IRF8 directs stress-induced autophagy in macrophages and promotes clearance of Listeria monocytogenes.

abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...

journal_title：Nature communications

authors： Munck C,Albertsen M,Telke A,Ellabaan M,Nielsen PH,Sommer MOA

更新日期：2015-09-30 00:00:00

abstract：:In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we report a genome editing approach in which adeno-associated virus...

journal_title：Nature communications

authors： Yu W,Mookherjee S,Chaitankar V,Hiriyanna S,Kim JW,Brooks M,Ataeijannati Y,Sun X,Dong L,Li T,Swaroop A,Wu Z

更新日期：2017-03-14 00:00:00

abstract：:Stress granules (SG) are translationally silent sites of RNA triage induced by environmental stresses including viral infection. Here we show that HIV-1 Gag blocks SG assembly irrespective of eIF2α phosphorylation and even when SG assembly is forced by overexpression of Ras-GAP SH3 domain-binding protein (G3BP1) or TI...

journal_title：Nature communications

authors： Valiente-Echeverría F,Melnychuk L,Vyboh K,Ajamian L,Gallouzi IE,Bernard N,Mouland AJ

更新日期：2014-09-17 00:00:00

abstract：:Heterostructured material systems devoid of ferroic components are presumed not to display ordering associated with ferroelectricity. In heterostructures composed of transition metal oxides, however, the disruption introduced by an interface can affect the balance of the competing interactions among electronic spins, ...

journal_title：Nature communications

authors： Rogdakis K,Seo JW,Viskadourakis Z,Wang Y,Qune LF,Choi E,Burton JD,Tsymbal EY,Lee J,Panagopoulos C

更新日期：2012-01-01 00:00:00

abstract：:Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-...

journal_title：Nature communications

authors： Wang J,Zhang Y,Liu H,Shang Y,Zhou L,Wei P,Yin WB,Deng Z,Qu X,Zhou Q

更新日期：2019-07-29 00:00:00

abstract：:Supersymmetry is a conjectured symmetry between bosons and fermions aiming at solving fundamental questions in string and quantum field theory. Its subsequent application to quantum mechanics led to a ground-breaking analysis and design machinery, later fruitfully extrapolated to photonics. In all cases, the algebraic...

journal_title：Nature communications

authors： García-Meca C,Ortiz AM,Sáez RL

更新日期：2020-02-10 00:00:00

abstract：:Tenuazonic acid (TeA) is a well-known mycotoxin produced by various plant pathogenic fungi. However, its biosynthetic gene has been unknown to date. Here we identify the TeA biosynthetic gene from Magnaporthe oryzae by finding two TeA-inducing conditions of a low-producing strain. We demonstrate that TeA is synthesize...

journal_title：Nature communications

authors： Yun CS,Motoyama T,Osada H

更新日期：2015-10-27 00:00:00

abstract：:Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56A...

journal_title：Nature communications

authors： Topal S,Vasseur P,Radman-Livaja M,Peterson CL

更新日期：2019-09-26 00:00:00

abstract：:Sponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symbioses. Here we present a global Porifera microbiome survey, set out to establish the ecological and evolutionary drivers of these host-microbe interactions. We show that sponges are a reservoir of exceptional microbia...

journal_title：Nature communications

authors： Thomas T,Moitinho-Silva L,Lurgi M,Björk JR,Easson C,Astudillo-García C,Olson JB,Erwin PM,López-Legentil S,Luter H,Chaves-Fonnegra A,Costa R,Schupp PJ,Steindler L,Erpenbeck D,Gilbert J,Knight R,Ackermann G,Victor Lopez

更新日期：2016-06-16 00:00:00

abstract：:Carminic acid, a glucosylated anthraquinone found in scale insects like Dactylopius coccus, has since ancient times been used as a red colorant in various applications. Here we show that a membrane-bound C-glucosyltransferase, isolated from D. coccus and designated DcUGT2, catalyzes the glucosylation of flavokermesic ...

journal_title：Nature communications

authors： Kannangara R,Siukstaite L,Borch-Jensen J,Madsen B,Kongstad KT,Staerk D,Bennedsen M,Okkels FT,Rasmussen SA,Larsen TO,Frandsen RJN,Møller BL

更新日期：2017-12-07 00:00:00

abstract：:The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (...

journal_title：Nature communications

authors： Alcala N,Leblay N,Gabriel AAG,Mangiante L,Hervas D,Giffon T,Sertier AS,Ferrari A,Derks J,Ghantous A,Delhomme TM,Chabrier A,Cuenin C,Abedi-Ardekani B,Boland A,Olaso R,Meyer V,Altmuller J,Le Calvez-Kelm F,Durand G,V

