Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.

abstract：:Fluorescence imaging in the second near-infrared window (NIR-II) allows visualization of deep anatomical features with an unprecedented degree of clarity. NIR-II fluorophores draw from a broad spectrum of materials spanning semiconducting nanomaterials to organic molecular dyes, yet unfortunately all water-soluble org...

journal_title：Nature communications

authors： Antaris AL,Chen H,Diao S,Ma Z,Zhang Z,Zhu S,Wang J,Lozano AX,Fan Q,Chew L,Zhu M,Cheng K,Hong X,Dai H,Cheng Z

更新日期：2017-05-19 00:00:00

abstract：:Transmission-blocking interventions aim to reduce the prevalence of infection in endemic communities by targeting Plasmodium within the insect host. Although many studies have reported the successful reduction of infection in the mosquito vector, direct evidence that there is an onward reduction in infection in the ve...

journal_title：Nature communications

authors： Blagborough AM,Churcher TS,Upton LM,Ghani AC,Gething PW,Sinden RE

更新日期：2013-01-01 00:00:00

abstract：:Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein...

journal_title：Nature communications

authors： Schulte L,Mao J,Reitz J,Sreeramulu S,Kudlinzki D,Hodirnau VV,Meier-Credo J,Saxena K,Buhr F,Langer JD,Blackledge M,Frangakis AS,Glaubitz C,Schwalbe H

更新日期：2020-11-04 00:00:00

abstract：:Layer 5 (L5) cortical projection neurons innervate far-ranging brain areas to coordinate integrative sensory processing and adaptive behaviors. Here, we characterize a plasticity in L5 auditory cortex (ACtx) neurons that innervate the inferior colliculus (IC), thalamus, lateral amygdala and striatum. We track daily ch...

journal_title：Nature communications

authors： Asokan MM,Williamson RS,Hancock KE,Polley DB

更新日期：2018-06-25 00:00:00

abstract：:Synthetic DNA-based data storage systems have received significant attention due to the promise of ultrahigh storage density and long-term stability. However, all known platforms suffer from high cost, read-write latency and error-rates that render them noncompetitive with modern storage devices. One means to avoid th...

journal_title：Nature communications

authors： Tabatabaei SK,Wang B,Athreya NBM,Enghiad B,Hernandez AG,Fields CJ,Leburton JP,Soloveichik D,Zhao H,Milenkovic O

更新日期：2020-04-08 00:00:00

abstract：:Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify...

journal_title：Nature communications

authors： Hiraoka Y,Matsuoka T,Ohno M,Nakamura K,Saijo S,Matsumura S,Nishi K,Sakamoto J,Chen PM,Inoue K,Fushiki T,Kita T,Kimura T,Nishi E

更新日期：2014-01-01 00:00:00

abstract：:Bone tissue, by definition, is an organic-inorganic nanocomposite, where metabolically active cells are embedded within a matrix that is heavily calcified on the nanoscale. Currently, there are no strategies that replicate these definitive characteristics of bone tissue. Here we describe a biomimetic approach where a ...

journal_title：Nature communications

authors： Thrivikraman G,Athirasala A,Gordon R,Zhang L,Bergan R,Keene DR,Jones JM,Xie H,Chen Z,Tao J,Wingender B,Gower L,Ferracane JL,Bertassoni LE

更新日期：2019-08-06 00:00:00

abstract：:Impaired function in the medial prefrontal cortex (mPFC) contributes to depression, and the therapeutic response produced by novel rapid-acting antidepressants such as ketamine are mediated by mPFC activity. The mPFC contains multiple types of pyramidal cells, but it is unclear whether a particular subtype mediates th...

journal_title：Nature communications

authors： Hare BD,Shinohara R,Liu RJ,Pothula S,DiLeone RJ,Duman RS

更新日期：2019-01-15 00:00:00

abstract：:Liquids cooled towards the glass transition temperature transform into amorphous solids that have a wide range of applications. While the nature of this transformation is understood rigorously in the mean-field limit of infinite spatial dimensions, the problem remains wide open in physical dimensions. Nontrivial finit...

journal_title：Nature communications

authors： Berthier L,Charbonneau P,Ninarello A,Ozawa M,Yaida S

更新日期：2019-04-03 00:00:00

abstract：:Inflammation and thrombosis occur together in many diseases. The leukocyte integrin Mac-1 (also known as integrin αMβ2, or CD11b/CD18) is crucial for leukocyte recruitment to the endothelium, and Mac-1 engagement of platelet GPIbα is required for injury responses in diverse disease models. However, the role of Mac-1 i...

journal_title：Nature communications

authors： Wang Y,Gao H,Shi C,Erhardt PW,Pavlovsky A,A Soloviev D,Bledzka K,Ustinov V,Zhu L,Qin J,Munday AD,Lopez J,Plow E,Simon DI

