Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage.

abstract：:Acetic acid is an important bulk chemical that is currently produced via methanol carbonylation using fossil based CO. Synthesis of acetic acid from the renewable and cheap CO2 is of great importance, but state of the art routes encounter difficulties, especially in reaction selectivity and activity. Here we report a ...

journal_title：Nature communications

authors： Qian Q,Zhang J,Cui M,Han B

更新日期：2016-05-11 00:00:00

abstract：:Microbial fatty acid-derived fuels have emerged as promising alternatives to petroleum-based transportation fuels. Here we report a modular engineering approach that systematically removed metabolic pathway bottlenecks and led to significant titre improvements in a multi-gene fatty acid metabolic pathway. On the basis...

journal_title：Nature communications

authors： Xu P,Gu Q,Wang W,Wong L,Bower AG,Collins CH,Koffas MA

更新日期：2013-01-01 00:00:00

abstract：:Interactions between a protein and a ligand are essential to all biological processes. Binding and dissociation are the two fundamental steps of ligand-protein interactions, and determine the binding affinity. Intrinsic conformational dynamics of proteins have been suggested to play crucial roles in ligand binding and...

journal_title：Nature communications

authors： Seo MH,Park J,Kim E,Hohng S,Kim HS

更新日期：2014-04-24 00:00:00

abstract：:In the original version of this Article, financial support and contributions in manuscript preparation were not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include the following:'M.P. and P.O. would like to thank Prof. Roderick Y.H. Lim for advice during manuscript preparati...

journal_title：Nature communications

authors： Glentis A,Oertle P,Mariani P,Chikina A,El Marjou F,Attieh Y,Zaccarini F,Lae M,Loew D,Dingli F,Sirven P,Schoumacher M,Gurchenkov BG,Plodinec M,Vignjevic DM

更新日期：2018-03-07 00:00:00

abstract：:The extraction of a clear and simple footprint of the structure of large, weighted and directed networks is a general problem that has relevance for many applications. An important example is seen in origin-destination matrices, which contain the complete information on commuting flows, but are difficult to analyze an...

journal_title：Nature communications

authors： Louail T,Lenormand M,Picornell M,García Cantú O,Herranz R,Frias-Martinez E,Ramasco JJ,Barthelemy M

更新日期：2015-01-21 00:00:00

abstract：:It has been speculated that the partial pressure of carbon dioxide (pCO2) in shelf waters may lag the rise in atmospheric CO2. Here, we show that this is the case across many shelf regions, implying a tendency for enhanced shelf uptake of atmospheric CO2. This result is based on analysis of long-term trends in the air...

journal_title：Nature communications

authors： Laruelle GG,Cai WJ,Hu X,Gruber N,Mackenzie FT,Regnier P

更新日期：2018-01-31 00:00:00

abstract：:Hybridomas, fusions of primary mouse B cells and myelomas, are stable, rapidly-proliferating cell lines widely utilized for antibody screening and production. Antibody specificity of a hybridoma clone is determined by the immunoglobulin sequence of the primary B cell. Here we report a platform for rapid reprogramming ...

journal_title：Nature communications

authors： Pogson M,Parola C,Kelton WJ,Heuberger P,Reddy ST

更新日期：2016-08-17 00:00:00

abstract：:This corrects the article DOI: 10.1038/ncomms15533. ...

journal_title：Nature communications

authors： Ye L,Zhou X,Huang F,Wang W,Qi Y,Xu H,Shu Y,Shen L,Fei X,Xie J,Cao M,Zhou Y,Zhu W,Wang S,Ning G,Wang W

更新日期：2017-07-04 00:00:00

abstract：:The microbial communities living in the human intestine can have profound impact on our well-being and health. However, we have limited understanding of the mechanisms that control this complex ecosystem. Here, based on a deep phylogenetic analysis of the intestinal microbiota in a thousand western adults, we identify...

journal_title：Nature communications

authors： Lahti L,Salojärvi J,Salonen A,Scheffer M,de Vos WM

更新日期：2014-07-08 00:00:00

abstract：:Developing single-site catalysts featuring maximum atom utilization efficiency is urgently desired to improve oxidation-reduction efficiency and cycling capability of lithium-oxygen batteries. Here, we report a green method to synthesize isolated cobalt atoms embedded ultrathin nitrogen-rich carbon as a dual-catalyst ...

journal_title：Nature communications

authors： Wang P,Ren Y,Wang R,Zhang P,Ding M,Li C,Zhao D,Qian Z,Zhang Z,Zhang L,Yin L

更新日期：2020-03-27 00:00:00

abstract：:The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, dev...

journal_title：Nature communications

authors： Adhikari S,Nice EC,Deutsch EW,Lane L,Omenn GS,Pennington SR,Paik YK,Overall CM,Corrales FJ,Cristea IM,Van Eyk JE,Uhlén M,Lindskog C,Chan DW,Bairoch A,Waddington JC,Justice JL,LaBaer J,Rodriguez H,He F,Kostrzewa M

