Abstract:
:Shigella, the agent of bacillary dysentery, invades epithelial cells by locally inducing actin reorganization. Upon cell invasion, Shigella induces calcium (Ca(2+)) signalling, but its role in invasion has remained unclear. Here we show that components involved in inositol 1, 4, 5- trisphosphate (InsP3) signalling are implicated in Shigella invasion. Although global Ca(2+) responses are dispensable for bacterial invasion, local Ca(2+) responses of unprecedented long duration are associated with invasion sites. Fluorescence recovery after photo-bleaching experiments indicate that diffusion of small solutes is hindered at Shigella-invasion sites and that diffusion hindrance is dependent on bacterially induced actin reorganization. Computational simulations and experimental challenge of the model support the notion that local accumulation of InsP3 permitted by restricted diffusion and enrichment of InsP3 receptors account for sustained local Ca(2+) increases at entry sites. Thus, cytoskeletal reorganization through diffusion hindrance shapes the duration of local Ca(2+) signals.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Tran Van Nhieu G,Kai Liu B,Zhang J,Pierre F,Prigent S,Sansonetti P,Erneux C,Kuk Kim J,Suh PG,Dupont G,Combettes Ldoi
10.1038/ncomms2561subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1567issn
2041-1723pii
ncomms2561journal_volume
4pub_type
杂志文章abstract::Many volcanoes erupt compositionally homogeneous magmas over timescales ranging from decades to millennia. This monotonous activity is thought to reflect a high degree of chemical homogeneity in their magmatic systems, leading to predictable eruptive behaviour. We combine petrological analyses of erupted crystals with...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17590-x
更新日期:2020-07-28 00:00:00
abstract::Bloch electrons lacking inversion symmetry exhibit orbital magnetic moments owing to the rotation around their center of mass; this moment induces a valley splitting in a magnetic field. For the graphene/h-BN moiré superlattice, inversion symmetry is broken by the h-BN. The superlattice potential generates a series of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19043-x
更新日期:2020-10-23 00:00:00
abstract::Current knowledge on chromosomal mosaicism in human cell cultures is mostly based on cytogenetic banding methods. The recent development of high-resolution full-genome analysis methods applicable to single cells is providing new insights into genetic and cellular diversity. Here we study the genetic content of 92 indi...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5227
更新日期:2014-06-27 00:00:00
abstract::The polypterids (bichirs and ropefish) are extant basal actinopterygian (ray-finned) fishes that breathe air and share similarities with extant lobe-finned sarcopterygians (lungfishes and tetrapods) in lung structure. They are also similar to some fossil sarcopterygians, including stem tetrapods, in having large paire...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4022
更新日期:2014-01-01 00:00:00
abstract::When pressure is applied, the molecules inside a crystal undergo significant changes of their stereoelectronic properties. The most interesting are those enhancing the reactivity of systems that would be otherwise rather inert at ambient conditions. Before a reaction can occur, however, a molecule must be activated, w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10901
更新日期:2016-03-16 00:00:00
abstract::Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2251
更新日期:2012-01-01 00:00:00
abstract::Translation efficiency can be affected by mRNA stability and secondary structures, including G-quadruplex structures (G4s). The highly conserved DEAH-box helicase DHX36/RHAU resolves G4s on DNA and RNA in vitro, however a systems-wide analysis of DHX36 targets and function is lacking. We map globally DHX36 binding to ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10432-5
更新日期:2019-06-03 00:00:00
abstract::During mitosis, duplicated sister chromatids attach to microtubules emanating from opposing sides of the bipolar spindle through large protein complexes called kinetochores. In the absence of stable kinetochore-microtubule attachments, a cell surveillance mechanism known as the spindle assembly checkpoint (SAC) produc...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10036
更新日期:2015-12-01 00:00:00
abstract::As a versatile intermediate, difluorocarbene is an electron-deficient transient species, meaning that its oxidation would be challenging. Herein we show that the oxidation of difluorocarbene could occur smoothly to generate carbonyl fluoride. The oxidation process is confirmed by successful trifluoromethoxylation, 18O...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13359-z
更新日期:2019-11-25 00:00:00
abstract::The responses of atmospheric variability to Tibetan Plateau (TP) snow cover (TPSC) at seasonal, interannual and decadal time scales have been extensively investigated. However, the atmospheric response to faster subseasonal variability of TPSC has been largely ignored. Here, we show that the subseasonal variability of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06762-5
更新日期:2018-10-12 00:00:00
abstract::Neurons maintain axonal homeostasis via employing a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Abnormal MT-based trafficking hallmarks the pathology of neurodegenerative diseases, but the exact mechanism regulating MT dyna...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15287-9
更新日期:2020-03-24 00:00:00
abstract::A skullcap found in the Salkhit Valley in northeast Mongolia is, to our knowledge, the only Pleistocene hominin fossil found in the country. It was initially described as an individual with possible archaic affinities, but its ancestry has been debated since the discovery. Here, we determine the age of the Salkhit sku...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08018-8
更新日期:2019-01-30 00:00:00
abstract::The design and assembly of artificial protocell consortia displaying dynamical behaviours and systems-based properties are emerging challenges in bottom-up synthetic biology. Cellular processes such as morphogenesis and differentiation rely in part on reaction-diffusion gradients, and the ability to mimic rudimentary ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11316-4
更新日期:2019-07-25 00:00:00
abstract::Recent crystal structures of G-protein-coupled receptors (GPCRs) have revealed ordered internal water molecules, raising questions about the functional role of those waters for receptor activation that could not be answered by the static structures. Here, we used molecular dynamics simulations to monitor--at atomic an...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5733
