Abstract：
:The relationships of passerines (such as the well-studied zebra finch) with non-passerine birds is one of the great enigmas of avian phylogenetic research, because decades of extensive morphological and molecular studies yielded highly inconsistent results between and within data sets. Here we show the first application of the virtually homoplasy-free retroposon insertions to this controversy. Our study examined ~200,000 retroposon-containing loci from various avian genomes and retrieved 51 markers resolving early bird phylogeny. Among these, we obtained statistically significant evidence that parrots are the closest and falcons the second-closest relatives of passerines, together constituting the Psittacopasserae and the Eufalconimorphae, respectively. Our new and robust phylogenetic framework has substantial implications for the interpretation of various conclusions drawn from passerines as model organisms. This includes insights of relevance to human neuroscience, as vocal learning (that is, birdsong) probably evolved in the psittacopasseran ancestor, >30 million years earlier than previously assumed.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Suh A,Paus M,Kiefmann M,Churakov G,Franke FA,Brosius J,Kriegs JO,Schmitz Jdoi
10.1038/ncomms1448subject
Has Abstractpub_date
2011-08-23 00:00:00pages
443issn
2041-1723pii
ncomms1448journal_volume
2pub_type
杂志文章abstract：:Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, predictors of response to CTLA-4 and/or PD-1 blockade represent unmet clinical needs. Using a systems biology-...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00608-2
更新日期：2017-09-19 00:00:00
abstract：:Many drugs bind to and activate human pregnane X receptor (hPXR) to upregulate drug-metabolizing enzymes, resulting in decreased drug efficacy and increased resistance. This suggests that hPXR antagonists have therapeutic value. Here we report that SPA70 is a potent and selective hPXR antagonist. SPA70 inhibits hPXR i...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00780-5
更新日期：2017-09-29 00:00:00
abstract：:The photons in circularly polarized light can transfer their quantized spin angular momentum to micro- and nanostructures via absorption and scattering. This normally exerts positive torque on the objects wher the sign (i.e., handedness or angular direction) follows that of the spin angular momentum. Here we show that...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-07376-7
更新日期：2018-11-20 00:00:00
abstract：:Zinc finger E-box binding homeobox 1 (Zeb1) has been demonstrated to participate in the acquisition of the properties of cancer stem cells (CSCs). However, it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1 expression. Here, we show that Zeb1 depletion suppresses stemne...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18860-4
更新日期：2020-10-12 00:00:00
abstract：:Mineralisation of calcium phosphates in bone has been proposed to proceed via an initial amorphous precursor phase which transforms into nanocrystalline, carbonated hydroxyapatite. While calcium phosphates have been under intense investigation, the exact steps during the crystallisation of spherical amorphous particle...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06570-x
更新日期：2018-10-09 00:00:00
abstract：:Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timescale. However, it ha...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms2204
更新日期：2012-01-01 00:00:00
abstract：:Spin-orbit torque has recently been intensively investigated for the purposes of manipulating the magnetization in magnetic nano-devices and understanding fundamental physics. Therefore, the search for novel materials or material combinations that exhibit a strong enough spin-torque effect has become one of the top pr...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06518-1
更新日期：2018-09-28 00:00:00
abstract：:Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10461
更新日期：2016-02-15 00:00:00
abstract：:The efficiencies of perovskite solar cells (PSCs) are now reaching such consistently high levels that scalable manufacturing at low cost is becoming critical. However, this remains challenging due to the expensive hole-transporting materials usually employed, and difficulties associated with the scalable deposition of...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04028-8
更新日期：2018-04-24 00:00:00
abstract：:The microtubule-associated protein Tau plays a central role in the pathogenesis of Alzheimer's disease. Although Tau interaction with membranes is thought to affect some of its physiological functions and its aggregation properties, the sequence determinants and the structural and functional consequences of such inter...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01575-4
更新日期：2017-11-22 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-020-17055-1
更新日期：2020-07-06 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature communications
pub_type： 已发布勘误
doi：10.1038/s41467-019-13138-w
更新日期：2019-11-22 00:00:00
abstract：:The original version of this Article contained an error in the spelling of the author Álvaro Sebastián-Serrano, which was incorrectly given as Álvaro Sebastián Serrano. This has now been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-03022-4
更新日期：2018-01-30 00:00:00
abstract：:Overexpression of a drug's molecular target often increases drug resistance, offering a pathway for adaptive evolution and a tool for target identification. It is unclear though why this phenomenon applies to some drugs but not others. Here we gradually overexpressed antibiotic targets in Escherichia coli and found th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5296
更新日期：2014-07-01 00:00:00
abstract：:Modern beam shaping techniques have enabled the generation of optical fields displaying a wealth of structural features, which include three-dimensional topologies such as Möbius, ribbon strips and knots. However, unlike simpler types of structured light, the topological properties of these optical fields have hithert...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18792-z
