02 00:00:00

  • Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene.

    abstract：:Acute otitis media (AOM) is among the most common pediatric diseases, and the most frequent reason for antibiotic treatment in children. Risk of AOM is dependent on environmental and host factors, as well as a significant genetic component. We identify genome-wide significance at a locus on 6q25.3 (rs2932989, Pmeta=2....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms12792

    authors： van Ingen G,Li J,Goedegebure A,Pandey R,Li YR,March ME,Jaddoe VW,Bakay M,Mentch FD,Thomas K,Wei Z,Chang X,Hain HS,Uitterlinden AG,Moll HA,van Duijn CM,Rivadeneira F,Raat H,Baatenburg de Jong RJ,Sleiman PM,van der

    更新日期：2016-09-28 00:00:00

  • A molecular gradient along the longitudinal axis of the human hippocampus informs large-scale behavioral systems.

    abstract：:The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the longitudinal axis of the adult human hippocampus can be predicted within 2...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14518-3

    authors： Vogel JW,La Joie R,Grothe MJ,Diaz-Papkovich A,Doyle A,Vachon-Presseau E,Lepage C,Vos de Wael R,Thomas RA,Iturria-Medina Y,Bernhardt B,Rabinovici GD,Evans AC

    更新日期：2020-02-19 00:00:00

  • Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells.

    abstract：:Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immun...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-11157-1

    authors： Liu WL,Zou MZ,Liu T,Zeng JY,Li X,Yu WY,Li CX,Ye JJ,Song W,Feng J,Zhang XZ

    更新日期：2019-07-19 00:00:00

  • IRSp53 controls plasma membrane shape and polarized transport at the nascent lumen in epithelial tubules.

    abstract：:It is unclear whether the establishment of apical-basal cell polarity during the generation of epithelial lumens requires molecules acting at the plasma membrane/actin interface. Here, we show that the I-BAR-containing IRSp53 protein controls lumen formation and the positioning of the polarity determinants aPKC and po...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-17091-x

    authors： Bisi S,Marchesi S,Rizvi A,Carra D,Beznoussenko GV,Ferrara I,Deflorian G,Mironov A,Bertalot G,Pisati F,Oldani A,Cattaneo A,Saberamoli G,Pece S,Viale G,Bachi A,Tripodo C,Scita G,Disanza A

    更新日期：2020-07-14 00:00:00

  • The REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis.

    abstract：:Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a proteasome activator, show significantly attenuated intestinal inflammation and colitis-associated cancer in dextr...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms10761

    authors： Xu J,Zhou L,Ji L,Chen F,Fortmann K,Zhang K,Liu Q,Li K,Wang W,Wang H,Xie W,Wang Q,Liu J,Zheng B,Zhang P,Huang S,Shi T,Zhang B,Dang Y,Chen J,O'Malley BW,Moses RE,Wang P,Li L,Xiao J,Hoffmann A,Li X

    更新日期：2016-02-22 00:00:00

  • Low-buoyancy thermochemical plumes resolve controversy of classical mantle plume concept.

    abstract：:The Earth's biggest magmatic events are believed to originate from massive melting when hot mantle plumes rising from the lowermost mantle reach the base of the lithosphere. Classical models predict large plume heads that cause kilometre-scale surface uplift, and narrow (100 km radius) plume tails that remain in the m...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7960

    authors： Dannberg J,Sobolev SV

    更新日期：2015-04-24 00:00:00

  • Task complexity interacts with state-space uncertainty in the arbitration between model-based and model-free learning.

    abstract：:It has previously been shown that the relative reliability of model-based and model-free reinforcement-learning (RL) systems plays a role in the allocation of behavioral control between them. However, the role of task complexity in the arbitration between these two strategies remains largely unknown. Here, using a com...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13632-1

    authors： Kim D,Park GY,O Doherty JP,Lee SW

    更新日期：2019-12-16 00:00:00

  • A new hypothesis for the origin of Amazonian Dark Earths.

    abstract：:Amazonian Dark Earths (ADEs) are unusually fertile soils characterised by elevated concentrations of microscopic charcoal particles, which confer their distinctive colouration. Frequent occurrences of pre-Columbian artefacts at ADE sites led to their ubiquitous classification as Anthrosols (soils of anthropic origin)....