更新日期:2014-09-09 00:00:00
abstract::Alike materials in the solid state, the phase diagram of type-II superconductors exhibit crystalline, amorphous, liquid and spatially inhomogeneous phases. The multitude of different phases of vortex matter has thence proven to act as almost ideal model system for the study of both the underlying properties of superco...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms9813
更新日期:2015-11-02 00:00:00
abstract::Face recognition is highly proficient in humans and other social primates; it emerges in infancy, but the development of the neural mechanisms supporting this behaviour is largely unknown. We use blood-volume functional MRI to monitor longitudinally the responsiveness to faces, scrambled faces, and objects in macaque ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14897
更新日期:2017-03-31 00:00:00
abstract::CD24 is overexpressed in nearly 70% human cancers, whereas TP53 is the most frequently mutated tumour-suppressor gene that functions in a context-dependent manner. Here we show that both targeted mutation and short hairpin RNA (shRNA) silencing of CD24 retard the growth, progression and metastasis of prostate cancer. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6909
更新日期:2015-01-20 00:00:00
abstract::A planar slab of negative-index material works as a superlens with sub-diffraction-limited resolution, as propagating waves are focused and, moreover, evanescent waves are reconstructed in the image plane. Here we demonstrate a superlens for electric evanescent fields with low losses using perovskites in the mid-infra...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1249
更新日期:2011-01-01 00:00:00
abstract::Pentatricopeptide repeat (PPR) proteins control diverse aspects of RNA metabolism in eukaryotic cells. Although recent computational and structural studies have provided insights into RNA recognition by PPR proteins, their highly insoluble nature and inconsistencies between predicted and observed modes of RNA binding ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6729
更新日期:2014-12-17 00:00:00
abstract::Identification of the optimal quantum metrological protocols in realistic many particle quantum models is in general a challenge that cannot be efficiently addressed by the state-of-the-art numerical and analytical methods. Here we provide a comprehensive framework exploiting matrix product operators (MPO) type tensor...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13735-9
更新日期:2020-01-14 00:00:00
abstract::Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural history of antibiotics and resistance. In a previous study, we discovered that multi-drug resistance is common in bacteria isolated from Lechuguilla Cave, an un...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms13803
更新日期:2016-12-08 00:00:00
abstract::The ability to identify cause-effect relations is an essential component of the scientific method. The identification of causal relations is generally accomplished through statistical trials where alternative hypotheses are tested against each other. Traditionally, such trials have been based on classical statistics. ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09383-8
更新日期:2019-04-01 00:00:00
abstract::In recent years, there has been marked increase in research aimed to introduce alkali vapours into guided-wave configurations. Owing to the significant reduction in device dimensions, the increase in density of states, the interaction with surfaces and primarily the high intensities carried along the structure, a plet...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14461
更新日期:2017-02-09 00:00:00
abstract::Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to genomic instabilities similar to those observed in cancer. BIR proceeds by a migrating bubble where asynchrony between leading and lagging strand synthesis leads to accumulation of long single-stranded DNA (ssDNA). It remains unk...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01987-2
更新日期:2017-11-27 00:00:00
abstract::Despite highly promising characteristics of three-dimensionally (3D) nanostructured catalysts for the oxygen evolution reaction (OER) in polymer electrolyte membrane water electrolyzers (PEMWEs), universal design rules for maximizing their performance have not been explored. Here we show that woodpile (WP)-structured ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18686-0
更新日期:2020-10-01 00:00:00
abstract::The evolution of the seawater oxygen isotopic composition (δ18O) through geological time remains controversial. Yet, the past δ18Oseawater is key to assess past seawater temperatures, providing insights into past climate change and life evolution. Here we provide a new and unprecedentedly precise δ18O value of -1.33 ±...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03890-w
更新日期:2018-04-13 00:00:00
abstract::Black phosphorus, a fast emerging two-dimensional material, has been configured as field effect transistors, showing a hole-transport-dominated ambipolar characteristic. Here we report an effective modulation on ambipolar characteristics of few-layer black phosphorus transistors through in situ surface functionalizati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7485
更新日期:2015-03-12 00:00:00
abstract::The ultrafast dynamics of hot carriers in graphene are key to both understanding of fundamental carrier-carrier interactions and carrier-phonon relaxation processes in two-dimensional materials, and understanding of the physics underlying novel high-speed electronic and optoelectronic devices. Many recent experiments ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11617
更新日期:2016-05-25 00:00:00
abstract::Microbial community structure can be analyzed by quantifying cell numbers or by quantifying biomass for individual populations. Methods for quantifying cell numbers are already available (e.g., fluorescence in situ hybridization, 16-S rRNA gene amplicon sequencing), yet high-throughput methods for assessing community ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01544-x
更新日期:2017-11-16 00:00:00
abstract::Atomic layer deposition (ALD) enables the ultrathin high-quality oxide layers that are central to all modern metal-oxide-semiconductor circuits. Crucial to achieving superior device performance are the chemical reactions during the first deposition cycle, which could ultimately result in atomic-scale perfection of the...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03855-z
更新日期:2018-04-12 00:00:00