Abstract:
:Body temperature homoeostasis in mammals is governed centrally through the regulation of shivering and non-shivering thermogenesis and cutaneous vasomotion. Non-shivering thermogenesis in brown adipose tissue (BAT) is mediated by sympathetic activation, followed by PGC-1α induction, which drives UCP1. Here we identify nardilysin (Nrd1 and NRDc) as a critical regulator of body temperature homoeostasis. Nrd1(-/-) mice show increased energy expenditure owing to enhanced BAT thermogenesis and hyperactivity. Despite these findings, Nrd1(-/-) mice show hypothermia and cold intolerance that are attributed to the lowered set point of body temperature, poor insulation and impaired cold-induced thermogenesis. Induction of β3-adrenergic receptor, PGC-1α and UCP1 in response to cold is severely impaired in the absence of NRDc. At the molecular level, NRDc and PGC-1α interact and co-localize at the UCP1 enhancer, where NRDc represses PGC-1α activity. These findings reveal a novel nuclear function of NRDc and provide important insights into the mechanism of thermoregulation.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Hiraoka Y,Matsuoka T,Ohno M,Nakamura K,Saijo S,Matsumura S,Nishi K,Sakamoto J,Chen PM,Inoue K,Fushiki T,Kita T,Kimura T,Nishi Edoi
10.1038/ncomms4224subject
Has Abstractpub_date
2014-01-01 00:00:00pages
3224issn
2041-1723pii
ncomms4224journal_volume
5pub_type
杂志文章abstract::Natural killer (NK) cells limit viral replication by direct recognition of infected cells, antibody-dependent cellular cytotoxicity (ADCC), and releasing cytokines. Although growing evidence supports NK cell antiviral immunity in HIV-1 infection, further knowledge of their response is necessary. Here we show that NK c...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03618-w
更新日期:2018-03-23 00:00:00
abstract::Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize fitness of all traits leading to a "master of all traits". The shape of trade-offs has been shown to determine evolutionary trajectories and is often assumed to be static and independent of the actual evolutionary process. Her...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-017-01957-8
更新日期:2017-12-12 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 杂志文章,已发布勘误
doi:10.1038/s41467-020-17555-0
更新日期:2020-07-28 00:00:00
abstract::The ventral striatum has long been proposed as an integrator of biologically significant associative information to drive actions. Although inputs from the amygdala and hippocampus have been much studied, the role of prominent inputs from orbitofrontal cortex (OFC) are less well understood. Here, we recorded single-un...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms8195
更新日期:2015-05-21 00:00:00
abstract::Symbiotic associations occur in every habitat on earth, but we know very little about their evolutionary histories. Current models of trait evolution cannot adequately reconstruct the deep history of symbiotic innovation, because they assume homogenous evolutionary processes across millions of years. Here we use a rec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5087
更新日期:2014-06-10 00:00:00
abstract::Isolators, or optical diodes, are devices enabling unidirectional light propagation by using non-reciprocal optical materials, namely materials able to break Lorentz reciprocity. The realization of isolators at terahertz frequencies is a very important open challenge made difficult by the intrinsically lossy propagati...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms11216
更新日期:2016-04-06 00:00:00
abstract::Maintenance of working memory is thought to involve the activity of prefrontal neuronal populations with strong recurrent connections. However, it was recently shown that distractors evoke a morphing of the prefrontal population code, even when memories are maintained throughout the delay. How can a morphing code main...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-12841-y
更新日期:2019-11-01 00:00:00
abstract::Natural killer (NK) cells are reported to have immunological memory, with CD49a+ liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7Rα, are generated in the l...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-07405-5
更新日期:2018-11-19 00:00:00
abstract::From intracellular protein trafficking to large-scale motion of animal groups, the physical concepts driving the self-organization of living systems are still largely unraveled. Self-organization of active entities, leading to novel phases and emergent macroscopic properties, recently shed new light on these complex d...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-13031-6
更新日期:2019-11-08 00:00:00
abstract::Many microorganisms, with phytoplankton and zooplankton as prominent examples, display phototactic behaviour, that is, the ability to perform directed motion within a light gradient. Here we experimentally demonstrate that sensing of light gradients can also be achieved in a system of synthetic photo-activated micropa...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms12828
更新日期:2016-09-30 00:00:00
abstract::Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here we describe time-course single-cell-transcriptomic analysis of develop...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-021-20892-3
更新日期:2021-01-28 00:00:00
abstract::Turning graphene magnetic is a promising challenge to make it an active material for spintronics. Predictions state that graphene structures with specific shapes can spontaneously develop magnetism driven by Coulomb repulsion of π-electrons, but its experimental verification is demanding. Here, we report on the observ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-08060-6
更新日期:2019-01-14 00:00:00
abstract::Proteins are co-translationally inserted into the bacterial plasma membrane via the SecYEG translocon by lateral release of hydrophobic transmembrane segments into the phospholipid bilayer. The trigger for lateral opening of the translocon is not known. Here we monitor lateral opening by photo-induced electron transfe...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms6263
更新日期:2014-10-15 00:00:00