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-20184-2

    authors： Silva LCR,Corrêa RS,Wright JL,Bomfim B,Hendricks L,Gavin DG,Muniz AW,Martins GC,Motta ACV,Barbosa JZ,Melo VF,Young SD,Broadley MR,Santos RV

    更新日期：2021-01-04 00:00:00

  • Actin-based confinement of calcium responses during Shigella invasion.

    abstract：:Shigella, the agent of bacillary dysentery, invades epithelial cells by locally inducing actin reorganization. Upon cell invasion, Shigella induces calcium (Ca(2+)) signalling, but its role in invasion has remained unclear. Here we show that components involved in inositol 1, 4, 5- trisphosphate (InsP3) signalling are...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms2561

    authors： Tran Van Nhieu G,Kai Liu B,Zhang J,Pierre F,Prigent S,Sansonetti P,Erneux C,Kuk Kim J,Suh PG,Dupont G,Combettes L

    更新日期：2013-01-01 00:00:00

  • Metasurface eyepiece for augmented reality.

    abstract：:Recently, metasurfaces composed of artificially fabricated subwavelength structures have shown remarkable potential for the manipulation of light with unprecedented functionality. Here, we first demonstrate a metasurface application to realize a compact near-eye display system for augmented reality with a wide field o...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-07011-5

    authors： Lee GY,Hong JY,Hwang S,Moon S,Kang H,Jeon S,Kim H,Jeong JH,Lee B

    更新日期：2018-11-01 00:00:00

  • An epitranscriptomic mechanism underlies selective mRNA translation remodelling in melanoma persister cells.

    abstract：:Cancer persister cells tolerate anticancer drugs and serve as the founders of acquired resistance and cancer relapse. Here we show that a subpopulation of BRAFV600 mutant melanoma cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation that evolves in parallel wi...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13360-6

    authors： Shen S,Faouzi S,Bastide A,Martineau S,Malka-Mahieu H,Fu Y,Sun X,Mateus C,Routier E,Roy S,Desaubry L,André F,Eggermont A,David A,Scoazec JY,Vagner S,Robert C

    更新日期：2019-12-16 00:00:00

  • Optical imaging of strain in two-dimensional crystals.

    abstract：:Strain engineering is widely used in material science to tune the (opto-)electronic properties of materials and enhance the performance of devices. Two-dimensional atomic crystals are a versatile playground to study the influence of strain, as they can sustain very large deformations without breaking. Various optical ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-02830-y

    authors： Mennel L,Furchi MM,Wachter S,Paur M,Polyushkin DK,Mueller T

    更新日期：2018-02-06 00:00:00

  • Ice sheets as a significant source of highly reactive nanoparticulate iron to the oceans.

    abstract：:The Greenland and Antarctic Ice Sheets cover ~ 10% of global land surface, but are rarely considered as active components of the global iron cycle. The ocean waters around both ice sheets harbour highly productive coastal ecosystems, many of which are iron limited. Measurements of iron concentrations in subglacial run...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4929

    authors： Hawkings JR,Wadham JL,Tranter M,Raiswell R,Benning LG,Statham PJ,Tedstone A,Nienow P,Lee K,Telling J

    更新日期：2014-05-21 00:00:00

  • Millimetre-long transport of photogenerated carriers in topological insulators.

    abstract：:Excitons are spin integer particles that are predicted to condense into a coherent quantum state at sufficiently low temperature. Here by using photocurrent imaging we report experimental evidence of formation and efficient transport of non-equilibrium excitons in Bi2-xSbxSe3 nanoribbons. The photocurrent distribution...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-13711-3

    authors： Hou Y,Wang R,Xiao R,McClintock L,Clark Travaglini H,Paulus Francia J,Fetsch H,Erten O,Savrasov SY,Wang B,Rossi A,Vishik I,Rotenberg E,Yu D

    更新日期：2019-12-16 00:00:00

  • Multi-cohort study identifies social determinants of systemic inflammation over the life course.

    abstract：:Chronic inflammation has been proposed as having a prominent role in the construction of social inequalities in health. Disentangling the effects of early life and adulthood social disadvantage on inflammation is key in elucidating biological mechanisms underlying socioeconomic disparities. Here we explore the relatio...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-08732-x

    authors： Berger E,Castagné R,Chadeau-Hyam M,Bochud M,d'Errico A,Gandini M,Karimi M,Kivimäki M,Krogh V,Marmot M,Panico S,Preisig M,Ricceri F,Sacerdote C,Steptoe A,Stringhini S,Tumino R,Vineis P,Delpierre C,Kelly-Irving M

    更新日期：2019-02-15 00:00:00

  • Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest.

    abstract：:Mammalian female meiosis is error prone, with rates of meiotic chromosome missegregations strongly increasing towards the end of the reproductive lifespan. A strong reduction of BubR1 has been observed in oocytes of women approaching menopause and in ovaries of aged mice, which led to the hypothesis that a gradual dec...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7946

    authors： Touati SA,Buffin E,Cladière D,Hached K,Rachez C,van Deursen JM,Wassmann K

    更新日期：2015-04-21 00:00:00

  • YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells.

    abstract：:Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. S...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-020-14293-1

    authors： Choi SY,Bae H,Jeong SH,Park I,Cho H,Hong SP,Lee DH,Lee CK,Park JS,Suh SH,Choi J,Yang MJ,Jang JY,Onder L,Moon JH,Jeong HS,Adams RH,Kim JM,Ludewig B,Song JH,Lim DS,Koh GY