更新日期：2019-08-20 00:00:00

abstract：:Excessive nitrogen runoff leads to degraded water quality, harming human and ecosystem health. We examine the impact of changes in land use and land management for six combinations of socioeconomic pathways and climate outcomes, and find that societal choices will substantially impact riverine total nitrogen loading (...

journal_title：Nature communications

authors： Sinha E,Michalak AM,Calvin KV,Lawrence PJ

更新日期：2019-02-26 00:00:00

abstract：:Extensive efforts have been expended in developing hybrid quantum systems to overcome the short coherence time of superconducting circuits by introducing the naturally long-lived spin degree of freedom. Among all the possible materials, single-crystal yttrium iron garnet has shown up recently as a promising candidate ...

journal_title：Nature communications

authors： Zhang X,Zou CL,Zhu N,Marquardt F,Jiang L,Tang HX

更新日期：2015-11-16 00:00:00

abstract：:Long duration gamma-ray bursts (GRBs), the brightest events since the Big Bang itself, are believed to originate in an ultra-relativistic jet breaking out from a massive stellar envelope. Despite decades of study, there is still no consensus on their emission mechanism. One unresolved question is the origin of the tig...

journal_title：Nature communications

authors： Ito H,Matsumoto J,Nagataki S,Warren DC,Barkov MV,Yonetoku D

更新日期：2019-04-03 00:00:00

abstract：:Upon muscle injury, the high mobility group box 1 (HMGB1) protein is upregulated and secreted to initiate reparative responses. Here we show that HMGB1 controls myogenesis both in vitro and in vivo during development and after adult muscle injury. HMGB1 expression in muscle cells is regulated at the translational leve...

journal_title：Nature communications

authors： Dormoy-Raclet V,Cammas A,Celona B,Lian XJ,van der Giessen K,Zivojnovic M,Brunelli S,Riuzzi F,Sorci G,Wilhelm BT,Di Marco S,Donato R,Bianchi ME,Gallouzi IE

更新日期：2013-01-01 00:00:00

abstract：:Dynamic changes in histone modifications under various physiological cues play important roles in gene transcription and cancer. Identification of new histone marks critical for cancer development is of particular importance. Here we show that, in a glucose-dependent manner, E3 ubiquitin ligase NEDD4 ubiquitinates his...

journal_title：Nature communications

authors： Zhang X,Li B,Rezaeian AH,Xu X,Chou PC,Jin G,Han F,Pan BS,Wang CY,Long J,Zhang A,Huang CY,Tsai FJ,Tsai CH,Logothetis C,Lin HK

更新日期：2017-03-16 00:00:00

abstract：:To colonise their host, pathogens must counter local environmental and immunological challenges. Here, we reveal that the fungal pathogen Candida albicans exploits diverse host-associated signals to promote immune evasion by masking of a major pathogen-associated molecular pattern (PAMP), β-glucan. Certain nutrients, ...

journal_title：Nature communications

authors： Pradhan A,Avelar GM,Bain JM,Childers D,Pelletier C,Larcombe DE,Shekhova E,Netea MG,Brown GD,Erwig L,Gow NAR,Brown AJP

更新日期：2019-11-22 00:00:00

abstract：:Accumulating evidence suggests that transcriptional regulation is required for maintenance of long-term memories (LTMs). Here we characterize global transcriptional and epigenetic changes that occur during LTM storage in the Drosophila mushroom bodies (MBs), structures important for memory. Although LTM formation requ...

journal_title：Nature communications

authors： Hirano Y,Ihara K,Masuda T,Yamamoto T,Iwata I,Takahashi A,Awata H,Nakamura N,Takakura M,Suzuki Y,Horiuchi J,Okuno H,Saitoe M

更新日期：2016-11-14 00:00:00

abstract：:No method exists to measure large-scale translation of genes in uncultured organisms in microbiomes. To overcome this limitation, we develop MetaRibo-Seq, a method for simultaneous ribosome profiling of tens to hundreds of organisms in microbiome samples. MetaRibo-Seq was benchmarked against gold-standard Ribo-Seq in ...

journal_title：Nature communications

authors： Fremin BJ,Sberro H,Bhatt AS

更新日期：2020-06-29 00:00:00

abstract：:Previous studies have utilized monoamine oxidase (MAO) and L-3,4-dihydroxyphenylalanine decarboxylase (DDC) for microbe-based production of tetrahydropapaveroline (THP), a benzylisoquinoline alkaloid (BIA) precursor to opioid analgesics. In the current study, a phylogenetically distinct Bombyx mori 3,4-dihydroxyphenyl...

journal_title：Nature communications

authors： Vavricka CJ,Yoshida T,Kuriya Y,Takahashi S,Ogawa T,Ono F,Agari K,Kiyota H,Li J,Ishii J,Tsuge K,Minami H,Araki M,Hasunuma T,Kondo A