abstract::Plant diseases caused by fungi and oomycetes pose an increasing threat to food security and ecosystem health worldwide. These filamentous pathogens, while taxonomically distinct, modulate host defense responses by secreting effectors, which are typically identified based on the presence of signal peptides. Here we sho...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5686
更新日期:2014-08-26 00:00:00
abstract::The midge, Belgica antarctica, is the only insect endemic to Antarctica, and thus it offers a powerful model for probing responses to extreme temperatures, freeze tolerance, dehydration, osmotic stress, ultraviolet radiation and other forms of environmental stress. Here we present the first genome assembly of an extre...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms5611
更新日期:2014-08-12 00:00:00
abstract::The effective delivery of therapeutics to disease sites significantly contributes to drug efficacy, toxicity and clearance. Here we demonstrate that clinically approved iron oxide nanoparticles (Ferumoxytol) can be utilized to carry one or multiple drugs. These so called 'nanophores' retain their cargo within their po...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4384
更新日期:2014-03-04 00:00:00
abstract::It is unclear why atmospheric oxygen remained trapped at low levels for more than 1.5 billion years following the Paleoproterozoic Great Oxidation Event. Here, we use models for erosion, weathering and biogeochemical cycling to show that this can be explained by the tectonic recycling of previously accumulated sedimen...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms14379
更新日期:2017-02-02 00:00:00
abstract::G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity-a measure ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-02868-y
更新日期:2018-02-28 00:00:00
abstract::The proton-activated sodium channel ASIC1 belongs to the ENaC/Degenerins family of ion channels. Little is known about gating of the pore in any member of this class. Here we outline the shape of the ion pathway of ASIC1 in the open and closed conformations by measuring apparent rates of cysteine modification by thiol...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1409
更新日期:2011-07-19 00:00:00
abstract::Long-range chromosomal interactions bring distal regulatory elements and promoters together to regulate gene expression in biological processes. By performing promoter capture Hi-C (PCHi-C) on human embryonic stem cell-derived cardiomyocytes (hESC-CMs), we show that such promoter interactions are a key mechanism by wh...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-04931-0
更新日期:2018-06-28 00:00:00
abstract::The central issues for understanding iron (Fe)-based superconductors are the symmetry and structure of the superconducting gap. So far the experimental data and theoretical models have been highly controversial. Some experiments favor two or more constant or nearly constant gaps, others indicate strong anisotropy and ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms1115
更新日期:2010-11-16 00:00:00
abstract::The contrast and sensitivity of in vivo fluorescence imaging has been revolutionized by molecular fluorophores operating in the second near-infrared window (NIR-II; 1000-1700 nm), but an ongoing challenge is the solvatochromism-caused quenching in aqueous solution for the long-wavelength absorbing fluorophores. Herein...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-09043-x
更新日期:2019-03-05 00:00:00
abstract::Non-pial neocortical astrocytes have historically been thought to comprise largely a nondiverse population of protoplasmic astrocytes. Here we show that astrocytes of the mouse somatosensory cortex manifest layer-specific morphological and molecular differences. Two- and three-dimensional observations revealed that as...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-03940-3
更新日期:2018-04-24 00:00:00
abstract::Although chemically very simple, Fe2O3 is known to undergo a series of enigmatic structural, electronic and magnetic transformations at high pressures and high temperatures. So far, these transformations have neither been correctly described nor understood because of the lack of structural data. Here we report a syste...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms10661
更新日期:2016-02-11 00:00:00
abstract::Eumelanin is a ubiquitous biological pigment, and the origin of its broadband absorption spectrum has long been a topic of scientific debate. Here, we report a first-principles computational investigation to explain its broadband absorption feature. These computations are complemented by experimental results showing a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms4859
更新日期:2014-05-22 00:00:00
abstract::Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly understood. Many dis...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-10355-1
更新日期:2019-06-07 00:00:00
abstract::Both basal ganglia (BG) and orbitofrontal cortex (OFC) have been widely implicated in social and non-social decision-making. However, unlike OFC damage, BG pathology is not typically associated with disturbances in social functioning. Here we studied the behavior of patients with focal lesions to either BG or OFC in a...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-019-08766-1
更新日期:2019-02-18 00:00:00
abstract::Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, here we identify PWW...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06235-9
更新日期:2018-09-18 00:00:00
abstract::Researchers strive to produce nanoparticles with complexity in composition and structure. Although traditional spherical, cylindrical and membranous, or planar, nanostructures are ubiquitous, scientists seek more complicated geometries for potential functionality. Here we report the simple solution construction of mul...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/ncomms3297
更新日期:2013-01-01 00:00:00
abstract::Large-scale genomic data highlight the complexity and diversity of the molecular changes that drive cancer progression. Statistical analysis of cancer data from different tissues can guide drug repositioning as well as the design of targeted treatments. Here, we develop an improved Bayesian network model for tumour mu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-018-06867-x
更新日期:2018-10-19 00:00:00