    更新日期：2020-01-24 00:00:00

  • Shaping the topology of folding pathways in mechanical systems.

    abstract：:Disordered mechanical systems, when strongly deformed, have complex configuration spaces with multiple stable states and pathways connecting them. The topology of such pathways determines which states are smoothly accessible from any part of configuration space. Controlling this topology would allow us to limit access...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-018-06720-1

    authors： Stern M,Jayaram V,Murugan A

    更新日期：2018-10-16 00:00:00

  • A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism.

    abstract：:Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms9143

    authors： Krarup A,Truan D,Furmanova-Hollenstein P,Bogaert L,Bouchier P,Bisschop IJM,Widjojoatmodjo MN,Zahn R,Schuitemaker H,McLellan JS,Langedijk JPM

    更新日期：2015-09-03 00:00:00

  • BORDER proteins protect expression of neighboring genes by promoting 3' Pol II pausing in plants.

    abstract：:Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms that prevent transcriptional interference are not well understood. Here ...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-019-12328-w

    authors： Yu X,Martin PGP,Michaels SD

    更新日期：2019-09-25 00:00:00

  • Dendritic core-shell nickel-iron-copper metal/metal oxide electrode for efficient electrocatalytic water oxidation.

    abstract：:Electrochemical water splitting requires efficient water oxidation catalysts to accelerate the sluggish kinetics of water oxidation reaction. Here, we report a promisingly dendritic core-shell nickel-iron-copper metal/metal oxide electrode, prepared via dealloying with an electrodeposited nickel-iron-copper alloy as a...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/s41467-017-02429-9

    authors： Zhang P,Li L,Nordlund D,Chen H,Fan L,Zhang B,Sheng X,Daniel Q,Sun L

    更新日期：2018-01-26 00:00:00

  • IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes.

    abstract：:Autophagy, activated by many stresses, plays a critical role in innate immune responses. Here we show that interferon regulatory factor 8 (IRF8) is required for the expression of autophagy-related genes in dendritic cells. Furthermore in macrophages, IRF8 is induced by multiple autophagy-inducing stresses, including I...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms7379

    authors： Gupta M,Shin DM,Ramakrishna L,Goussetis DJ,Platanias LC,Xiong H,Morse HC 3rd,Ozato K

    更新日期：2015-03-16 00:00:00

  • Robust microscale superlubricity under high contact pressure enabled by graphene-coated microsphere.

    abstract：:Superlubricity of graphite and graphene has aroused increasing interest in recent years. Yet how to obtain a long-lasting superlubricity between graphene layers, under high applied normal load in ambient atmosphere still remains a challenge but is highly desirable. Here, we report a direct measurement of sliding frict...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms14029

    authors： Liu SW,Wang HP,Xu Q,Ma TB,Yu G,Zhang C,Geng D,Yu Z,Zhang S,Wang W,Hu YZ,Wang H,Luo J

    更新日期：2017-02-14 00:00:00

  • Room-temperature sub-band gap optoelectronic response of hyperdoped silicon.

    abstract：:Room-temperature infrared sub-band gap photoresponse in silicon is of interest for telecommunications, imaging and solid-state energy conversion. Attempts to induce infrared response in silicon largely centred on combining the modification of its electronic structure via controlled defect formation (for example, vacan...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms4011

    authors： Mailoa JP,Akey AJ,Simmons CB,Hutchinson D,Mathews J,Sullivan JT,Recht D,Winkler MT,Williams JS,Warrender JM,Persans PD,Aziz MJ,Buonassisi T

    更新日期：2014-01-01 00:00:00

  • Glycosphingolipid-functionalized nanoparticles recapitulate CD169-dependent HIV-1 uptake and trafficking in dendritic cells.

    abstract：:Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs). Such interactions, which seem to be independent of viral envelope glycoprotein g...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms5136

    authors： Yu X,Feizpour A,Ramirez NG,Wu L,Akiyama H,Xu F,Gummuluru S,Reinhard BM

    更新日期：2014-06-20 00:00:00

  • Negative Poisson's ratio in 1T-type crystalline two-dimensional transition metal dichalcogenides.

    abstract：:Materials with a negative Poisson's ratio, also known as auxetic materials, exhibit unusual and counterintuitive mechanical behaviour-becoming fatter in cross-section when stretched. Such behaviour is mostly attributed to some special re-entrant or hinged geometric structures regardless of the chemical composition and...

    journal_title：Nature communications

    pub_type： 杂志文章

    doi：10.1038/ncomms15224

    authors： Yu L,Yan Q,Ruzsinszky A

    更新日期：2017-05-25 00:00:00