更新日期：2019-05-01 00:00:00

abstract：:In patients with damage to the primary visual cortex (V1), residual vision can guide goal-directed movements to targets in the blind field without awareness. This phenomenon has been termed blindsight, and its neural mechanisms are controversial. There should be visual pathways to the higher visual cortices bypassing ...

journal_title：Nature communications

authors： Kinoshita M,Kato R,Isa K,Kobayashi K,Kobayashi K,Onoe H,Isa T

更新日期：2019-01-11 00:00:00

abstract：:The superconducting state is formed by the condensation of Cooper pairs and protected by the superconducting gap. The pairing interaction between the two electrons of a Cooper pair determines the gap function. Thus, it is pivotal to detect the gap structure for understanding the mechanism of superconductivity. In cupr...

journal_title：Nature communications

authors： Gu Q,Wan S,Tang Q,Du Z,Yang H,Wang QH,Zhong R,Wen J,Gu GD,Wen HH

更新日期：2019-04-08 00:00:00

abstract：:Determining nanoscale protein distribution via Photoactivated Localization Microscopy (PALM) mandates precise knowledge of the applied fluorophore's blinking properties to counteract overcounting artifacts that distort the resulting biomolecular distributions. Here, we present a readily applicable methodology to deter...

journal_title：Nature communications

authors： Platzer R,Rossboth BK,Schneider MC,Sevcsik E,Baumgart F,Stockinger H,Schütz GJ,Huppa JB,Brameshuber M

更新日期：2020-10-05 00:00:00

abstract：:Solitary, persistent wave packets called solitons hold potential to transfer information and energy across a wide range of spatial and temporal scales in physical, chemical, and biological systems. Mechanical solitons characteristically emerge either as a single wave packet or uncorrelated propagating topological enti...

journal_title：Nature communications

authors： Zhang Y,Li B,Zheng QS,Genin GM,Chen CQ

更新日期：2019-12-06 00:00:00

abstract：:Despite the success of current therapies for acute myocardial infarction (MI), many patients still develop adverse cardiac remodeling and heart failure. With the growing prevalence of heart failure, a new therapy is needed that can prevent remodeling and support tissue repair. Herein, we report on injectable recombina...

journal_title：Nature communications

authors： McLaughlin S,McNeill B,Podrebarac J,Hosoyama K,Sedlakova V,Cron G,Smyth D,Seymour R,Goel K,Liang W,Rayner KJ,Ruel M,Suuronen EJ,Alarcon EI

更新日期：2019-10-25 00:00:00

abstract：:Prompt identification of acute coronary syndrome is a challenge in clinical practice. The 12-lead electrocardiogram (ECG) is readily available during initial patient evaluation, but current rule-based interpretation approaches lack sufficient accuracy. Here we report machine learning-based methods for the prediction o...

journal_title：Nature communications

authors： Al-Zaiti S,Besomi L,Bouzid Z,Faramand Z,Frisch S,Martin-Gill C,Gregg R,Saba S,Callaway C,Sejdić E

更新日期：2020-08-07 00:00:00

abstract：:Cell-to-cell variability (noise) is an important feature of gene expression that impacts cell fitness and development. The regulatory mechanism of this variability is not fully understood. Here we investigate the effect on gene expression noise in divergent gene pairs (DGPs). We generated reporters driven by divergent...

journal_title：Nature communications

authors： Yan C,Wu S,Pocetti C,Bai L

更新日期：2016-03-24 00:00:00

abstract：:Complex behaviours may be viewed as sequences of modular actions, each elicited by specific sensory cues in their characteristic timescales. From this perspective, we can construct models in which unitary behavioural modules are hierarchically placed in context of related actions. Here, we analyse antennal positioning...

journal_title：Nature communications

authors： Natesan D,Saxena N,Ekeberg Ö,Sane SP

更新日期：2019-12-06 00:00:00

abstract：:The Spitzenkörper (SPK) constitutes a collection of secretory vesicles and polarity-related proteins intimately associated with polarized growth of fungal hyphae. Many SPK-localized proteins are known, but their assembly and dynamics remain poorly understood. Here, we identify protein-protein interaction cascades lead...

journal_title：Nature communications

authors： Zheng P,Nguyen TA,Wong JY,Lee M,Nguyen TA,Fan JS,Yang D,Jedd G

更新日期：2020-06-05 00:00:00

abstract：:The decoy effect is a cognitive bias documented in behavioural economics by which the presence of a third, (partly) inferior choice causes a significant shift in people's preference for other items. Here, we performed an experiment with human volunteers who played a variant of the repeated prisoner's dilemma game in w...

journal_title：Nature communications

authors： Wang Z,Jusup M,Shi L,Lee JH,Iwasa Y,Boccaletti S

更新日期：2018-07-27 00:00:00