Cytomembrane nanovaccines show therapeutic effects by mimicking tumor cells and antigen presenting cells.


:Most cancer vaccines are unsuccessful in eliciting clinically relevant effects. Without using exogenous antigens and adoptive cells, we show a concept of utilizing biologically reprogrammed cytomembranes of the fused cells (FCs) derived from dendritic cells (DCs) and cancer cells as tumor vaccines. The fusion of immunologically interrelated two types of cells results in strong expression of the whole tumor antigen complexes and the immunological co-stimulatory molecules on cytomembranes (FMs), allowing the nanoparticle-supported FM (NP@FM) to function like antigen presenting cells (APCs) for T cell immunoactivation. Moreover, tumor-antigen bearing NP@FM can be bio-recognized by DCs to induce DC-mediated T cell immunoactivation. The combination of these two immunoactivation pathways offers powerful antitumor immunoresponse. Through mimicking both APCs and cancer cells, this cytomembrane vaccine strategy can develop various vaccines toward multiple tumor types and provide chances for accommodating diverse functions originating from the supporters.


Nat Commun


Nature communications


Liu WL,Zou MZ,Liu T,Zeng JY,Li X,Yu WY,Li CX,Ye JJ,Song W,Feng J,Zhang XZ




Has Abstract


2019-07-19 00:00:00












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    更新日期:2014-12-11 00:00:00

  • Electron cascade for distant spin readout.

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    authors: New AM,Lehner B

    更新日期:2019-08-14 00:00:00

  • Probing the active fraction of soil microbiomes using BONCAT-FACS.

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    authors: Couradeau E,Sasse J,Goudeau D,Nath N,Hazen TC,Bowen BP,Chakraborty R,Malmstrom RR,Northen TR

    更新日期:2019-06-24 00:00:00

  • Proteomic maps of breast cancer subtypes.

    abstract::Systems-wide profiling of breast cancer has almost always entailed RNA and DNA analysis by microarray and sequencing techniques. Marked developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analysed 40 oestrogen receptor posi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Tyanova S,Albrechtsen R,Kronqvist P,Cox J,Mann M,Geiger T

    更新日期:2016-01-04 00:00:00

  • Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation.

    abstract::CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. ...

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    authors: Wang L,Liu R,Ye P,Wong C,Chen GY,Zhou P,Sakabe K,Zheng X,Wu W,Zhang P,Jiang T,Bassetti MF,Jube S,Sun Y,Zhang Y,Zheng P,Liu Y

    更新日期:2015-01-20 00:00:00

  • Gas-responsive porous magnet distinguishes the electron spin of molecular oxygen.

    abstract::Gas-sensing materials are becoming increasingly important in our society, requiring high sensitivity to differentiate similar gases like N2 and O2. For the design of such materials, the driving force of electronic host-guest interaction or host-framework changes during the sorption process has commonly been considered...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Kosaka W,Liu Z,Zhang J,Sato Y,Hori A,Matsuda R,Kitagawa S,Miyasaka H

    更新日期:2018-12-21 00:00:00

  • Diverse protein assembly driven by metal and chelating amino acids with selectivity and tunability.

    abstract::Proteins are versatile natural building blocks with highly complex and multifunctional architectures, and self-assembled protein structures have been created by the introduction of covalent, noncovalent, or metal-coordination bonding. Here, we report the robust, selective, and reversible metal coordination properties ...

    journal_title:Nature communications

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    authors: Yang M,Song WJ

    更新日期:2019-12-05 00:00:00

  • Structural lubricity in soft and hard matter systems.

    abstract::Over the recent decades there has been tremendous progress in understanding and controlling friction between surfaces in relative motion. However the complex nature of the involved processes has forced most of this work to be of rather empirical nature. Two very distinctive physical systems, hard two-dimensional layer...

    journal_title:Nature communications

    pub_type: 杂志文章,评审


    authors: Vanossi A,Bechinger C,Urbakh M

    更新日期:2020-09-16 00:00:00

  • Halogen bonding as a supramolecular dynamics catalyst.

    abstract::Dynamic processes have many implications in functional molecules, including catalysts, enzymes, host-guest complexes, and molecular machines. Here, we demonstrate via deuterium NMR relaxation experiments how halogen bonding directly impacts the dynamics in solid 2,3,5,6-tetramethylpyrazine cocrystals, catalyzing the m...