更新日期：2020-10-16 00:00:00

abstract：:Cerebral cavernous malformations (CCMs) are vascular abnormalities that primarily occur in adulthood and cause cerebral hemorrhage, stroke, and seizures. CCMs are thought to be initiated by endothelial cell (EC) loss of any one of the three Ccm genes: CCM1 (KRIT1), CCM2 (OSM), or CCM3 (PDCD10). Here we report that mic...

journal_title：Nature communications

authors： Zhou HJ,Qin L,Jiang Q,Murray KN,Zhang H,Li B,Lin Q,Graham M,Liu X,Grutzendler J,Min W

更新日期：2021-01-25 00:00:00

abstract：:Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...

journal_title：Nature communications

authors： Kim KE,Jeong S,Chu K,Lee JH,Kim GY,Xue F,Koo TY,Chen LQ,Choi SY,Ramesh R,Yang CH

更新日期：2018-01-26 00:00:00

abstract：:Intratumor heterogeneity (ITH) and tumor evolution have been well described for clear cell renal cell carcinomas (ccRCC), but they are less studied for other kidney cancer subtypes. Here we investigate ITH and clonal evolution of papillary renal cell carcinoma (pRCC) and rarer kidney cancer subtypes, integrating whole...

journal_title：Nature communications

authors： Zhu B,Poeta ML,Costantini M,Zhang T,Shi J,Sentinelli S,Zhao W,Pompeo V,Cardelli M,Alexandrov BS,Otlu B,Hua X,Jones K,Brodie S,Dabrowska ME,Toro JR,Yeager M,Wang M,Hicks B,Alexandrov LB,Brown KM,Wedge DC,Chanoc

更新日期：2020-06-18 00:00:00

abstract：:Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a p...

journal_title：Nature communications

authors： Ming XY,Fu L,Zhang LY,Qin YR,Cao TT,Chan KW,Ma S,Xie D,Guan XY

更新日期：2016-12-07 00:00:00

abstract：:In melanoma, therapies with inhibitors to oncogenic BRAFV600E are highly effective but responses are often short-lived due to the emergence of drug-resistant tumor subpopulations. We describe here a mechanism of acquired drug resistance through the tumor microenvironment, which is mediated by human tumor-associated B ...

journal_title：Nature communications

authors： Somasundaram R,Zhang G,Fukunaga-Kalabis M,Perego M,Krepler C,Xu X,Wagner C,Hristova D,Zhang J,Tian T,Wei Z,Liu Q,Garg K,Griss J,Hards R,Maurer M,Hafner C,Mayerhöfer M,Karanikas G,Jalili A,Bauer-Pohl V,Weihsengru

更新日期：2017-09-19 00:00:00

abstract：:Haploinsufficiency of the SLC2A1 gene and paucity of its translated product, the glucose transporter-1 (Glut1) protein, disrupt brain function and cause the neurodevelopmental disorder, Glut1 deficiency syndrome (Glut1 DS). There is little to suggest how reduced Glut1 causes cognitive dysfunction and no optimal treatm...

journal_title：Nature communications

authors： Tang M,Gao G,Rueda CB,Yu H,Thibodeaux DN,Awano T,Engelstad KM,Sanchez-Quintero MJ,Yang H,Li F,Li H,Su Q,Shetler KE,Jones L,Seo R,McConathy J,Hillman EM,Noebels JL,De Vivo DC,Monani UR

更新日期：2017-01-20 00:00:00

abstract：:The superconducting gap structure in iron-based high-temperature superconductors (Fe-HTSs) is non-universal. In contrast to other unconventional superconductors, in the Fe-HTSs both d-wave and extended s-wave pairing symmetries are close in energy. Probing the proximity between these very different superconducting sta...

journal_title：Nature communications

authors： Guguchia Z,Amato A,Kang J,Luetkens H,Biswas PK,Prando G,von Rohr F,Bukowski Z,Shengelaya A,Keller H,Morenzoni E,Fernandes RM,Khasanov R

更新日期：2015-11-09 00:00:00

abstract：:High-index dielectric nanoparticles supporting a distinct series of Mie resonances have enabled a new class of optical antennas with unprecedented functionalities. The great wealth of multipolar responses has not only brought in new physical insight but also spurred practical applications. However, how to make such a ...

journal_title：Nature communications

authors： Tian J,Luo H,Yang Y,Ding F,Qu Y,Zhao D,Qiu M,Bozhevolnyi SI

更新日期：2019-01-23 00:00:00

abstract：:Insulin resistance is closely associated with obesity and is one of the earliest symptoms of type-2 diabetes. Endothelial cells are involved in the pathogenesis of insulin resistance through their role in insulin delivery and adipose tissue angiogenesis. Here we show that Ecscr (endothelial cell surface expressed chem...

journal_title：Nature communications

authors： Akakabe Y,Koide M,Kitamura Y,Matsuo K,Ueyama T,Matoba S,Yamada H,Miyata K,Oike Y,Ikeda K

更新日期：2013-01-01 00:00:00

abstract：:Covalent functionalization tailors carbon nanotubes for a wide range of applications in varying environments. Its strength and stability of attachment come at the price of degrading the carbon nanotubes sp2 network and destroying the tubes electronic and optoelectronic features. Here we present a non-destructive, cova...

