Abstract：
:Generation of periodic patterns is fundamental to the differentiation of multiple tissues during development. How such patterns form robustly is still unclear. The Drosophila eye comprises ∼750 units, whose crystalline order is set during differentiation of the eye imaginal disc: an activation wave sweeping across the disc is coupled to lateral inhibition, sequentially selecting pro-neural cells. Using mathematical modelling, here we show that this template-based lateral inhibition is highly sensitive to spatial variations in biochemical parameters and cell sizes. We reveal the basis of this sensitivity, and suggest that it can be overcome by assuming a short-range diffusible activator. Clonal experiments identify Scabrous, a previously implicated inhibitor, as the predicted activator. Our results reveal the mechanism by which periodic patterning in the fly eye is stabilized against spatial variations, highlighting how the need to maintain robustness shapes the design of patterning circuits.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Gavish A,Shwartz A,Weizman A,Schejter E,Shilo BZ,Barkai Ndoi
10.1038/ncomms10461subject
Has Abstractpub_date
2016-02-15 00:00:00pages
10461issn
2041-1723pii
ncomms10461journal_volume
7pub_type
杂志文章abstract：:Spontaneous molecular oscillations are ubiquitous in biology. But to our knowledge, periodic cell migratory patterns have not been observed. Here we report the highly regular, periodic migration of cells along rectilinear tracks generated inside three-dimensional matrices, with each excursion encompassing several cell...
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更新日期：2015-03-03 00:00:00
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更新日期：2012-05-01 00:00:00
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更新日期：2018-11-27 00:00:00
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更新日期：2017-05-16 00:00:00
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更新日期：2014-10-21 00:00:00
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更新日期：2018-07-02 00:00:00
abstract：:In certain regions of the predominantly nitrogen limited ocean, microbes can become co-limited by phosphorus. Within such regions, a proportion of the dissolved organic phosphorus pool can be accessed by microbes employing a variety of alkaline phosphatase (APase) enzymes. In contrast to the PhoA family of APases that...
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doi：10.1038/ncomms15465
更新日期：2017-05-19 00:00:00
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更新日期：2016-08-19 00:00:00
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更新日期：2018-02-12 00:00:00
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doi：10.1038/ncomms15589
更新日期：2017-06-08 00:00:00
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doi：10.1038/ncomms4669
更新日期：2014-05-14 00:00:00
abstract：:Nonsyndromic cleft lip with or without a cleft palate (NSCL/P) is among the most common human congenital birth defects and imposes a substantial physical and financial burden on affected individuals. Here, we conduct a case-control-based GWAS followed by two rounds of replication; we include six independent cohorts fr...
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pub_type： 杂志文章,meta分析
doi：10.1038/ncomms7414
更新日期：2015-03-16 00:00:00
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更新日期：2015-09-29 00:00:00
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更新日期：2014-01-01 00:00:00
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更新日期：2018-12-21 00:00:00
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更新日期：2016-10-04 00:00:00
abstract：:Over the last century the North Anatolian Fault Zone in Turkey has produced a remarkable sequence of large earthquakes. These events have now left an earthquake gap south of Istanbul and beneath the Marmara Sea, a gap that has not been filled for 250 years. Here we investigate the nature of the eastern end of this gap...
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更新日期：2013-01-01 00:00:00
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更新日期：2018-08-17 00:00:00
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更新日期：2014-09-17 00:00:00
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更新日期：2019-07-19 00:00:00
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更新日期：2014-09-02 00:00:00
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更新日期：2018-09-21 00:00:00
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更新日期：2016-08-26 00:00:00