    journal_title:Nature communications

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    authors: Szell PMJ,Zablotny S,Bryce DL

    更新日期:2019-02-22 00:00:00

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    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Nakamura S,Karalay Ö,Jäger PS,Horikawa M,Klein C,Nakamura K,Latza C,Templer SE,Dieterich C,Antebi A

    更新日期:2016-03-22 00:00:00

  • Multimode entanglement in reconfigurable graph states using optical frequency combs.

    abstract::Multimode entanglement is an essential resource for quantum information processing and quantum metrology. However, multimode entangled states are generally constructed by targeting a specific graph configuration. This yields to a fixed experimental setup that therefore exhibits reduced versatility and scalability. Her...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Cai Y,Roslund J,Ferrini G,Arzani F,Xu X,Fabre C,Treps N

    更新日期:2017-06-06 00:00:00

  • The low-affinity complex of cytochrome c and its peroxidase.

    abstract::The complex of yeast cytochrome c peroxidase and cytochrome c is a paradigm of the biological electron transfer (ET). Building on seven decades of research, two different models have been proposed to explain its functional redox activity. One postulates that the intermolecular ET occurs only in the dominant, high-affi...

    journal_title:Nature communications

    pub_type: 杂志文章


    authors: Van de Water K,Sterckx YG,Volkov AN

    更新日期:2015-05-06 00:00:00

  • Nucleoporin 107, 62 and 153 mediate Kcnq1ot1 imprinted domain regulation in extraembryonic endoderm stem cells.

    abstract::Genomic imprinting is a phenomenon that restricts transcription to predominantly one parental allele. How this transcriptional duality is regulated is poorly understood. Here we perform an RNA interference screen for epigenetic factors involved in paternal allelic silencing at the Kcnq1ot1 imprinted domain in mouse ex...

    journal_title:Nature communications

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    authors: Sachani SS,Landschoot LS,Zhang L,White CR,MacDonald WA,Golding MC,Mann MRW

    更新日期:2018-07-18 00:00:00

  • A surface-stabilized ozonide triggers bromide oxidation at the aqueous solution-vapour interface.

    abstract::Oxidation of bromide in aqueous environments initiates the formation of molecular halogen compounds, which is important for the global tropospheric ozone budget. In the aqueous bulk, oxidation of bromide by ozone involves a [Br•OOO-] complex as intermediate. Here we report liquid jet X-ray photoelectron spectroscopy m...

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    authors: Artiglia L,Edebeli J,Orlando F,Chen S,Lee MT,Corral Arroyo P,Gilgen A,Bartels-Rausch T,Kleibert A,Vazdar M,Andres Carignano M,Francisco JS,Shepson PB,Gladich I,Ammann M

    更新日期:2017-09-26 00:00:00

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    abstract::Visualization of ion transport in electrolytes provides fundamental understandings of electrolyte dynamics and electrolyte-electrode interactions. However, this is challenging because existing techniques are hard to capture low ionic concentrations and fast electrolyte dynamics. Here we show that stimulated Raman scat...

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    authors: Cheng Q,Wei L,Liu Z,Ni N,Sang Z,Zhu B,Xu W,Chen M,Miao Y,Chen LQ,Min W,Yang Y

    更新日期:2018-07-30 00:00:00

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    abstract::Mutational inactivation of the SWI/SNF chromatin regulator ATRX occurs frequently in gliomas, the most common primary brain tumors. Whether and how ATRX deficiency promotes oncogenesis by epigenomic dysregulation remains unclear, despite its recent implication in both genomic instability and telomere dysfunction. Here...

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    authors: Danussi C,Bose P,Parthasarathy PT,Silberman PC,Van Arnam JS,Vitucci M,Tang OY,Heguy A,Wang Y,Chan TA,Riggins GJ,Sulman EP,Lang F,Creighton CJ,Deneen B,Miller CR,Picketts DJ,Kannan K,Huse JT

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    abstract::Precise frequency discrimination is a hallmark of auditory function in birds and mammals and is required for distinguishing similar sounding words, like 'bat,' 'cat' and 'hat.' In the cochlea, tuning and spectral separation result from longitudinal differences in basilar membrane stiffness and numerous individual grad...

