Abstract：
:Non-CG methylation has been associated with stemness regulation in embryonic stem cells. By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin α7 (ITGA7) is characterized as a potential cancer stem cell (CSC) marker. Clinical data show that a high frequency of ITGA7+ cells in OSCC tissues is significantly associated with poor differentiation, lymph node metastasis and worse prognosis. Functional studies demonstrate that both sorted ITGA7+ cells and ITGA7 overexpressing cells display enhanced stemness features, including elevated expression of stemness-associated genes and epithelial-mesenchymal transition features, as well as increased abilities to self-renew, differentiate and resist chemotherapy. Mechanistic studies find that ITGA7 regulates CSC properties through the activation of the FAK-mediated signalling pathways. As knockdown of ITGA7 can effectively reduce the stemness of OSCC cells, ITGA7 could be a potential therapeutic target in OSCC treatment.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Ming XY,Fu L,Zhang LY,Qin YR,Cao TT,Chan KW,Ma S,Xie D,Guan XYdoi
10.1038/ncomms13568subject
Has Abstractpub_date
2016-12-07 00:00:00pages
13568issn
2041-1723pii
ncomms13568journal_volume
7pub_type
杂志文章abstract：:Current-induced magnetic domain wall (DW) motion is an important operating principle of spintronic devices. Injected current generates spin torques (STs) on the DWs in two ways. One is the spin transfer from magnetic domains to the walls by the current flowing in the magnet. Current flow in attached heavy metals also ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06223-z
更新日期：2018-09-17 00:00:00
abstract：:Break-induced replication (BIR) is a DNA double-strand break repair pathway that leads to genomic instabilities similar to those observed in cancer. BIR proceeds by a migrating bubble where asynchrony between leading and lagging strand synthesis leads to accumulation of long single-stranded DNA (ssDNA). It remains unk...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01987-2
更新日期：2017-11-27 00:00:00
abstract：:Receptor families of the innate immune response engage in 'cross-talk' to tailor optimal immune responses against invading pathogens. However, these responses are subject to multiple levels of regulation to keep in check aberrant inflammatory signals. Here, we describe a role for the orphan receptor interleukin-17 rec...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7669
更新日期：2015-03-26 00:00:00
abstract：:Oxygen defect control has long been considered an important route to functionalizing complex oxide films. However, the nature of oxygen defects in thin films is often not investigated beyond basic redox chemistry. One of the model examples for oxygen-defect studies is the layered Ruddlesden-Popper phase La2-xSr x CuO4...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02568-z
更新日期：2018-01-08 00:00:00
abstract：:Exocytic transmitter release is regulated by the SNARE complex, which contains a vesicular protein, synaptobrevin2 (Sb2). However, Sb2 vesicular arrangement is unclear. Here we use super-resolution fluorescence microscopy to study the prevalence and distribution of endogenous and exogenous Sb2 in single vesicles of as...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4780
更新日期：2014-05-07 00:00:00
abstract：:The main advantage of organic transistors with dual gates/bases is that the threshold voltages can be set as a function of the applied second gate/base bias, which is crucial for the application in logic gates and integrated circuits. However, incorporating a dual gate/base structure into an ultra-short channel vertic...
journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2020-09-18 00:00:00
abstract：:Vortices in quantum condensates exist owing to a macroscopic phase coherence. Here we show, both experimentally and theoretically, that a quantum vortex with a well-defined core can exist in a rather thick normal metal, proximized with a superconductor. Using scanning tunneling spectroscopy we reveal a proximity vorte...
journal_title：Nature communications
pub_type： 杂志文章
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更新日期：2018-06-11 00:00:00
abstract：:Transcription in all living organisms is accomplished by multi-subunit RNA polymerases (msRNAPs). msRNAPs are highly conserved in evolution and invariably share a ∼400 kDa five-subunit catalytic core. Here we characterize a hypothetical ∼100 kDa single-chain protein, YonO, encoded by the SPβ prophage of Bacillus subti...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15774
更新日期：2017-06-06 00:00:00
abstract：:Graphite dual-ion batteries represent a potential battery concept for large-scale stationary storage of electricity, especially when constructed free of lithium and other chemical elements with limited natural reserves. Owing to their non-rocking-chair operation mechanism, however, the practical deployment of graphite...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06923-6
更新日期：2018-10-26 00:00:00
abstract：:Fullerene peapods, which are carbon nanotubes encapsulating fullerene molecules, can offer enhanced functionality with respect to empty nanotubes. Their prospective applications include, for example, data storage devices, single-electron transistors and spin-qubit arrays for quantum computing. However, the present inc...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1034
更新日期：2010-07-13 00:00:00
abstract：:Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1): programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to these therapies has increasingly been observed. In this study, to elucidate mechanisms of adaptive resistance, we analyse the tumour immune mic...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10501
更新日期：2016-02-17 00:00:00
abstract：:Biologists have long been fascinated by the amazing diversity of animal colour patterns. Despite much interest, the underlying evolutionary and developmental mechanisms contributing to their rich variety remain largely unknown, especially the vivid and complex colour patterns seen in vertebrates. Here, we show that co...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1071
更新日期：2010-09-07 00:00:00
