Abstract:
:Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international air travel has elevated the risk of re-introducing parasites to elimination areas and dispersing drug-resistant parasites to new regions. A simple genetic marker that quickly and accurately identifies the geographic origin of infections would be a valuable public health tool for locating the source of imported outbreaks. Here we analyse the mitochondrion and apicoplast genomes of 711 Plasmodium falciparum isolates from 14 countries, and find evidence that they are non-recombining and co-inherited. The high degree of linkage produces a panel of relatively few single-nucleotide polymorphisms (SNPs) that is geographically informative. We design a 23-SNP barcode that is highly predictive (~92%) and easily adapted to aid case management in the field and survey parasite migration worldwide.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Preston MD,Campino S,Assefa SA,Echeverry DF,Ocholla H,Amambua-Ngwa A,Stewart LB,Conway DJ,Borrmann S,Michon P,Zongo I,Ouédraogo JB,Djimde AA,Doumbo OK,Nosten F,Pain A,Bousema T,Drakeley CJ,Fairhurst RM,Sutherland CJdoi
10.1038/ncomms5052subject
Has Abstractpub_date
2014-06-13 00:00:00pages
4052issn
2041-1723pii
ncomms5052journal_volume
5pub_type
杂志文章abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17712-5
更新日期:2020-07-27 00:00:00
abstract::The impact of liquid drops on solid surfaces is ubiquitous in nature, and of practical importance in many industrial processes. A drop hitting a flat surface retains a circular symmetry throughout the impact process. Here we show that a drop impinging on Echevaria leaves exhibits asymmetric bouncing dynamics with dist...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10034
更新日期:2015-11-25 00:00:00
abstract::Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific metabolic changes remains unclear. Here we show, using the comprehensive measurement of metabolic enzymes by large-scale targeted proteomics, that the metabolism both carbon and nitrogen is altered during the malignant progression of ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-15136-9
更新日期:2020-03-17 00:00:00
abstract::The original version of this Article contained an error in Fig. 2f, in which the phospholipid was incorrectly labelled 'PE' rather than the correct 'PC'. This has now been corrected in the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-019-08907-6
更新日期:2019-02-19 00:00:00
abstract::The immunogenic heat shock proteins (HSPs) gp96, hsp70 and calreticulin (CRT) bind to CD91 on antigen-presenting cells (APCs) for cross-presentation of the HSP-chaperoned peptides. This event leads to priming of T-cell responses. Here we show that CD91 serves as a signalling receptor for these HSPs, allowing for the m...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1524
更新日期:2011-11-01 00:00:00
abstract::Many applications proposed for graphene require multiple sheets be assembled into a monolithic structure. The ability to maintain structural integrity upon large deformation is essential to ensure a macroscopic material which functions reliably. However, it has remained a great challenge to achieve high elasticity in ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2251
更新日期:2012-01-01 00:00:00
abstract::Crucial steps in the miniaturisation of biosensors are the conversion of a biological signal into an electrical current as well as the direct sampling of bodily fluids. Here we show that protein sensors in combination with a nanopore, acting as an electrical transducer, can accurately quantify metabolites in real time...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06534-1
更新日期:2018-10-05 00:00:00
abstract::Peptide-major histocompatibility complex class II (pMHCII)-based nanomedicines displaying tissue-specific autoantigenic epitopes can blunt specific autoimmune conditions by re-programming cognate antigen-experienced CD4+ T-cells into disease-suppressing T-regulatory type 1 (TR1) cells. Here, we show that single pMHCII...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09893-5
更新日期:2019-05-14 00:00:00
abstract::Innovations in soft material synthesis and fabrication technologies have led to the development of integrated soft electronic devices. Such soft devices offer opportunities to interact with biological cells, mimicking their soft environment. However, existing fabrication technologies cannot create the submicron-scale,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14814-y
更新日期:2020-02-21 00:00:00
abstract::Hydroarylation is an environmentally attractive strategy which incorporates all of the atoms contained in the substrates into the desired products. Almost all the hydroarylations of norbornene reported to date involve an exo-selective reaction. Here we show the endo-selective hydroarylation of norbornene in the Rh(I)-...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01531-2
更新日期:2017-11-13 00:00:00
abstract::Field-effect transistors based on carbon nanotubes have been shown to be faster and less energy consuming than their silicon counterparts. However, ensuring these advantages are maintained for integrated circuits is a challenge. Here we demonstrate that a significant reduction in the use of field-effect transistors ca...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1682
更新日期:2012-02-14 00:00:00
abstract::Single impurities with nonzero spin and multiple ground states offer a degree of freedom that can be utilized to store the quantum information. However, Fe(2+) dopant is known for having a single nondegenerate ground state in the bulk host semiconductors and thus is of little use for spintronic applications. Here we s...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10484
更新日期:2016-01-28 00:00:00
abstract::We demonstrate a method based on symmetry to predict the structure of self-assembling, multicomponent colloidal mixtures. This method allows us to feasibly enumerate candidate structures from all symmetry groups and is many orders of magnitude more computationally efficient than combinatorial enumeration of these cand...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10031-4
更新日期:2019-05-02 00:00:00