    journal_title:Nature communications

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    authors: Thiede BR,Mann ZF,Chang W,Ku YC,Son YK,Lovett M,Kelley MW,Corwin JT

    更新日期:2014-05-20 00:00:00

  • Terminal uranium(V)-nitride hydrogenations involving direct addition or Frustrated Lewis Pair mechanisms.

    abstract::Despite their importance as mechanistic models for heterogeneous Haber Bosch ammonia synthesis from dinitrogen and dihydrogen, homogeneous molecular terminal metal-nitrides are notoriously unreactive towards dihydrogen, and only a few electron-rich, low-coordinate variants demonstrate any hydrogenolysis chemistry. Her...

    journal_title:Nature communications

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    authors: Chatelain L,Louyriac E,Douair I,Lu E,Tuna F,Wooles AJ,Gardner BM,Maron L,Liddle ST

    更新日期:2020-01-17 00:00:00

  • Publisher Correction: Hypermethylation of gene body CpG islands predicts high dosage of functional oncogenes in liver cancer.

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    authors: Arechederra M,Daian F,Yim A,Bazai SK,Richelme S,Dono R,Saurin AJ,Habermann BH,Maina F

    更新日期:2018-09-25 00:00:00

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    abstract::High-intensity lasers can be used to generate shockwaves, which have found applications in nuclear fusion, proton imaging, cancer therapies and materials science. Collisionless electrostatic shocks are one type of shockwave widely studied for applications involving ion acceleration. Here we show a novel mechanism for ...

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    authors: Turrell AE,Sherlock M,Rose SJ

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    abstract::When immersed into water, most solids develop a surface charge, which is neutralized by an accumulation of dissolved counterions at the interface. Although the density distribution of counterions perpendicular to the interface obeys well-established theories, little is known about counterions' lateral organization at ...

    journal_title:Nature communications

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    authors: Ricci M,Spijker P,Voïtchovsky K

    更新日期:2014-07-16 00:00:00

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    abstract::The three-dimensional architecture of the genome affects genomic functions. Multiple genome architectures at different length scales, including chromatin loops, domains, compartments, and lamina- and nucleolus-associated regions, have been discovered. However, how these structures are arranged in the same cell and how...

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    authors: Biasiucci A,Leeb R,Iturrate I,Perdikis S,Al-Khodairy A,Corbet T,Schnider A,Schmidlin T,Zhang H,Bassolino M,Viceic D,Vuadens P,Guggisberg AG,Millán JDR

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    abstract::Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temperature also exhibit emergent physical phenomena and are of great promise for optoelectronic applications. Here, we demonstrate that nanostructured, multilayer transition metal dichalcogenides (TMDCs) by themselves pro...

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    更新日期:2020-07-15 00:00:00

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    authors: Santoro M,Gorelli FA,Bini R,Haines J,van der Lee A

    更新日期:2013-01-01 00:00:00

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    abstract::Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity in floral traits, along with its recent genome sequence, makes mei an ideal model system for studying the evolution of woody plants. Here, we investigate the genetic architecture of floral trai...

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    更新日期:2018-04-27 00:00:00

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    abstract::Van der Waals (vdW) forces act ubiquitously in condensed matter. Despite being weak on an atomic level, they substantially influence molecular and biological systems due to their long range and system-size scaling. The difficulty to isolate and measure vdW forces on a single-molecule level causes our present understan...

    journal_title:Nature communications

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    authors: Wagner C,Fournier N,Ruiz VG,Li C,Müllen K,Rohlfing M,Tkatchenko A,Temirov R,Tautz FS

    更新日期:2014-11-26 00:00:00

  • Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury.

    abstract::Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by tracking individual tubular cells in conditional Pax8/Confetti mice that kidney function is  recovered after AKI despite substantial t...

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    authors: Lazzeri E,Angelotti ML,Peired A,Conte C,Marschner JA,Maggi L,Mazzinghi B,Lombardi D,Melica ME,Nardi S,Ronconi E,Sisti A,Antonelli G,Becherucci F,De Chiara L,Guevara RR,Burger A,Schaefer B,Annunziato F,Anders HJ,La

    更新日期:2018-04-09 00:00:00

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    abstract::Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on ART combination therapies (ACTs). Decreased sensitivity to ARTs is emerging, making it critically important to understand the mechan...

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    更新日期:2018-09-18 00:00:00