更新日期：2017-05-30 00:00:00

abstract：:Main group elements usually assume a typical oxidation state while forming compounds with other species. Group I elements are usually in the +1 state in inorganic materials. Our recent work reveals that pressure may make the inner shell 5p electrons of Cs reactive, causing Cs to expand beyond the +1 oxidation state. H...

journal_title：Nature communications

authors： Botana J,Miao MS

更新日期：2014-09-10 00:00:00

abstract：:Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of chromatin accessibility and gene expression with ultra-low input of cells, and map the chromatin accessibility an...

journal_title：Nature communications

authors： Liu L,Leng L,Liu C,Lu C,Yuan Y,Wu L,Gong F,Zhang S,Wei X,Wang M,Zhao L,Hu L,Wang J,Yang H,Zhu S,Chen F,Lu G,Shang Z,Lin G

更新日期：2019-01-21 00:00:00

abstract：:Van der Waals materials and heterostructures that manifest strongly bound exciton states at room temperature also exhibit emergent physical phenomena and are of great promise for optoelectronic applications. Here, we demonstrate that nanostructured, multilayer transition metal dichalcogenides (TMDCs) by themselves pro...

journal_title：Nature communications

authors： Zhang H,Abhiraman B,Zhang Q,Miao J,Jo K,Roccasecca S,Knight MW,Davoyan AR,Jariwala D

更新日期：2020-07-15 00:00:00

abstract：:Although a hydrophobic microtexture at a solid surface most often reflects rain owing to the presence of entrapped air within the texture, it is much more challenging to repel hot water. As it contacts a colder material, hot water generates condensation within the cavities at the solid surface, which eventually builds...

journal_title：Nature communications

authors： Mouterde T,Lecointre P,Lehoucq G,Checco A,Clanet C,Quéré D

更新日期：2019-03-29 00:00:00

abstract：:Stacking faults are known as defective structures in crystalline materials that typically lower the structural quality of the material. Here, we show that a particular type of defect, that is, stacking fault tetrahedra (SFTs), exhibits pronounced quantized electronic behaviour, revealing a potential synthetic route to...

journal_title：Nature communications

authors： Schouteden K,Amin-Ahmadi B,Li Z,Muzychenko D,Schryvers D,Van Haesendonck C

更新日期：2016-12-23 00:00:00

abstract：:APOBEC3A is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells. While the APOBEC3A-induced vulnerability of cancers offers an opportunity for therapy, APOBEC3A protein and mRNA are difficult to quantify in tumors due to their low abundance. Here, we describe a quantitative ...

journal_title：Nature communications

authors： Jalili P,Bowen D,Langenbucher A,Park S,Aguirre K,Corcoran RB,Fleischman AG,Lawrence MS,Zou L,Buisson R

更新日期：2020-06-12 00:00:00

abstract：:Base editors (BEs) are RNA-guided CRISPR-Cas-derived genome editing tools that induce single-nucleotide changes. The limitations of current BEs lie in their low precision (especially when multiple target nucleotides of the deaminase are present within the activity window) and their restriction to targets that are in p...

journal_title：Nature communications

authors： Tan J,Zhang F,Karcher D,Bock R

更新日期：2020-01-31 00:00:00

abstract：:Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of antibiotics and switching between them in ON/OFF manner. Using a multiplexe...

journal_title：Nature communications

authors： Yoshida M,Reyes SG,Tsuda S,Horinouchi T,Furusawa C,Cronin L

更新日期：2017-06-08 00:00:00

abstract：:Solar-driven photocatalysis has attracted significant attention in water splitting, CO2 reduction and organic synthesis. The syntheses of valuable azo- and azoxyaromatic dyes via selective photoreduction of nitroaromatic compounds have been realised using supported plasmonic metal nanoparticles at elevated temperature...

journal_title：Nature communications

authors： Dai Y,Li C,Shen Y,Lim T,Xu J,Li Y,Niemantsverdriet H,Besenbacher F,Lock N,Su R

更新日期：2018-01-04 00:00:00

abstract：:Land-atmosphere exchanges influence atmospheric CO2. Emphasis has been on describing photosynthetic CO2 uptake, but less on respiration losses. New global datasets describe upper canopy dark respiration (R d) and temperature dependencies. This allows characterisation of baseline R d, instantaneous temperature response...

journal_title：Nature communications

authors： Huntingford C,Atkin OK,Martinez-de la Torre A,Mercado LM,Heskel MA,Harper AB,Bloomfield KJ,O'Sullivan OS,Reich PB,Wythers KR,Butler EE,Chen M,Griffin KL,Meir P,Tjoelker MG,Turnbull MH,Sitch S,Wiltshire A,Malhi Y

更新日期：2017-11-17 00:00:00

abstract：:Understanding the structural biology of the insulin receptor and how it signals is of key importance in the development of insulin analogs to treat diabetes. We report here a cryo-electron microscopy structure of a single insulin bound to a physiologically relevant, high-affinity version of the receptor ectodomain, th...