journal_title：Nature communications

authors： Setaro A,Adeli M,Glaeske M,Przyrembel D,Bisswanger T,Gordeev G,Maschietto F,Faghani A,Paulus B,Weinelt M,Arenal R,Haag R,Reich S

更新日期：2017-01-30 00:00:00

abstract：:Highly pure semiconducting single-walled carbon nanotubes (SWNTs) are essential for the next generation of electronic devices, such as field-effect transistors and photovoltaic applications; however, contamination by metallic SWNTs reduces the efficiency of their associated devices. Here we report a simple and efficie...

journal_title：Nature communications

authors： Toshimitsu F,Nakashima N

更新日期：2014-10-03 00:00:00

abstract：:The success of protein evolution campaigns is strongly dependent on the sequence context in which mutations are introduced, stemming from pervasive non-additive interactions between a protein's amino acids ('intra-gene epistasis'). Our limited understanding of such epistasis hinders the correct prediction of the funct...

journal_title：Nature communications

authors： Zurek PJ,Knyphausen P,Neufeld K,Pushpanath A,Hollfelder F

更新日期：2020-11-26 00:00:00

abstract：:Electrospun nanofibres are promising in biomedical applications to replicate features of the natural extracellular matrix (ECM). However, nearly all electrospun scaffolds are either non-degradable or degrade hydrolytically, whereas natural ECM degrades proteolytically, often through matrix metalloproteinases. Here we ...

journal_title：Nature communications

authors： Wade RJ,Bassin EJ,Rodell CB,Burdick JA

更新日期：2015-03-23 00:00:00

abstract：:It is commonly assumed that neural systems efficiently process natural sensory input. However, the mechanisms by which such efficient processing is achieved, and the consequences for perception and behaviour remain poorly understood. Here we show that small conductance calcium-activated potassium (SK) channels enable ...

journal_title：Nature communications

authors： Huang CG,Zhang ZD,Chacron MJ

更新日期：2016-04-18 00:00:00

abstract：:The identification of causal variants in sequencing studies remains a considerable challenge that can be partially addressed by new gene-specific knowledge. Here, we integrate measures of how essential a gene is to supporting life, as inferred from viability and phenotyping screens performed on knockout mice by the In...

journal_title：Nature communications

authors： Cacheiro P,Muñoz-Fuentes V,Murray SA,Dickinson ME,Bucan M,Nutter LMJ,Peterson KA,Haselimashhadi H,Flenniken AM,Morgan H,Westerberg H,Konopka T,Hsu CW,Christiansen A,Lanza DG,Beaudet AL,Heaney JD,Fuchs H,Gailus-Durner

更新日期：2020-01-31 00:00:00

abstract：:SIRT1, the founding member of the mammalian family of seven NAD(+)-dependent sirtuins, is composed of 747 amino acids forming a catalytic domain and extended N- and C-terminal regions. We report the design and characterization of an engineered human SIRT1 construct (mini-hSIRT1) containing the minimal structural eleme...

journal_title：Nature communications

authors： Dai H,Case AW,Riera TV,Considine T,Lee JE,Hamuro Y,Zhao H,Jiang Y,Sweitzer SM,Pietrak B,Schwartz B,Blum CA,Disch JS,Caldwell R,Szczepankiewicz B,Oalmann C,Yee Ng P,White BH,Casaubon R,Narayan R,Koppetsch K,Bourb

更新日期：2015-07-02 00:00:00

abstract：:Magnetic reconnection is a fundamental process in magnetized plasma where magnetic energy is converted to plasma energy. Despite huge differences in the physical size of the reconnection layer, remarkably similar characteristics are observed in both laboratory and magnetosphere plasmas. Here we present the comparative...

journal_title：Nature communications

authors： Yamada M,Chen LJ,Yoo J,Wang S,Fox W,Jara-Almonte J,Ji H,Daughton W,Le A,Burch J,Giles B,Hesse M,Moore T,Torbert R

更新日期：2018-12-06 00:00:00

abstract：:In reducing the high operating temperatures (≥800 °C) of solid-oxide fuel cells, use of protonic ceramics as an alternative electrolyte material is attractive due to their high conductivity and low activation energy in a low-temperature regime (≤600 °C). Among many protonic ceramics, yttrium-doped barium zirconate has...

journal_title：Nature communications

authors： Bae K,Jang DY,Choi HJ,Kim D,Hong J,Kim BK,Lee JH,Son JW,Shim JH

更新日期：2017-02-23 00:00:00

abstract：:A non-syngas direct steam reforming route is investigated for the conversion of methanol to hydrogen and carbon dioxide over a CuZnGaO(x) catalyst at 150-200 °C. This route is in marked contrast with the conventional complex route involving steam reformation to syngas (CO/H2) at high temperature, followed by water gas...

journal_title：Nature communications

authors： Yu KM,Tong W,West A,Cheung K,Li T,Smith G,Guo Y,Tsang SC

更新日期：2012-01-01 00:00:00