Abstract：
:Fibroblastic reticular cells (FRCs) are immunologically specialized myofibroblasts of lymphoid organ, and FRC maturation is essential for structural and functional properties of lymph nodes (LNs). Here we show that YAP and TAZ (YAP/TAZ), the final effectors of Hippo signaling, regulate FRC commitment and maturation. Selective depletion of YAP/TAZ in FRCs impairs FRC growth and differentiation and compromises the structural organization of LNs, whereas hyperactivation of YAP/TAZ enhances myofibroblastic characteristics of FRCs and aggravates LN fibrosis. Mechanistically, the interaction between YAP/TAZ and p52 promotes chemokine expression that is required for commitment of FRC lineage prior to lymphotoxin-β receptor (LTβR) engagement, whereas LTβR activation suppresses YAP/TAZ activity for FRC maturation. Our findings thus present YAP/TAZ as critical regulators of commitment and maturation of FRCs, and hold promise for better understanding of FRC-mediated pathophysiologic processes.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Choi SY,Bae H,Jeong SH,Park I,Cho H,Hong SP,Lee DH,Lee CK,Park JS,Suh SH,Choi J,Yang MJ,Jang JY,Onder L,Moon JH,Jeong HS,Adams RH,Kim JM,Ludewig B,Song JH,Lim DS,Koh GYdoi
10.1038/s41467-020-14293-1subject
Has Abstractpub_date
2020-01-24 00:00:00pages
519issue
1issn
2041-1723pii
10.1038/s41467-020-14293-1journal_volume
11pub_type
杂志文章abstract：:Lipidic cubic phase (LCP) crystallization has proven successful for high-resolution structure determination of challenging membrane proteins. Here we present a technique for extruding gel-like LCP with embedded membrane protein microcrystals, providing a continuously renewed source of material for serial femtosecond c...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4309
更新日期：2014-01-01 00:00:00
abstract：:Memories link information about specific experiences to more general knowledge that is abstracted from and contextualizes those experiences. Hippocampal-cortical activity patterns representing features of past experience are reinstated during awake memory reactivation events, but whether representations of both specif...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04498-w
更新日期：2018-06-07 00:00:00
abstract：:With a recent increase in interest in metal-gas batteries, the lithium-carbon dioxide cell has attracted considerable attention because of its extraordinary carbon dioxide-capture ability during the discharge process and its potential application as a power source for Mars exploration. However, owing to the stable lit...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-14121-1
更新日期：2020-01-23 00:00:00
abstract：:CRISPR/Cas9 technology offers novel approaches for the development of new therapies for many unmet clinical needs, including a significant number of inherited monogenic diseases. However, in vivo correction of disease-causing genes is still inefficient, especially for those diseases without selective advantage for cor...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07827-1
更新日期：2018-12-21 00:00:00
abstract：:Neutrophils are an essential part of the innate immune system. To study their importance, experimental studies often aim to deplete these cells, generally by injecting anti-Ly6G or anti-Gr1 antibodies. However, these approaches are only partially effective, transient or lack specificity. Here we report that neutrophil...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-16596-9
更新日期：2020-06-02 00:00:00
abstract：:In the quantum Hall regime, near integer filling factors, electrons should only be transmitted through spatially separated edge states. However, in mesoscopic systems, electronic transmission turns out to be more complex, giving rise to a large spectrum of magnetoresistance oscillations. To explain these observations,...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1038
更新日期：2010-07-27 00:00:00
abstract：:Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They are generated from long precursor transcripts by the primary piRNA biogenesis pathway but the factors involved in pachytene piRNA precursors processing are poorly understood. Here we show that the Tudor domain-containing 5 (TDRD5) protein is...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02622-w
更新日期：2018-01-09 00:00:00
abstract：:Building a population-specific catalogue of single nucleotide variants (SNVs), indels and structural variants (SVs) with frequencies, termed a national pan-genome, is critical for further advancing clinical and public health genetics in large cohorts. Here we report a Danish pan-genome obtained from sequencing 10 trio...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6969
更新日期：2015-01-19 00:00:00
abstract：:Polyelectrolyte gel diodes that are double layers of two oppositely charged polyelectrolyte gels, sandwiched by two symmetric electrodes, are emergent ionic devices. These diodes are designed to rectify ion currents with a physical mechanism that is analogous to conventional semiconductor diodes-the asymmetry in the p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5162
更新日期：2014-06-17 00:00:00
abstract：:Mineralisation of calcium phosphates in bone has been proposed to proceed via an initial amorphous precursor phase which transforms into nanocrystalline, carbonated hydroxyapatite. While calcium phosphates have been under intense investigation, the exact steps during the crystallisation of spherical amorphous particle...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06570-x
更新日期：2018-10-09 00:00:00
abstract：:The application of nanoparticle drug formulations, such as nanoliposomal doxorubicin (Doxil), is increasingly integrated in clinical cancer care. Despite nanomedicine's remarkable potential and growth over the last three decades, its clinical benefits for cancer patients vary. Here we report a non-invasive quantitativ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11838
更新日期：2016-06-20 00:00:00
abstract：:The Non-Proliferation Treaty and other non-proliferation agreements are in place worldwide to ensure that nuclear material and facilities are used only for peaceful purposes. Antineutrino detectors, sensitive to reactor power and fuel changes, can complement the tools already at the disposal of international agencies ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11434-z
更新日期：2019-08-06 00:00:00
abstract：:Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to thermodynamic stability, prediction of poorly-behaving biologics is di...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15667-1
更新日期：2020-04-14 00:00:00