abstract：:Highly pure semiconducting single-walled carbon nanotubes (SWNTs) are essential for the next generation of electronic devices, such as field-effect transistors and photovoltaic applications; however, contamination by metallic SWNTs reduces the efficiency of their associated devices. Here we report a simple and efficie...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6041
更新日期：2014-10-03 00:00:00
abstract：:Under climate warming, migratory birds should align reproduction dates with advancing plant and arthropod phenology. To arrive on the breeding grounds earlier, migrants may speed up spring migration by curtailing the time spent en route, possibly at the cost of decreased survival rates. Based on a decades-long series ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06673-5
更新日期：2018-10-15 00:00:00
abstract：:Understanding how cellular functions emerge from the underlying molecular mechanisms is a key challenge in biology. This will require computational models, whose predictive power is expected to increase with coverage and precision of formulation. Genome-scale models revolutionised the metabolic field and made the firs...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-08903-w
更新日期：2019-03-21 00:00:00
abstract：:Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans and Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental ancestry in over 6,500 Latin Americans and evaluate the impact of ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07748-z
更新日期：2018-12-19 00:00:00
abstract：:Layered materials embrace rich intercalation reactions to accommodate high concentrations of foreign species within their structures, and find many applications spanning from energy storage, ion exchange to secondary batteries. Light alkali metals are generally most easily intercalated due to their light mass, high ch...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13809
更新日期：2016-12-14 00:00:00
abstract：:Our ability to uncover complex network structure and dynamics from data is fundamental to understanding and controlling collective dynamics in complex systems. Despite recent progress in this area, reconstructing networks with stochastic dynamical processes from limited time series remains to be an outstanding problem...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5323
更新日期：2014-07-11 00:00:00
abstract：:The impact of discontinuation of anti-VEGF cancer therapy in promoting cancer metastasis is unknown. Here we show discontinuation of anti-VEGF treatment creates a time-window of profound structural changes of liver sinusoidal vasculatures, exhibiting hyper-permeability and enlarged open-pore sizes of the fenestrated e...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms12680
更新日期：2016-09-01 00:00:00
abstract：:Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic mark...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5052
更新日期：2014-06-13 00:00:00
abstract：:Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19197-8
更新日期：2020-10-27 00:00:00
abstract：:Supported atomic clusters with uniform metal sites and definite low-nuclearity are intermediate states between single-atom catalysts (SACs) and nanoparticles in size. Benefiting from the presence of metal-metal bonds, supported atomic clusters can trigger synergistic effects among every metal atom, which contributes t...
journal_title：Nature communications
pub_type： 杂志文章,评审
doi：10.1038/s41467-020-19571-6
更新日期：2020-11-18 00:00:00
abstract：:Terephthalic acid (TPA) is an important industrial chemical currently produced by energy intensive and potentially hazardous p-xylene (pX) oxidation process. Here we report the development of metabolically engineered Escherichia coli system for biological transformation of pX into TPA. The engineered E. coli strain ha...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15689
更新日期：2017-05-31 00:00:00
abstract：:There has been much research on renewable energy-harvesting techniques. However, owing to increasing energy demands, significant energy-related issues remain to be solved. Efforts aimed at reducing the amount of energy loss in electric/electronic systems are essential for reducing energy consumption and protecting the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-03893-7
更新日期：2018-04-12 00:00:00
abstract：:Congenital Zika syndrome (CZS) causes early brain development impairment by affecting neural progenitor cells (NPCs). Here, we analyze NPCs from three pairs of dizygotic twins discordant for CZS. We compare by RNA-Seq the NPCs derived from CZS-affected and CZS-unaffected twins. Prior to Zika virus (ZIKV) infection the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02790-9
更新日期：2018-02-02 00:00:00
abstract：:Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine cell numbers prevents invasion of endothelial cells into the dee...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10219-8
更新日期：2019-06-06 00:00:00
abstract：:Shigella, the agent of bacillary dysentery, invades epithelial cells by locally inducing actin reorganization. Upon cell invasion, Shigella induces calcium (Ca(2+)) signalling, but its role in invasion has remained unclear. Here we show that components involved in inositol 1, 4, 5- trisphosphate (InsP3) signalling are...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2561
更新日期：2013-01-01 00:00:00
abstract：:Nonreciprocal microwave devices are ubiquitous in radar and radio communication and indispensable in the readout chains of superconducting quantum circuits. Since they commonly rely on ferrite materials requiring large magnetic fields that make them bulky and lossy, there has been significant interest in magnetic-fiel...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00447-1
更新日期：2017-09-19 00:00:00
abstract：:Bioluminescent organisms are likely to have an evolutionary drive towards high radiance. As such, bio-optimized materials derived from them hold great promise for photonic applications. Here, we show that biologically produced fluorescent proteins retain their high brightness even at the maximum density in solid state...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6722
更新日期：2014-12-08 00:00:00
abstract：:The original version of this Article contained errors in Fig. 3. In panel a, bars from a chart depicting the percentage of antibody-positive individuals in non-infectious and infectious groups were inadvertently included in place of bars depicting the percentage of infectious individuals, as described in the Article a...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-03769-w
更新日期：2018-04-11 00:00:00