更新日期：2020-10-09 00:00:00
abstract：:A variety of flexible and stretchable electronics have been reported for use in flexible electronic devices or biomedical applications. The practical and wider application of such flexible electronics has been limited because commercial electronic components are difficult to be directly integrated into flexible stretc...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1980
更新日期：2012-01-01 00:00:00
abstract：:Although the amyloid β-protein (Aβ) is believed to play an initiating role in Alzheimer's disease (AD), the molecular characteristics of the key pathogenic Aβ forms are not well understood. As a result, it has proved difficult to identify optimal agents that target disease-relevant forms of Aβ. Here, we combined the u...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05068-w
更新日期：2018-07-11 00:00:00
abstract：:The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA. The mechanistic details of the initiation and early stages of capsid assembly remain to be delineated. We present coarse-grai...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11568
更新日期：2016-05-13 00:00:00
abstract：:Vortices play a crucial role in determining the properties of superconductors as well as their applications. Therefore, characterization and manipulation of vortices, especially at the single-vortex level, is of great importance. Among many techniques to study single vortices, scanning tunnelling microscopy (STM) stan...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms13880
更新日期：2016-12-09 00:00:00
abstract：:Semiconductor-based surface-enhanced Raman spectroscopy (SERS) substrates represent a new frontier in the field of SERS. However, the application of semiconductor materials as SERS substrates is still seriously impeded by their low SERS enhancement and inferior detection sensitivity, especially for non-metal-oxide sem...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-02166-z
更新日期：2017-12-08 00:00:00
abstract：:FBXW2 inhibits proliferation of lung cancer cells by targeting SKP2 for degradation. Whether and how FBXW2 regulates tumor invasion and metastasis is previously unknown. Here, we report that FBXW2 is an E3 ligase for β-catenin. FBXW2 binds to β-catenin upon EGF-AKT1-mediated phosphorylation on Ser552, and promotes its...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-09289-5
更新日期：2019-03-27 00:00:00
abstract：:Respiration by soil bacteria and fungi is one of the largest fluxes of carbon (C) from the land surface. Although this flux is a direct product of microbial metabolism, controls over metabolism and their responses to global change are a major uncertainty in the global C cycle. Here, we explore an in silico approach to...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-11488-z
更新日期：2019-08-08 00:00:00
abstract：:To colonise their host, pathogens must counter local environmental and immunological challenges. Here, we reveal that the fungal pathogen Candida albicans exploits diverse host-associated signals to promote immune evasion by masking of a major pathogen-associated molecular pattern (PAMP), β-glucan. Certain nutrients, ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13298-9
更新日期：2019-11-22 00:00:00
abstract：:Systems allowing label-free molecular detection are expected to have enormous impact on biochemical sciences. Research focuses on materials and technologies based on exploiting localized surface plasmon resonances in metallic nanostructures. The reason for this focused attention is their suitability for single-molecul...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms7150
更新日期：2015-02-02 00:00:00
abstract：:Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterized p...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms16065
更新日期：2017-07-19 00:00:00
abstract：:Motile plant structures such as Mimosa pudica leaves, Impatiens glandulifera seedpods, and Dionaea muscipula leaves exhibit fast nastic movements in a few seconds or less. This motion is stimuli-independent mechanical movement following theorema egregium rules. Artificial analogs of tropistic motion in plants are exem...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20843-4
更新日期：2021-01-21 00:00:00
abstract：:Using asymmetric catalysis to simultaneously form carbon-carbon bonds and generate single isomer products is strategically important. Suzuki-Miyaura cross-coupling is widely used in the academic and industrial sectors to synthesize drugs, agrochemicals and biologically active and advanced materials. However, widely ap...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15762
更新日期：2017-06-13 00:00:00
abstract：:Sponges (phylum Porifera) are early-diverging metazoa renowned for establishing complex microbial symbioses. Here we present a global Porifera microbiome survey, set out to establish the ecological and evolutionary drivers of these host-microbe interactions. We show that sponges are a reservoir of exceptional microbia...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms11870
更新日期：2016-06-16 00:00:00
abstract：:With damage tolerance rivalling advanced engineering alloys and thermoplastic forming capabilities analogous to conventional plastics, metallic glasses are emerging as a modern engineering material. Here, we take advantage of their unique electrical and rheological properties along with the classic Lorentz force conce...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10576
更新日期：2016-02-08 00:00:00
abstract：:Thermal melanism theory states that dark-colored ectotherm organisms are at an advantage at low temperature due to increased warming. This theory is generally supported for ectotherm animals, however, the function of colors in the fungal kingdom is largely unknown. Here, we test whether the color lightness of mushroom...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-10767-z
更新日期：2019-06-28 00:00:00