abstract：:Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the u...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05068-w
更新日期：2018-07-11 00:00:00
abstract：:To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of the circuit and identify the origins of failures. Here, we take snapshots of a large gen...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18630-2
更新日期：2020-10-05 00:00:00
abstract：:Gluconeogenesis is a fundamental metabolic process that allows organisms to make sugars from non-carbohydrate stores such as lipids and protein. In eukaryotes only one gluconeogenic route has been described from organic acid intermediates and this relies on the enzyme phosphoenolpyruvate carboxykinase (PCK). Here we s...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7659
更新日期：2015-04-10 00:00:00
abstract：:Tunnel junctions, an established platform for high resolution spectroscopy of superconductors, require defect-free insulating barriers; however, oxides, the most common barrier, can only grow on a limited selection of materials. We show that van der Waals tunnel barriers, fabricated by exfoliation and transfer of laye...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03000-w
更新日期：2018-02-09 00:00:00
abstract：:Macrophage-mediated inflammation is thought to have a causal role in osteoarthritis-related pain and severity, and has been suggested to be triggered by endotoxins produced by the gastrointestinal microbiome. Here we investigate the relationship between joint pain and the gastrointestinal microbiome composition, and o...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12873-4
更新日期：2019-10-25 00:00:00
abstract：:Wntless transports Wnt morphogens to the cell surface and is required for Wnt secretion and morphogenic gradients formation. Recycling of endocytosed Wntless requires the sorting nexin-3 (SNX3)-retromer-dependent endosome-to-Golgi transport pathway. Here we demonstrate the essential role of SNX3-retromer assembly for ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06114-3
更新日期：2018-09-13 00:00:00
abstract：:Transmission-blocking interventions aim to reduce the prevalence of infection in endemic communities by targeting Plasmodium within the insect host. Although many studies have reported the successful reduction of infection in the mosquito vector, direct evidence that there is an onward reduction in infection in the ve...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2840
更新日期：2013-01-01 00:00:00
abstract：:AML1-ETO (AE) is a fusion transcription factor, generated by the t(8;21) translocation, that functions as a leukemia promoting oncogene. Here, we demonstrate that TATA-Box Binding Protein Associated Factor 1 (TAF1) associates with K43 acetylated AE and this association plays a pivotal role in the proliferation of AE-e...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12735-z
更新日期：2019-10-29 00:00:00
abstract：:GFI1 is a transcriptional regulator expressed in lymphoid cells, and an "oncorequisite" factor required for development and maintenance of T-lymphoid leukemia. GFI1 deletion causes hypersensitivity to ionizing radiation, for which the molecular mechanism remains unknown. Here, we demonstrate that GFI1 is required in T...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03817-5
更新日期：2018-04-12 00:00:00
abstract：:Even as the study of plant genomics rapidly develops through the use of high-throughput sequencing techniques, traditional plant phenotyping lags far behind. Here we develop a high-throughput rice phenotyping facility (HRPF) to monitor 13 traditional agronomic traits and 2 newly defined traits during the rice growth p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6087
更新日期：2014-10-08 00:00:00
abstract：:Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of substrate compliance in live tissues has not been accomplished to date. Here we propose that stem cells can be regulated solely through in situ modulation of tissue biomechanics. By first establishing, via high-resolution Brillou...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09331-6
更新日期：2019-04-03 00:00:00
abstract：:Heterostructures formed by stacking layered materials require atomically clean interfaces. However, contaminants are usually trapped between the layers, aggregating into randomly located blisters, incompatible with scalable fabrication processes. Here we report a process to remove blisters from fully formed heterostru...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07558-3
更新日期：2018-12-19 00:00:00
abstract：:Base editing tools with diversified editing scopes and minimized RNA off-target activities are required for broad applications. Nevertheless, current Streptococcus pyogenes Cas9 (SpCas9)-based adenine base editors (ABEs) with minimized RNA off-target activities display constrained editing scopes with efficient editing...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19730-9
更新日期：2020-11-17 00:00:00
abstract：:One of the best performing semiconducting polymers used in bulk heterojunction devices is PCDTBT, a polycarbazole derivative with solar-conversion efficiencies as high as 7.2%. Here we report the formation of bilayer ordering in PCDTBT, and postulate that this structural motif is a direct consequence of the polymer's ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1790
更新日期：2012-04-24 00:00:00
abstract：:Recent years have witnessed thriving progress of flexible and portable electronics, with very high demand for cost-effective and tailor-made multifunctional devices. Here, we report on an ingenious origami hierarchical sensor array (OHSA) written with a conductive ink. Thanks to origami as a controllable hierarchical ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09070-8
更新日期：2019-03-08 00:00:00
abstract：:One of the key applications of quantum information is simulating nature. Fermions are ubiquitous in nature, appearing in condensed matter systems, chemistry and high energy physics. However, universally simulating their interactions is arguably one of the largest challenges, because of the difficulties arising from an...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms8654
更新日期：2015-07-08 00:00:00
abstract：:Metal particles supported on oxide surfaces are used as catalysts for a wide variety of processes in the chemical and energy conversion industries. For catalytic applications, metal particles are generally formed on an oxide support by physical or chemical deposition, or less commonly by exsolution from it. Although f...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9120
更新日期：2015-09-11 00:00:00