journal_title：Nature communications

authors： Weis F,Menting JG,Margetts MB,Chan SJ,Xu Y,Tennagels N,Wohlfart P,Langer T,Müller CW,Dreyer MK,Lawrence MC

更新日期：2018-10-24 00:00:00

abstract：:The maturation of HIV-1 viral particles is essential for viral infectivity. During maturation, many copies of the capsid protein (CA) self-assemble into a capsid shell to enclose the viral RNA. The mechanistic details of the initiation and early stages of capsid assembly remain to be delineated. We present coarse-grai...

journal_title：Nature communications

authors： Grime JMA,Dama JF,Ganser-Pornillos BK,Woodward CL,Jensen GJ,Yeager M,Voth GA

更新日期：2016-05-13 00:00:00

abstract：:The energy band alignment in solar cell devices is critically important because it largely governs elementary photovoltaic processes, such as the generation, separation, transport, recombination and collection of charge carriers. Despite the expenditure of considerable effort, the measurement of energy band depth prof...

journal_title：Nature communications

authors： Chen Q,Mao L,Li Y,Kong T,Wu N,Ma C,Bai S,Jin Y,Wu D,Lu W,Wang B,Chen L

更新日期：2015-07-13 00:00:00

abstract：:Acanthamoeba are infected by a remarkable diversity of large dsDNA viruses, the infectious cycles of which have been characterized using genomics, transcriptomics and electron microscopy. Given their gene content and the persistence of the host nucleus throughout their infectious cycle, the Marseilleviridae were initi...

journal_title：Nature communications

authors： Fabre E,Jeudy S,Santini S,Legendre M,Trauchessec M,Couté Y,Claverie JM,Abergel C

更新日期：2017-04-21 00:00:00

abstract：:The use of graphene in electronic devices requires a band gap, which can be achieved by creating nanostructures such as graphene nanoribbons. A wide variety of atomically precise graphene nanoribbons can be prepared through on-surface synthesis, bringing the concept of graphene nanoribbon electronics closer to reality...

journal_title：Nature communications

authors： Jacobse PH,Kimouche A,Gebraad T,Ervasti MM,Thijssen JM,Liljeroth P,Swart I

更新日期：2017-07-25 00:00:00

abstract：:Chromosomal regions of identical or nearly identical DNA sequence can preferentially associate with one another in the apparent absence of DNA breakage. Molecular mechanism(s) underlying such homology-dependent pairing phenomena remain(s) unknown. Using Neurospora crassa repeat-induced point mutation (RIP) as a model ...

journal_title：Nature communications

authors： Gladyshev E,Kleckner N

更新日期：2014-04-03 00:00:00

abstract：:The anterior temporal lobes (ATL) have become a key brain region of interest in cognitive neuroscience founded upon neuropsychological investigations of semantic dementia (SD). The purposes of this investigation are to generate a single unified model that captures the known cognitive-behavioural variations in SD and m...

journal_title：Nature communications

authors： Ding J,Chen K,Liu H,Huang L,Chen Y,Lv Y,Yang Q,Guo Q,Han Z,Lambon Ralph MA

更新日期：2020-05-22 00:00:00

abstract：:Epigenetic annotation studies of genetic risk variants for multiple sclerosis (MS) implicate dysfunctional lymphocytes in MS susceptibility; however, the role of central nervous system (CNS) cells remains unclear. We investigated the effect of the risk variant, rs7665090G, located near NFKB1, on astrocytes. We demonst...

journal_title：Nature communications

authors： Ponath G,Lincoln MR,Levine-Ritterman M,Park C,Dahlawi S,Mubarak M,Sumida T,Airas L,Zhang S,Isitan C,Nguyen TD,Raine CS,Hafler DA,Pitt D

更新日期：2018-12-17 00:00:00

abstract：:Acute myeloid leukaemia (AML) affects children and adults of all ages. AML remains one of the major causes of death in children with cancer and for children with AML relapse is the most common cause of death. Here, by modelling AML in vivo we demonstrate that AML is discriminated by the age of the cell of origin. Youn...

journal_title：Nature communications

authors： Chaudhury S,O'Connor C,Cañete A,Bittencourt-Silvestre J,Sarrou E,Prendergast Á,Choi J,Johnston P,Wells CA,Gibson B,Keeshan K

更新日期：2018-12-11 00:00:00

abstract：:A major conundrum in climate science is how to account for dependence between climate models. This complicates interpretation of probabilistic projections derived from such models. Here we show that this problem can be addressed using a novel method to test multiple non-exclusive hypotheses, and to make predictions un...

journal_title：Nature communications

authors： Olson R,An SI,Fan Y,Chang W,Evans JP,Lee JY

更新日期：2019-07-09 00:00:00