abstract::Plant hormone cytokinins are perceived by a subfamily of sensor histidine kinases (HKs), which via a two-component phosphorelay cascade activate transcriptional responses in the nucleus. Subcellular localization of the receptors proposed the endoplasmic reticulum (ER) membrane as a principal cytokinin perception site,...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-17949-0
更新日期:2020-08-27 00:00:00
abstract::Given the limited availability of serological testing to date, the seroprevalence of SARS-CoV-2-specific antibodies in different populations has remained unclear. Here, we report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seroreactivity was 0.26% in 387 hospitalized patients admitted...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18468-8
更新日期:2020-09-17 00:00:00
abstract::Topological defects in matter behave collectively to form highly non-trivial structures called topological textures that are characterised by conserved quantities such as the winding number. Here we show that an epitaxial ferroelectric square nanoplate of bismuth ferrite subjected to a large strain gradient (as much a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-02813-5
更新日期:2018-01-26 00:00:00
abstract::Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populations retaining or l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12685
更新日期:2016-09-02 00:00:00
abstract::The Earth's sole active carbonatite volcano, Oldoinyo Lengai (Tanzania), is presently erupting unique natrocarbonatite lavas that are characterized by Na- and K-bearing magmatic carbonates of nyerereite [Na2Ca(CO3)2] and gregoryite [(Na2,K2,Ca)CO3]. Contrarily, the vast majority of older, plutonic carbonatite occurren...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3687
更新日期:2013-01-01 00:00:00
abstract::Strategies involving metastable phases have been the basis of the design of numerous alloys, yet research on metastable high-entropy alloys is still in its infancy. In dual-phase high-entropy alloys, the combination of local chemical environments and loading-induced crystal structure changes suggests a relationship be...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-14641-1
更新日期:2020-02-11 00:00:00
abstract::The damming of rivers represents one of the most far-reaching human modifications of the flows of water and associated matter from land to sea. Dam reservoirs are hotspots of sediment accumulation, primary productivity (P) and carbon mineralization (R) along the river continuum. Here we show that for the period 1970-2...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms15347
更新日期:2017-05-17 00:00:00
abstract::Transition-metal dissolution from cathode materials, manganese in particular, has been held responsible for severe capacity fading in lithium-ion batteries, with the deposition of the transition-metal cations on anode surface, in elemental form or as chelated-complexes, as the main contributor for such degradations. I...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-11439-8
更新日期:2019-07-31 00:00:00
abstract::New exotic phenomena have recently been discovered in oxides of paramagnetic Ir(4+) ions, widely known as 'iridates'. Their remarkable properties originate from concerted effects of the crystal field, magnetic interactions and strong spin-orbit coupling, characteristic of 5d metal ions. Despite numerous experimental r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12195
更新日期:2016-07-20 00:00:00
abstract::Range expansions are central to two ecological issues reshaping patterns of global biodiversity: biological invasions and climate change. Traditional theory considers range expansion as the outcome of the demographic processes of birth, death and dispersal, while ignoring the evolutionary implications of such processe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14303
更新日期:2017-01-27 00:00:00
abstract::The original version of this Article omitted the Received and Accepted dates; they should have been 22nd January 2018 and 19th April 2018, respectively. This has been corrected in the PDF and HTML versions of the Article. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-018-04902-5
更新日期:2018-06-13 00:00:00
abstract::The relationships of passerines (such as the well-studied zebra finch) with non-passerine birds is one of the great enigmas of avian phylogenetic research, because decades of extensive morphological and molecular studies yielded highly inconsistent results between and within data sets. Here we show the first applicati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1448
更新日期:2011-08-23 00:00:00
abstract::Antimicrobial resistance is a global public health concern, and livestock play a significant role in selecting for resistance and maintaining such reservoirs. Here we study the succession of dairy cattle resistome during early life using metagenomic sequencing, as well as the relationship between resistome, gut microb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12111-x
更新日期:2019-09-27 00:00:00
abstract::Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms2204
更新日期:2012-01-01 00:00:00
abstract::Bismuth chalcogenides and lead telluride/selenide alloys exhibit exceptional thermoelectric properties that could be harnessed for power generation and device applications. Since phonons play a significant role in achieving these desired properties, quantifying the interaction between phonons and electrons, which is e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms7559
更新日期:2015-03-27 00:00:00
abstract::Berry phase associated with energy bands in crystals can lead to quantised observables like quantised dipole polarizations in one-dimensional topological insulators. Recent theories have generalised the concept of quantised dipoles to multipoles, resulting in the discovery of multipole topological insulators which exh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-16350-1
更新日期:2020-05-15 00:00:00
abstract::Cholesterol is a key component of cell membranes with a proven modulatory role on the function and ligand-binding properties of G-protein-coupled receptors (GPCRs). Crystal structures of prototypical GPCRs such as the adenosine A2A receptor (A2AR) have confirmed that cholesterol finds stable binding sites at the recep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14505
更新日期:2017-02-21 00:00:00